Erythema refers to redness of the skin that blanches under pressure. It is caused by increased blood flow within subpapillary plexus or increased visibility due to changes in adjacent tissues. Common causes of erythema include drug reactions, viral infections, streptococcal infections, systemic diseases like lupus erythematosus or lymphoma. Target lesions seen in erythema multiforme consist of three zones - a dark or blanched center surrounded by a pale zone which is surrounded by an outer rim of erythema. Treatment of erythema multiforme involves treating any underlying cause, using systemic antibiotics or steroids, and antivirals to prevent recurrence.