Urethritis is an inflammation of the urethra that is typically caused by a bacterium or virus. Common causes include herpes simplex virus, E. coli, chlamydia, and gonorrhea. Symptoms in males include blood in urine or semen, painful urination and ejaculation, itching, and discharge. In females, symptoms can include pelvic discomfort, stomach pain, fever, chills, discharge, and itching. Treatment involves antibiotics, anti-inflammatories, and home remedies like cranberry juice to prevent bacteria from sticking to the urethra.