This document discusses the physical principles of ultrasound used in medical imaging. It defines key terms like frequency, wavelength, attenuation and resolution. It describes how piezoelectric transducers convert electrical pulses to ultrasound pulses and echoes. It explains how sector and linear array transducers work and the different display modes. It also discusses artifacts and the safety of diagnostic medical ultrasound.
Training Material inherited form Philips Basics of Ultrasonography. Covers the fundamentals of Ultrasound Waveform, Piezoelectric Effect, Phased Echo Concept, Goal of Ultrasound, Ultrasound Image Construction process, Types of Resolution, Probe Internals, The Doppler Effect, Spectrum Waveform and concept, Color Doppler, Components of Ultrasound.
Ultrasound Physics Made easy - By Dr Chandni WadhwaniChandni Wadhwani
History of ultrasound, Principle of Ultrasound.
Ultrasound wave and its interactions
Ultrasound machine and its parts, Image display, Artifacts and their clinical importance
what is Doppler ultrasound, Elastography and Recent advances in field of ultrasound.
Safety issues in ultrasound.
• What is Ultrasound imaging?
• Why Ultrasound?
• Common Uses
• History
• Properties of Ultrasound
• Equipment types
• How does the procedure work?
• Physics
• Benefits and Risks etc.
Training Material inherited form Philips Basics of Ultrasonography. Covers the fundamentals of Ultrasound Waveform, Piezoelectric Effect, Phased Echo Concept, Goal of Ultrasound, Ultrasound Image Construction process, Types of Resolution, Probe Internals, The Doppler Effect, Spectrum Waveform and concept, Color Doppler, Components of Ultrasound.
Ultrasound Physics Made easy - By Dr Chandni WadhwaniChandni Wadhwani
History of ultrasound, Principle of Ultrasound.
Ultrasound wave and its interactions
Ultrasound machine and its parts, Image display, Artifacts and their clinical importance
what is Doppler ultrasound, Elastography and Recent advances in field of ultrasound.
Safety issues in ultrasound.
• What is Ultrasound imaging?
• Why Ultrasound?
• Common Uses
• History
• Properties of Ultrasound
• Equipment types
• How does the procedure work?
• Physics
• Benefits and Risks etc.
Learn from our Slideshare about the differences between ultrasound transducers. We also cover tips on how to treat your probes and how to select the right one.
Usg transducer and basic principles of ultrasound Doppler, this slide describe the basic physics of ultrasound transducer and Doppler , must know thing is given in this presentaion. Good review for radiology resident. Thanks.
An overview of Doppler Effect in Ultrasonography - the medical imaging of the body using Ultrasound.
Includes Colour Doppler, Power Doppler, Spectral Doppler, Continuous Wave Doppler, Pulsed Wave Doppler, and comparisons with other Radiographic imaging modalities.
Learn from our Slideshare about the differences between ultrasound transducers. We also cover tips on how to treat your probes and how to select the right one.
Usg transducer and basic principles of ultrasound Doppler, this slide describe the basic physics of ultrasound transducer and Doppler , must know thing is given in this presentaion. Good review for radiology resident. Thanks.
An overview of Doppler Effect in Ultrasonography - the medical imaging of the body using Ultrasound.
Includes Colour Doppler, Power Doppler, Spectral Doppler, Continuous Wave Doppler, Pulsed Wave Doppler, and comparisons with other Radiographic imaging modalities.
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. Course Objectives
• Identify history & define ultrasound
• Define piezoelectric effect
• Define frequency & wavelength; identify their relationship
• Define bandwidth
• Define attenuation; identify relationship to frequency
• Define resolution & its components; identify relationship
to frequency
• Identify basic transducer types
• Define electronic array
• Differentiate between sector & linear array
• Identify types of image display
• Identify artifacts useful to diagnosis
• Discuss safety of medical ultrasound
3. History of Ultrasound
• Piezoelectricity discovered by the Curies in
1880 using natural quartz
• SONAR was first used in 1940’s war-time
• Diagnostic Medical applications in use
since late 1950’s
5. Ultrasound: Medical Definition
• Diagnostic Medical Ultrasound is the use of
high frequency sound to aid in the diagnosis
and treatment of patients.
• Frequency ranges used in medical
ultrasound imaging are 2 - 15 MHz
6. Piezoelectric Effect
• Definition: The principle of converting
energy by applying pressure to a crystal.
• The reverse of the piezoelectric effect
converts the energy back to its original
form.
7. Piezoelectric Effect and
Ultrasound Transducers
• A transducer converts one type of energy
into another.
• Based upon the pulse-echo principle
occurring with ultrasound piezoelectric
crystals, ultrasound transducers convert:
– Electricity into sound = pulse
– Sound into electricity = echo
8. Pulse
• Pulse of sound is sent to soft tissues
• Sound interaction with soft tissue =
bioeffects
• Pulsing is determined by the transducer or
probe crystal(s) and is not operator
controlled
9. Echo
• Echo produced by soft tissues
• Tissue interaction with sound =
acoustic propagation properties
• Echoes are received by the transducer
crystals
• Echoes are interpreted and processed by
the ultrasound machine
10. Frequency
• Number of complete cycles per unit of time
• Man-made transducer frequency is
predetermined by design
• Ultrasound transducers are referred to by
the operating, resonant or main frequency
11. Frequency Units
• One cycle per second = one Hertz (Hz)
• One thousand Hertz = One kilohertz (KHz)
• One million Hertz = One megahertz (MHz)
Example: a 7.5 MHz transducer operates at
7,500,000 cycles per second
12. Wavelength
• Definition: The distance between
consecutive cycles of sound.
Transducer frequency
Transducer wavelength
14. Bandwidth
• All ultrasound transducers contain a range
of frequencies, termed bandwidth
• Broad bandwidth technology produces
medical transducers that contain more than
one operating frequency, for example:
– 2.5 - 3.5 MHz for general abdominal imaging
– 5.0 - 7.5 MHz for superficial imaging
15. Attenuation
• Definition: The reduction in power and
intensity as sound travels through a
medium.
Transducer frequency
Depth of penetration
• Higher frequencies attenuate, or are
absorbed, faster than lower frequencies
17. Time Gain Compensation
• Operator controlled adjustment to
compensate for the attenuation of
sound as it travels into the tissue
• Must be adjusted manually for each
tissue type examined and may be
manipulated throughout an exam to
optimize the image
18. RESOLUTION
• The ability to differentiate between
structures that are closely related, both in
terms of space and echo amplitude
• Wavelength (frequency) dependent
– Gray Scale Resolution
– Axial Resolution
– Lateral Resolution
19. Frequency vs. Resolution
Transducer frequency
Resolution and image detail
• Higher frequency transducers provide
better image resolution
– better gray scale resolution
– improved ability to distinguish fine detail
21. Gray Scale Resolution
• Adequate gray scale resolution allows for
the differentiation of subtle changes in the
tissues
• Dynamic Range determines how many
shades of gray are demonstrated on an
image
23. Axial & Lateral Resolution
• Spatial Resolution describes how physically
close two objects can be and displayed
separately.
– Axial: along the beam path
– Lateral: perpendicular to beam path
• All current equipment has an overall spatial
resolution of 1.0 mm or less.
24. Frequency Summary
• High frequency • Low frequency
– improved – poorer resolution
resolution
– depth of penetration – full depth of
loss penetration
– higher frequency – lower frequency
transducers for transducers for general
superficial uses abdominopelvic uses
27. Electronic Arrays
• Groups of piezoelectric material working
singly or in groups
Transducer
1 2 3 4 5 6 7 8 126
28. Electronic Transducers
• Sector Array • Linear Array
– crystals are placed – crystals are placed
parallel or in parallel
concentric rings
– transducer face is – transducer face is
curved flat
– produces sector or – produces
pie-shaped image rectangular image
29. Display Field of View
• Field Of View -- the display of the echo
amplitudes
• shape dependent on transducer type and
function
30. Field of View Shapes
• SECTOR FOV • LINEAR FOV
• produced by • produced by
oscillating linear arrays
rotating
curved arrays
phased arrays
• typically used in • typically used in
abdominal application superficial application
36. Artifacts
• Portions of the display
which are not a “true”
representation of the
tissue imaged
• Medical Diagnostic
Ultrasound imaging
utilizes certain
artifacts to
characterize tissue
37. Artifacts
• The ability to differentiate solid vs. cystic
tissue is the hallmark of ultrasound imaging
• Acoustic Shadowing and Acoustic
Enhancement are the two artifacts that
provide the most useful diagnostic
information
38. Shadowing
• Diminished sound or loss of sound
posterior to a strongly reflecting or strongly
attenuating structure
– Strong reflectors
• large calcifications, bone
– Strong attenuators
• solid tissue, significantly dense or malignant masses
40. Enhancement
• Increased through transmission of the sound
wave posterior to a weakly attenuating
structure
• Gain curve expected a certain loss or
attenuation with depth of travel
– Occurs posterior to
• simple cysts or weakly attenuating masses
42. Bioeffects
• Prudent use assures patient safety
• Effects at intensities higher than those used
in diagnostic medical ultrasound include:
cavitation
sister chromatid exchange
43. AIUM Statement
• “No confirmed biological effects on patients
or operators caused by exposure at
intensities typical of diagnostic
ultrasound…
• ...current data indicate that the benefits…
outweigh the risks.”
44. Summary
• Ultrasound > 20,000 Hz
• Piezoelectric Effect = pulse-echo principle
• Frequency & wavelength are inversely proportional
• Broad bandwidth enables multihertz probes
• Attenuation & frequency are inversely related
• Resolution determines image clarity
• Electronic Arrays may be sector or linear
• Display mode chosen determines how image is registered
• Shadowing & Enhancement are the artifacts most used in
ultrasound diagnosis
• Diagnostic Medical Ultrasound is safe!