Vulva development in Caenorhabditis elegans here is the simplest way to understand the development of the vulva in C.elegans hope you will find in intresting plz do coment like it and share it

1. Caenorhabditis elegans
Valva development

2. Caenorhabditis elegans is a free-living
(not parasitic), transparent nematode(roundworm),
about 1mm in length, that lives in temperate soil
environments.

3. Valva development

4. Most C. elegans worms are
hermaphrodites, meaning that
they have both male and female
sex organs.
The vulva is part of
the female sex
apparatus.

5. The adult vulva comprises 22 cells
which are the progeny of three
ancestral cells.
PRIMARY VALVA CELL
FATE
P6.PP5.P P7.P
SECONDARY VALVA CELL
FATE
SECONDARY VALVA CELL
FATE
7 CELLS 8 CELLS 7 CELLS

6. PRIMARY VALVA CELL
FATE
P6.PP5.P P7.P
SECONDARY VALVA CELL
FATE
SECONDARY VALVA CELL
FATE
7 CELLS
8 CELLS 7 CELLS

7. OCCUPYING CORRECT POSITION
These 22 cells then reorganize their
positions to construct the vulva.
A critical aspect of vulva development is that it
must occur in the correct position relative to the
gonad.
If the vulva develops in the wrong place then the
gonadwill not receive spermand the egg cells
will never be fertilized.

8. The positional information needed by the vulva
progenitor cells is provided by a cell within the
gonad called the anchor cell.
ANCHOR CELLS
The anchor cell secretes an extracellular signaling
compound that induces P5.p, P6.p and P7.p to
differentiate.

9. ANCHOR CELLS
LIN-3
LIN-3
LIN-3
LIN-3
LIN-3
LIN-3
LIN-3
This signaling compound is the protein called LIN-3,
coded by the lin-3 gene

10. LIN-3 forms a concentration gradient and therefore has
different effects on P6.p, the cell which is closest to it, and
the more distant P5.p and P7.p
Therefore, P6.p adopt the primary cell fate whereas P5.p
and P7.p take on secondary cell fates.

11. ANCHOR CELLS
P6.P
PRIMARY VALVA CELL FATE
LIN 3
PROTEIN
GRADIENT
(HIGH)

12. P5.P
P7.P
SECONDARY VALVA CELL FATE
LIN 3
PROTEIN
GRADIENT
(LOW)
LIN 3
PROTEIN
GRADIENT
(LOW)
ANCHOR CELLS

13. ANCHOR CELLS
P6.P
PRIMARY VALVA CELL FATE
P5.P P7.P
SECONDARY VALVA
CELL FATE
SECONDARY VALVA
CELL FATE
LIN 3
PROTEIN
GRADIENT