A Transfersome carrier is an artificial vesicle or a cell engaged in exocytosis, and thus suitable for controlled and, potentially targeted drug delivery,.

1. Transferosomes
Mr. Sagar Kishor Savale
[Department of Pharmaceutics]
avengersagar16@gmail.com
2015-2016
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Department of Pharmacy (Pharmaceutics) | Sagar savale

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Transferosomes
 The term ‘Transfersome’ indicates ‘transferre’ means ‘to carry across’ and ‘some’ means ‘
for a body’.
 A Transfersome carrier is an artificial vesicle or a cell engaged in exocytosis, and thus
suitable for controlled and, potentially targeted drug delivery,.
 Transferosomes are supramolecular entities that can pass through a permeability barrier and
thereby transport material from the application to the destination.
 These are complex, vesicular aggregates optimized to attain flexible and self-regulating
membrane.
 They are more elastic than standard liposomes.

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Compositions of Transferosomes
 The transfersome is composed of two main aggregates namely,
 Firstly, an amphiphillic ingredient (phosphatidylcholine), in which the aqueous solvents self-
assembles into lipid bilayer that closes into a simple lipid vesicle.
 Secondly, a bilayer softening component (such as a biocompatible surfactant or amphiphile
drug) that increases lipid bilayer flexibility and permeability.

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Advantages
 These shows greater permeation of the drugs through the skin because of its flexible
membranes.
 These serves as carrier for both small and large molecular weight drugs.
 In Transfersomes, percentage of the drug entrapment is more.
 Protects the entrapped drug from atmospheric degradation.
 These are biocompatible and biodegradable.
 Site Specific therapy.

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Limitation
 Transfersomes are chemically unstable because of their predisposition to
oxidative degradation.
 Lack of purity of the natural phospholipids.
 Transfersomes formulations are expensive to prepare.

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Preparation
Material required for the preparation of transfersome are phospholipids
like soya phosphatidyl choline, egg phosphatidyl choline, etc.
 Surfactants like sodium cholate, tween-80, span-80,etc.
Alcohol like methanol, ethanol,etc.
Dye like Nile-red and saline phosphate buffer.

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Applications
As a carriers for NSAIDS like Diclofenac, etc.
As a carrier for proteins.
As a carrier for Insulin.
As a carrier for Interferon.
As a means for transdermal immunization.
As a carrier for corticosteroids .
As a carrier for topical analgesics and anesthetic agents.
As a carrier for anticancer drugs.

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Transfersome Technology is best suited for non-invasive delivery
of therapeutic molecules across open biological barriers.
Systemic delivery of therapeutically amounts of macromoleules,
such as insulin or interferon, across intact mammalian skin.
Transport of small molecule drug.
Peripheral tissue targeting.
Applications

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Applications of Transferosomes
 Curcumine
 Ketoprofen
 Indinavir sulfate
 Insulin
 Capsaicin
 Tamoxifen
 Methotrexate
 Trimicilone acetonide

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REFERENCES
 Lombry c., Dujardin N., preat V .; Transdermal delivery of macromolecule using skin
electroporation, pharma research 2000; 17: 32- 37.
 Henry S., Mc Allister D.V ., Allen M.G., Microfabricated microneedles, a novel approach to
transdermal drug delivery j pharma sci. 1998;87; 922-925.
 Barry B.W., Novel mechanism and device to enable successful transdermal drug delivery, Enr J
pharm Sci,2001:14:101-114.
 Cevc G., Drug delivery across the skin. Exp. Opin invest Drugs 1997:1887-1973.
 Bhatia A., Kumar R., Tamoxifen in Topical liposomes, development and Characterization and in-
vitro evaluation, j pharm Sci; 20047(2), 252-259.