This document summarizes various fungal diseases that affect humans and animals. It describes five main groups of fungal diseases: superficial mycoses, cutaneous mycoses, subcutaneous mycoses, systemic mycoses, and opportunistic mycoses. For each group, it provides examples of pathogenic fungi, the locations they infect, and the resulting diseases. It also discusses the transmission routes and typical symptoms for some of the major fungal diseases like blastomycosis, coccidioidomycosis, cryptococcosis, and histoplasmosis.
Largest viruses that infect vertebrates
Can be seen under light microscope
Poxvirus diseases are characterized by skin lesions – localized or generalized
Important diseases caused by poxviruses are-
Smallpox
Monkeypox
Cowpox
Tanapox
Molluscum contagiosum
A bacteriophage (informally, phage) is a virus that infects and replicates within a bacterium. The term is derived from "bacteria" and the Greek (phagein), "to devour". Bacteriophages are composed of proteins that encapsulate a DNA or RNA genome, and may have relatively simple or elaborate structures. Their genomes may encode as few as four genes, and as many as hundreds of genes. Phages replicate within the bacterium following the injection of their genome into its cytoplasm. Bacteriophages are among the most common and diverse entities in the biosphere.
Phages are widely distributed in locations populated by bacterial hosts, such as soil or the intestines of animals. One of the densest natural sources for phages and other viruses is sea water, where up to 9×108 virions per milliliter have been found in microbial mats at the surface,] and up to 70% of marine bacteria may be infected by phages. They have been used for over 90 years as an alternative to antibiotics in the former Soviet Union and Central Europe, as well as in France. They are seen as a possible therapy against multi-drug-resistant strains of many bacteria (see phage therapy). Nevertheless, phages of Inoviridae have been shown to complicate biofilms involved in pneumonia and cystic fibrosis, shelter the bacteria from drugs meant to eradicate disease and promote persistent infection
Poxviruses are brick or oval-shaped viruses with large double-stranded DNA genomes. Poxviruses exist throughout the world and cause disease in humans and many other types of animals. Poxvirus infections typically result in the formation of lesions, skin nodules, or disseminated rash.
Largest viruses that infect vertebrates
Can be seen under light microscope
Poxvirus diseases are characterized by skin lesions – localized or generalized
Important diseases caused by poxviruses are-
Smallpox
Monkeypox
Cowpox
Tanapox
Molluscum contagiosum
A bacteriophage (informally, phage) is a virus that infects and replicates within a bacterium. The term is derived from "bacteria" and the Greek (phagein), "to devour". Bacteriophages are composed of proteins that encapsulate a DNA or RNA genome, and may have relatively simple or elaborate structures. Their genomes may encode as few as four genes, and as many as hundreds of genes. Phages replicate within the bacterium following the injection of their genome into its cytoplasm. Bacteriophages are among the most common and diverse entities in the biosphere.
Phages are widely distributed in locations populated by bacterial hosts, such as soil or the intestines of animals. One of the densest natural sources for phages and other viruses is sea water, where up to 9×108 virions per milliliter have been found in microbial mats at the surface,] and up to 70% of marine bacteria may be infected by phages. They have been used for over 90 years as an alternative to antibiotics in the former Soviet Union and Central Europe, as well as in France. They are seen as a possible therapy against multi-drug-resistant strains of many bacteria (see phage therapy). Nevertheless, phages of Inoviridae have been shown to complicate biofilms involved in pneumonia and cystic fibrosis, shelter the bacteria from drugs meant to eradicate disease and promote persistent infection
Poxviruses are brick or oval-shaped viruses with large double-stranded DNA genomes. Poxviruses exist throughout the world and cause disease in humans and many other types of animals. Poxvirus infections typically result in the formation of lesions, skin nodules, or disseminated rash.
Coccidioidomycosis is a fungal disease commonly known as valley fever. Caused by inhalation of coccidioides immitis. Mainly disturb western hemisphere of earth.
Fungal Infections/ Mycoses ppt by Dr.C.P.PRINCEDR.PRINCE C P
PPT prepared by :
DR.PRINCE C P
Associate Professor &HOD
Department of Microbiology,
Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution)
According to tissue involved, MYCOSES are classified into:
Superficial (Surface )
Cutaneous
Subcutaneous
Deep Cutaneous
Systemic (Primary )
Systemic ( Opportunistic)
Mycotic Poisoning
most of the fungal infections are opportunistic in nature.
candida albicans is the common Fungal pathogen.
Tick-borne parasitic infections are serious problem in the world as the population of ticks is increasing with people building homes in areas where ticks and their host live. Ticks are second to mosquitoes as an excellent vector for vector-borne diseases. There are only two known tick-borne parasitic infections: Babesiosis and Theileriosis. Babesiosis is due to the tick-borne parasites of the Babesia protozoa genus while Theileriosis is caused by Theilerias species which are obligate protozoan parasites. They are both transmitted by the Ixodid ticks. The symptoms of the infection includes lacrimation, nasal discharge, muscle pains etc. Tick-borne parasitic diseases can be prevented by avoiding places where ticks often live and also by using insect repellents.
carbon dioxide, nitrous oxide, methane production have a tremendous impact on climate change, microbes play a key role in the production and control of these gases
microbe mediated insect resistance is a major concern in agriculture due to the enhanced application of pesticides and rapid development of insect resistance
Current trends and future prospects of halophilic microbes in agricultureNagaraju Yalavarthi
halophiles are the microorganisms that capable of living under salt conditions, generally many microbes are susceptible to higher salt concentration whereas these microbes tolerate higher salinity
phyllosphere is a dynamic rapidly changing area surrounding the germinating seed. there are two categories of microbes one is positively enhancing and negatively reducing the plant yield
differentiation in microbes is a peculiar character, different microbes have a different mode of life some lives as a single cell, and some lives as complex life cycle by having different types of cells, coccoid, rod or sedentary cells it's all depend upon their
it is a tri-trophic interaction between insect and plant, plant and microbe as well as microbe insect which results in the fitness of the plant. sometimes negative interactions result in the loss of crop or insect or microbial relationship....
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
3. Medically important fungi
GROUP PATHOGEN LOCATION DISEASE
1)Superficial
mycosis
Piedraia hortae . scalp Black piedra.
Trichosporon beigelii. Beard
,mustache
White piedra.
Malassezia furfur. Trunk ,neck
,face, arms.
Tinea versicolor.
2)Cutaneous
mycosis
Trichophyton mentagrophytis
,T.verrucossum, T.rubrum.
Beard hair Tinea barbae.
Trichophyton ,Microsporum canis. Scalp hair Tinea captis
Trichophyton rubrum
,T.mentagrophytes ,Microsporum
canis.
Smooth or
bare parts
of skin
Tinea corporis
T.Rubrum , T.mentagrophytes
,Epidermophyton floccosum .
Groin,
buttocks
Tinea cruris(jock
itch).
T.rubrum ,T.mentagrophytes
,E.floccosum.
feet Tinea pedis
T.rubrum. T. mentagophytes, E.
floccosum.
nails Tinea unguium
(oncomycosis).
4. GROUP PATHOGEN LOCATION DISEASE
3)Subcutinous
mycosis
Phialophora
verrucosa
Legs ,feet Chromoblastomycos
is
sporothrix schenckii Puncture wounds Sporotrichosis
4)Systemic
mycosis
Coccidiodes immitis Lungs ,other parts of
body.
Coccidioidomycosis.
Cryptococcus
neoformis
Lungs ,skin,bones
,viscera,central
nevous system.
Cryptococcosis.
Histoplasma
capsulatum
Within phagocytosis Histoplasmosis
5)Oppurtunistic
mycosis
Aspergillus
fumigatus, A.flavus,
Respiratory system Aspergillosis
Candida albicans Skin or mucous
membrane
Candidiasis
Pneumocystis
jivoroveci
Lungs some time
brain
Pneumocystis
pneumonia
Encephalitozooon Lungs some times
brain
microsporidiosis
5. INTRODUCTION
• Fungal disease are usually divided into
four types based on the level of infected
tissue and mode of entry into the host
1)Superficial,
2)Cutaneous,
3)Subcutaneous and,
4)Systemic.
6. • Systemic mycoses are typically transmitted
through air. e.g.,Blastomycosis,
Coccidioidomycosis, Cry-ptomycosis,and
Histoplasmosis.
• Fungal pathogens do not appear to be
transmitted by arthropods.
• A number of fungal pathogens are transmitted
through direct contact. e.g., superficial
-mycosis, cutaneous mycoses(called as ring
worms,tineas,or dermatomycosis.)
7. • Fungal diseases can also be transmitted through
food and water .
• Opportunistic diseases are typically arise from
the endogenous microbial flora when the host
can no longer control them. E.g., Aspergillosis,
Microsporidoisis, Pneumocystis Pneumonia.
• Discipline that deals with the fungi that cause
human diseases is MEDICAL MYCOLOGY .
• The fungal diseases are called as MYCOSIS.
8. • Superficial ,cutaneous ,and subcutaneous
mycosis are direct contact infections of the
skin ,hair, and nails.
9. INTRODUCTION
• Based on transmission fungal diseases
are basically classified into THREE types,
a)AIR BORNE DISEASES
b)DIRECT CONTACT DISEASES and
c)OPPURTUNISTIC DISEASES
10. a)AIR BORNE DISEASES
• There are four air borne diseases which
are most predominant in the world and
India are as follows ….
1) Blastomycosis,
2) Coccidioidomycosis,
3) Cryptococcosis and
4) Histoplasmosis.
11. 1)BLASTOMYCOSIS
• Casual organism: Blastomyces dermatitidis.
• HABITAT: fungus grows as a budding yeast in
humans but on culture media and in the
environment grows as a mold.
• INFECTION:
initial infection occurs when Blastospores are
inhaled into lungs.
The fungus can spread rapidly ,especially to the
skin ,where cutaneous ulcers and abscess
formation occur.
12. • B.dermatitidis can be isolated from the pus
and biopsy sections.
• TREATMENT: Amphotericin B
(fungizone),itraconazole(sporanox),or
ketoconazole(nizoral) are the drugs of
choice for treatment.
• Surgery may be necessary for the
drainage of large abscesses.
16. 2)coccidioidomycosis(valley
fever)
• CAUSATIVE ORGANISM: Coccidioides immitis.
• It is also known as VALLEY FEVER or
Sanjoaquin fever or Desert Rheumatism
because of its geographical distribution.
• HABITAT: They exists in the semi arid ,highly
alkaline soils .
• In the soil and on culture media ,this fungus
grows as a mold that forms an Arthroconidia at
the tips of hyphae .
17. • DIAGNOSIS: Diagnosis is accomplished by
identification of the large sperules(approxmately
80 μm in diameter) in pus ,sputum,and
aspirates.
• culturing clinical samples in the presence of
pencillin and streptomycin on sabourd agar
(used to isolate fungi) also a diagnostic.
TREATMENT : Micanazole(lotrimin),
Itraconazole, Ketraconazole and Amphotericin
B.
21. 3)CRYPTOCOCCOSIS.
• CAUSATIVE ORGANISM: Cryptococcus
neoformans.
• HABITAT: Aged, dried pigeon dropping's are the
apparent source of infection.
saprophytic with world wide distribution.
cryptococcus found approximately 15% of AIDS
patients.
MODE OF SPREAD : The fungus enters in to
the body by respiratory tract, causing a minor
pulmonary infections spread to the skin
,bones ,viscera and the central nervous system
22. • DIAGNOSIS: it involves in accomplished
by detection of the thick walled, spherical
yeast cells in pus, sputum, or exudate
smears using India ink to define the
organism.
• TREATMRNT : It includes Amphotericin B
or Itraconazole.
• There is no preventive or control
measures.
23. 3)CRYPTOCOCCOSIS IN HUMANS
Mouth infected with cryptococcus
Eye infected with cryptococcus
LLuunnggss e efffefetetedd w witihth c crryypptotoccooccccuuss
27. 4)HISTOPLASMOSIS.
• CAUSATIVE ORGANISM: Histoplasma
capsulatum. A facultative parasitic fungus that
grows as intracellular.
• HABITAT: It is present in the form of mycelium in
the soils throughout the world.
• At 25 C it grows as a mold producing small
microconidia.(1 to 5 μm in diameter), large
macroconidia (8 to 16 in diameter), are also
formed on conidiophores.
28. • MODE OF SPREAD : Humans aquire
histoplasmosis from airborne microconidia.
• TREATMENT: Amphotericin B ,Ketoconazole, or
Itraconazole.
32. 2)DIRECT CONTACT DISEASES
• A)superficial mycosis
BLACK PIEDRA
WHITE PIEDRA
SOME TIMES CALLED
AS TINEAS
33. Superficial mycosis
• These are very common in the tropics.
• The fungi responsible are limited to the outer
surface of hair and skin and hence are called as
superficial.
• Infections of the hair shaft are collectively called
as PIEDRAS. E.g., Black piedra-caused by
Piedraia hortae and forms hard, Black nodules
on the hairs of the scalp. WHITE PIEDRA- is
caused by the yeast Trichosporon beigelii and
forms light colored nodules on the beard and
mustache.
37. 1)TINEA BARBAE
• C.O: Trichophyton
mentagrophytes.
• It is predominantly a
disease of men who live
in rural areas and
acquire the fungus from
infected animals.
38. 2)TINEA CAPITIS
• It is an infection to scalp hair .
• It is characterized by loss of
hair, inflammation and scaling.
• It is predominantly of a
childhood disease.
• A woods lamp (a UV light )can
help in the diagnosis of the
tinea capitis ,because fungus
infected hair flourescences
when illuminated by UV
radiation.
39. 3)TINEA CORPORIS
• It is caused by Trichophyton
rubrum, T.mentagrophytes or
Microsporus canis.
• It occurs any party of the
skin.
• The disease is characterized
by circular ,red,well-demarcated
,scaly,
vesiculopustular lesions
accompanied by itching.
•
40. 4)Athelets foot
• It is scientifically
called as TINEA
PEDIS.
• They infect feet and
hands
• It is caused by T.
rubrum ,T
.mentagrophytes .
42. • Subcutaneous mycoses are normal saprophytic
inhabitants of soil and decaying vegetation
because they are unable to penetrate the skin.
• In chromoblastomycosis the nodules are dark
brown.
• These fungi exist world wide
• Most of the infections involve in the legs and
feet.
44. • Sporotrichosis is caused by a dimorphic
fungi( i.e sporothrix schenckii.)
• The disease occurs throughout the world .
• The fungus is found on the living plants and soil.
• The disease have an occupational hazard to the
florists ,gardeners ,and forestry workers.
• Sporotrichosis typically treated by ingestion of
potassium iodide or Itraconazole (sporanox).
46. • Aspergillosis is widely
distributed throughout the
world than any other fungi
can(omnipresent).
• Aspergillus fumigatus is the
casual organism of
aspergillosis some times A.
flavus also causes the disease.
• Invasive disease typically
results in the pulmonary
infection(with fever chest pain,
and cough).
• The major portal of entry is
respiratory tract.
48. 2) CANDIDIASIS
• Oral candidiasis or thrush is a
fairly common disease in
newborns.
• It is caused by a dimorphic fungi
i.e Candida albicans or C.glabrata.
• These are normal microbiota of
gastro intestinal tract ,respiratory
tract ,and mouth.
• In healthy individuals they will not
produce disease because growth
is suppressed by other microbiota.
• Candidiasis is a sexually
transmitted disease.
50. • Microsporidia is a term used to describe obligate
,intracellular fungi that belongs to the phylum
microspora.
• It is an emerging infectious disease found mostly in HIV
patients.
• Its unique character is the production of highly resistant
spores.
• It also possess a unique organelle known as the polar
tubule.
• Microspora infection leads to the wide variety of patient
symptoms.
• These includes hepatitis ,pneumonia ,skin lesions etc..,
52. 4)PNEUMOCYCTIS PNEUMONIA
• It is found in the lungs of
wide variety of mammals.
• Serological data indicates
that humans are exposed
to pneumocystis by the
age of 2-4.
• This pneumonia also
occurs in premature
malnourished infants and
in more than 80% of AIDS
patients.