This document provides an overview of parenteral controlled drug delivery systems, including their objectives, advantages, types of formulations, approaches for formulation, routes of administration, additives used, and recent developments. The key types of formulations discussed are dissolution-controlled depots, adsorption-type depots, encapsulation-type depots, and esterification-type depots. Various approaches for implants and infusion devices are also summarized.

1. PARENTERAL CONTROLLED DRUG DELIVERY SYSTEM Prepared By SAI S. V M.Pharm – I st Year Dept. of Pharmaceutics KLE University, Belgaum.

10. APPROACHES FOR FORMUALATION

22. CLASSIFICATION INJECTABLES IMPLANTS INFUSION DEVICES Solutions Suspensions and Emulsions Microspheres and Microcapsules Nanoparticles and Niosomes Liposomes . Resealed Erythrocytes Osmotic Pumps Vapor Pressure Powered Pumps Intraspinal Infusion Pumps Intrathecal Infusion Pumps

36. Liposomes

40. Approaches to implantable drug delivery CDD by diffusion Activation process Feedback regulated Osmotic pressure Vapour pressure Magnetically activated Phonophoresis Hydration activated Hydrolysis activated Bioerosion Bioresponsive Polymer membrane Matrix diffusion Microreservoir

46. Microreservoir Partition Drug Delivery Device

50. Vapor pressure activated

53. Magnetically activated 1mm Magnet ring Coated Polymer Magnet inside polymer matrix

57. INFUSION DEVICES

59. Intraspinal infusion device

67. Needle free injections Decreased pain on injection Increased bioavailability of intradermal vaccines