This document discusses amino acids and proteins. It explains that in amino acids, the carboxylic acid closest to the amine group is the stronger acid because its conjugate base is more stable due to electron delocalization. Similarly, the amine group closest to the carboxylic acid is the stronger acid because the carboxylic acid withdraws electron density from the amine, making it a weaker base. The document also defines the 10/20/30/40 structure of proteins as involving primary, secondary, tertiary and quaternary levels of structure and describes alpha helices and beta pleated sheets. It compares acid/base hydrolysis to enzyme cleavage in digesting proteins, noting enzyme cleavage is more selective.
It is also called as Co-ordination polymerisation. Zeigler (1953) and Natta (1955) discovered that in the presence of a combination of transition metal halides like TCl4, ZnBr3 etc, with an organometallic compound like triethyl-aluminium or trimethyl-aluminium, stereospecific polymerisation can be carried out. Combination of metal halides and organometallic compounds are called Zeigler Natta catalyst.
It is also called as Co-ordination polymerisation. Zeigler (1953) and Natta (1955) discovered that in the presence of a combination of transition metal halides like TCl4, ZnBr3 etc, with an organometallic compound like triethyl-aluminium or trimethyl-aluminium, stereospecific polymerisation can be carried out. Combination of metal halides and organometallic compounds are called Zeigler Natta catalyst.
BASIC DISCUSSION ABOUT THE CROWN ETHER AND CRYPTAND. INCLUDING THEIR BACKGROUND,STRUCTURE,NOMENCLATURE,CAVITY SIZE, SELECTIVITY, SYNTHESIS AND APPLICATIONS.
It is also called as Co-ordination polymerisation. Zeigler (1953) and Natta (1955) discovered that in the presence of a combination of transition metal halides like TCl4, ZnBr3 etc, with an organometallic compound like triethyl-aluminium or trimethyl-aluminium, stereospecific polymerisation can be carried out. Combination of metal halides and organometallic compounds are called Zeigler Natta catalyst.
It is also called as Co-ordination polymerisation. Zeigler (1953) and Natta (1955) discovered that in the presence of a combination of transition metal halides like TCl4, ZnBr3 etc, with an organometallic compound like triethyl-aluminium or trimethyl-aluminium, stereospecific polymerisation can be carried out. Combination of metal halides and organometallic compounds are called Zeigler Natta catalyst.
BASIC DISCUSSION ABOUT THE CROWN ETHER AND CRYPTAND. INCLUDING THEIR BACKGROUND,STRUCTURE,NOMENCLATURE,CAVITY SIZE, SELECTIVITY, SYNTHESIS AND APPLICATIONS.
Crown ethers
NOMENCLATURE
GENERAL SYNTHESIS OF CROWN ETHER
AZA CROWN
CRYPTAND
APPLICATIONS
1. SYNTHETIC APPLICTION
Esterification
Saponification
Anhydride formation
Potassium permanganate oxidation
Aromatic substitution reactions
Elimination reactions
Displacement reaction
Generation of carbenes
Superoxide anion
Alkylations – 1. o-alkylations
2. c-alkylations
3. n-alkylations
2. ANALYTICAL APPLICATION
Determination of gold in geological samples
Super critical fluid extraction of trace metal from solid and liquid materials
Application of ionic liquids in analytical chemistry
Oxidation and determination of aldehydes
Crown ethers are used in the laboratory as phase transfer catalyst
OTHER APPLICATION
It is used in photocynation
Resolution of racemic mixture
Benzoin condensation
Hetrocyclisation
Synthesis of furanones
Acetylation of secondary amines in presence of primary amine
The NO2 group attached with organic chain is called as nitro functional group. All the compounds containing the nitro functional group are called as organic nitro compounds.
Pinacol pinacolone rearrangement involves conversion of 1,2 - diols to carbonyl compounds in presence of acid catalyst with change in carbon skeleton. It is an example of whitmore shift.
Crown ethers
NOMENCLATURE
GENERAL SYNTHESIS OF CROWN ETHER
AZA CROWN
CRYPTAND
APPLICATIONS
1. SYNTHETIC APPLICTION
Esterification
Saponification
Anhydride formation
Potassium permanganate oxidation
Aromatic substitution reactions
Elimination reactions
Displacement reaction
Generation of carbenes
Superoxide anion
Alkylations – 1. o-alkylations
2. c-alkylations
3. n-alkylations
2. ANALYTICAL APPLICATION
Determination of gold in geological samples
Super critical fluid extraction of trace metal from solid and liquid materials
Application of ionic liquids in analytical chemistry
Oxidation and determination of aldehydes
Crown ethers are used in the laboratory as phase transfer catalyst
OTHER APPLICATION
It is used in photocynation
Resolution of racemic mixture
Benzoin condensation
Hetrocyclisation
Synthesis of furanones
Acetylation of secondary amines in presence of primary amine
The NO2 group attached with organic chain is called as nitro functional group. All the compounds containing the nitro functional group are called as organic nitro compounds.
Pinacol pinacolone rearrangement involves conversion of 1,2 - diols to carbonyl compounds in presence of acid catalyst with change in carbon skeleton. It is an example of whitmore shift.
1st year Organic Chem in Nursing-my group's powerpoint presentation. Enjoy! Not responsible for any error in information..it's been 3 years and I'm not sure if I corrected the information after we presented and were critiqued
How the law protects investment in technology - trade secrets, patents, desig...Jane Lambert
On Wednesday 27 Nov 2013 I addressed a seminar on trade secrets, patents, copyrights, design rights, semiconductor topographies and plant varieties. Although I delivered my talk without slides I have prepare these as an aide mémoire for those who attended the talk. They are supplemented by an accompanying handout.
Patent law developed during the industrial revolution when technology meant new products and processes but it now includes software, data, silicon chips and new plant and seed varieties. Consequently patents are fine for protecting developments in manufacturing but not quite so good protecting the new information based industries.
In addition to my overview of these rights I discussed the advantages and disadvantages of patents as opposed to trade secrets law. I suggested a simple IP strategy for most and discussed enforcement.
This was a presentation by Ian Wishart, an experienced patent attorney, who is also a director of an insurance company that specializes in insuring against the costs and consequences of intellectual property infringement litigation. Mr Wishart presented his paper to Ideas North West in Accrington on the same occasion that I gave my paper on IP enforcement without going bust. In this paper he discussed some of the policies that his company can arrange.
Organic compound nomenclature (ALkanes, ALKYL GROUP, ALKENE, ALKYNES)Tasneem Ahmad
for vedio click on this linkhttps://www.youtube.com/watch?v=ZzIxkWDlf5Q&feature=youtu.be
Organic compound nomenclature (ALkanes, ALKYL GROUP, ALKENE, ALKYNES)
The complete presentation on Organic Compound, IMPORTANCE, PROPERTIES, SOURCE, USED, Nomenclature Of Organic Compound
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
4. Amino Acid
Reason:
- Recall factors which affects the acidity of org compounds
stability of conjugate base
- –NH3+ is an electron withdrawing group; – COOH closer to
it will form a more stable conjugate base since the –ve
charge the O atom will be more dispersed.
5. Amino Acid
How do I assign pKa i.e which –NH3+ is stronger?
pKa1 = 2.04
pKa2 = 9.08
pKa3 = 10.69
6. Amino Acid
NH3+ closer to –COOH is the stronger acid.
pKa1 = 2.23
pKa3 = 9.95
pKa2 = 4.42
7. Amino Acid
Reason:
–COOH is an electron withdrawing group; –NH2 closer will
be a weaker base since its lone pairs are less available for
dative bonding to H+ stronger acid
10. Digestion of Proteins
1
2
Acid/ Base hydrolysis
Enzyme cleavage
- Non selective
- Overlapping fragments
-Selective
-No overlapping fragments
-Need 2 sets of data fr
different enzymes
11. Sequencing Approach
Digestion of Proteins
1
2
Acid/ Base hydrolysis
Enzyme cleavage
- spot repetition of residues
in fragments
- determine terminal
residues; common in 2 sets
of data
- spot repetition between
the sets of data.
