1. Fungi are eukaryotic organisms that do not contain chlorophyll and have cell walls. They can grow as filaments called hyphae and reproduce through spores.
2. Around 300 fungal species are known to be pathogenic to humans, causing infections of the skin, nails, mucous membranes, and various internal organs depending on factors like host immunity.
3. Common pathogenic fungi include Candida, Aspergillus, Cryptococcus, and dermatophytes that cause superficial infections. Opportunistic fungi can cause serious disease in immunocompromised individuals.
“mykos” meaning mushroom.
Mycology is the study of fungi.
The fungi possess rigid cell walls:
Chitin and ergosterol, mannan and other polysaccharides.
Beta-glucan is most important, because it is the target of antifungal drug caspofungin.
Fungi are eukaryotic organisms VS bacteria (prokaryotic).
The cell membrane of fungus contains ergosterol, unlike human cell membrane which contains cholesterol.
Most fungi are obligate aerobes or facultative anaerobes, but none are obligate anaerobes.
The natural habitat of most fungi is environment, require a preformed organic source of carbon, association with decaying matter.
C. albicans is an exception!!!
“mykos” meaning mushroom.
Mycology is the study of fungi.
The fungi possess rigid cell walls:
Chitin and ergosterol, mannan and other polysaccharides.
Beta-glucan is most important, because it is the target of antifungal drug caspofungin.
Fungi are eukaryotic organisms VS bacteria (prokaryotic).
The cell membrane of fungus contains ergosterol, unlike human cell membrane which contains cholesterol.
Most fungi are obligate aerobes or facultative anaerobes, but none are obligate anaerobes.
The natural habitat of most fungi is environment, require a preformed organic source of carbon, association with decaying matter.
C. albicans is an exception!!!
Fungal Infections/ Mycoses ppt by Dr.C.P.PRINCEDR.PRINCE C P
PPT prepared by :
DR.PRINCE C P
Associate Professor &HOD
Department of Microbiology,
Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution)
According to tissue involved, MYCOSES are classified into:
Superficial (Surface )
Cutaneous
Subcutaneous
Deep Cutaneous
Systemic (Primary )
Systemic ( Opportunistic)
Mycotic Poisoning
most of the fungal infections are opportunistic in nature.
candida albicans is the common Fungal pathogen.
Fungi are eukaryotic microorganisms which are heterotrophic and essentially aerobic with limited anaerobic capabilities. Fungi synthesize lysine by the L-αadipic acid biosynthetic pathway. They possess chitinous cell walls, plasma membranes containing ergosterol, 80SrRNA and microtubules composed of tubulin. Fungi grow as yeasts, molds (filamentous) or a combination of both (i.e. dimorphism).
Fungal infection of the skin, most common on the exposed surfaces of the body, namely the face, arms and shoulders.
Most common fungal diseases ; Ringworm. A common fungal skin infection that often looks like a circular rash.
and invade the genital ridges in the sixth week of
development. here they form primitive sex cords. in
the absence of tdf, medullary cords disappear and
get replaced by a vascular stroma (ovarian medulla).
cortical cords develop and surround one or more
primitive germ cells. the germ cells subsequently
develop into oogonia, while the surrounding epithelial
cells form the follicular cells. this differentiates
undifferentiated gonads into ovaries. stroma of ovary
develops from basal mesenchyme. granulosa and theca
cells develop from celomic epithelium.
development of genital ducts
development of genital duct system and the external
genitalia occurs under the influence of hormones
circulating in the fetus. sertoli cells in the fetal testes
produce a nonsteroidal substance known as müllerian
inhibiting substance (mis) that causes regression of
müllerian ducts. androgen from the fetal testes causes
masculinization of external genitalia. in the absence of
mis, müllerian ducts develop and mesonephric duct
system regresses. in the absence of androgen, external
genitalia differentiate into female phenotype. the
müllerian duct develops between the fifth and sixth
weeks lateral to intermediate cell mass and wolffian
duct. the müllerian duct has the following three parts:
•cranial vertical portion that opens into celomic
cavity. later it differentiates into fallopian tubes.
•horizontal part crosses the mesonephric duct.
•caudal vertical part that fuses with its partner
from opposite side. this fused part later differ
entiates into uterus, cervix, and upper one-third
of the vagina.
the dorsal celomic epithelium (which forms
müllerian duct) remains open at its site of origin and
ultimately forms the fimbriated ends of the fallopian
tubes. at their point of origin, each of the müllerian
ducts forms a solid bud. each bud penetrates the
mesenchyme lateral and parallel to the wolffian duct.
as the solid buds elongate, a lumen appears in the
cranial part, beginning at each celomic opening. the first time
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
3. • Fungi are eukaryotic organisms, do not
contain chlorophyll, have cell walls,
filamentous structures, and produce
spores.
• Grow as saprophytes and decompose
dead organic matter. Between 100,000 to
200,000 species depending on how they
are classified.
• About 300 species are presently known to
be pathogenic for man.
4. Features Fungi Bacteria
Nucleus eukaryotic prokaryotic
Cell membrane Sterols present absent
Cytoplasm Mitochondria
and ER present
Absent
Cell wall
content
Chitin Peptidoglycan
Spores Sexual asexual Endospores
5. 2 types
1. Yeasts 2.
Molds.
1. Yeasts grow as single cells , reproduce by
budding.
2. Molds grow by filamentous hyphae, and form a
mat ( mycelium). Form septate and aseptate
hyphae.
6.
7.
8.
9.
10. Several medically imp. Fungi are thermally
Diamorphic.
i.e, different structures at different temperatures.
Molds in environment at ambient temperatures and
as yeasts at body temperature.
11.
12.
13.
14.
15.
16.
17.
18.
19. There are four types of Mycotic
diseases:
1. Hypersensitivity - allergic reaction to molds
and spores.
2. Mycotoxicoses - poisoning of man and animals
by feeds and food products contaminated by
fungi producing toxins from the grain substrate.
3. Mycetismus- ingestion of preformed toxin
(mushroom poisoning).
4. Infections.
In this lecture , we shall be concerned only with
the last type.
20. • The establishment of a mycotic infection
depends on size of inoculum on the resistance
of the host.
• Severity of infection depend mostly on
immunologic status of host.
• Thus, the demonstration of fungi, for example, in
blood drawn from an intravenous catheter can
correspond to colonization of the catheter, to
transient fungemia (i.e., dissemination of fungi
through the blood stream), or to a true infection.
21. • Most mycotic agents are soil
saprophytes and are generally not
communicable from person-to-person
(occasional exceptions: Candida and
some dermatophytes).
• Outbreaks of disease may occur, but
these are due to a common
environmental exposure, not
communicability.
22. . CLINICAL CLASSIFICATION OF
THE MYCOSES
a.Superficial mycoses
b. Subcutaneous mycoses
c. Systemic mycoses
d. Opportunistic mycoses
23. a. Superficial mycoses
(or cutaneous mycoses) are
fungal diseases that are
confined to the outer layers of
the skin, nail, or hair,
(keratinized layers) rarely
invading the deeper tissue or
viscera. The fungi involved are
called dermatophytes
24. b. Subcutaneous mycoses are
confined to the subcutaneous tissue
rarely spread systemically.
Form deep, ulcerated skin lesions or
fungating masses, most commonly
involving the lower extremities.
Causative organisms are soil
saprophytes which are introduced
through trauma to the feet or legs.
25. c. Systemic mycoses may
involve deep viscera and
become widely disseminated.
Each fungus type has its own
predilection for various organs.
26. d. Opportunistic mycoses
are infections due to fungi
with low inherent virulence.
The etiologic agents are
organisms which are
common in all
environments.
27. YEASTS
• Yeasts are single-celled budding
organisms.
• They do not produce mycelia.
• Colonies visible on the plates in 24-48
hours. Their soft, moist colonies resemble
bacterial cultures rather than molds.
• Many species of yeasts which can be
pathogenic for humans.
• Two most significant species: Candida
albicans and Cryptococcus neoformans
28. SUPERFICIAL MYCOSES
• The superficial (cutaneous) mycoses
are usually confined to the outer layers
of skin, hair, and nails, and do not
invade living tissues.
• The fungi are called dermatophytes.
• Tinea means "ringworm" or "moth-like".
Dermatologists use the term to refer to a
variety of lesions of the skin or scalp.
29. CLINICAL MANIFESTATIONS
ETIOLOGIC AGENTS
• 1. Trichophyton These infect skin, hair and
nails.
• 2. Microsporum may infect skin and hair,
rarely nails. easily identified on the scalp
because infected hairs fluoresce a bright
green color when illuminated with a UV-
emitting Wood's light.
• 3. Epidermophyton floccosum. These
infect skin and nails and rarely hair
30. Trychophyton rubrum, right and left great toe.
Tinea unguium.
Tinea unguium (onychomycosis) - nails. Clipped
and used for culture
31. Tinea versicolor on chest.
Characterized by a blotchy discoloration of
skin which may itch. Caused by
Malassezia furfur
32. • Tinea capitis - head. Frequently found in
children.
• Tinea cruris - "jock itch". Infection of the
groin, perineum or perianal area.
• Tinea barbae - ringworm of the bearded
areas of the face and neck.
• Tinea pedis - "athlete's foot". Infection of
toe webs and soles of feet.
33. THE ID REACTION
•Patients infected with a dermatophyte
may show a lesion, on the hands, from
which no fungi can be recovered .
• These lesions, which often occur on
the dominant hand (i.e. right-handed or
left-handed), are secondary to
immunological sensitization to a primary
lesion.
•Secondary lesions will not respond to
topical treatment but will resolve if the
primary infection is successfully
treated.
34. Subcutaneous Mycosis
1. Sporothrix schenckii:
Diamorphic , occupational disease typically
itroduced in gardners by a thorn, , causes
pustule and spread by lymphatics.
2. Chromomycosis: soil fungi , introduced by
trauma , typically in legs or during war injuries.
3. Mycetoma: enters through wounds on hand
and feet and produce abscesses with draining
sinuses.
46. CRYPTOCOCCOSIS
(Cryptococcus neoformans)
• Meningitis or pulmonary disease.
• Portal of entry is the respiratory system.
• Infection subacute or chronic.. symptoms begin with
vision problems and headache, then progress to
delirium, nuchal rigidity leading to coma and death .
• CSF is examined for chemistry (elevated protein and
decreased glucose), cells (usually monocytes), and
evidence of the organism.
• Visual demonstration of the organism (India Ink
preparation) The India Ink test, which demonstrates
the capsule of this yeast
48. Black grain mycetoma: subcutaneous
nodule due to Madurella Mycetomatis,
magnified x 100
49. A. CANDIDIASIS (Candida albicans)
• Candidiasis. Candida albicans ,
endogenous organism. found in 40-80%
of normal human beings.
• Present in the mouth, gut, and vagina,
• Commensal or a pathogenic organism.
• Usually alteration in cellular immunity,
normal flora or normal physiology.
Although most frequently infects the skin
and mucosae, Candida can cause
pneumonia, septicemia or endocarditis in
the immuno-compromised patient
50. Gram-stain of vaginal smear showing
Candida albicans epithelial cells and many
gram-negative rods. (1,000X oil)
55. • Aspergillus species are highly
aerobic and are found in almost
all oxygen-rich environments,
where they commonly grow as
molds on the surface of a
substrate, as a result of the high
oxygen tension.
56. The most common causing
pathogenic species
• The most common pathogenic species are
• Aspergillus fumigatus : causing allergic
disease
• Aspergillus flavus.,produces aflatoxin which
is both a toxin and a carcinogen, and which can
potentially contaminate foods such as nuts.
• Other species are important as agricultural
pathogens.
Aspergillus spp. cause disease on many grain
crops, especially maize, and synthesize
mycotoxins including aflatoxin.
57. • Aspergillosis
• Pulmonary aspergillosis.
• Aspergillosis is the group of diseases caused
by Aspergillus. The most common subtype
among paranasal sinus infections associated
with aspergillosis is Aspergillus fumigatus.
• symptoms: include fever, cough, chest pain
or breathlessness, Usually, only patients with
already weakened immune systems or who
suffer other lung conditions are susceptible.
58. Major forms of disease
• Allergic bronchopulmonary aspergillosis or
ABPA, which affects patients with respiratory
diseases like asthma, cystic fibrosis, and
sinusitis).
• Acute invasive aspergillosis, a form that grows
into surrounding tissue, more common in those
with weakened immune systems such as AIDS or
chemotherapy patients.
• Disseminated invasive aspergillosis, an
infection spread widely through the body.
• Aspergilloma, a "fungus ball" that can form
within cavities such as the lung
61. DIAGNOSIS
1. Skin scrapings suspected to contain
dermatophytes or pus from a lesion can be
mounted in KOH on a slide and examined
directly under the microscope.
2. Skin testing (dermal hypersensitivity).
3. Serology may be helpful when it is applied
to a specific fungal disease.
4. Direct fluorescent microscopy may be used
for identification.
5. Biopsy and histopathology.
6. Culture: Sabouraud dextrose agar.
62.
63.
64.
65. TREATMENT
The primary antifungal agents are:
1. Amphotericin B. drug of choice for most
systemic fungal infection, administered I.V.
(patient usually needs to be hospitalized), often for
2-3 months. The drug is rather toxic; thrombo-
phlebitis, nephrotoxicity, fever, chills and anemia
frequently occur during administration
2. Azoles: ketoconazole, fluconazole, oral.
3. Griseofulvin: slow-acting drug which is
used for severe skin and nail infections,
oral.
4. 5-fluorocytosine:inhibits RNA synthesis,
oral.