Inflammatory bowel disease (IBD) refers to chronic inflammatory conditions of the intestines, including Crohn's disease and ulcerative colitis. The exact causes are unknown but may involve genetic and environmental factors that trigger an immune response in the gastrointestinal tract. Crohn's disease causes transmural inflammation throughout the digestive tract and can involve any part from mouth to anus, while ulcerative colitis only affects the large intestine and causes ulcers, sores and bleeding within the colon. Both involve periods of active disease and remission.

1. INFLAMMATORY BOWEL DISEASE SMS 2044

2. INFLAMMATORY BOWEL DISEASE IBD is a group of inflammatory conditions of large intestine ,in some cases small intestine.

6. Different Clinical, Endoscopic, and Radiographic Features of Crohn’s & Ulcerative Colitis Ulcerative Colitis Crohn's Disease CLINICAL Gross blood in stool Yes Occasionally Mucus Yes Occasionally Systemic symptoms Occasionally Frequently Pain Occasionally Frequently Abdominal mass Rarely Yes Significant perineal disease No Frequently Fistulas No Yes Small intestinal obstruction No Frequently Colonic obstruction Rarely Frequently Response to antibiotics No Yes Recurrence after surgery No Yes ANCA-positive Frequently Rarely

7. Ulcerative Colitis Crohn's Disease ENDOSCOPIC Rectal sparing Rarely Frequently Continuous disease Yes Occasionally "Cobblestoning" No Yes Granuloma on biopsy No Occasionally RADIOGRAPHIC Small bowel significantly abnormal No Yes Abnormal terminal ileum Occasionally Yes Segmental colitis No Yes Asymmetrical colitis No Yes Stricture Occasionally Frequently

8. Intestines - Pathology Idiopathic Inflammatory Bowel Diseases (CD) (UC) Fissuring Ulcer noncaseating granulomas

18. Patients with ulcerative colitis can occasionally have aphthous ulcers involving the tongue, lips , palate and pharynx Endoscopic image of ulcerative colitis showing loss of vascular pattern of the sigmoid colon, granularity and some friability of the mucosa.

25. H&E stain of a colonic biopsy showing a crypt abscess:a classic finding in ulcerative colitis [ edit ] General

26. Crohn's Disease

33. Classification contd..

38. www.freelivedoctor.com

40. f) chronic course may lead to: i) fibrosing strictures - terminal ileum - fistulas other areas ii) protein loss iii) Vit B 12 loss iv) bile salt loss - steatorrhea v) linear serpentine ulcers www.freelivedoctor.com

48. Comparison of UC and CD ULCERATIVE COLITIS CROHN’S Age Any Any Sex m=f M=f Anatomical distribution Colon only Any part of G.I Presentation Bloody diarrhoea Variable; pain diarrhoea, Weight loss Risk factors more common in non smokers More common in smokers

49. Treatment of Inflammatory Bowel Disease