1. Felix Bloch and Edward Purcell independently discovered nuclear magnetic resonance in 1946, which led to the development of NMR and its use for molecular analysis between 1950-1970.
2. In 1971, Raymond Damadian showed tissues and tumors had differing nuclear magnetic relaxation times, motivating the use of magnetic resonance for disease detection. He then spent seven years creating the first MRI machine.
3. The first commercial MRI was introduced in 1980 by FONAR and MRI continued developing, including the creation of open MRI machines and use of surface coils to optimize imaging of specific regions.
3 tesla mri, its physics, advantages and disadvantages, its comparison with 1.5 tesla mri scanner, clinical applications of 3 tesla mri, various artifacts related to 3 tesla, physics of silent mri, advantages of silent mri
3 tesla mri, its physics, advantages and disadvantages, its comparison with 1.5 tesla mri scanner, clinical applications of 3 tesla mri, various artifacts related to 3 tesla, physics of silent mri, advantages of silent mri
This presentation contains very basic information regarding common MRI sequences of BRAIN MRI. This will be helpful for neurologist, medical students and graduates.
This presentation contains very basic information regarding common MRI sequences of BRAIN MRI. This will be helpful for neurologist, medical students and graduates.
Anatomy of Brain by MRI
In this presentation we will discuss the cross sectional anatomy of brain. Then we will discuss the Most common diseases to be evaluated by brain imaging.
In my opinion this presentation is a road map for beginars.
Computed tomography (CT scan) is a medical imaging procedure that uses computer-processed X-rays to produce tomographic images or 'slices' of specific areas of the body. These cross-sectional images are used for diagnostic and therapeutic purposes in various medical disciplines.
Significance of Brain imaging in Psychiatry. Most of the major Psychiatric disorders are associated with statistically significant differences on various Neuroimaging measures, when comparing groups of patients and controls.
Describes the imaging diagnostic criteria of acute diverticulitis in barium studies , ultrasound , computed tomography and MRI .and the classification and complications of acute diverticulitis
Describe types of bowel wall thickening on enhanced CT scan and the diagnostic signs to differentiate inflammatory , neoplastic , ischemic and other causes of bowel wall thickening .
Describes the basic radiology of diffuse interstitial disease ,with differential diagnosis of nodular interstitial pattern and how to approach HRCT findings .
Describes the basic radiology of diffuse interstitial disease ,with differential diagnosis of reticular interstitial pattern and how to approach HRCT findings .
Describes parts of the mediastinum and anatomical landmarks and common mediastinal pathologies and there radiological features and differentiation in a simple educational way with multiple CT examples of different cases .
Describes cross sectional anatomy of the mediastinum , and lobar and segmental anatomy of the lung with teaching points and radiological guidelines and multiple examples of lobar and segmental pathologies and how we localize these pathologies .Also the types of chest CT images and indications of chest CT.
Definition of stroke and cerebrovascular disorders and pathophysiology of cerebral infarct and CT imaging overview of acute-subacute and chronic infarcts and penumbra.
causes of cerebral edema , Radiological signs of acute infarct and hemorrhagic infarct and comparison of MRI and CT in the diagnosis of acute infarct
Role of diffusion weighted imaging (DWI) and diffusion perfusion mismatch
Describe different types of cerebral hemorrhage , causes ,and ,radiological features and important distinguishing imaging criteria with illustrative diagrams and CT images with notice on the complications of brain injury , types of skull fractures with plain x ray images and anatomy of the meninges and the importance of CT imaging in cases of head injury
Brain CT Anatomy and Basic Interpretation Part IISakher Alkhaderi
Detailed anatomy of the brain ventricles , CSF production and pathway and arterial supply and venous drainage of the brain and corresponding CT cross sectional anatomy and definition of sulcus and gyrus and fissure and the names of the important gyri .
Brain CT Anatomy and Basic Interpretation Part ISakher Alkhaderi
Detailed anatomy and Radiological guidelines for radiologist and general physicians to facilitate use of BRAIN CT SCAN in medical diagnosis and emergencies supported by images and scientific data.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. "Felix Bloch and Edward Purcell, both of whom were
awarded the Nobel Prize in 1952, discovered the
nuclear magnetic resonance (NMR) phenomenon
independently in 1946. In the period between 1950 and
1970, NMR was developed and used for chemical and
physical molecular analysis. In 1971 Raymond Damadian
showed that the nuclear magnetic relaxation times of
tissues and tumors differed, thus motivating
scientists to consider magnetic resonance for the
detection of diseases. Dr. Damadian and his team
spent the next seven years diligently designing and
creating the first MRI machine for medical imaging of
the human body."
MRI HISTORY
FONAR introduced the world's first commercial MRI (a whole-body MRI scanner)
in 1980, and went public in 1981.
8. The OPEN MRI's started to come into production . The initial intent was to provide a
tool to perform the MRI diagnostic testing for patients that were a) Claustrophobic
or 2) Too obese to fit into the Closed models.
14. Surface Coils.
Surface coils are designed to provide a very high RF sensitivity over a small reg
interest. These coils are often single or multi-turn loops which are placed direct
the anatomy of interest. The size of these coils can be optimized for the specifi
region of interest.
50. Diffusion weighted imaging (DWI) is a form of MR
imaging based upon measuring the random
Brownian motion of water molecules within a
voxel of tissue. The relationship between histology
and diffusion is complex, however generally
densely cellular tissues or those with cellular
swelling exhibit lower diffusion coefficients, and
thus diffusion is particularly useful in tumour
characterisation and cerebral ischaemia.
51. DW imaging has a major role in the following clinical
situations 3-5:
early identification of ischemic stroke
differentiation of acute from chronic stroke
differentiation of acute stroke from other stroke mimics
differentiation of epidermoid cyst from arachnoid cyst
differentiation of abscess from necrotic tumors
assessment of cortical lesions in CJD
differentiation of herpes encephalitis from diffuse temporal
gliomas
assessment of the extent of diffuse axonal injury
grading of gliomas and meningiomas (need further study)
assessment of active demyelination
57. Functional magnetic resonance
imaging or functional MRI (fMRI) is
a functional neuroimaging procedure
using MRItechnology that measures brain activity by
detecting associated changes in blood flow.[1][2] This
technique relies on the fact that cerebral blood flow
and neuronal activation are coupled. When an area of
the brain is in use, blood flow to that region also
increases.
The primary form of fMRI uses the blood-oxygen-level
dependent (BOLD) contrast,[3] discovered by Seiji
Ogawa. This is a type of specialized brain and body
scan used to map neural activity in the brain or spinal
cord of humans or other animals by imaging the
change in blood flow (hemodynamic response)
related to energy use by brain cells.
58.
59. MRI
SPECTROSCOPY
The basic principle that enables MR
spectroscopy (MRS) is the electron
cloud around an atom that shields the
nucleus from the magnetic field to a
greater or lesser degree. This naturally
results in slightly resonant frequencies,
which in turn return a slightly different
signal.
60. MR spectroscopy
MR spectroscopy (MRS)
Hunter's angle
lactate peak: resonates at 1.3 ppm
lipids peak: resonate at 1.3 ppm
alanine peak: resonates at 1.48 ppm
N-acetylaspartate (NAA) peak: resonates at 2.0
glutamine-glutamate peak: resonate at 2.2-2.4 ppm
gamma-aminobutyric acid (GABA) peak: resonate at
2.2-2.4 ppm
citrate peak: resonates at 2.6 ppm
creatine peak: resonates at 3.0 ppm
choline peak: resonates at 3.2 ppm
myo-inositol peak: resonates at 3.5 ppm
61.
62.
63.
64. Magnetic resonance elastography (MRE) is a non-
invasive medical imaging technique that measures
the mechanical properties (stiffness) of soft tissues by
introducing shear waves and imaging their
propagation using MRI. Pathological tissues are often
stiffer than the surrounding normal tissue. For instance,
malignant breast tumors are much harder than
healthy fibro-glandular tissue. This characteristic has
been used by physicians for screening and diagnosis
of many diseases, through palpation. MRE calculates
the mechanical parameter as elicited by palpation,
in a non-invasive and objective way.