Viruses are the most common cause of infectious diarrhea, responsible for up to 3/4 of all cases globally. Rotaviruses cause the majority (50-80%) of viral gastroenteritis cases and are responsible for over half a million deaths per year in developing nations, mostly in undernourished infants and young children. Rotaviruses are naked double-stranded RNA viruses that are transmitted via the fecal-oral route and cause acute onset vomiting and diarrhea. Rapid antigen testing of stool samples can diagnose rotavirus infection. While rotavirus vaccines are now available for children, rotaviruses remain a major public health challenge worldwide, especially in developing countries.