Viruses are the smallest infectious agents and can infect all forms of life. They are obligate intracellular parasites that contain either RNA or DNA. Many important human viruses are described including influenza, measles, hepatitis B, and HIV. Viruses have a protein coat that protects their genetic material and use host cells to replicate. Host responses to viral infection include innate immune defenses and adaptive immune responses like antibodies and T cells. Acute viral infections are generally mild and short-lived while some viruses can establish persistent infections by becoming latent or causing chronic or latent infections.
General Characters and Classification of Viruses. Includes ICTV classification and Baltimore classification of viruses. A brief explanation of the Viral structure and Lifecycle.
Viruses are microscopic organisms that exist almost everywhere on earth. They can infect animals, plants, fungi, and even bacteria.Viruses vary in complexity. They consist of genetic material, RNA or DNA, surrounded by a coat of protein, lipid (fat), or glycoprotein. Viruses cannot replicate without a host, so they are classified as parasitic.They are considered the most abundant biological entity on the planet.
Here we discuss the general properties of viruses in detail.
General Characters and Classification of Viruses. Includes ICTV classification and Baltimore classification of viruses. A brief explanation of the Viral structure and Lifecycle.
Viruses are microscopic organisms that exist almost everywhere on earth. They can infect animals, plants, fungi, and even bacteria.Viruses vary in complexity. They consist of genetic material, RNA or DNA, surrounded by a coat of protein, lipid (fat), or glycoprotein. Viruses cannot replicate without a host, so they are classified as parasitic.They are considered the most abundant biological entity on the planet.
Here we discuss the general properties of viruses in detail.
A picornavirus is a virus belonging to the family Picornaviridae, a family of viruses in the order Picornavirales. Vertebrates, including humans, serve as natural hosts. Picornaviruses are nonenveloped viruses that represent a large family of small, cytoplasmic, plus-strand RNA viruses with a 30-nm icosahedral capsid.
Poxviruses are brick or oval-shaped viruses with large double-stranded DNA genomes. Poxviruses exist throughout the world and cause disease in humans and many other types of animals. Poxvirus infections typically result in the formation of lesions, skin nodules, or disseminated rash.
This lecture presentation contains description of arbovirus particularly detailing Dengue virus infections. Lecture outlined general characteristics of Arbovirus, classification of Arboviruses, salient features of Dengue virus, dengue pathogenesis, clinical course, laboratory diagnosis, complications of secondary dengue and some recent aspect of dengue vaccine preparation.
The Paramyxoviridae is a family of single-stranded RNA viruses known to cause different types of infections in vertebrates. Examples of these infections in humans include the measles virus, mumps virus, parainfluenza virus, and respiratory syncytial virus (RSV).
A picornavirus is a virus belonging to the family Picornaviridae, a family of viruses in the order Picornavirales. Vertebrates, including humans, serve as natural hosts. Picornaviruses are nonenveloped viruses that represent a large family of small, cytoplasmic, plus-strand RNA viruses with a 30-nm icosahedral capsid.
Poxviruses are brick or oval-shaped viruses with large double-stranded DNA genomes. Poxviruses exist throughout the world and cause disease in humans and many other types of animals. Poxvirus infections typically result in the formation of lesions, skin nodules, or disseminated rash.
This lecture presentation contains description of arbovirus particularly detailing Dengue virus infections. Lecture outlined general characteristics of Arbovirus, classification of Arboviruses, salient features of Dengue virus, dengue pathogenesis, clinical course, laboratory diagnosis, complications of secondary dengue and some recent aspect of dengue vaccine preparation.
The Paramyxoviridae is a family of single-stranded RNA viruses known to cause different types of infections in vertebrates. Examples of these infections in humans include the measles virus, mumps virus, parainfluenza virus, and respiratory syncytial virus (RSV).
Picornaviruses presentation for medical student created by: Farhang Shapouran
References : Moray medical microbiology, Jawetz medical microbiology, ICTV
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
3. • Definition :
1. Viruses are the smallest infective
agents. Most form of life—not only
humans animals and plants, but
bacteria also are susceptible to
infection with appropriate viruses.
2. Obligate intracellular parasites
3. Have only RNA or DNA. A imp.
distinguishing factor from bacteria and
other infectious agents.
9. Some medically important RNA viruses
Orthomyxovirus Influenza Influenza
Paramyxoviruses Para influenza,
Respiratory
syncytial,
measles, mumps
Respiratory inf.
Measles, mumps.
Rhabdoviruses Rabies Rabies
Picornaviruses Enteroviruses,
rhinoviruses,
Meningitis,
paralysis, colds,
10. Flaviviruses Flavivirus Encephalitis,
febrile disease.
Bunyaviruses Buniyaviruses,
Hantan virus
Encephalitis,
febrile disease
Reoviruses Rotavirus gastroenteritis
Arenaviruses Lynphocytic
choriomeningitis,
Lassa virus.
Meningitis ,
febrile disease
Retroviruses HTLV -I, II,
HIV -I, II
T cell leukemia,-
lymphoma, AIDS
11. • Virus like particles, or incomplete viruses.
• Bacteriophage: bacteriophage
from 'bacteria' and Greek φ γε νᾰ ῖ phagein "to eat") is any
one of a number of viruses that infect
bacteria. Bacteriophages are among the
most common biological entities on Earth
• Plasmid: DNA molecule that is separate from, and can replicate
independently of, the chromosomal DNA. Are double-stranded and,
in many cases, circular. Plasmids usually occur naturally in bacteria,
but are sometimes found in eukaryotic organisms
• Prion : infectious particles composed of protein and no
detectable nucleic acid or envelope. cause of certain slow diseases
like Creutzfeldt-Jacob Disease (CJD) in human and scrapie in
sheep
12. Three main properties :
1. Small size. 10nm- 300nm.
Bacteria are approx.
1000nm and R.B.C 7500nm.
2. Genome . DNA or RNA
3. Metabolically inert . No
metabolic activity outside
susceptible host cells;
13. No active Ribosome's or protein
synthesizing equipment
Some have enzymes within their
particle.
Cannot multiply in inanimate media
but only in living cells.
On entry into susceptible cell, viral
genome or nucleic acid is
transcribed into ----or itself acts as
--------virus specific messenger or
mRNA which then directs the
replication of new virus particles.
14.
15. STRUCTURE OF VIRUSES
• Virus basically consists of a core of
nucleic acid surrounded by a
protein coat.
• Protein coat protects the viral
genome from inactivation by
adverse environment factors e.g.
nucleases in the blood stream. It is
antigenic and often responsible for
stimulating the production of
16. The structure which makes up a virus particle
are known as :
• VIRION : Intact virus particle.
• Capsid : The protein coat .
• Capsomere : the protein structural units of
which the Capsid is composed.
• Nucleic acid : RNA or DNA
• Envelope : particles of many viruses
surrounded by a lipoprotein envelope,
containing viral antigens, but also partly
derived from the plasma or, in some cases the
nuclear membrane of the host cell.
17.
18. THREE TYPES OF SYMMETRY
• 1. Cubic. in which particle are
icosohedral protein shells with nucleic
acid contained inside.
• 2. Helical. In which the particles
contains an elongated nucleocpsid ;
the capsomere are arranged round the
spiral of nucleic acid. Most helical
viruses possess an outer envelope.
• 3. Complex. Does not confirm to any
22. THREE METHODS OF
CULTIVATION
• Tissue Culture . Cells obtained from man
or animal are grown in artificial culture in
glass vessels in the Lab, Cells are living and
metabolizing and can support viral replication.
• Chick Embryo. Fertile chick eggs are used.
• Lab. Animals. Mice Rabbits Ferrets and
Monkeys
23. THREE EFFECTS OF VIRUSES ON CELLS
1. Cell Death . The infection is lethal : it causes a
cytopathic effect (CPE) which kills the cells.
2. Cell Transformation. The cell is transformed
from a normal to a malignant or cancerous
cell
3. Latent Infection . The virus remains within
the cell in a potentially active state but
produces no obvious effect on the cells
function.
30. THREE TYPES OF VIRAL DISEASES
Viruses are imp. and common
cause of human disease
especially in children.
1. Most are mild and patients
makes a complete
recovery.
2. Many infections are silent
and the virus multiplies in
the body without causing
any symptoms.
3. Few are severe and always
31.
32.
33.
34.
35. Host responses to viral
infection:
SPECIFIC IMMUNE
RESPONSES
(Adaptive Immunity)
NON SPECIFIC
DEFENSES
(Innate Immunity)
1. Neutralizing antibody
response
1. Interferon - alpha-
interferon mainly,
stimulated in
surrounding cells
2. Cell-mediated
responses (i.e.,
cytotoxic T
lymphocytes)
2. Body fluids -
stomach acid, tears
3. Complement-
mediated lysis
3. Mechanical barriers
- respiratory
36.
37.
38. Acute infections:
• 1.Hit and run infections.
Characterized by the
common cold viruses
(rhinoviruses).
• 2. Short incubation period
(36 to 48 hours).
39.
40. Pathology in the upper respiratory tract due to epithelial
cell killing and secondary invasion by normal flora of
oral bacteria. Symptoms last for 5-7 days eliminated
by the host.
Protection not good since there are >1000 serotypes of
rhinovirus. orthomyxoviruses, which include influenza
A and B.
Protection against subsequent infection may be poor
because these viruses can change their antigenic
profile of their surface proteins, e.g. hemagglutinin
(HA) and neuraminidase (NA), by either point
mutations (drift), or recombination, which results in a
completely different gene (shift). (Influenza viruses are
capable of antigenic shift because they have
segmented single-stranded RNA genomes).
41. Systemic infections.
1. Characterized by the common childhood diseases
caused by measles, chickenpox, mumps, and
rubella.
2. Incubation period is long - 14 to 21 days. There
are two viremic phases during the incubation
period:
Replication at primary site ---- Primary viremia ----
replication in lymphoreticular system and viscera
---- Secondary viremia ---- target organs
42.
43.
44.
45.
46.
47.
48.
49. Several types of persistent viral infections
exist:
• Latent infections: After an acute cytocidal stage,
the virus becomes latent.
• The virus when latent does not replicate ,
produces limited mRNA. Latency may occur in
non-dividing cells such as neurons (HSV I, HSV-II
and VZV).
• Chronic infections: Persistence of virus after
acute phase with active replication of virus. May
cause disease in normal individuals, e.g. hepatitis
B, or not, e.g. JC and EBV.
• Chronic infection with neoplasia: Transformation
of virus infected cells usually after years of
persistence, e.g. HTLV-I , HTLV-II, hepatitis B,
Hep C, and HPV 16 and 18.
50. • The outcome can change depending on
the state of the individual, i.e. whether
they become immunocompromised.
• The site of viral persistence is
important as it would be difficult to
remain completely latent or with
minimal viral transcription and
translation in rapidly dividing cells such
as those lining the small intestine.
• Viral persistence requires viruses to develop
ways to evade immune responses. Herpes
51.
52. Thank you & Remember
Keep on alert for viruses around you, they can
1. transform you
2. have cyto- pathic effects on you
3. Stay latent inside you…………….
``And you can do nothing much about them…..so
relax and keep going as best as you can.``
Editor's Notes
ss
Text books have been written on virology and one example of the victory of humans on an infectious disease is small ox, usually infection of child hood, can be mild to very deadly disease.Just a very brief and simple introduction to viral diseases in one small lecture is an impossible task to do. Which I will attempt by over simplyfying, and keeping the basic gacts intact, the basic core concepts, doing injustice to such important infectious agents.
Text book on virology have been written , a important example of human conquering one disease fully has been small pox,
A regular icosahedron has 60 rotational (or orientation-preserving) symmetries, and a symmetry order of 120 including transformations that combine a reflection and a rotation. A regular dodecahedron has the same set of symmetries, since it is the dual of the icosahedron.
The set of orientation-preserving symmetries forms a group referred to as A5 (the alternating group on 5 letters), and the full symmetry group (including reflections) is the product A5 × C2. The latter group is also known as the Coxeter group H3
Some virus leave tell tale signs or cause cell death which can be morphologically observed under the microscope in tissue culture or of different affected organs.