Lymphatic System

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The lymphatic system carries fluid lost from capillaries back to the bloodstream through lymphatic vessels and ducts. It also transports fat and plays a major role in immunity. Lymph nodes along lymphatic pathways contain lymphocytes and macrophages that fight microbes. The tonsils, spleen, and thymus are lymphatic organs - the tonsils trap pathogens in the mouth and throat, the spleen filters the blood and destroys old red blood cells, and the thymus matures T cells that respond to foreign substances.

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The lymphatic system is part of the immune system. It also maintains fluid balance and plays a role in absorbing fats and fat-soluble nutrients. The lymphatic or lymph system involves an extensive network of vessels that passes through almost all our tissues to allow for the movement of a fluid called lymph. Lymph circulates through the body in a similar way to blood. There are about 600 lymph nodes in the body. These nodes swell in response to infection, due to a build-up of lymph fluid, bacteria, or other organisms and immune system cells. A person with a throat infection, for example, may feel that their "glands" are swollen. Swollen glands can be felt especially under the jaw, in the armpits, or in the groin area. These are, in fact, not glands but lymph nodes.

Anatomy and physiology of Lymphatic System

Lymphatic system

Lymphatic system

Lymphatic system

Lymphatic SYSTEM The lymphatic system involves an extensive network of vessels that passes through almost all our tissues to allow for the movement of a fluid called… lymph. Since the lymphatic system does not have a heart to pump it, its upward movement depends on the motions of the muscle and joint pumps. There are about 600 lymph nodes in the body. These nodes swell in response to infection, due to a build-up of lymph fluid, bacteria, or other organisms. A person with a throat infection, for example, may feel that their "glands" are swollen. Swollen glands can be felt especially under the jaw, in the armpits, or in the groin area. Swollen glands can be felt especially under the jaw, in the armpits, or in the groin area. These are, in fact, not glands but lymph nodes. Fast facts about the lymphatic system The lymphatic system plays a key role in immunity, fluid balance, and absorption of fats and fat-soluble nutrients. The lymph nodes swell in response to infection, due to a build-up of lymph fluid, bacteria, or other organisms and immune system cells. If lymph nodes remain swollen, if they are hard and rubbery, and if there are other symptoms, you should see a doctor. The lymphatic system has three main functions: It maintains the balance of fluid between the blood and tissues, known as fluid homeostasis. It forms part of the body's immune system and helps defend against bacteria and other intruders. It facilitates absorption of fats and fat-soluble nutrients in the digestive system. BLOOD PLASMA The lymphatic system consists of lymph vessels, ducts, nodes, and other tissues. Around 2 liters of fluid leak from the cardiovascular system into body tissues every day. The lymphatic system is a network of vessels that collect these fluids, or lymph. Lymph is a clear fluid that is derived from blood plasma. The lymph vessels form a network of branches that reach most of the body's tissues. They work in a similar way to the blood vessels. The lymph vessels work with the veins to return fluid from the tissues. The lymph vessels work with the veins to return fluid from the tissues. Unlike blood, the lymphatic fluid is not pumped but squeezed through the vessels when we use our muscles. Lymph is drained progressively towards larger vessels until it reaches the two main channels, the lymphatic ducts in our trunk. In the lymph nodes, immune cells assess for foreign material, such as bacteria, viruses, or fungus.

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What is lymph ?Tissue fluid (interstitial fluid) that enters the lymphatic vessels Reabsorbs excess interstitial fluid:returns it to the venous circulationmaintain blood volume levelsprevent interstitial fluid levels from rising out of control.Transport dietary lipids:transported through lactealsdrain into larger lymphatic vesselseventually into the bloodstream.lymphocyte development, and the immune response.

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• Gross anatomy: – Components of the lymphatic system: lymphatic plexuses, lymphatics, lymphoid tissue – Plan of the lymphatic system: Superficial lymphatic vessels, deep lymphatic vessels, lymph nodes, lymph trunks, cysterna chyli, lymph ducts: right lymph duct and thoracic duct. – Lymphatic drainage of the lower limb • Superficial inguinal lymph nodes: arrangement and drainage area. • Deep inguinal lymph nodes: arrangement and drainage area. The popliteal lymph nodes – Lymphatic drainage of the upper limb • Superficial and deep lymphatics. Supratrochlear and infraclavicular lymph nodes. • Axillary lymph nodes: arrangement and drainage area. – Plan of the lymphatic drainage of the head and neck: deep cervical lymph nodes, inner and outer circle of lymph nodes. • Deep cervical lymph nodes: location of the upper and lower groups, jugulodigastric node, jugulo-omohyoid, supraclavicular lymph nodes. Drainage area and efferent vessels. • The outer circle of lymph nodes: submental, submandibular, buccal, mandibular, parotid, mastoid, occipital: location, drainage area and efferent vessels. • The inner circle of lymph nodes: pretracheal, paratracheal and retropharyndeal. • The tonsils and Waldeyer’s ring. – Lymphatic drainage of the thorax: • Lymph nodes of the chest wall: Parasternal, intercostal, and phrenic • Lymph nodes of the mediastinum: Nodes around the division of the trachea and the main bronchi, anterior and posterior mediastinal nodes. – Plan of lymphatic drainage of the abdomen: lumbar and intestinal lymph trunks. • Pre-aortic lymph nodes: mesenteric, celiac, superior and inferior mesenteric lymph nodes. • Para-aortic lymph nodes. • MALT & Peyer’s patches. – Lymphatic drainage in the pelvis: External and internal iliac lymph nodes, lymph nodes in fascial sheaths, sacral and common iliac lymph nodes. • Applied anatomy • Functional and clinical importance of the lymphatic system; Virchow’s lymph nodes; Retropharyngeal abscess; Clinical applications of enlarged thoracic lymph nodes: involvement of left recurrent laryngeal nerve and phrenic nerve. Pressure on the esophagus. Carinal lymph nodes and bronchoscopy; Communications of lymphatics between thorax and abdomen. • Radiographic anatomy: – Lymphangiogrms. • Surface anatomy of palpable lymph node groups: superficial inguinal, axillary, infraclavicular, outer circle of crevical lymph nodes, deep cervical lymph nodes.

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The lymphatic system is a sub-system of circulatory system and immune system. It is a type of drainage system of human body which collects all the tissue fluids (constantly leaking out of the bloodstream) and takes back to the major veins through a network of lymph vessels. The lymphatic system consists of - Lymph – colourless tissue fluid Lymphatic organs – Thymus, Bone Marrow, Lymph nodes, Spleen, Tonsils. Lymph vessels – through which lymph circulation takes place. It maintains balance between blood and tissues: Blood volume : 5 – 6L Interstitial fluid volume: 10 – 11L Lymph volume: 2 – 3L. It helps in Immunity. It fascilitate absorption of fats and hormones: Breakdown products of fat and fat-soluble vitamins are absorbed into the central lacteals (lymphatic vessels) of the villi. Normal blood circulation forces fluid out of the bloodstream and that leads in the increase in the interstitial fluid volume. Due to osmotic pressure this interstitial fluid will be collected by the fine lymphatic capillaries. Now this fluid is lymph and it has the same mineral distribution as that of blood plasma. The lymph is transported to lymph nodes and organs where the pathogen will be killed by lymphocytes and lymph will be filtered. The back flow of lymph is prevented by the valves present in lymph vessels. Lymph moves from lymphatic vessels to lymphatic trunks, collecting ducts, and ultimately into the Subclavian veins.

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lymphatic system:DEFINITION: The lymphatic system is a network of vessels and organs that regulates the amount of fluid in the human body and defends it against infections Lymph Lymph is a transudative fluid that is transparent and yellow. It is formed when fluid leaves the capillary bed in tissues due to hydrostatic pressure. LYMPHATIC VESSELS : THE TUBAL STRUCTURES CARRY THE LYMPH FLUID FROM THE TISSUE TO THE BLOOD STREAM. TYPES OF VESSELS : AFFERENT VS EFFERENT LYMPH VESSELS: Lymphatic capillaries Lymphatic capillaries are the smallest lymphatic vessels that collect the interstitial fluid from the tissues. There are also special types of lymphatic capillaries called lacteals. These capillaries absorb nutrients from the small intestine. COMPOSITION OF THE LYMPH FLUID: (around 95%) comprised of water. The remaining 5% is composed of proteins, lipids, carbohydrates VOLUME OF LYMPH : The average adult produces between 3-4 litres/ day. Lymphatic pathway/circulation: TYPES OF LYMPHATIC VESSELS SUPERFICIAL AND DEEP LYMPHATIC VESSELS. LYMPHATIC TRUNKS: The efferent vessels empty into the lymphatic trunks. There are four pairs of trunks: Lumbar, Bronchomediastinal, Subclavian and Jugular. LYMPHATIC DUCT: The lymphatic trunks then converge into the two lymphatic ducts; the right lymph duct and thoracic duct. Lymphatic vessels vs. blood vessels Lymphoid organs : The Lymphoid organs are the sites where the maturation and proliferation of lymphocytes occur and help carry out various immune functions. Types of Lymphoid Organs 1. Primary Lymphoid Organs: bone marrow and thymus 2. Secondary Lymphoid Organs: lymph nodes, spleen, tonsils, Peyer’s patches of the small intestine, and Mucosal associated lymphoid tissues (MALT). 3. Tertiary Lymphoid Organs: These organs also play a prominent role in the immune response to cancer. The Lymphoid Organs Functions The functions of lymphoid organs are as follows:1. The main function of lymphoid organs is developing and providing immunity to the body.2. The primary lymphoid organs, i.e., the bone marrow and thymus, are the sites where the proliferation and maturation of B-lymphocytes and T-lymphocytes take place.3. Bone marrow is involved in the production of blood cells, i.e., RBCs (or erythrocytes), WBCs (or leucocytes), and Platelets (or thrombocytes).4. The spleen helps in the removal of damaged red blood cells. In foetal conditions, this is also a haematopoietic organ.5. Lymph nodes and spleen helps in filtering out and destroying the unwanted lymphocytes. They also help in maintaining the population of mature lymphocytes to enable the adaptive immune response to begin.6. The tonsils prevent foreign materials and pathogens from entering the body. Lymphocytes: Lymphocytes are a type of WBC (leucocytes) that are the main components of our immune system. Clinical Relevance: lymphoma, Lymphatic filariasis, Lymphadenopathy, Lymphedema

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The lymphatic system is a network of tissues, vessels and organs that work together to move a colorless, watery fluid called lymph back into your circulatory system (your bloodstream). Some 20 liters of plasma flow through your body’s arteries and smaller arteriole blood vessels and capillaries every day. After delivering nutrients to the body’s cells and tissues and receiving their waste products, about 17 liters are returned to the circulation by way of veins. The remaining three liters seep through the capillaries and into your body’s tissues. The lymphatic system collects this excess fluid, now called lymph, from tissues in your body and moves it along until it's ultimately returned to your bloodstream. Your lymphatic system has many functions. Its key functions include: Maintains fluid levels in your body: As just described, the lymphatic system collects excess fluid that drains from cells and tissue throughout your body and returns it to your bloodstream, which is then recirculated through your body. Absorbs fats from the digestive tract: Lymph includes fluids from your intestines that contain fats and proteins and transports it back to your bloodstream. Protects your body against foreign invaders: The lymphatic system is part of the immune system. It produces and releases lymphocytes (white blood cells) and other immune cells that monitor and then destroy the foreign invaders — such as bacteria, viruses, parasites and fungi — that may enter your body. Transports and removes waste products and abnormal cells from the lymph.

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