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Renal pathology
Renal pathology deals with diagnosing and characterizing kidney diseases through examination of renal biopsy specimens using light microscopy, electron microscopy, and immunofluorescence. The renal pathologist must synthesize findings across these diagnostic tools to reach a definitive diagnosis. Medical kidney diseases can affect the glomerulus, tubules and interstitium, blood vessels, or a combination of these renal compartments.
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Renal pathology
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- 2. Renal pathology isa subspecialty of anatomic pathology that deals with the diagnosis and characterization of medical diseases (nontumor) of the kidneys. In the academic setting, renal pathologists work closely with nephrologists and transplant surgeons, who typically obtain diagnostic specimens via percutaneous renal biopsy. The renal pathologist must synthesize findings from light microscopy, electron microscopy, and immunofluorescence to obtain a definitive diagnosis. Medical renal diseases may affect the glomerulus, the tubules and interstitium, the vessels, or a combination of these compartments.
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- 5. Typical stains usedin renal evaluating renal biopsy
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- 8. Clinical Presentations ofGlomerular Diseases symptomatic proteinuria •nephrotic syndrome (proteinuria, hypoproteinemia, lyperlipidemia, edema) •asymptomatic hematuria •glomerulonephritis (hematuria, proteinuria, hypertension, renal failure) •acute glomerulonephritis (neprhitis with short term renal failure) •crescentic glomerulonephritis (nephritis with rapidly progressive renal failure) •chronic glomerulonephritis (chronic progression of renal failure) •End Stage Renal Disease (irreversible renal failure)
- 9. The Nephrotic Syndrome Thenephrotic syndrome is characterized by massive proteinuria, which leads to hypoproteinemia/hypoalbunemia, hyperlipidemia with elevated cholesterols, triglicerides and other lipids, and edema. The edema results not only from the hypoosmolar state caused by the loss of plasma proteins, but also from abnormal salt and water retention.
- 11. Histologic feature thatis found in any patient with nephrotic range proteinuria no matter what the cause
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- 32. Type II Membranoproliferative Glomerulonephritis,(Dense Deposit Disease)
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