Enteroviruses are a genus of picornaviruses that includes poliovirus, coxsackieviruses, and echoviruses. There are over 71 serotypes that are classified into 5 groups. They primarily infect humans through the oral-fecal route. While most infections are mild, some can cause paralysis, meningitis, or neonatal disease. Diagnosis involves virus isolation in cell culture or molecular techniques. There is no antiviral treatment, but vaccines exist to prevent poliovirus infection.
The Paramyxoviridae is a family of single-stranded RNA viruses known to cause different types of infections in vertebrates. Examples of these infections in humans include the measles virus, mumps virus, parainfluenza virus, and respiratory syncytial virus (RSV).
The Paramyxoviridae is a family of single-stranded RNA viruses known to cause different types of infections in vertebrates. Examples of these infections in humans include the measles virus, mumps virus, parainfluenza virus, and respiratory syncytial virus (RSV).
Polio: flaccid paralysis, major and minor
disease, fecal-oral
Coxsackievirus A: vesicular diseases,
meningitis; coxsackievirus B (body):
pleurodynia, myocarditis
Other echovirus and enteroviruses: like
coxsackievirus
Rhinoviruses: common cold, acid labile, does
not replicate above 33° C
Biology, Virulence, and Disease
• Small size, icosahedral capsid, positive RNA
genome with terminal protein
• Genome is sufficient for infection
• Encodes RNA-dependent RNA polymerase,
replicates in cytoplasm
Enteroviruses
• Capsid virus resistant to inactivation
• Disease due to lytic infection of important
target tissue
• Polio: cytolytic infection of motor neurons of
anterior horn and brainstem, paralysis
• Coxsackievirus A: herpangina, hand-foot-
and-mouth disease, common cold,
meningitis
• Coxsackievirus B: pleurodynia, neonatal
myocarditis, type 1 diabetes
Rhinoviruses
• Acid labile and cannot replicate at body
temperature
• Restricted to upper respiratory tract
• Common cold
Epidemiology
• Enteroviruses transmitted by fecal-oral route
and aerosols
• Rhinoviruses transmitted by aerosols and
contact
Diagnosis
• Immune assays (ELISA) or RT-PCR genome
analysis of blood, CSF, or other relevant
sample
Treatment, Prevention, and Control
• OPV and IPV polio vaccines
P
icornaviridae is one of the largest families of viruses and
includes some of the most important human and animal
viruses (Box 46-1). As the name indicates, these viruses are
small (pico) ribonucleic acid (RNA) viruses that have a
naked capsid structure. The family has more than 230
members divided into nine genera, including Enterovirus,
Rhinovirus, Hepatovirus (hepatitis A virus; discussed in
Chapter 55), Cardiovirus, and Aphthovirus. The enterovi-
ruses are distinguished from the rhinoviruses by the stabil-
ity of the capsid at pH 3, the optimum temperature
for growth, the mode of transmission, and their diseases
إياك أن تتلاعب بفتاة انحنى ظهر أبيها
لتصل إلى ما هي عليه
فتهدم ما بناه ..
فيكون لك بناءً يهدمه أحدهم يوماً ما
كن قويا" كجراح ينجز عملية في الدماغ لمعلم أخبره ذات يوم انه طالب فاشل
اختر الألم قبل أن يختارك فألم الإجتهاد أهون بكثير من ألم الندم
أراك فتضحك الدنيا لعيني وتبتسم الأماكن والزوايا أرى كل الوجوه تفيض حبًا كان شعوري اكتنف البرايا.
القلم الذي لا يحمل ضمير الإنسانية وهموم المظلومين وجوع الفقراء وأنين الوطن لا يصلح للكتابة.
كنتُ أبرر فقدان شغفي بأنها استراحة محارب، ولكنه يبدو أنني رميت سيفي وغادرت المعركة..
سيُحبك الحظ أن احببتها صنعانية..
اللهم صل وسلم وبارك علـّۓ نبينا محمد وعلى آله❤️
«سأبـدع فـي نسـيانك وإن رأيتـك سأقـول يخـلق مـن الشـبه اربعـين..!🖤»
" نحن نتكئ دوماً على من نثق بقلوبهم لا بأيديهم..
فقوّة البدن قد تخون ، لكن قوّة المشاعر لا تخون أبداً "
لن يفهمك إلا إثنان ، أحدهما مرّ بنفس حالتك ، والآخر يحبك جداً ..
Polio viruses and polio immunisation ppt by Dr Prince C PDR.PRINCE C P
The causative agent of poliomyelitis (commonly known as polio), is a human Enterovirus and member of the family of Picornaviridae.
Poliovirus was first isolated in 1909 by Karl Landsteiner and Erwin Popper.
Poliovirus is one of the most well-characterized viruses, and has become a useful model system for understanding the biology of RNA viruses.
A breakthrough came in 1948 when the virus was successfully cultivated in human tissue in the laboratory by John Enders.
Enders, Weller and Robins, passaged the same strain in non neuronal cell culture.
Vaccines against poliomyelitis: the formalin-inactivated vaccine (IPV) by Jonas Salk(1953) and the live-attenuated vaccines (OPV) by Albert Sabin (1956)
Picornaviruses presentation for medical student created by: Farhang Shapouran
References : Moray medical microbiology, Jawetz medical microbiology, ICTV
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
2. Enteroviruses
A genus of the picornavirus family
Naked ssRNA virus
Are stable in acidic pH
Enter the body mainly via ingestion
Primary site of replication is lymphoid
tissue in the gut.
Spread to blood and into lumen of gut to
be excreted in feces
4. At least 71 serotypes are known:
divided into 5 groups
Polioviruses
Coxsackie A viruses
Coxsackie B viruses
Echoviruses
Enteroviruses
Enteroviruses
5.
6. Poliovirus
First identified in 1909
First grown in cell culture in 1949 which
became the basis for vaccines.
3 serotypes of poliovirus (1, 2, and 3)
but no common antigen.
Humans are the only susceptible hosts.
Polioviruses are distributed globally.
Immunization has eradicated poliovirus
in most regions of the world except in
the Indian Subcontinent and Africa.
7. Pathogenesis
Incubation period : 7 - 14 days.
After ingestion, the virus multiplies
in the tonsils and Peyer's patches of
the ileum
Transient viraemia occurs
In few cases, involves the CNS
Spreads along axons of peripheral
nerves to involve anterior horn cells
of spinal cord, intermediate grey
ganglia and even posterior horn cells
9. Clinical Manifestations
Subclinical infection (90 - 95%)
A minor influenza-like illness
Recovers within a few days
May be accompanied by aseptic meningitis
Major illness (1 - 2%)
Signs of aseptic meningitis.
Infection of anterior horn cells: flaccid paralysis.
Infection of medulla: respiratory paralysis and death.
10. Laboratory Diagnosis
Virus Isolation
Mainstay of diagnosis
Can be readily isolated in cell culture
from throat swabs, feces, rectal swabs
& CSF.
Serology
Very rarely used
12. Prevention
No specific antiviral therapy is available.
Intramuscular Poliovirus Vaccine (IPV)
Formalin inactivated virus of all 3 serotypes.
Oral Poliovirus Vaccine (OPV)
Consists of live attenuated virus of all 3 serotypes.
Produces local immunity through the induction of
an IgA response as well as systemic immunity.
13. Prevention
The normal response rate to OPV is
close to 100%.
OPV is used for the WHO poliovirus
eradication campaign.
Poliovirus was targeted for eradication
by the WHO by the end of year 2005
Eradicated from most regions of the
world except the Indian subcontinent
and sub-Saharan Africa.
17. Coxsackieviruses
Coxsackieviruses are distinguished from other
enteroviruses by their pathogenicity for suckling rather
than adult mice.
Two groups on the basis of the lesions in suckling mice.
Group A: diffuse myositis with acute inflammation
and necrosis of fibers of voluntary muscles. Has 23
serotypes
Group B: focal areas of degeneration in the brain,
necrosis in the skeletal muscles, and inflammatory
changes in the dorsal fat pads, the pancreas and
occasionally the myocardium. Have 6 serotypes
18. Echoviruses
Were accidentally discovered in human
feces, unassociated with human disease
during epidemiological studies of
polioviruses. The viruses were named
echoviruses (enteric, cytopathic, human,
orphan viruses).
Altogether, There are 32 echoviruses
(types 1-9, 11-27, 29-34
19. New Enteroviruses
Newly identified picornaviruses that are not
polioviruses, coxsackie, and echovirus : 5
types (68 - 72).
Enterovirus 70 causes acute haemorrhagic
conjunctivitis
Enterovirus 71 has been associated with
epidemics of aseptic meningitis, encephalitis,
paralytic poliomyelitis-like disease and
hand-foot-mouth disease.
21. Laboratory Diagnosis
Virus Isolation
Mainstay of diagnosis of enterovirus infection
Coxsackie B and Echoviruses can be readily grown in cell culture from
throat swabs, feces, and rectal swabs. They can also be isolated from the
CSF
Coxsackie A viruses cannot be easily isolated in cell culture. Can be
isolated readily in suckling mice. Molecular techniques may provide a
better alternative.
Serology
Very rarely used for diagnosis since cell culture is efficient.
Neutralization tests or EIAs
23. Management and Prevention
No specific antiviral therapy available
IVIG in the treatment of neonatal
infections or severe infections in
immunocompromised individuals.
HNIG to prevent outbreaks of
neonatal infection with good results.
No vaccine available