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Preconception to pOst-partum study of cardiometabolic health in Primigravid PregnancY
Cardiovascular Risk Following Hypertension
in Pregnancy
Dr Carmel McEniery
Professor Ian Wilkinson
Funded by
Wellcome
Placental Syndromes
Funded by
Wellcome
− Acute onset of high blood pressure + protein in the urine in pregnancy
− More common in first or IVF pregnancies, obesity and high blood pressure
− Complications cause seizures, spontaneous abortions, fetal growth restriction,
preterm delivery, placental abruption, and intrauterine fetal death
500,000
Fetal deaths yearly
Rana, Circ Res, 2019
Hallum, Eur J Prev Cardiol. 2023
POPPY’s Central Hypothesis
Supported by Pilot Studies
Women’s pre-pregnancy cardiometabolic health can explain and predict risk of
placental syndromes and its association with post-partum cardiometabolic health
Funded by
Wellcome
Research Aims
− Identify vascular profiles of before during and after pregnancy, in women with and
without preeclampsia
− Develop pre-conception and early-pregnancy screening tools for predicting pregnancy
complications, facilitating early detection and informing preventative treatment plans.
Funded by
Wellcome
Study Design
Pre-conception 6 weeks 22 weeks 34 weeks 9-12 months post-
delivery
Cardiovascular
health Adaptation to pregnancy
Planned Study Period: Five years
Cardiovascular
health
Largest observational prospective study following women pre-conception to post-partum
SphygmoCor Technology
Funded by
Wellcome
Identify at risk
phenotypes through
central pressure and
waveform parameters
Inform Preventative
and Targeted
Treatment
Measure hemodynamic
changes before, during
and after pregnancy
Accessible, non-invasive
technology enables novel in-
pregnancy monitoring of at
home and in clinic vascular
biomarkers
Funded by
Wellcome
Uganda
Population
− 3000 women planning
their first pregnancy
− 500 women not planning
a pregnancy
Study Sites
− 7 UK
− 1 Uganda
Funded by
Wellcome
Preeclampsia Does Discriminate
Maternal Mortality Rate by Race
Preeclamptic induced maternal deaths:
16%
High-income
countries
26%
Low-income
countries
Prevalence of hypertensive disorders of pregnancy per 100,000 women
Mayrink, Int J Gynecol Obstet. 2023
Li Jiang, Nat. Rev. Endocrinol. 2022
MBRACE-UK 2016
Funded by
Wellcome
CONNEQT data cloud enables;
- At home or remote community monitoring
of vascular risk pre and post pregnancy
- Affordable access to healthcare providers
and follow up assessments
The POPPY study will:
- Determine disparities of cardiovascular
health in ethnically diverse populations.
- Demonstrate feasibility of use and
integration of SphygmoCor technology in
marginalized and low resource communities.
SphygmoCor Technology
Accessible Risk Monitoring
Funded by
Wellcome
Recruitment and Engagement
Existing Media Coverage
including;
- Television
- Papers
- Social media
Increasing awareness of the
POPPY study for recruitment
Funded by
Wellcome
Team

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The POPPY STUDY (Preconception to post-partum cardiovascular function in primigravid pregnancy) Novel use of pressure pulse waveform analysis technologies to identify early risk factors for preeclampsia and other placental syndromes.

  • 1. Preconception to pOst-partum study of cardiometabolic health in Primigravid PregnancY Cardiovascular Risk Following Hypertension in Pregnancy Dr Carmel McEniery Professor Ian Wilkinson Funded by Wellcome
  • 2. Placental Syndromes Funded by Wellcome − Acute onset of high blood pressure + protein in the urine in pregnancy − More common in first or IVF pregnancies, obesity and high blood pressure − Complications cause seizures, spontaneous abortions, fetal growth restriction, preterm delivery, placental abruption, and intrauterine fetal death 500,000 Fetal deaths yearly Rana, Circ Res, 2019 Hallum, Eur J Prev Cardiol. 2023
  • 3. POPPY’s Central Hypothesis Supported by Pilot Studies Women’s pre-pregnancy cardiometabolic health can explain and predict risk of placental syndromes and its association with post-partum cardiometabolic health Funded by Wellcome Research Aims − Identify vascular profiles of before during and after pregnancy, in women with and without preeclampsia − Develop pre-conception and early-pregnancy screening tools for predicting pregnancy complications, facilitating early detection and informing preventative treatment plans.
  • 4. Funded by Wellcome Study Design Pre-conception 6 weeks 22 weeks 34 weeks 9-12 months post- delivery Cardiovascular health Adaptation to pregnancy Planned Study Period: Five years Cardiovascular health Largest observational prospective study following women pre-conception to post-partum
  • 5. SphygmoCor Technology Funded by Wellcome Identify at risk phenotypes through central pressure and waveform parameters Inform Preventative and Targeted Treatment Measure hemodynamic changes before, during and after pregnancy Accessible, non-invasive technology enables novel in- pregnancy monitoring of at home and in clinic vascular biomarkers
  • 6. Funded by Wellcome Uganda Population − 3000 women planning their first pregnancy − 500 women not planning a pregnancy Study Sites − 7 UK − 1 Uganda
  • 7. Funded by Wellcome Preeclampsia Does Discriminate Maternal Mortality Rate by Race Preeclamptic induced maternal deaths: 16% High-income countries 26% Low-income countries Prevalence of hypertensive disorders of pregnancy per 100,000 women Mayrink, Int J Gynecol Obstet. 2023 Li Jiang, Nat. Rev. Endocrinol. 2022 MBRACE-UK 2016
  • 8. Funded by Wellcome CONNEQT data cloud enables; - At home or remote community monitoring of vascular risk pre and post pregnancy - Affordable access to healthcare providers and follow up assessments The POPPY study will: - Determine disparities of cardiovascular health in ethnically diverse populations. - Demonstrate feasibility of use and integration of SphygmoCor technology in marginalized and low resource communities. SphygmoCor Technology Accessible Risk Monitoring
  • 9. Funded by Wellcome Recruitment and Engagement Existing Media Coverage including; - Television - Papers - Social media Increasing awareness of the POPPY study for recruitment