This document discusses the evaluation, staging, surgical treatment options, complications, and prognosis for lung cancer. Key points include:
- Evaluation involves imaging like CT scans, biopsies, and pulmonary function tests. Surgery is indicated for early stage tumors.
- Surgical options include lobectomy, pneumonectomy, wedge resection or segmental resection depending on tumor size and location.
- Complications can include air leaks, infection, hemorrhage or formation of a bronchopleural fistula. Outcomes depend on cancer cell type and stage, with earlier stage having higher 5-year survival rates.
This is a brief review of airway management (basics, exams and devices).
Special thanks to Dr. S. Malek for kind sharing of his valuable slides on this topic.
The technique of pulmonary resection had dramatically changed from mass ligation of pulmonary hilum to individual ligation of hilar structures and recently to video-assisted thoracoscopic pulmonary resection. However, the safe performance of lung resection requires a perfect knowledge of hilar anatomy and a technique with which the surgeon is familiar.
This is a brief review of airway management (basics, exams and devices).
Special thanks to Dr. S. Malek for kind sharing of his valuable slides on this topic.
The technique of pulmonary resection had dramatically changed from mass ligation of pulmonary hilum to individual ligation of hilar structures and recently to video-assisted thoracoscopic pulmonary resection. However, the safe performance of lung resection requires a perfect knowledge of hilar anatomy and a technique with which the surgeon is familiar.
This introductory lecture in thoracic surgery covers the following topics:
Development of the lung.
Developmental Anomalies.
Anatomy of the lungs and the bronchial tree.
Diagnostic procedures in thoracic surgery.
Closed tube thoracostomy.
Aspirated tracheobronchial foreign bodies.
Pulmonary hydatid cysts.
Pulmonary medicine- Scope and Future by Dr. Jebin Abraham, MD.Jebin Abraham
Pulmonary Medicine is a branch of medicine that deals with respiratory diseases, chest wall diseases, sleep disorders, allergy and much more. This presentation describes this specialty branch in detail with scope and current perspectives being emphasized. It will help in PG aspirant medicos, academicians and undergraduate students to know about Pulmonary Medicine in detail.
Despite modern anti-tuberculous chemotherapy, approximately 2% of all cases of pulmonary mycobacterial infection require surgical treatment.Therefore, surgical treatment of pulmonary mycobacterial disease is rarely necessary.Types of surgical procedures for PTB include: Collapse therapy, pulmonary resection, lung decortication, drainage procedures such as closed tube thoracostomy, rib resection and open window thoracotomy beside pulmonary resection+ collapse therapy (thoracoplasty). The decreasing morbidity and mortality of pulmonary resection for PTB is due to careful patient selection ( failure of chemotherapy, massive haemoptysis, BPF), improved anaesthetic techniques, stapling devices and better chemotherapy.The prognosis after successful resection is excellent ( 90% survive and remain disease free).
This introductory lecture in thoracic surgery covers the following topics:
Development of the lung.
Developmental Anomalies.
Anatomy of the lungs and the bronchial tree.
Diagnostic procedures in thoracic surgery.
Closed tube thoracostomy.
Aspirated tracheobronchial foreign bodies.
Pulmonary hydatid cysts.
Pulmonary medicine- Scope and Future by Dr. Jebin Abraham, MD.Jebin Abraham
Pulmonary Medicine is a branch of medicine that deals with respiratory diseases, chest wall diseases, sleep disorders, allergy and much more. This presentation describes this specialty branch in detail with scope and current perspectives being emphasized. It will help in PG aspirant medicos, academicians and undergraduate students to know about Pulmonary Medicine in detail.
Despite modern anti-tuberculous chemotherapy, approximately 2% of all cases of pulmonary mycobacterial infection require surgical treatment.Therefore, surgical treatment of pulmonary mycobacterial disease is rarely necessary.Types of surgical procedures for PTB include: Collapse therapy, pulmonary resection, lung decortication, drainage procedures such as closed tube thoracostomy, rib resection and open window thoracotomy beside pulmonary resection+ collapse therapy (thoracoplasty). The decreasing morbidity and mortality of pulmonary resection for PTB is due to careful patient selection ( failure of chemotherapy, massive haemoptysis, BPF), improved anaesthetic techniques, stapling devices and better chemotherapy.The prognosis after successful resection is excellent ( 90% survive and remain disease free).
Lung cancer causes due to various reasons. once it is identified at initial stage it can be cured by surgery.Get to know about types of surgery for lung cancer.
Valular heart disease is very common in most of Afro Asian counteries mainly due to Rheumatic heart disease..Definitive treatment is surgery.which may be valve replacement or reapir. In this ppp I have discussed this subject in a simple way
In detail about the GINGIVOBUCCAL COMPLEX CANCER
ANATOMY of Oral Cavity, Tonge, GBC.are well explained in detail.
RISK FACTORS
PREMALIGNANT LESIONS
PREMALIGNANT CONDITIONS
A Brief description of Tracheotomy.. Good enough for Undergraduate MBBS Students. . You can staright away download this and present in your class seminars.. ;)
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
4. Fit patient
No evidence of spread of tumour outside the
chest
No clinical or investigatory evidence of
inoperability
Tumour graded up to T2,N1,M0 are indicated
for surgical resection
5. Reduction of bronchial infection
Reduction of bronchospasm
Deep breathing exercise instructed by
physiotherapist
Arrangement 3-4pints of compatible blood
transfusion
Consent-which also includes the consent for
death on table
6. Tumour inability to separate from aorta/sup vena
cava
Inability to separate from lower end of trachea
Spread of tumour along the pulm vein to left
atrium
Spread along the pulmonary artery
Involvement of the oesophagial mucosa
Contalateral/supraclavicular node involvement
Malignant pleural/pericardial effusion
Phrenic nerve,recurrent laryngeal nerve
involvement
8. A thoractomy is performed to
diagnose lung cancer, remove
lung cancer, and for other
benign conditions. It is mainly
performed in early stage non-
small cell lung cancer
patients.
9. A double lumen endotracheal tube is used to
ventilate one lung keeping the other collapsed
to facilitate surgery
Patient is turned on unaffected side in lateral
position keeping upper arm supported in
90”flexion & lower limb flexed at hip & knee
Posterolateral incision is taken for best
exposure allowing hilium to be approached
both in front & behind
Rib spreader is inserted following the
approximation of subcutaneous tissues &
muscles
10. The anesthetist is now
able to deflate the
affected lung for better
view of intrathoracic
structures
Finally the appropriate
surgical method for
resection of tumour is
performed
12. Surgical resection
Surgical resection with
complete mediastinal
lymph node dissection
En block resection of
tumour with involved
chest wall
Sleeve resection or
pneumonectomy
Stage IA,IB,IIA,IIB
& some IIIA
Stage IIIA
• Tumours with chest wall
invasionT3
• Sup sulcus tumours
• Proximal airway involvt
13. • Stage IIIA,IIIB,N2
• Stage IIIB + carinal
invasion T4 Without N2
involt
Rt & chemotherapy
Pneumonectomy with
tracheal sleeve
resection with direct
reanastomosis of
contralat mainstem
bronchus
14. Surgical removal of a lobe
of a lung
Indication
1. Peripheral growth but
confined to one lobe
2. Patient unfit for
pneumonectomy for
elderly age& impaired
lung function
15. Following dissection of fissures & hilar
structures in thoracotomy the branches of
pulmonary artery & vein is isolated & ligated
The bronchus is later sewn or stapled
After the completion of operation the
remaining lung is reinflated
16. it is the surgical removal of a
small portion of the lung
along with healthy tissue
that surrounds the lung.
It is carried out by
thoracoscopy or VATS
The newer methods are
excision of portion of lobes
using stapling
devices,cautery or laser
ablation
17. Surgical removal of a lobe
along with some part of
the involved bronchus
Indication-a tumor arising
at the origin of a lobar
bronchus precluding
simple lobectomy, but
not infiltrating as far as
to require
pneumonectomy.
18. It is a most valuable procedure in cases
wherein the growth involves a part of
bronchus
Here a sleeve of the main bronchus is removed
with the lobe & the two ends of the main
bronchus are re-anastomosed
19. It is the surgical removal of one or
more bronchopulmonary
segments of an individual lobe
through ligation & division of
bronchopulmonary structures
Indication-localized peripheral
tumour in an elderly patient
with poor respiratory function
20. When a segment is to be resected the
appropriate segmental artery & bronchus are
divided at the hilium & clamp is then placed at
the distal end of bronchus
The remaining lung is inflated by increasing
endotracheal pressure
21. It is the surgical removal of
the whole lung
Indication
1. Tumours involving many
lobes but confined to the
lung
2. Centrally tumours
involving the main
bronchus or those that
straddle the fissures
22. Standard pneumonectomy
Extended radical pneumonectomy
Here the pulmonary artery is first dissected ,
divide & sutured followed by superior or
inferior pulmonary vein
Finally the main bronchus is divided keeping in
mind no blind stump remains to prevent
bronchoplueral fistula.
Mortality rate is 5-10%
23. A type of minimally
invasive surgery
it is used to detect
stage, and/or remove
lung cancer.
3 1/4-1/2” incisions are
made between ribs &3
ports are inserted to
hold instruments.
24. VATS
here a camera is
attached to the
thoracoscope with the
image displayed on
television screen
pneumonectomy ,
lobectomy & empyema
drainage are possible
25. Advantages of thoracoscopy
over thoracotomy
Mean blood loss is less
No intraoperative death cases or any major
complications
Shorter hospitalization
Lesser post operative pain
Lesser postoperative complication
Less impairment of pulmonary functions
Better quality of life
26. Principle
After lobectomy/ segmental resection
• Early expansion of remainder of lung
• Prevent trachobronchial infection
• Efficient physiotherapy
• Fluid overload to be avoided
• Mobilization in 2-3days
• Breathing exercise
28. 4 strategies
1. Patient controlled analgesia with I V bolus
opiates
2. Paravertebral,extraplueral catheter delivered
3. Oral analgesic& paracetamol
4. Avoid rib fracture & entrapment of intercostal
nerves to prevent chronic unavoidable pain
29. Large calibre 24-28F Intercostal
drains inserted by making exit
site thr 7th-8th intercostal space
Apical drain & Basal drain
The intercostal tubes are
connected to underwater seal
The tube is clamped & released
every hourly for 1min &
draining is noted
Tube is removed after 24hrs
Suction should never be
performed
30. Early
Sputum retention
Atrial fibrillation
Bronchospasm
Surgical emphysema
Hemorrhage
Persistent air leak
Late
Empyema
Bronchoplueral fistula
31. Serious complication
Following
pneumonectomy the
space left behind is
initially filled with air
which gradually gets filled
with tissue fluid
Dehiscence of bronchial
stump leads to fistula
formation & the fluid is
expectorated in large
quantities
32. • In order to avoid bronchoplueral fistula the
bronchus is divided close to the trachea or
adjacent lobar bronchus
• The bronchial stump is usual stapled after
pneumonectomy
• Postoperatively the patient is nursed sitting up
turned to affected side to prevent infected
fluid entering remaining lung & use of chest
drain
34. Stage
Stage I
Stage II
Stage IIIa
Stage IIIb,IV
Treatment
Surgery followed by chemotherapy
Surgery followed by chemotherapy
& radiation
Surgery followed by radiotherapy
with/without chemotherapy before
or after surgery
Surgery for lung tumour & brain
tumour
5-year survival rates
60 to 70%
40 to 50%
15 to 30%
10 to 15%