Lung cancer surgery
•Download as PPTX, PDF•
4 likes•2,372 views
Lung cancer causes due to various reasons. once it is identified at initial stage it can be cured by surgery.Get to know about types of surgery for lung cancer.
Report
Share
Report
Share
Recommended
Lung cancer treatment
Lung cancer treatment depends on the type and stage of cancer. The most common types are small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC). For early-stage NSCLC, surgery such as lobectomy or pneumonectomy is the standard treatment and can be curative. Adjuvant chemotherapy may be given after surgery. Later stage NSCLC is typically treated with chemotherapy, radiation therapy, or a combination. SCLC is usually treated with chemotherapy and radiation therapy since it often cannot be completely surgically removed. The 5-year survival rate after treatment ranges from 75% for stage 1 to less than 30% for stage 3 lung cancer.
Principles of surgical oncology
Presentation encompasses basic oncological principles adhered to in managing surgical patients with cancers
Basic Principles of Oncoplastic breast surgery
This document provides information on breast oncoplastic surgery techniques:
- Oncoplastic surgery (OPS) integrates plastic surgery with breast-conserving cancer surgery to allow for wider excisions without compromising breast shape. It ranges from simple reshaping to advanced mammoplasty techniques.
- Key factors in determining the appropriate OPS approach are excision volume, tumor location, breast density, and glandular composition. Excisions over 20% of breast volume or from certain locations risk deformity. OPS allows excision of up to 1000g compared to 80g for standard surgery.
- OPS techniques are classified into Level I involving reshaping and Level II involving skin excision and reshaping using
CLASSIFICATION OF LUNG TUMORS
Non–small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. Histologically, NSCLC is divided into adenocarcinoma, squamous cell carcinoma (SCC) (see the image below), and large cell carcinoma. Small cell lung cancer (SCLC), previously known as oat cell carcinoma, is considered distinct from other lung cancers, which are called non–small cell lung cancers (NSCLCs) because of their clinical and biologic characteristics.
D2 distal gastrectomy final
This document discusses the current evidence for D1 and D2 gastrectomy in treating gastric cancer. It begins by defining the lymph node stations and different levels of lymphadenectomy. It then reviews several key randomized controlled trials that compared D1 and D2 gastrectomy. While initial Western trials found higher morbidity and mortality with D2 without survival benefits, later long-term follow up and recent trials demonstrate lower recurrence rates and improved survival with D2 gastrectomy when performed safely. The consensus is that D2 gastrectomy with preservation of the spleen and pancreas can achieve radical treatment for gastric cancer with excellent outcomes when performed by experienced surgeons.
Surgical Approach to Non Small Cell Lung Cancer
1) Surgery is still the mainstay of curative treatment for NSCLC, though diagnostic role has decreased with less invasive techniques preferred if doubt remains after needle biopsies.
2) Pre-operative assessment is key to determine operability and extent of surgery. N2 involvement means surgery is not recommended initially.
3) Lobectomy is the standard resection but sublobar options are available for selected patients based on cardiopulmonary reserve and disease characteristics like small GGO lesions. Pneumonectomy should be avoided with sleeve lobectomy preferred.
4) Minimally invasive surgery like VATS is becoming the preferred approach over thoracotomy for select patients when oncologic principles can be maintained
Lung cancer anatomy to pathological classification
The document summarizes lung cancer anatomy, risk factors, epidemiology, clinical features, diagnosis, staging and pathological classification. It notes that tobacco consumption causes 80-90% of lung cancers. Diagnostic workup includes imaging like CT, PET scans and biopsies to determine cancer type which are most commonly adenocarcinoma, squamous cell carcinoma, small cell lung cancer or large cell carcinoma. Staging uses the AJCC TNM system and influences treatment options and prognosis.
Oncoplastic breast surgery
Oncoplastic Breast surgery is simultaneous application of lumpectomy and reconstructive techniques. The word ‘oncoplastic’ is derived from the Greek words ‘onco’ (tumour) and ‘plastic’ (to mould).
Approximately 10% to 30% of patients submitted to BCS alone are not satisfied with the aesthetic outcomes like “swan beak/ parrot beak deformities. The main reasons are related this is the tumour resection which can produce asymmetry, retraction, and volume changes in the breast.
Recently, increasing attention has been focused on oncoplastic procedures since the immediate application of plastic breast surgery techniques provide a wider local excision while still achieving the goals of a better breast shape and symmetry to obtain oncologically sound and aesthetically pleasing results. Thus, by means of customized techniques the surgeon ensures that oncologic principles are not jeopardized while meeting the needs of the patient from an aesthetic point of view.
Recommended
Lung cancer treatment
Lung cancer treatment depends on the type and stage of cancer. The most common types are small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC). For early-stage NSCLC, surgery such as lobectomy or pneumonectomy is the standard treatment and can be curative. Adjuvant chemotherapy may be given after surgery. Later stage NSCLC is typically treated with chemotherapy, radiation therapy, or a combination. SCLC is usually treated with chemotherapy and radiation therapy since it often cannot be completely surgically removed. The 5-year survival rate after treatment ranges from 75% for stage 1 to less than 30% for stage 3 lung cancer.
Principles of surgical oncology
Presentation encompasses basic oncological principles adhered to in managing surgical patients with cancers
Basic Principles of Oncoplastic breast surgery
This document provides information on breast oncoplastic surgery techniques:
- Oncoplastic surgery (OPS) integrates plastic surgery with breast-conserving cancer surgery to allow for wider excisions without compromising breast shape. It ranges from simple reshaping to advanced mammoplasty techniques.
- Key factors in determining the appropriate OPS approach are excision volume, tumor location, breast density, and glandular composition. Excisions over 20% of breast volume or from certain locations risk deformity. OPS allows excision of up to 1000g compared to 80g for standard surgery.
- OPS techniques are classified into Level I involving reshaping and Level II involving skin excision and reshaping using
CLASSIFICATION OF LUNG TUMORS
Non–small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. Histologically, NSCLC is divided into adenocarcinoma, squamous cell carcinoma (SCC) (see the image below), and large cell carcinoma. Small cell lung cancer (SCLC), previously known as oat cell carcinoma, is considered distinct from other lung cancers, which are called non–small cell lung cancers (NSCLCs) because of their clinical and biologic characteristics.
D2 distal gastrectomy final
This document discusses the current evidence for D1 and D2 gastrectomy in treating gastric cancer. It begins by defining the lymph node stations and different levels of lymphadenectomy. It then reviews several key randomized controlled trials that compared D1 and D2 gastrectomy. While initial Western trials found higher morbidity and mortality with D2 without survival benefits, later long-term follow up and recent trials demonstrate lower recurrence rates and improved survival with D2 gastrectomy when performed safely. The consensus is that D2 gastrectomy with preservation of the spleen and pancreas can achieve radical treatment for gastric cancer with excellent outcomes when performed by experienced surgeons.
Surgical Approach to Non Small Cell Lung Cancer
1) Surgery is still the mainstay of curative treatment for NSCLC, though diagnostic role has decreased with less invasive techniques preferred if doubt remains after needle biopsies.
2) Pre-operative assessment is key to determine operability and extent of surgery. N2 involvement means surgery is not recommended initially.
3) Lobectomy is the standard resection but sublobar options are available for selected patients based on cardiopulmonary reserve and disease characteristics like small GGO lesions. Pneumonectomy should be avoided with sleeve lobectomy preferred.
4) Minimally invasive surgery like VATS is becoming the preferred approach over thoracotomy for select patients when oncologic principles can be maintained
Lung cancer anatomy to pathological classification
The document summarizes lung cancer anatomy, risk factors, epidemiology, clinical features, diagnosis, staging and pathological classification. It notes that tobacco consumption causes 80-90% of lung cancers. Diagnostic workup includes imaging like CT, PET scans and biopsies to determine cancer type which are most commonly adenocarcinoma, squamous cell carcinoma, small cell lung cancer or large cell carcinoma. Staging uses the AJCC TNM system and influences treatment options and prognosis.
Oncoplastic breast surgery
Oncoplastic Breast surgery is simultaneous application of lumpectomy and reconstructive techniques. The word ‘oncoplastic’ is derived from the Greek words ‘onco’ (tumour) and ‘plastic’ (to mould).
Approximately 10% to 30% of patients submitted to BCS alone are not satisfied with the aesthetic outcomes like “swan beak/ parrot beak deformities. The main reasons are related this is the tumour resection which can produce asymmetry, retraction, and volume changes in the breast.
Recently, increasing attention has been focused on oncoplastic procedures since the immediate application of plastic breast surgery techniques provide a wider local excision while still achieving the goals of a better breast shape and symmetry to obtain oncologically sound and aesthetically pleasing results. Thus, by means of customized techniques the surgeon ensures that oncologic principles are not jeopardized while meeting the needs of the patient from an aesthetic point of view.
MANAGEMENT OF EARLY STAGE NON SMALL CELL LUNG CARCINOMA
1. The document discusses management guidelines for early stage non-small cell lung cancer (NSCLC), including treatment options for operable versus inoperable patients such as surgery, chemotherapy, and radiation therapy.
2. Key findings from studies on lymphadenectomy, sublobar resection versus lobectomy, and video-assisted thoracoscopic surgery (VATS) versus open surgery are summarized, finding no clear survival benefits to more extensive procedures in early stage disease.
3. The roles of postoperative radiotherapy and chemotherapy are examined based on clinical trials, with chemoradiation found potentially beneficial in stage III disease but not stage I/II, and cisplatin-based chemotherapy improving survival in stage II/III
carcinoma urinary bladder management
NMIBC: non muscle invasive bladder cancer
MIBC: muscle invasive bladder cancer:
Metastatic Disease
Surgery
Chemotherapy
Immunotherapy
Radiotherapy
EORTC bladder cancer calculator
CUETO risk calculator (Spanish Urological Oncology Group).
Urinary Diversion
oncoplasty breast
1. Oncoplastic breast surgery (OPBS) combines oncological surgery with plastic surgery techniques to allow for wide excision of breast cancer tumors while maintaining the natural shape of the breast.
2. OPBS techniques have evolved since the 1980s and can be used for breast-conserving surgery, post-mastectomy reconstruction, or correction of defects after standard breast-conserving surgery.
3. OPBS is generally indicated for early-stage breast cancers less than 4cm and can extend the use of breast-conserving surgery to larger tumors. Selection depends on factors like excision volume, tumor location, and breast density.
Video assisted thoracic surgery
VATS is a minimally invasive surgical procedure used to diagnose and treat lung and chest illnesses. It was developed in the 1990s as video equipment and surgical tools improved. During VATS, small incisions are made between the ribs and an endoscope is inserted to give the surgeon a magnified view. It is used for conditions like empyema, pleural effusions, lung biopsies, and mediastinal masses. Advantages over open thoracotomy include less pain, blood loss, faster recovery, and shorter hospital stay without compromising patient survival.
Surgical Management of Carcinoma Esophagus
In Depth review of the Surgical management of esophageal carcinoma including management overview, endoscopic management, Type of surgeries, Open, and minimally invasive, Extent of lymphadenectomy. Literature review of evidence for type of surgery and complications
Chest wall tumor
- Primary chest wall tumors account for 5% of all thoracic tumors, with 40-60% being malignant. The rib cage is the most common site.
- Common primary bone tumors of the chest wall include osteochondroma, chondroma, fibrous dysplasia, chondrosarcoma, Ewing's sarcoma, and osteosarcoma. Common primary soft tissue tumors include desmoid tumors, soft tissue sarcomas, hemangiomas, and neurofibromas.
- Diagnosis involves imaging like CT, MRI, PET-CT and tissue biopsy. Surgical resection is the main treatment for primary chest wall neoplasms and reconstruction is needed for large defects. Prognosis depends
Video assisted thoracic surgery (vats)
1. Video-assisted thoracoscopic surgery (VATS) is a minimally invasive procedure used to diagnose and treat illnesses of the lungs and chest cavity.
2. VATS involves making small incisions and inserting surgical instruments and a camera to allow the surgeon to see inside the chest. This avoids the need for large incisions.
3. VATS is used for procedures like lung biopsies, removal of parts of the lung, treatment of collapsed lungs, and draining fluid from the chest cavity. It offers benefits like less pain, shorter recovery time, and smaller scars compared to traditional open chest surgery.
May 2015 Webinar – Liver Metastases
A common site for advanced colorectal cancer to spread is the liver. In this webinar we will discuss why that happens and some treatment options available for patients facing liver metastases.
Presenting is Dr. Fakih’s whos research focuses on drug development, surveillance and prevention of colorectal cancer. In January 2015, he was appointed as the Interim Chair of Medical Oncology at City of Hope.
Ca rectum Management seminar 2019
seminar on ca rectum management including evolution of trials
Dr. kavita sehrawat
2019
MAMC ,DELHI
Breast conserving therapy/ Krūts saaudzējošā terapija
Breast conserving therapy (BCT) involves breast conserving surgery followed by radiation therapy to eliminate residual cancer cells. BCT aims to provide equivalent survival to mastectomy with an acceptable cosmetic outcome and low recurrence rates. Patient selection involves evaluating tumor characteristics, breast imaging to determine extent of disease, and ruling out contraindications like multicentric tumors or prior radiation to the breast. The goal of surgery is a complete excision with negative margins followed by radiation therapy. Complications can include seroma, infection, and arm issues, though are less common than following mastectomy. BCT provides an alternative to mastectomy for many breast cancer patients when appropriate criteria are met.
Transanal total mesorectal excision
1) Transanal total mesorectal excision (TME) is a novel technique for resection of rectal cancers.
2) TME involves excising the rectum and the surrounding mesorectum in one block through the anus to minimize local recurrence.
3) This "down-to-up" transanal approach aims to improve on open TME by reducing morbidity and impairment of function compared to traditional surgery.
Breast Conservation Treatment
Breast Conservation Surgery is defined as the complete removal of the tumour with a concentric margin of surrounding healthy tissue with maintenance of acceptable cosmesis, and should be followed by radiation therapy to achieve an acceptably low rate of local recurrence. Breast conservation treatment is BCS with radiotherapy.
Principles of Cancer Surgery
The document provides an overview of the principles of cancer surgery. It discusses key terminology like oncology, surgical oncology, and cancer. The roles of the surgical oncologist include performing cancer operations, understanding radiation and chemotherapy, and providing reconstructive options. Cancer surgery involves diagnosis, staging, preoperative optimization, removal of the primary tumor and lymph nodes, removal of metastases if possible, and palliation for unresectable cancers to improve quality of life. The goal is an oncologic cure through radical but safe resection while minimizing complications.
Peritoneal surface malignancies
1. Cytoreductive surgery (CRS) followed by intraperitoneal chemotherapy, either intraoperatively (HIPEC) or postoperatively, is the standard treatment for peritoneal surface malignancies like carcinomatosis and mesothelioma.
2. The extent of disease is measured by the peritoneal cancer index (PCI) and the completeness of cytoreduction (CC score), which help determine prognosis and likelihood of benefit from CRS and HIPEC.
3. Multiple clinical studies have shown median survival benefits of 2-4 times longer compared to systemic chemotherapy alone for conditions treated with CRS and HIPEC.
Axillary reverse mapping
Axillary reverse mapping (ARM) has been explained in this presentation using several articles and diagrams.
Open right hemicolectomy/ step by step/ operative surgery
Open right hemicolectomy is performed to treat malignant tumors, polyps, and other conditions in the ileocecal region, ascending colon, and hepatic flexure. The procedure involves mobilizing the right colon, ligating blood vessels, resecting the involved bowel segments, and creating an ileocolic or ileotransverse anastomosis. Key steps include careful dissection to avoid injury to nearby structures like the duodenum and ureter, and ensuring a well-vascularized, tension-free anastomosis to minimize risks of leakage. Post-operative care focuses on early ambulation and advancing diet based on progress.
Anal Cancer
Anal cancer is usually treated with chemoradiation using radiation therapy and chemotherapy. The cancer is squamous cell carcinoma affecting the anal canal. Radiation treatment is planned using CT and PET scans to determine the location and size of the tumor and nearby lymph nodes. Treatment aims to deliver a high dose of radiation to the tumor and lymph nodes while avoiding nearby organs like the bladder and bowels to minimize side effects such as diarrhea, cramps and urinary issues.
Complete mesocolic excision
Complete Mesocolic Excision (CME) is a surgical technique for colon cancer based on Total Mesorectal Excision principles for rectal cancer. CME involves sharp dissection along embryonic planes between the visceral and parietal fascia to remove the colon and intact mesocolon lymphovascular package. Central ligation of supplying vessels also aims to maximize lymph node harvest. A study of over 1,300 colon cancer patients who underwent CME found improved 5-year cancer survival rates and reduced local recurrence compared to previous techniques, correlated with higher lymph node counts. CME principles include producing an intact specimen and maximizing lymph node dissection for improved oncologic outcomes.
Approach to Mediastinal Mass
1. The document discusses the approach to evaluating and diagnosing mediastinal masses, with a focus on distinguishing masses by their location in the anterior, middle, or posterior mediastinum.
2. Common diseases found in each compartment are reviewed, along with their typical presentations and investigations such as biopsy methods.
3. Surgical and non-surgical treatment options are presented for various mediastinal pathologies like thymoma, teratomas, and lymphomas.
Mediastinal tumors
The document discusses the anatomy and divisions of the mediastinum. It is divided into superior, anterior, middle and posterior compartments by imaginary lines. The superior mediastinum contains structures like the thymus, great vessels and nerves. The anterior mediastinum contains the thymus and lymph nodes. The middle mediastinum contains the heart and great vessels. The posterior mediastinum contains the esophagus and descending aorta. Common mediastinal tumors are discussed along with their locations.
BALKAN MCO 2011 - D. Jovanovic - Diagnostic procedures, staging and surgery o...
BALKAN MCO 2011 - D. Jovanovic - Diagnostic procedures, staging and surgery o...European School of Oncology
This document provides information on diagnosing and staging lung cancer through symptoms, signs, diagnostic procedures, imaging, and surgery. It discusses common symptoms of primary lung tumors and intrathoracic metastases. Diagnostic procedures include noninvasive imaging like CT scans and invasive techniques like bronchoscopy. Imaging helps characterize tumors and guide biopsies. The TNM system is used for staging, and surgery is the main treatment for early stage I/II NSCLC when possible through procedures like lobectomy or segmentectomy. Pneumonectomy may be needed for larger central tumors. Accurate staging guides treatment decisions between surgery, chemotherapy, or radiation.Lung Cancer: Diagnosis, Staging, and Treatment
- A 60 year old smoker presented for a routine physical and was found to have an abnormality on chest x-ray
- The next appropriate test would be a CT scan of the chest with IV contrast to further characterize any lung lesions found on CXR
- A CT-guided biopsy would not be the next test, as further imaging is needed first to identify and stage any potential lung cancer before invasive testing
The best answer is A) CT chest with IV contrast to further evaluate and characterize any lung abnormalities found on CXR before considering an invasive biopsy.
More Related Content
What's hot
MANAGEMENT OF EARLY STAGE NON SMALL CELL LUNG CARCINOMA
1. The document discusses management guidelines for early stage non-small cell lung cancer (NSCLC), including treatment options for operable versus inoperable patients such as surgery, chemotherapy, and radiation therapy.
2. Key findings from studies on lymphadenectomy, sublobar resection versus lobectomy, and video-assisted thoracoscopic surgery (VATS) versus open surgery are summarized, finding no clear survival benefits to more extensive procedures in early stage disease.
3. The roles of postoperative radiotherapy and chemotherapy are examined based on clinical trials, with chemoradiation found potentially beneficial in stage III disease but not stage I/II, and cisplatin-based chemotherapy improving survival in stage II/III
carcinoma urinary bladder management
NMIBC: non muscle invasive bladder cancer
MIBC: muscle invasive bladder cancer:
Metastatic Disease
Surgery
Chemotherapy
Immunotherapy
Radiotherapy
EORTC bladder cancer calculator
CUETO risk calculator (Spanish Urological Oncology Group).
Urinary Diversion
oncoplasty breast
1. Oncoplastic breast surgery (OPBS) combines oncological surgery with plastic surgery techniques to allow for wide excision of breast cancer tumors while maintaining the natural shape of the breast.
2. OPBS techniques have evolved since the 1980s and can be used for breast-conserving surgery, post-mastectomy reconstruction, or correction of defects after standard breast-conserving surgery.
3. OPBS is generally indicated for early-stage breast cancers less than 4cm and can extend the use of breast-conserving surgery to larger tumors. Selection depends on factors like excision volume, tumor location, and breast density.
Video assisted thoracic surgery
VATS is a minimally invasive surgical procedure used to diagnose and treat lung and chest illnesses. It was developed in the 1990s as video equipment and surgical tools improved. During VATS, small incisions are made between the ribs and an endoscope is inserted to give the surgeon a magnified view. It is used for conditions like empyema, pleural effusions, lung biopsies, and mediastinal masses. Advantages over open thoracotomy include less pain, blood loss, faster recovery, and shorter hospital stay without compromising patient survival.
Surgical Management of Carcinoma Esophagus
In Depth review of the Surgical management of esophageal carcinoma including management overview, endoscopic management, Type of surgeries, Open, and minimally invasive, Extent of lymphadenectomy. Literature review of evidence for type of surgery and complications
Chest wall tumor
- Primary chest wall tumors account for 5% of all thoracic tumors, with 40-60% being malignant. The rib cage is the most common site.
- Common primary bone tumors of the chest wall include osteochondroma, chondroma, fibrous dysplasia, chondrosarcoma, Ewing's sarcoma, and osteosarcoma. Common primary soft tissue tumors include desmoid tumors, soft tissue sarcomas, hemangiomas, and neurofibromas.
- Diagnosis involves imaging like CT, MRI, PET-CT and tissue biopsy. Surgical resection is the main treatment for primary chest wall neoplasms and reconstruction is needed for large defects. Prognosis depends
Video assisted thoracic surgery (vats)
1. Video-assisted thoracoscopic surgery (VATS) is a minimally invasive procedure used to diagnose and treat illnesses of the lungs and chest cavity.
2. VATS involves making small incisions and inserting surgical instruments and a camera to allow the surgeon to see inside the chest. This avoids the need for large incisions.
3. VATS is used for procedures like lung biopsies, removal of parts of the lung, treatment of collapsed lungs, and draining fluid from the chest cavity. It offers benefits like less pain, shorter recovery time, and smaller scars compared to traditional open chest surgery.
May 2015 Webinar – Liver Metastases
A common site for advanced colorectal cancer to spread is the liver. In this webinar we will discuss why that happens and some treatment options available for patients facing liver metastases.
Presenting is Dr. Fakih’s whos research focuses on drug development, surveillance and prevention of colorectal cancer. In January 2015, he was appointed as the Interim Chair of Medical Oncology at City of Hope.
Ca rectum Management seminar 2019
seminar on ca rectum management including evolution of trials
Dr. kavita sehrawat
2019
MAMC ,DELHI
Breast conserving therapy/ Krūts saaudzējošā terapija
Breast conserving therapy (BCT) involves breast conserving surgery followed by radiation therapy to eliminate residual cancer cells. BCT aims to provide equivalent survival to mastectomy with an acceptable cosmetic outcome and low recurrence rates. Patient selection involves evaluating tumor characteristics, breast imaging to determine extent of disease, and ruling out contraindications like multicentric tumors or prior radiation to the breast. The goal of surgery is a complete excision with negative margins followed by radiation therapy. Complications can include seroma, infection, and arm issues, though are less common than following mastectomy. BCT provides an alternative to mastectomy for many breast cancer patients when appropriate criteria are met.
Transanal total mesorectal excision
1) Transanal total mesorectal excision (TME) is a novel technique for resection of rectal cancers.
2) TME involves excising the rectum and the surrounding mesorectum in one block through the anus to minimize local recurrence.
3) This "down-to-up" transanal approach aims to improve on open TME by reducing morbidity and impairment of function compared to traditional surgery.
Breast Conservation Treatment
Breast Conservation Surgery is defined as the complete removal of the tumour with a concentric margin of surrounding healthy tissue with maintenance of acceptable cosmesis, and should be followed by radiation therapy to achieve an acceptably low rate of local recurrence. Breast conservation treatment is BCS with radiotherapy.
Principles of Cancer Surgery
The document provides an overview of the principles of cancer surgery. It discusses key terminology like oncology, surgical oncology, and cancer. The roles of the surgical oncologist include performing cancer operations, understanding radiation and chemotherapy, and providing reconstructive options. Cancer surgery involves diagnosis, staging, preoperative optimization, removal of the primary tumor and lymph nodes, removal of metastases if possible, and palliation for unresectable cancers to improve quality of life. The goal is an oncologic cure through radical but safe resection while minimizing complications.
Peritoneal surface malignancies
1. Cytoreductive surgery (CRS) followed by intraperitoneal chemotherapy, either intraoperatively (HIPEC) or postoperatively, is the standard treatment for peritoneal surface malignancies like carcinomatosis and mesothelioma.
2. The extent of disease is measured by the peritoneal cancer index (PCI) and the completeness of cytoreduction (CC score), which help determine prognosis and likelihood of benefit from CRS and HIPEC.
3. Multiple clinical studies have shown median survival benefits of 2-4 times longer compared to systemic chemotherapy alone for conditions treated with CRS and HIPEC.
Axillary reverse mapping
Axillary reverse mapping (ARM) has been explained in this presentation using several articles and diagrams.
Open right hemicolectomy/ step by step/ operative surgery
Open right hemicolectomy is performed to treat malignant tumors, polyps, and other conditions in the ileocecal region, ascending colon, and hepatic flexure. The procedure involves mobilizing the right colon, ligating blood vessels, resecting the involved bowel segments, and creating an ileocolic or ileotransverse anastomosis. Key steps include careful dissection to avoid injury to nearby structures like the duodenum and ureter, and ensuring a well-vascularized, tension-free anastomosis to minimize risks of leakage. Post-operative care focuses on early ambulation and advancing diet based on progress.
Anal Cancer
Anal cancer is usually treated with chemoradiation using radiation therapy and chemotherapy. The cancer is squamous cell carcinoma affecting the anal canal. Radiation treatment is planned using CT and PET scans to determine the location and size of the tumor and nearby lymph nodes. Treatment aims to deliver a high dose of radiation to the tumor and lymph nodes while avoiding nearby organs like the bladder and bowels to minimize side effects such as diarrhea, cramps and urinary issues.
Complete mesocolic excision
Complete Mesocolic Excision (CME) is a surgical technique for colon cancer based on Total Mesorectal Excision principles for rectal cancer. CME involves sharp dissection along embryonic planes between the visceral and parietal fascia to remove the colon and intact mesocolon lymphovascular package. Central ligation of supplying vessels also aims to maximize lymph node harvest. A study of over 1,300 colon cancer patients who underwent CME found improved 5-year cancer survival rates and reduced local recurrence compared to previous techniques, correlated with higher lymph node counts. CME principles include producing an intact specimen and maximizing lymph node dissection for improved oncologic outcomes.
Approach to Mediastinal Mass
1. The document discusses the approach to evaluating and diagnosing mediastinal masses, with a focus on distinguishing masses by their location in the anterior, middle, or posterior mediastinum.
2. Common diseases found in each compartment are reviewed, along with their typical presentations and investigations such as biopsy methods.
3. Surgical and non-surgical treatment options are presented for various mediastinal pathologies like thymoma, teratomas, and lymphomas.
Mediastinal tumors
The document discusses the anatomy and divisions of the mediastinum. It is divided into superior, anterior, middle and posterior compartments by imaginary lines. The superior mediastinum contains structures like the thymus, great vessels and nerves. The anterior mediastinum contains the thymus and lymph nodes. The middle mediastinum contains the heart and great vessels. The posterior mediastinum contains the esophagus and descending aorta. Common mediastinal tumors are discussed along with their locations.
What's hot (20)
MANAGEMENT OF EARLY STAGE NON SMALL CELL LUNG CARCINOMA
MANAGEMENT OF EARLY STAGE NON SMALL CELL LUNG CARCINOMA
Breast conserving therapy/ Krūts saaudzējošā terapija
Breast conserving therapy/ Krūts saaudzējošā terapija
Open right hemicolectomy/ step by step/ operative surgery
Open right hemicolectomy/ step by step/ operative surgery
Viewers also liked
BALKAN MCO 2011 - D. Jovanovic - Diagnostic procedures, staging and surgery o...
BALKAN MCO 2011 - D. Jovanovic - Diagnostic procedures, staging and surgery o...European School of Oncology
This document provides information on diagnosing and staging lung cancer through symptoms, signs, diagnostic procedures, imaging, and surgery. It discusses common symptoms of primary lung tumors and intrathoracic metastases. Diagnostic procedures include noninvasive imaging like CT scans and invasive techniques like bronchoscopy. Imaging helps characterize tumors and guide biopsies. The TNM system is used for staging, and surgery is the main treatment for early stage I/II NSCLC when possible through procedures like lobectomy or segmentectomy. Pneumonectomy may be needed for larger central tumors. Accurate staging guides treatment decisions between surgery, chemotherapy, or radiation.Lung Cancer: Diagnosis, Staging, and Treatment
- A 60 year old smoker presented for a routine physical and was found to have an abnormality on chest x-ray
- The next appropriate test would be a CT scan of the chest with IV contrast to further characterize any lung lesions found on CXR
- A CT-guided biopsy would not be the next test, as further imaging is needed first to identify and stage any potential lung cancer before invasive testing
The best answer is A) CT chest with IV contrast to further evaluate and characterize any lung abnormalities found on CXR before considering an invasive biopsy.
Surgical Management of Bronchogenic Carcinoma
This document discusses the evaluation, staging, surgical treatment options, complications, and prognosis for lung cancer. Key points include:
- Evaluation involves imaging like CT scans, biopsies, and pulmonary function tests. Surgery is indicated for early stage tumors.
- Surgical options include lobectomy, pneumonectomy, wedge resection or segmental resection depending on tumor size and location.
- Complications can include air leaks, infection, hemorrhage or formation of a bronchopleural fistula. Outcomes depend on cancer cell type and stage, with earlier stage having higher 5-year survival rates.
Pulmonary resection
lecture about pulmonary resection for undergraduate medical students with audio lecture notes in Arabic.
Lung Cancer
This document discusses lung cancer, including its causes, symptoms, diagnosis, staging, and treatment options. The main causes of lung cancer are tobacco smoking and secondhand smoke. Symptoms can include cough, dyspnea, hemoptysis, and chest pain. Diagnostic tests include chest X-ray, CT scans, PET scans, and biopsies. Staging involves the TNM system and determines appropriate treatment such as surgery, chemotherapy, radiation therapy, or targeted therapies. Treatment depends on the cancer stage and may involve a combination of options.
Pulmonary surgery
Pulmonary surgeryShrimad Rajchandra College of Physiotherapy,Shree Swaminarayan Physiotherapy College
This document discusses pulmonary surgery procedures including lobectomy, pneumonectomy, and segmental resection. It describes the indications, risks, and postoperative physiotherapy treatment for lung surgery. Key points covered are clearing lung secretions, expanding the lungs, preventing complications like infection and blood clots, regaining movement, and conditioning exercises to aid recovery.Lung cancer
This document discusses lung cancer treatment and recent advances. It begins with an introduction on lung cancer being the most common malignancy worldwide and a leading cause of cancer death. It then covers topics like incidence and prevalence rates, classification and pathology of lung cancer types (non-small cell vs. small cell), staging systems, risk factors, investigations, imaging, surgery, chemotherapy regimens for different stages, and prognosis factors. Key points emphasized are the rising rates of adenocarcinoma, importance of imaging and staging for determining treatment options, and multimodality therapy for locally advanced stages.
Lung Cancer Stages, Treatments and Targeted Therapies
Audio and slides for this presentation are available on YouTube: http://youtu.be/rt_O7m2eTYA
David Barbie, MD, of the Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute, discusses the stages of lung cancer, how the disease is treated, and new targeted therapies for patients. This presentation was originally given at Dana-Farber's "Living with Lung Cancer" forum on Nov. 2, 2013.
Lung Cancer
This document discusses lung cancer, including its anatomy, staging, diagnostic imaging, and treatment options. It provides details on the lobes of the lungs, lymph node stations, and the importance of lymph node involvement in staging. Imaging techniques like CT, PET, and PET/CT are described. Treatment depends on cancer type and stage, and may involve surgery, chemotherapy, radiation therapy, or a combination. Side effects of radiation treatment are also outlined.
Viewers also liked (12)
BALKAN MCO 2011 - D. Jovanovic - Diagnostic procedures, staging and surgery o...
BALKAN MCO 2011 - D. Jovanovic - Diagnostic procedures, staging and surgery o...
Lung Cancer Stages, Treatments and Targeted Therapies
Lung Cancer Stages, Treatments and Targeted Therapies
Similar to Lung cancer surgery
Lobectomy
1) A lobectomy is a type of lung surgery where one lobe of the lung is removed due to conditions like lung cancer, tuberculosis, or trauma. It aims to remove diseased portions while conserving more lung function than a pneumonectomy.
2) Indications for lobectomy include benign conditions like infectious diseases, developmental anomalies, and bleeding; and malignant conditions like non-small cell lung cancer, pulmonary metastases, and certain tumors.
3) Contraindications include poor lung function, recent heart issues, and large tumors over 6cm which make VATS technically challenging. Complications can include prolonged air leaks, pneumonia, and injuries to nearby structures.
Lung Cancer Surgery: Types, Procedures, and Recovery | The Lifesciences Magazine
Lung Cancer Surgery: Types, Procedures, and Recovery | The Lifesciences MagazineThe Lifesciences Magazine
Lung Cancer Surgery, also known as thoracic surgery or pulmonary resection, involves the surgical removal of cancerous tumors and surrounding tissues from the lungs.Pulmonary surgeries
Pulmonary surgeries are performed to remove part or all of the lung, repair lung tissues, or drain fluid from the chest cavity. Common reasons for lung surgery include suspected abnormal growths, infections, trauma, lung replacement, and conditions such as cancer, blebs, or collapsed lungs. The main types of pulmonary surgeries are pneumonectomy (removal of an entire lung), lobectomy (removal of one or more lung lobes), wedge resection, segmentectomy, and sleeve resection. Surgeries are performed by cardiothoracic surgeons through various incisions and can treat conditions like bronchiectasis, tuberculosis, and emphysema. Complications may include nerve damage or deformity.
Anaesthesia for thoracoscopic surgery
This document provides information on anaesthesia for thoracoscopic surgery. It discusses that thoracoscopy is minimally invasive thoracic surgery using small incisions and instruments to examine the inside of the chest. It can be used for diagnostic procedures and some operations. The document discusses patient positioning, monitoring requirements, pre-operative evaluation and preparation, choices of anaesthesia including local/regional and general, management of anaesthesia including ventilation issues, and post-operative care considerations like pain management and respiratory care.
Mesotheliomahelp org treatment_surgery
We know that mesothelioma patients would rather stay local when receiving treatment,rnso we will review options for private medical centers, surgical consultants, clinical trials,rnand match you up with friendly, local physicians wherever we can.
Trans-anal Endoscopic Microsurgery TEM
Trans-anal Endoscopic Microsurgery TEM; Trans-anal Endoscopic operation TEO; Trans-anal Endoscopic Surgery TES.
Breast oncoplastic surgery
This document discusses oncoplastic breast surgery techniques. It begins by explaining breast conserving treatment and its goals of providing survival equivalent to mastectomy while achieving low recurrence rates. It then discusses various breast conserving surgery procedures like lumpectomy and quadrantectomy. The document focuses on the compromise between wide excision margins and satisfactory aesthetic results in breast conserving surgery. It also discusses various reconstruction techniques used after breast conserving surgery, including breast implants, fat grafting, flap procedures, and oncoplastic breast reconstruction. The principles and mechanisms of oncoplastic surgery are explained. Techniques for peripheral and central tumors are classified.
LUNG SURGERY AND IT'S REASONS..pdf
definition, thoracotomy, video-assisted thoracoscopic surgery, lobectomy, lung transplant, pneumonectomy, wedge rection, pre-operative and post-operative nursing management.
THORACOTOMY.pptx
A thoracotomy is a major surgery that involves making an incision between the ribs to access the chest cavity. The most common reason for a thoracotomy is to treat lung cancer. A posterolateral thoracotomy is the standard incision approach, allowing access to lungs, bronchi, pleura, and other chest structures. Thoracotomies are also used to diagnose and treat other conditions affecting the lungs, heart, and chest. The surgery involves opening the chest wall and may require collapsing one lung. Possible complications include prolonged recovery, infection, and blood clots.
Video assisted thoracic surgery
VATS is a minimally invasive surgical procedure used to diagnose and treat lung and chest conditions. It involves 1-inch incisions between the ribs rather than large incisions. The surgeon inserts surgical instruments and a camera to view internal organs on a monitor. VATS has advantages over open thoracotomy such as less pain, shorter recovery time, and lower costs. It is used for lung biopsies, cancer staging, lung resection, and other procedures. Patients are positioned laterally for access and proper positioning of instruments is important for effective surgery. VATS has reduced risks compared to open thoracotomy.
Lung cancer treatment options
This information represents the views of the doctors and nurses serving on the American Cancer Society's Cancer Information Database Editorial Board.
Video-assisted thoracic surgery (VATS).pptx
Presentation about video-assisted thoracic surgery (VATS), which is minimally invasive thoracic surgery that does not use a formal thoracotomy incision, it is principally employed in the management of (pulmonary, mediastinal, and pleural pathology.
Anaesthesia for robotic cardiac surgery
Robotic cardiac surgery involves performing cardiac surgery using robotic arms controlled by a surgeon seated at a console. Key steps include creating a capnothorax by insufflating CO2 into the chest cavity and using one lung ventilation. This causes physiological perturbations from reduced venous return and increased airway pressures that require careful management to prevent hypoxia, hypercarbia, and hemodynamic instability. The anesthetic plan must consider patient positioning, prolonged surgery times, hypothermia, and effects of one lung ventilation.
Surgical management of Carcinoma Esophagus
A detailed dicussion on surgical procedures & steps to be followed during surgery for Carcinoma esophagus.
Source- Schwartz's Principles of Surgery, 9th Edition
Laparoscopy and colonic cancer
This document discusses laparoscopic colonic surgery. It provides an overview of different types of laparoscopic colon surgery techniques including standard laparoscopic surgery, laparoscopic-assisted surgery, and hand-assisted laparoscopic surgery. It also discusses indications for laparoscopic colonic resection including colon cancer. Guidelines are provided for performing laparoscopic colonic resection while maintaining oncologic principles.
Laparoscopic Surgery - Minimal Scars, Maximum Precision.pdf
What Is Laparoscopic Surgery?
Laparoscopic surgery, also known as minimally invasive surgery, is a modern surgical technique that allows surgeons to perform procedures with smaller incisions compared to traditional open surgery. Let's explore more: https://www.southlakegeneralsurgery.com/laparoscopic-surgery-minimal-scars-maximum-precision/
Lung cancer
This document discusses lung cancer, including its definition, types, symptoms, risk factors, diagnostic tests, staging, and treatment options. It notes that lung cancer is characterized by uncontrolled cell growth in lung tissues and can spread through metastasis. The main types are small cell lung cancer and non-small cell lung cancer (which includes adenocarcinoma, squamous cell carcinoma, and large cell carcinoma). Risk factors include smoking tobacco as well as exposure to other carcinogens. Diagnosis involves imaging tests, biopsies, and evaluating the tumor size, lymph node involvement, and metastasis. Treatment involves surgery, chemotherapy, radiation therapy, and palliative care.
Per.8 luis alan (2) (1)
Lung cancer is caused by abnormal lung cell growth that interferes with lung function. It can be treated with surgery to remove the tumor, chemotherapy, and radiation. Surgery involves removing the affected lung lobe, while chemotherapy may help prevent cancer recurrence after surgery or is used with radiation for advanced cases. Reducing smoking and exposure to other lung carcinogens can decrease lung cancer risk.
Laparoscopy
Laparoscopy, also known as keyhole surgery, allows surgeons to examine the abdominal organs through small incisions using a laparoscope. It was developed in the early 1900s and is now commonly used to diagnose and treat conditions of the appendix, gallbladder, intestines, and other abdominal organs. The key advantages of laparoscopy over open surgery are reduced pain, scarring, and recovery time for patients. However, it requires more technical skill from surgeons due to limited movement and vision within the abdominal cavity. Complications can include injuries from trocar insertion or electrical burns, but the risks of laparoscopy are generally low when performed by an experienced surgeon.
Radiation therapy for lung cancer
This document discusses radiation therapy for lung cancer. It describes how radiation therapy uses high-energy rays to kill cancer cells. It explains that radiation therapy may be given after chemotherapy to treat large tumors or sick patients. It also discusses the different types of radiation therapy, including external beam radiation therapy which is administered from outside the body over 20-36 treatments, and internal brachytherapy which places a radiation source inside the body during bronchoscopy. Finally, it notes that treatment is carefully planned to determine the needed radiation dose and location before daily treatments using skin marks or tattoos to target the same area.
Similar to Lung cancer surgery (20)
Lung Cancer Surgery: Types, Procedures, and Recovery | The Lifesciences Magazine
Lung Cancer Surgery: Types, Procedures, and Recovery | The Lifesciences Magazine
Laparoscopic Surgery - Minimal Scars, Maximum Precision.pdf
Laparoscopic Surgery - Minimal Scars, Maximum Precision.pdf
More from Daniel Henny
Top ear phones and its reviews
Get the Top earphone reviews with alluring styles.These earphone gives you perfect music and make you to feel amazing.The above slide shows some of the earphone reviews for you!!!
Sandwich Recipes
Are you the fan of sandwich ? Then try out your favorite sandwich at home with amazing taste.Here are hundreds of recipes for you.
Meizu smartphone reviews
Smartphones are becoming popular nowadays because of its amazing features and useful apps which is helpful for our day-to-day life. The above slide shows some of the smartphones which contains extraordinary features.
Healthy cheese recipes
Are you addicted to cheese cakes ? Here are alluring cheese cake recipes for you so try out these recipes by visiting the above slide
Lung carcinoid tumor
Get the facts and more details about lung carcinoid tumor in the above slides.This slide shows more information regarding lung cancer and its various details
Smart Watch for you!!!
Smartwatch make our life much easier and provides great benefits in our day-to-day life.To know more detailed reviews about smartwatch visit the above slide
Sweet corn recipes
Sweet corn gives an amazing taste and provides more vitamins to the body.Try out varieties of sweet corn recipes at home by visiting the above slides
Coconut recipes
Do you like coconut ? Then try out varieties of coconut recipes at home with alluring tatse we are here to help you to cook amazing coconut recipes with fine tatse.
Asus laptop reviews
Laptops are portable and make our work too smart and easy you can work from anywhere at anytime especially the Asus laptop gives slim and perfect look which contains amazing features. The following slide shows some of the laptop reviews with alluring look.
Lenovo Tablet Reviews
Lenovo are one of the top brands that contains amazing features and alluring styles.There are more laptop models in lenovo with great look and features,The above slide shows some of the laptop reviews with comparisons
Does lung cancer causes back pain
Lung cancer causes various symptoms and signs which depends on staging.Are you need to know about lung cancer cause any back pain then visit the above slide to know more facts about cancer causes and backpain.
Headphone Reviews
Headphones is a pair of listening device that gives you a amazing sound .whether you are looking for a amazing headphone then the above slide shows some of the headphone reviews with comparison
Chocolate Recipes
Are you looking for chocolate recipes?Then try out much more varieties of chocolate recipes at home with fabulous taste.The above slide shows some of the chocolate recipes which can be made easily at home
Panasonoc reviews
Smartphones are becoming popular nowadays.Get to know more about smartphone reviews that suits best for you.The above slideshow Panasonic smartphone and its detailed reviews
How garlic act against lung cancer
Get to know how garlic fight against lung cancer and its medicinal value.The above slide shows details information on garlic that fight againts cancer
Bean recipes
Beans are a nutritional powerhouse packed with protein, fiber, vitamins and minerals while being low in fat. The document provides recipes for several healthy bean dishes including bean chili soup, sprouted bean snacks, baked beans, aloo bean curry and Korean sprout bean salad. All the recipes can be easily prepared at home and provide nutritional benefits from the bean ingredients.
Karbonn Reviews
Smartphone are becoming more popular nowadays and help our day-to-day life much smarter than ever.Get to know Karbonn smartphone reviews by the above slide
Music therapy for lung cancer
Get a music therapy for lung cancer in order to relax your mind and stress factors.The above slide shows some of the music therapy tips for lung cancer patients.
Lyf smartphone
Get the quality and best lyf smartphones with amazing features.Here are detailed reviews of your smartphone with amazing features.The above slide shows comparison and reviews of lyf smartphones.
Chronic cough and lung cancer
This document discusses chronic cough as a potential symptom of lung cancer. It notes that a cough persisting for more than two weeks without another cause could indicate lung cancer and should not be ignored. Changes in a chronic cough such as increased mucus, hoarseness, or coughing up blood are especially concerning and mean a person should see a doctor to check for potential lung cancer or other issues. Smoking cessation is recommended to reduce the risk of developing a chronic cough or lung cancer.
More from Daniel Henny (20)
Recently uploaded
Histololgy of Female Reproductive System.pptx
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Lecture 6 -- Memory 2015.pptlearning occurs when a stimulus (unconditioned st...
learning occurs when a stimulus (unconditioned stimulus) eliciting a response (unconditioned response) • is paired with another stimulus (conditioned stimulus)
Ageing, the Elderly, Gerontology and Public Health
Challenges associated with ageing from a public health perspective
Travel Clinic Cardiff: Health Advice for International Travelers
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
LOW BIRTH WEIGHT. PRETERM BABIES OR SMALL FOR DATES BABIES
low birth weight presentation. Low birth weight (LBW) infant is defined as the one whose birth weight is less than 2500g irrespective of their gestational age. Premature birth and low birth weight(LBW) is still a serious problem in newborn. Causing high morbidity and mortality rate worldwide. The nursing care provide to low birth weight babies is crucial in promoting their overall health and development. Through careful assessment, diagnosis,, planning, and evaluation plays a vital role in ensuring these vulnerable infants receive the specialize care they need. In India every third of the infant weight less than 2500g.
Birth period, socioeconomical status, nutritional and intrauterine environment are the factors influencing low birth weight
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation. Skin Diseases That Happen During Summer.
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Pollen and Fungal allergy: aeroallergy.pdf
Pollen and Fungal allergy: aeroallergy.pdfChulalongkorn Allergy and Clinical Immunology Research Group
Pollen and Fungal allergy
Presented by Chaloemchai Chumsaengchotsakul, MD.
June 14, 2024Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...
Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...PVI, PeerView Institute for Medical Education
Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, prepared useful Practice Aids pertaining to Alzheimer’s disease for this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
CLEAR ALIGNER THERAPY IN ORTHODONTICS .pptx
Dr. ZANAB FARHEEN FAYAZ ,MDS(ORTHODONTICS & DENTOFACIAL ORTHOPEDICS ).
10 Benefits an EPCR Software should Bring to EMS Organizations
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
Know the difference between Endodontics and Orthodontics.
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
Recently uploaded (20)
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
Tele Optometry (kunj'sppt) / Basics of tele optometry.
Tele Optometry (kunj'sppt) / Basics of tele optometry.
Lecture 6 -- Memory 2015.pptlearning occurs when a stimulus (unconditioned st...
Lecture 6 -- Memory 2015.pptlearning occurs when a stimulus (unconditioned st...
Ageing, the Elderly, Gerontology and Public Health
Ageing, the Elderly, Gerontology and Public Health
Travel Clinic Cardiff: Health Advice for International Travelers
Travel Clinic Cardiff: Health Advice for International Travelers
LOW BIRTH WEIGHT. PRETERM BABIES OR SMALL FOR DATES BABIES
LOW BIRTH WEIGHT. PRETERM BABIES OR SMALL FOR DATES BABIES
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...
Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...
Cell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune Disease
10 Benefits an EPCR Software should Bring to EMS Organizations
10 Benefits an EPCR Software should Bring to EMS Organizations
Know the difference between Endodontics and Orthodontics.
Know the difference between Endodontics and Orthodontics.
Lung cancer surgery
- 2. Lung cancer surgery • Surgery to remove the cancer may be an option for early stage non-small cell lung cancer. • If surgery can be done(http://lungcancersymptomsx.com/lung-cancer- surgery.html), it provides the best chance to cure NSCLC. • Lung cancer surgery is a complex operation that can have serious consequences, so it should be done by a surgeon who has a lot of experience operating on lung cancers. • Other tests will check the function of your heart and other organs to be sure you’re healthy enough for surgery.
- 4. Types of lung surgery • There are so many operation which helps to treat non-small cell lung cancer. • This surgery can cure the cancer depends on its stage. • Pneumonectomy surgery removes an entire lung. This might be needed if the tumor is close to the center of the chest.
- 6. • The other surgery is called Lobectomy . The lungs are made up of 5lobes . • Three on the right and two on the left. • In this surgery, the entire lobe containing the tumor(s) is removed. This is often the preferred type of operation for NSCLC if it can be done.
- 8. • This type of surgery is called segmentecmony and is also called as wedge resection. • In these surgeries, only part of a lobe is removed. • This approach might be used, for example, if a person doesn’t have enough lung function to withstand removing the whole lobe.
- 10. • This operation is called sleeve resection which is used to treat some cancers in large airways in the lungs. • The large airway with a tumor as similar to the sleeve of a shirt with a stain a couple of inches above the wrist. • The sleeve resection would be like cutting across the sleeve above and below the stain and then sewing the cuff back onto the shortened sleeve. • A surgeon may be able to do this operation instead of a pneumonectomy to preserve more lung function.
- 12. Video thoracic surgery • Doctors treat early-stage lung cancers in the outer parts of the lung with a procedure called video-assisted thoracic surgery. • During this operation, a thin, rigid tube with a tiny video camera on the end is placed through a small cut in the side of the chest to help the surgeon see inside the chest on a TV monitor. • One of the incisions is enlarged if a lobectomy or pneumonectomy is done to allow the specimen to be removed. • This would cause less pain after surgery and less hospital stay
- 14. Possible risk on surgery • Possible side effects (http://lungcancersymptomsx.com/long- term-side-effects-of-chemotherapy-for-lung-cancer.html) during and soon after surgery can include reactions to anesthesia, excess bleeding, blood clots in the legs or lungs, wound infections, and pneumonia. • Recovering from surgery takes time from weeks to month. • People who have VATS instead of thoracotomy tend to have less pain after surgery and to recover more quickly.
- 15. Thank you!!!