This document discusses transferosomes, a novel vesicular carrier for transdermal drug delivery. Transferosomes are highly deformable lipid vesicles that can squeeze through pores much smaller than their diameter and deliver drugs across the skin. They are composed of phospholipids that form the bilayer and surfactants that provide flexibility. Transferosomes can carry both hydrophilic and lipophilic drugs and have advantages over other delivery systems like increased skin permeation and sustained release of drugs. The document covers the composition, mechanisms of action, materials used, methods of preparation and characterization of transferosomes.
Transfersomes are elastic or deformable liposomes that can efficiently deliver drugs through the skin. They are composed of phospholipids and an edge activator that make the lipid bilayer highly flexible. This flexibility allows transfersomes to deform and pass through pores much smaller than their diameter. When applied to skin, they can penetrate the stratum corneum via osmotic gradients or hydration forces. Transfersomes have been used to deliver a variety of drugs including peptides, proteins, and vaccines both systemically and topically.
Transferosomes are a novel vesicular drug carrier system composed of phospholipids, surfactants, and water that can enhance transdermal drug delivery. They are highly flexible and deformable, allowing them to squeeze through the skin's layers more easily than other carriers. Transferosomes can transport both low and high molecular weight drugs into or through the skin, depending on the application method. They are prepared using phospholipids that form lipid bilayers, along with edge activators that increase bilayer flexibility. Transferosomes have advantages like high drug entrapment efficiency, protection of drugs from degradation, and ability to deliver a wide range of drug molecules. They have potential applications in controlled drug release and delivery of proteins, peptides, and other large
This document discusses transfersomes, a novel lipid-based vesicular system for transdermal drug delivery. Transfersomes can penetrate the skin through intracellular or transcellular routes due to their elastic and deformable nature. They have advantages like accommodating both hydrophilic and hydrophobic drugs, achieving high skin penetration ability due to flexibility. The document covers transfersome formulation methods, characterization techniques, mechanisms of penetration, marketed products, and concludes they are a promising system for transdermal delivery of a wide range of drugs.
This document discusses aquasomes, which are nanoparticulate drug delivery systems composed of a ceramic core coated with polyhydroxy oligomers. It describes how aquasomes are prepared through a simple process involving the preparation of a ceramic core, coating it with carbohydrates, and immobilizing drug molecules. The document evaluates various properties of the ceramic core, sugar coating, and drug-loaded aquasomes. Aquasomes offer advantages like increased drug efficacy and avoidance of multiple injections. They have applications in oxygen carrying, immunotherapy, and delivery of drugs, enzymes, insulin, and vaccines.
Transferosomes are novel, ultradeformable vesicular carriers composed of phospholipids and surfactants that can efficiently deliver drugs through the skin. They overcome barriers to skin penetration by squeezing through tight spaces between skin cells. Transferosomes are prepared using film dispersion or modified shaking methods. They have advantages like improved skin permeation, high drug loading, and protection of drugs. Transferosomes have applications in transdermal delivery of peptides, proteins, and other drugs.
The document provides information on the formulation and evaluation of Tramadol Hydrochloride loaded transferosome gel. Key points include:
1) Nine different transferosome formulations were prepared using different ratios of soya lecithin, propylene glycol, and other excipients to encapsulate Tramadol HCl.
2) Characterization of the formulations found that formulation F5 had the highest entrapment efficiency of 92.71% and drug content of 97.8%.
3) In vitro drug release studies through a cellophane membrane showed sustained release of Tramadol HCl from the transferosome gel formulations over 24 hours, with F5 releasing 88.18%
This document summarizes a seminar presentation on liposomes and niosomes. It discusses various types of liposomes and methods for preparing liposomes, including solvent dispersion methods like ethanol injection, ether injection, and reverse phase evaporation. Characterization techniques for liposomes like size, shape, encapsulation efficiency, and drug release are also outlined. Finally, the document notes therapeutic applications of liposomes for drug delivery and discusses characterization of liposomes through parameters like vesicle shape, size, surface charge, and drug entrapment efficiency.
Nucleic acid based therapeutic drug delivery systemtadisriteja9
Nucleic acid based Drug delivery system is one of the trending research area, which i have taken and made as Powerpoint for easy and quick learning purpose
Transfersomes are elastic or deformable liposomes that can efficiently deliver drugs through the skin. They are composed of phospholipids and an edge activator that make the lipid bilayer highly flexible. This flexibility allows transfersomes to deform and pass through pores much smaller than their diameter. When applied to skin, they can penetrate the stratum corneum via osmotic gradients or hydration forces. Transfersomes have been used to deliver a variety of drugs including peptides, proteins, and vaccines both systemically and topically.
Transferosomes are a novel vesicular drug carrier system composed of phospholipids, surfactants, and water that can enhance transdermal drug delivery. They are highly flexible and deformable, allowing them to squeeze through the skin's layers more easily than other carriers. Transferosomes can transport both low and high molecular weight drugs into or through the skin, depending on the application method. They are prepared using phospholipids that form lipid bilayers, along with edge activators that increase bilayer flexibility. Transferosomes have advantages like high drug entrapment efficiency, protection of drugs from degradation, and ability to deliver a wide range of drug molecules. They have potential applications in controlled drug release and delivery of proteins, peptides, and other large
This document discusses transfersomes, a novel lipid-based vesicular system for transdermal drug delivery. Transfersomes can penetrate the skin through intracellular or transcellular routes due to their elastic and deformable nature. They have advantages like accommodating both hydrophilic and hydrophobic drugs, achieving high skin penetration ability due to flexibility. The document covers transfersome formulation methods, characterization techniques, mechanisms of penetration, marketed products, and concludes they are a promising system for transdermal delivery of a wide range of drugs.
This document discusses aquasomes, which are nanoparticulate drug delivery systems composed of a ceramic core coated with polyhydroxy oligomers. It describes how aquasomes are prepared through a simple process involving the preparation of a ceramic core, coating it with carbohydrates, and immobilizing drug molecules. The document evaluates various properties of the ceramic core, sugar coating, and drug-loaded aquasomes. Aquasomes offer advantages like increased drug efficacy and avoidance of multiple injections. They have applications in oxygen carrying, immunotherapy, and delivery of drugs, enzymes, insulin, and vaccines.
Transferosomes are novel, ultradeformable vesicular carriers composed of phospholipids and surfactants that can efficiently deliver drugs through the skin. They overcome barriers to skin penetration by squeezing through tight spaces between skin cells. Transferosomes are prepared using film dispersion or modified shaking methods. They have advantages like improved skin permeation, high drug loading, and protection of drugs. Transferosomes have applications in transdermal delivery of peptides, proteins, and other drugs.
The document provides information on the formulation and evaluation of Tramadol Hydrochloride loaded transferosome gel. Key points include:
1) Nine different transferosome formulations were prepared using different ratios of soya lecithin, propylene glycol, and other excipients to encapsulate Tramadol HCl.
2) Characterization of the formulations found that formulation F5 had the highest entrapment efficiency of 92.71% and drug content of 97.8%.
3) In vitro drug release studies through a cellophane membrane showed sustained release of Tramadol HCl from the transferosome gel formulations over 24 hours, with F5 releasing 88.18%
This document summarizes a seminar presentation on liposomes and niosomes. It discusses various types of liposomes and methods for preparing liposomes, including solvent dispersion methods like ethanol injection, ether injection, and reverse phase evaporation. Characterization techniques for liposomes like size, shape, encapsulation efficiency, and drug release are also outlined. Finally, the document notes therapeutic applications of liposomes for drug delivery and discusses characterization of liposomes through parameters like vesicle shape, size, surface charge, and drug entrapment efficiency.
Nucleic acid based therapeutic drug delivery systemtadisriteja9
Nucleic acid based Drug delivery system is one of the trending research area, which i have taken and made as Powerpoint for easy and quick learning purpose
This document discusses emulsions and suspensions. It defines emulsions as thermodynamically unstable systems of two immiscible liquids, one dispersed as globules in the other. Several theories of emulsification are described, including the electric double layer theory and hydration theory. Methods for preparing emulsions are outlined, such as the dry gum, wet gum, bottle, and beaker methods. Factors that can cause emulsion instability like flocculation, creaming, coalescence, and breaking are explained. Suspensions are defined as coarse dispersions where the internal phase is uniformly dispersed. Methods for preparing suspensions include precipitation and dispersion techniques. Small and large scale preparation methods are provided. Factors that influence suspension stability like particle
NIOSOMES , GENERAL CHARACTERISTICS OF NIOSOME , TYPES OF NIOSOMES , OTHERS TYPES OF NIOSOMES , NIOSOMES VS LIPOSOMES , COMPONENTS OF NIOSOMES , Non-ionic surfactant , Cholesterol , Charge inducing molecule , METHOD OF PREPARATION , preparation of small unilamellar vesicles , Sonication , Micro fluidization , preparation of large unilamellar vesicles , Reverse Phase Evaporation , Ether Injection , preparation of Multilamellar vesicles , Hand shaking method , Trans membrane pH gradient drug uptake process (remote loading) , Miscellaneous method :Multiple membrane extrusion method , The “Bubble” Method , Formation of Niosomes From Proniosomes , SEPARATION OF UNENTRAPPED DRUGS , Gel Filtration , Dialysis , Centrifugation , FACTORS AFFECTING THE PHYSICOCHEMICAL PROPERTIES OF NIOSOMES , Membrane Additives , Temperature of Hydration , PROPERTIES OF DRUGS , AMOUNT AND TYPE OF SURFACTANT
Structure of Surfactants , Resistance to Osmotic Stress , Characterization of niosomes ,Therapeutic applications of Niosomes , For Controlled Release of Drugs , To Improve the Stability and Physical Properties of the Drugs , For Targeting and Retention of Drug in Blood Circulation , Proniosomes , Aspasomes , Vesicles in Water and Oil System (v/w/o) ,Bola - niosomes , Discomes , Deformable niosomes or elastic niosomes , According to the nature of lamellarity ,Small Unilamellar vesicles (SUV) 25 – 500 nm in size.,Large Unilamellar vesicles (LUV) 0.1 – 1μm in size , Multilamellar vesicles (MLV) 1-5 μm in size , According to the size:Small Niosomes (100 nm – 200 nm) , Large Niosomes (800 nm – 900 nm),Big Niosomes (2 μm – 4 μm)
Liposomes, Structure of liposome, phospholipids, classification of liposomes, method of preparation of liposomes, mechanism of liposome formation, application of liposomes.
This document discusses targeted drug delivery systems. It begins by defining targeted drug delivery as selectively delivering medication only to its site of action to increase concentration there and reduce it elsewhere. This improves efficacy and reduces side effects. It then lists the ideal characteristics of targeted systems and the advantages they provide like reduced toxicity and dosage. The document outlines various carrier systems and the biological processes involved in cellular uptake, transport across barriers, extravasation into tissues, and lymphatic uptake. It concludes by describing different strategies for targeted delivery, including passive, active, and physical targeting approaches.
Aquasomes are nanoparticle carrier systems composed of a solid nanocrystalline core coated with polyhydroxy oligomers. They are able to protect fragile biological molecules through water-like properties and high surface exposure. Aquasomes are prepared through a self-assembly process involving interaction of charged groups, hydrogen bonding, and structural stability. This allows active loading of molecules like proteins, antigens, and genes. Characterization techniques confirm the structure, drug loading, and release kinetics of aquasomes, which have applications in delivery of vaccines, hemoglobin, insulin, and enzymes orally and intravenously.
This ppt is quite helpful for students/ researchers to understand the mechanism behind ethosomes penetration in the skin barrier when applied topically as well as it helps you to brief on drug detailing while formulating the ethosomes formulation.
for any more question you want to ask, feel free to contact: shikhasingh_ss@yahoo.com
thank you!
This document provides an overview of a seminar presentation on liposomes. It begins with an introduction defining liposomes as vesicles with an aqueous volume enclosed by a phospholipid bilayer. It then discusses the composition of liposomes, including the structure of phospholipids. Various methods for preparing liposomes are described, such as mechanical dispersion, freeze drying, sonication, and microemulsification. Liposomes can be classified based on their structure, preparation method, or composition. The document concludes by discussing techniques for characterizing liposomes, including evaluating their physical properties like size, surface charge, and drug encapsulation efficiency.
This document provides an overview of pulmonary drug delivery systems. It discusses the anatomy and physiology of the lungs, advantages and disadvantages of pulmonary delivery, and different technologies used. Aerosols, propellants, and container types are described. Current pulmonary delivery devices discussed include metered dose inhalers, dry powder inhalers, and nebulizers. The document also covers evaluation methods for pharmaceutical aerosols and pulmonary drug delivery systems such as cascade impactors and in vitro and in vivo tests.
Computers in pharmaceutical research and development, General overview, Brief...Manikant Prasad Shah
This document discusses the history of computers in pharmaceutical research and development. It describes how computers first began to be used in the 1940s and the early pioneers in computational chemistry in the 1950s and 1960s. It outlines the advancements made in the field in the following decades, including the development of quantum chemistry models, molecular mechanics, and other approaches. The document emphasizes that computational chemistry experts now play an important role in drug discovery by maximizing the benefits of computer technologies.
The document discusses controlled release drug delivery systems. It explains that controlled release systems aim to maintain drug levels within a therapeutic range by slowing drug release, reducing fluctuations in plasma drug concentrations. This improves therapeutic outcomes by minimizing side effects. The key types of controlled release systems discussed are diffusion-controlled, dissolution/coating-controlled, biodegradable, osmotic pumps, and prodrugs. Factors to consider in designing these systems include drug properties, route of administration, and pharmacological effects.
Evaluation Of Ocular Drug Delivery SystemAnal Mondal
This document discusses evaluation methods for ocular drug delivery systems. It describes various techniques to test the thickness, drug content uniformity, weight uniformity, and moisture absorption of ocular films. Dissolution testing methods are also summarized, including bottle, diffusion, rotating basket, and rotating paddle methods. In vivo testing in animal eyes is described. Accelerated stability testing aims to predict stability over prolonged storage. Additional tests include checking for metal particles in ointments and performing sterility testing and leakage testing of ointment tubes.
This presentation involves the information about Modified-Release Drug Products, Targeted Drug Delivery Systems and Biotechnological Products in Pharmaceutics
A Transfersome carrier is an artificial vesicle or a cell engaged in exocytosis, and thus suitable for controlled and, potentially targeted drug delivery,.
This document discusses drug targeting and delivery methods for treating tumors. It describes two main categories of drug targeting - passive and active. Passive targeting relies on physiological differences between normal and tumor tissues, while active targeting conjugates drugs to nanoparticles targeted to the tumor site. Several targeted therapy approaches are mentioned, including hormone therapy, signal transduction inhibitors, gene therapy, immunotherapy, and antibody-directed enzyme prodrug therapy. Stimuli-responsive drug release mechanisms using pH, temperature, or enzyme differences in the tumor microenvironment are also discussed. Limitations and side effects of targeted therapies are outlined. The document concludes by discussing the potential for future targeted delivery systems aiming at multiple targets simultaneously.
Tumour targeting and Brain specific drug deliverySHUBHAMGWAGH
The document discusses tumor targeting and brain specific drug delivery. It provides an introduction to targeted drug delivery and outlines strategies for tumor targeting including passive targeting via the enhanced permeability and retention effect, active targeting using ligands, and triggered drug delivery responsive to microenvironment changes. It also discusses challenges of drug delivery to the brain posed by the blood-brain barrier and factors that affect crossing it, as well as diseases related to the brain and strategies to enhance brain-specific drug delivery.
This document provides information on pulmonary drug delivery systems and aerosols. It discusses the advantages of pulmonary drug delivery such as localized drug deposition reducing systemic exposure and avoidance of first-pass metabolism. Aerosols are defined as colloidal systems containing liquid/solid particles suspended in a propellant. The document outlines the manufacturing process, components, and quality control tests of aerosols including pressure filling, cold filling, and compressed gas filling apparatuses. Evaluation tests like flash point and flame projection are also mentioned.
This document provides an overview of nanoparticles for drug delivery. It defines nanoparticles as sub-nano sized colloidal structures composed of synthetic or semi-synthetic polymers with a size range of 10-1000 nm. The document then classifies nanoparticles and discusses commonly used polymer materials. It describes advantages such as improved drug stability and targeting abilities. Preparation methods like emulsion polymerization and solvent evaporation are summarized. Key characterization techniques and applications for cancer therapy and prolonged circulation are also highlighted.
This document provides an introduction to targeted drug delivery and summarizes key points about nanoparticles and liposomes. It discusses advantages of targeted delivery including reducing toxicity and maximizing therapeutic effects. Nanoparticles and liposomes are described as methods for targeted delivery. Key preparation techniques for nanoparticles include solvent evaporation, double emulsification, and nano precipitation. Evaluation parameters like particle size, zeta potential, and in vitro drug release are also summarized. The document concludes with describing applications of liposomes for drug and gene delivery.
Skin acts as a major target as well as a principal barrier for topical/transdermal drug delivery. Despite the many advantages of this system, the major obstacle is the low diffusion rate of drugs across the stratum corneum. Several methods have been tried to increase the permeation rate of drugs temporarily. One simple and convenient approach is application of drugs in formulation with elastic vesicles or skin enhancers. Vesicular system is one of the most convenient methods for transdermal delivery of active substances and in that ethosomes are most useful vesicular systems. Ethosomal carriers are systems containing soft vesicles, composed of hydroalcoholic or hydro/glycolic phospholipid in which the concentration of alcohols is relatively high. The high concentration of ethanol brings increase in fluidity of lipids hence increase in permeability of the skin and improves the drug penetration. Ethosomal formulation may contain many drugs such as acyclovir, salbutamol, Insulin, cyclosporine, fluconazole, minodixil, etc. These are prepared by hot method and cold methods. The size of Ethosomal formulation can be decreased by sonication and extrusion method. The high concentration of ethanol makes the ethosomes unique and useful for transcellular delivery, delivery of hormones, anti-arthritis, anti-HIV etc. Thus, it can be a logical conclusion that ethosomal formulation possesses promising future in effective dermal/transdermal delivery of bioactive agents.
Skin acts as a major target as well as a principal barrier for
topical/transdermal drug delivery. Despite the many advantages of this
system, the major obstacle is the low diffusion rate of drugs across the
stratum corneum. Several methods have been tried to increase the
permeation rate of drugs temporarily. One simple and convenient
approach is application of drugs in formulation with elastic vesicles or
skin enhancers. Vesicular system is one of the most convenient
methods for transdermal delivery of active substances and in that
ethosomes are most useful vesicular systems. Ethosomal carriers are
systems containing soft vesicles, composed of hydroalcoholic or
hydro/glycolic phospholipid in which the concentration of alcohols is
relatively high. The high concentration of ethanol brings increase in fluidity of lipids hence
increase in permeability of the skin and improves the drug penetration. Ethosomal
formulation may contain many drugs such as acyclovir, salbutamol, Insulin, cyclosporine,
fluconazole, minodixil, etc. These are prepared by hot method and cold methods. The size of
Ethosomal formulation can be decreased by sonication and extrusion method. The high
concentration of ethanol makes the ethosomes unique and useful for transcellular delivery,
delivery of hormones, anti-arthritis, anti-HIV etc. Thus, it can be a logical conclusion that
ethosomal formulation possesses promising future in effective dermal/transdermal delivery of
bioactive agents.
This document discusses emulsions and suspensions. It defines emulsions as thermodynamically unstable systems of two immiscible liquids, one dispersed as globules in the other. Several theories of emulsification are described, including the electric double layer theory and hydration theory. Methods for preparing emulsions are outlined, such as the dry gum, wet gum, bottle, and beaker methods. Factors that can cause emulsion instability like flocculation, creaming, coalescence, and breaking are explained. Suspensions are defined as coarse dispersions where the internal phase is uniformly dispersed. Methods for preparing suspensions include precipitation and dispersion techniques. Small and large scale preparation methods are provided. Factors that influence suspension stability like particle
NIOSOMES , GENERAL CHARACTERISTICS OF NIOSOME , TYPES OF NIOSOMES , OTHERS TYPES OF NIOSOMES , NIOSOMES VS LIPOSOMES , COMPONENTS OF NIOSOMES , Non-ionic surfactant , Cholesterol , Charge inducing molecule , METHOD OF PREPARATION , preparation of small unilamellar vesicles , Sonication , Micro fluidization , preparation of large unilamellar vesicles , Reverse Phase Evaporation , Ether Injection , preparation of Multilamellar vesicles , Hand shaking method , Trans membrane pH gradient drug uptake process (remote loading) , Miscellaneous method :Multiple membrane extrusion method , The “Bubble” Method , Formation of Niosomes From Proniosomes , SEPARATION OF UNENTRAPPED DRUGS , Gel Filtration , Dialysis , Centrifugation , FACTORS AFFECTING THE PHYSICOCHEMICAL PROPERTIES OF NIOSOMES , Membrane Additives , Temperature of Hydration , PROPERTIES OF DRUGS , AMOUNT AND TYPE OF SURFACTANT
Structure of Surfactants , Resistance to Osmotic Stress , Characterization of niosomes ,Therapeutic applications of Niosomes , For Controlled Release of Drugs , To Improve the Stability and Physical Properties of the Drugs , For Targeting and Retention of Drug in Blood Circulation , Proniosomes , Aspasomes , Vesicles in Water and Oil System (v/w/o) ,Bola - niosomes , Discomes , Deformable niosomes or elastic niosomes , According to the nature of lamellarity ,Small Unilamellar vesicles (SUV) 25 – 500 nm in size.,Large Unilamellar vesicles (LUV) 0.1 – 1μm in size , Multilamellar vesicles (MLV) 1-5 μm in size , According to the size:Small Niosomes (100 nm – 200 nm) , Large Niosomes (800 nm – 900 nm),Big Niosomes (2 μm – 4 μm)
Liposomes, Structure of liposome, phospholipids, classification of liposomes, method of preparation of liposomes, mechanism of liposome formation, application of liposomes.
This document discusses targeted drug delivery systems. It begins by defining targeted drug delivery as selectively delivering medication only to its site of action to increase concentration there and reduce it elsewhere. This improves efficacy and reduces side effects. It then lists the ideal characteristics of targeted systems and the advantages they provide like reduced toxicity and dosage. The document outlines various carrier systems and the biological processes involved in cellular uptake, transport across barriers, extravasation into tissues, and lymphatic uptake. It concludes by describing different strategies for targeted delivery, including passive, active, and physical targeting approaches.
Aquasomes are nanoparticle carrier systems composed of a solid nanocrystalline core coated with polyhydroxy oligomers. They are able to protect fragile biological molecules through water-like properties and high surface exposure. Aquasomes are prepared through a self-assembly process involving interaction of charged groups, hydrogen bonding, and structural stability. This allows active loading of molecules like proteins, antigens, and genes. Characterization techniques confirm the structure, drug loading, and release kinetics of aquasomes, which have applications in delivery of vaccines, hemoglobin, insulin, and enzymes orally and intravenously.
This ppt is quite helpful for students/ researchers to understand the mechanism behind ethosomes penetration in the skin barrier when applied topically as well as it helps you to brief on drug detailing while formulating the ethosomes formulation.
for any more question you want to ask, feel free to contact: shikhasingh_ss@yahoo.com
thank you!
This document provides an overview of a seminar presentation on liposomes. It begins with an introduction defining liposomes as vesicles with an aqueous volume enclosed by a phospholipid bilayer. It then discusses the composition of liposomes, including the structure of phospholipids. Various methods for preparing liposomes are described, such as mechanical dispersion, freeze drying, sonication, and microemulsification. Liposomes can be classified based on their structure, preparation method, or composition. The document concludes by discussing techniques for characterizing liposomes, including evaluating their physical properties like size, surface charge, and drug encapsulation efficiency.
This document provides an overview of pulmonary drug delivery systems. It discusses the anatomy and physiology of the lungs, advantages and disadvantages of pulmonary delivery, and different technologies used. Aerosols, propellants, and container types are described. Current pulmonary delivery devices discussed include metered dose inhalers, dry powder inhalers, and nebulizers. The document also covers evaluation methods for pharmaceutical aerosols and pulmonary drug delivery systems such as cascade impactors and in vitro and in vivo tests.
Computers in pharmaceutical research and development, General overview, Brief...Manikant Prasad Shah
This document discusses the history of computers in pharmaceutical research and development. It describes how computers first began to be used in the 1940s and the early pioneers in computational chemistry in the 1950s and 1960s. It outlines the advancements made in the field in the following decades, including the development of quantum chemistry models, molecular mechanics, and other approaches. The document emphasizes that computational chemistry experts now play an important role in drug discovery by maximizing the benefits of computer technologies.
The document discusses controlled release drug delivery systems. It explains that controlled release systems aim to maintain drug levels within a therapeutic range by slowing drug release, reducing fluctuations in plasma drug concentrations. This improves therapeutic outcomes by minimizing side effects. The key types of controlled release systems discussed are diffusion-controlled, dissolution/coating-controlled, biodegradable, osmotic pumps, and prodrugs. Factors to consider in designing these systems include drug properties, route of administration, and pharmacological effects.
Evaluation Of Ocular Drug Delivery SystemAnal Mondal
This document discusses evaluation methods for ocular drug delivery systems. It describes various techniques to test the thickness, drug content uniformity, weight uniformity, and moisture absorption of ocular films. Dissolution testing methods are also summarized, including bottle, diffusion, rotating basket, and rotating paddle methods. In vivo testing in animal eyes is described. Accelerated stability testing aims to predict stability over prolonged storage. Additional tests include checking for metal particles in ointments and performing sterility testing and leakage testing of ointment tubes.
This presentation involves the information about Modified-Release Drug Products, Targeted Drug Delivery Systems and Biotechnological Products in Pharmaceutics
A Transfersome carrier is an artificial vesicle or a cell engaged in exocytosis, and thus suitable for controlled and, potentially targeted drug delivery,.
This document discusses drug targeting and delivery methods for treating tumors. It describes two main categories of drug targeting - passive and active. Passive targeting relies on physiological differences between normal and tumor tissues, while active targeting conjugates drugs to nanoparticles targeted to the tumor site. Several targeted therapy approaches are mentioned, including hormone therapy, signal transduction inhibitors, gene therapy, immunotherapy, and antibody-directed enzyme prodrug therapy. Stimuli-responsive drug release mechanisms using pH, temperature, or enzyme differences in the tumor microenvironment are also discussed. Limitations and side effects of targeted therapies are outlined. The document concludes by discussing the potential for future targeted delivery systems aiming at multiple targets simultaneously.
Tumour targeting and Brain specific drug deliverySHUBHAMGWAGH
The document discusses tumor targeting and brain specific drug delivery. It provides an introduction to targeted drug delivery and outlines strategies for tumor targeting including passive targeting via the enhanced permeability and retention effect, active targeting using ligands, and triggered drug delivery responsive to microenvironment changes. It also discusses challenges of drug delivery to the brain posed by the blood-brain barrier and factors that affect crossing it, as well as diseases related to the brain and strategies to enhance brain-specific drug delivery.
This document provides information on pulmonary drug delivery systems and aerosols. It discusses the advantages of pulmonary drug delivery such as localized drug deposition reducing systemic exposure and avoidance of first-pass metabolism. Aerosols are defined as colloidal systems containing liquid/solid particles suspended in a propellant. The document outlines the manufacturing process, components, and quality control tests of aerosols including pressure filling, cold filling, and compressed gas filling apparatuses. Evaluation tests like flash point and flame projection are also mentioned.
This document provides an overview of nanoparticles for drug delivery. It defines nanoparticles as sub-nano sized colloidal structures composed of synthetic or semi-synthetic polymers with a size range of 10-1000 nm. The document then classifies nanoparticles and discusses commonly used polymer materials. It describes advantages such as improved drug stability and targeting abilities. Preparation methods like emulsion polymerization and solvent evaporation are summarized. Key characterization techniques and applications for cancer therapy and prolonged circulation are also highlighted.
This document provides an introduction to targeted drug delivery and summarizes key points about nanoparticles and liposomes. It discusses advantages of targeted delivery including reducing toxicity and maximizing therapeutic effects. Nanoparticles and liposomes are described as methods for targeted delivery. Key preparation techniques for nanoparticles include solvent evaporation, double emulsification, and nano precipitation. Evaluation parameters like particle size, zeta potential, and in vitro drug release are also summarized. The document concludes with describing applications of liposomes for drug and gene delivery.
Skin acts as a major target as well as a principal barrier for topical/transdermal drug delivery. Despite the many advantages of this system, the major obstacle is the low diffusion rate of drugs across the stratum corneum. Several methods have been tried to increase the permeation rate of drugs temporarily. One simple and convenient approach is application of drugs in formulation with elastic vesicles or skin enhancers. Vesicular system is one of the most convenient methods for transdermal delivery of active substances and in that ethosomes are most useful vesicular systems. Ethosomal carriers are systems containing soft vesicles, composed of hydroalcoholic or hydro/glycolic phospholipid in which the concentration of alcohols is relatively high. The high concentration of ethanol brings increase in fluidity of lipids hence increase in permeability of the skin and improves the drug penetration. Ethosomal formulation may contain many drugs such as acyclovir, salbutamol, Insulin, cyclosporine, fluconazole, minodixil, etc. These are prepared by hot method and cold methods. The size of Ethosomal formulation can be decreased by sonication and extrusion method. The high concentration of ethanol makes the ethosomes unique and useful for transcellular delivery, delivery of hormones, anti-arthritis, anti-HIV etc. Thus, it can be a logical conclusion that ethosomal formulation possesses promising future in effective dermal/transdermal delivery of bioactive agents.
Skin acts as a major target as well as a principal barrier for
topical/transdermal drug delivery. Despite the many advantages of this
system, the major obstacle is the low diffusion rate of drugs across the
stratum corneum. Several methods have been tried to increase the
permeation rate of drugs temporarily. One simple and convenient
approach is application of drugs in formulation with elastic vesicles or
skin enhancers. Vesicular system is one of the most convenient
methods for transdermal delivery of active substances and in that
ethosomes are most useful vesicular systems. Ethosomal carriers are
systems containing soft vesicles, composed of hydroalcoholic or
hydro/glycolic phospholipid in which the concentration of alcohols is
relatively high. The high concentration of ethanol brings increase in fluidity of lipids hence
increase in permeability of the skin and improves the drug penetration. Ethosomal
formulation may contain many drugs such as acyclovir, salbutamol, Insulin, cyclosporine,
fluconazole, minodixil, etc. These are prepared by hot method and cold methods. The size of
Ethosomal formulation can be decreased by sonication and extrusion method. The high
concentration of ethanol makes the ethosomes unique and useful for transcellular delivery,
delivery of hormones, anti-arthritis, anti-HIV etc. Thus, it can be a logical conclusion that
ethosomal formulation possesses promising future in effective dermal/transdermal delivery of
bioactive agents.
This document provides an overview of mucoadhesive drug delivery systems. It defines mucoadhesion and describes how mucoadhesive polymers can be used to target drugs to specific regions of the body for extended periods of time. The document discusses the various theories of mucoadhesion and factors that affect mucoadhesion and transmucosal permeability. It also outlines different routes of transmucosal delivery and considerations for formulation of mucoadhesive drug delivery systems.
This document provides an overview of transdermal drug delivery systems (TDDS). It defines TDDS and lists their advantages and disadvantages. It describes the structure of skin and the routes and mechanisms of absorption for TDDS. Factors affecting percutaneous absorption are outlined. Approaches to increase skin permeation include chemical, physical and carrier system methods. Transdermal patches, their components and types are defined. Evaluation methods for TDDS are provided in brief.
Transdermal Drug Delivery System (TDDS) is the one of the novel technology to deliver the molecules through the skin for long period of time.
Transdermal Drug Delivery System (TDDS) are defined as self contained, discrete dosage forms which are also known as “patches” 2, 3 when patches are applied to the intact skin, deliver the drug through the skin at a controlled rate to the systemic circulation
This document discusses targeted drug delivery systems. It begins by explaining the concept of targeted drug delivery, which aims to direct drugs only to their site of action to provide maximum therapeutic effects while reducing toxicity. It then discusses various drug carrier systems used for targeted delivery, including nanoparticles, liposomes, microcapsules, and vesicles. In particular, it focuses on liposomes, describing their composition, morphology, advantages, and methods of formulation including mechanical dispersion, solvent dispersion, and detergent removal.
The amount of drug that enters the body from site of administration to the systemic circulation is known as absorption. The rate of absorption affects the onset, duration and intensity of drug action.
Absorption involves several phases. First, the drug needs to be introduced via some route of administration and in a specific dosage form such as a tablet, capsule, and so on.
Absorption is a primary focus in drug development and medicinal chemistry, since the drug must be absorbed before any pharmacological effects can take place.
This document discusses targeted drug delivery systems. It describes how targeted drug delivery aims to selectively deliver pharmacological agents to the intended site of action in therapeutic concentrations while minimizing effects on other tissues. Key components of targeted delivery systems are the drug carrier and the target tissue. Common targeted drug carriers discussed are liposomes, niosomes and nanoparticles. The document provides details on the preparation, classification, advantages and applications of liposomes for targeted drug delivery.
Penetration Enhancers in Transdermal Drug Delivery SystemSimranDhiman12
Penetration Enhancers in Transdermal Drug Delivery System
Permeation enhancers are substances that reduce the skin barrier's ability to make skin more permeable and allow drug molecules to cross the skin at a faster rate
advantages and disadvantages
types of penetration enhancers
techniques
physical and chemical enhancers
transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream
This document provides an overview of transdermal drug delivery. It defines transdermal drug delivery and describes the three main routes of skin absorption: transfollicular, transcellular, and intercellular. It discusses factors that affect transdermal permeability such as lipid solubility and pH conditions. It also describes types of permeation enhancers and the four main types of transdermal drug delivery systems. The document outlines the advantages of transdermal delivery in maintaining drug levels and avoiding first-pass metabolism, and notes some disadvantages such as limited drug types and potential for irritation. It concludes that transdermal delivery technologies are growing rapidly in the pharmaceutical industry.
This document discusses buccal drug delivery systems. It begins with defining buccal drug delivery as a route of administration through the oral mucosa in the buccal region for local and systemic drug delivery. It then classifies drug delivery in the oral cavity and describes the anatomy and structure of the buccal mucosa. Key aspects covered include permeability through the buccal mucosa, penetration enhancers and their mechanisms of action, barriers to buccal delivery, advantages and limitations. The document concludes by outlining factors to consider when selecting drugs for buccal delivery such as molecular size and lipophilicity.
This document discusses transdermal drug delivery systems (TDDS). It begins by defining TDDS as topically administered drug delivery patches that release drugs through the skin for systemic effects at controlled rates. The document then covers the advantages and disadvantages of TDDS, skin structure and factors affecting drug penetration. It discusses penetration enhancers and the basic components of TDDS formulations. The document outlines various TDDS formulation techniques and concludes by discussing evaluation methods for TDDS including in vitro and in vivo testing.
1. DRUG RELEASE PROFILE IN CDDS
2. Drug release profile graph
3. CLASSIFICATION OF CONTROLLED RELEASE SYSTEMS
4. DIFFERENCES BETWEEN MATRIX & RESERVOIR SYSTEM
5. RETARDANTS USED IN MATRIX TABLET FORMULATION
6. CLASSIFICATION OF NOVEL DRUG DELIVERY SYSTEMS
7. FORMULATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
8. CLINICALLY APPROVED LIPOSOMAL FORMULATIONS
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This document reviews hyaluronic acid-core gel liposomes as a potential transdermal drug delivery system. It begins with an abstract that summarizes the development of liposomes and other vesicular systems for transdermal delivery. It then provides background on the skin as a barrier to drug penetration and strategies for enhancing penetration. The review focuses on novel gel-core liposomes that combine the advantages of liposomes and gel formulations. It suggests these "hyaluosomes" show promise as a transdermal liposomal system with favorable rheological properties and superior skin permeation compared to conventional and other non-conventional liposomal systems.
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1. TRANSFEROSOMES: A NOVEL VESICULAR
CARRIER FOR TRANSDERMAL DRUG DELIVERY
SYSTEM
Guided by
Mrs. D.Madhuri
M.Pharm( Ph.D.)
Presentation by
P.Mounica
Y18MPH325
Pharmaceutics
ACHARYA NAGARJUNA UNIVERSITY COLLEGE OF
PHARMACEUTICAL SCIENCES
2. CONTENTS:
Introduction
Advantages & disadvantages of different vesicular systems
Classification of vesicular drug delivery system
Why vesicular drug delivery system
Transferosomes
Why transferosomes for skin
Novel characteristics of transferosomes
Limitations of transferosomes
Composition of transferosomes
Mechanism of action
Materials
Methods of preparation
Optimization of formulation containing transferosomes
Characterization
Transferosome Vs other systems
Applications
Conclusion
3. Transdermal drug delivery system can deliver medicines via the skin portal to
systemic circulation at a predetermined rate and maintain clinically the effective
concentrations over a prolonged period of time.
The major limitation of TDDS is the permeability of the skin, it is permeable to
small molecules, lipophilic drugs and highly impermeable to macromolecules and
hydrophilic drugs.
4. Delivery via the transdermal route is an interesting option in this respect
because a transdermal route is convenient and safe. This offers several
potential advantages over conventional route like
Avoidance of first pass metabolism.
Predictable and extended duration of activity.
Minimizing undesirable side effects.
Utility of short half-life drugs.
Improving physiological and pharmacological response.
Avoiding the fluctuation in drug levels.
Inter-and intra-patient variations.
Provides patients convenience.
5. The main disadvantage of transdermal drug delivery is the poor penetration
of most compounds across human skin.
The main barrier and rate-limiting step for diffusion of drugs across the skin
is provided by the outermost layer of the skin, the stratum corneum.
Recent approaches in modulating vesicle compositions have been
investigated to develop systems that are capable of carrying drugs and
macromolecules to deeper tissues. These approaches have resulted in the
design of two novel vesicular carriers, ethosomes and ultra flexible lipid-based
elastic vesicles, transferosomes.
6. To date many chemical and physical approaches have been applied to increase the
efficacy of the material transfer across the intact skin, by use of the
Penetration enhancers
Iontophoresis
Sonophoresis
Colloidal carriers such as lipid vesicles (liposomes and proliposomes) and
Nonionic surfactant vesicles (niosomes and proniosomes)
7. Vesicles have a unique structure which is capable of entrapping hydrophilic,
lipophilic, amphiphilic and charged hydrophilic drugs.
Vesicles are colloidal particles having a water filled core surrounded by a wall of
lipids and surfactants (amphiphiles) arranges in bilayer.
If the proportion of water is increased, these amphiphiles can form one or more
concentric bilayers.
Hydrophilic drugs find a place in the internal aqueous environment while
amphiphilic, lipophilic drugs get entrapped in the bilayered wall with electrostatic
and/or hydrophobic forces.
The flexible or deformable vesicles are called elastic vesicles or Transfersomes
8. CLASSIFICATION OF VESICULAR DRUG DELIVERY SYSTEM
I. LIPOIDAL BIOCARRIERS
Liposomes Ethosomes Transferosomes
Sphigosomes Pharmacosomes
Virosomes Phytosomes
10. WHY VESICULAR DRUG DELIVERY SYSTEM
Prolongation of existence of drug in systemic circulation
Reduce toxicity
Improved bioavailability
Hydrophilic-lipophilic drugs can be incorporated
Sustained release systems: delay elimination of rapidly metabolizing drugs.
Vesicular drug delivery system
11. TRANSFEROSOMES
The term Transfersome and the underlying concept were introduced in 1991 by
Gregor Cevc.
The name means “carrying body”, and is derived from the Latin word 'transferred',
meaning „to carry across‟, and the Greek word „soma‟, for a „body‟.
A Transfersome carrier is an artificial vesicle designed to be like a cell vesicle or a
cell engaged in exocytosis, and thus suitable for controlled and, potentially targeted,
drug delivery.
Transfersome is a highly adaptable and stress-responsive, complex aggregate. Its
preferred form is an ultra deformable vesicle possessing an aqueous core surrounded
by the complex lipid bilayer. Interdependency of local composition and shape of the
bilayer makes the vesicle both self-regulating and self-optimizing. This enables the
Transfersome to cross various transport barriers efficiently, and then act as a Drug
carrier for non-invasive targeted drug delivery and sustained release of therapeutic
agents.
12. WHY ONLY TRANSFEROSOMES FOR SKIN?
Transfersomes are advantageous as phospholipids vesicles for transdermal drug
delivery. Because of their self-optimized and ultra flexible membrane properties,
they are able to deliver the drug reproducibly either into or through the skin,
depending on the choice of administration or application, with high efficiency.
Transfersomes overcome the skin penetration difficulty by squeezing themselves
along the intracellular sealing lipid of the stratum corneum.
13. Flexibility of transfersomes membrane is governed by mixing suitable surface-
active components in the proper ratios with phospholipids. The resulting flexibility
of transfersome membrane minimizes the risk of complete vesicle rupture in the
skin and allows transfersomes to follow the natural water gradient across the
epidermis, when applied under non-occlusive condition.
Transfersomes can penetrate the intact stratum corneum spontaneously along two
routes in the intracellular lipid that differ in their bilayers properties.
Micro routes for drug penetration across human skin
14. NOVEL CHARACTERISTICS OF TRANSFEROSOMES:
Transfersomes possess an infrastructure consisting of hydrophobic and hydrophilic
moieties together and as a result can accommodate drug molecules with wide range
of solubility.
Transfersomes can deform and pass through narrow constriction (from 5 to 10
times less than their own diameter) without measurable loss. This high deformability
gives better penetration of intact vesicles.
They can act as a carrier for low as well as high molecular weight drugs e.g.
analgesic, anesthetic, corticosteroids, sex hormone, anticancer, insulin, gap junction
protein, and albumin. They are biocompatible and biodegradable as they are made
from natural phospholipids similar to liposomes.
They have high entrapment efficiency, in case of lipophilic drug near to 90%.
They protect the encapsulated drug from metabolic degradation.
15. They act as depot, releasing their contents slowly and gradually.
They can be used for both systemic as well as topical delivery of drug.
Easy to scale up, as procedure is simple, do not involve lengthy procedure and
unnecessary use or pharmaceutically unacceptable additives
16. LIMITATIONS OF TRANSFERSOMES
They are chemically unstable due to their predisposition to oxidative
degradation.
Purity of natural phospholipids is difficult to achieve so, world is against
adoption of transfersomes as drug delivery vehicles.
These formulations are expensive
17. COMPOSITION OF TRANSFERSOMES
The transfersome is composed of two main aggregates
First one Amphipathic (such as phosphatidylcholine) ingredient, which in
aqueous solvents self-assembles into lipid bilayer that closes into a simple lipid
vesicle.
Second one bilayer softening component (such as a biocompatible surfactant
or an amphiphile drug) so, lipid bilayer flexibility and permeability are greatly
increased.
18. MECHANISM OFACTION:
The mechanism for penetration is the generation of “osmotic gradient” due to
evaporation of water while applying the lipid suspension (Transfersomes) on the
skin surface. The reason for this high flux rate is naturally occurring "transdermal
osmotic gradients" i.e. another much more prominent gradient is available across
the skin.
The transport of these elastic vesicles is thus independent of concentration. The
trans-epidermal hydration provides the driving force for the transport of the
vesicles.
As the vesicles are elastic, they can squeeze through the pores in stratum
corneum (though these pores are less than one-tenth of the diameter of vesicles).
19. Transfersomes are ultradeformable (up to 105 times that of conventional liposomes)
squeezing through small pores in the Subcutaneous
20. Two mechanisms of action have been proposed:
1. Transfersomes act as drug vectors, remaining intact after entering the skin.
2. Transfersomes act as penetration enhancers, disrupting the highly organized
intercellular lipids from stratum corneum, and therefore facilitating the drug
molecule penetration in and across the stratum corneum.
Cevc and coworkers proposed the first mechanism, suggesting that deformable
liposomes penetrate the stratum corneum because of the transdermal hydration
gradient normally existing in the skin, and then cross the epidermis, and enter the
systemic circulation.
The recent studies propose that the penetration and permeation of the vesicles across
the skin are due to the combination of the two mechanisms. Depending on the
nature of the active substance (lipophilic or hydrophilic) and the composition of the
transfersomes, one of the two mechanisms prevails.
21. Propensity of penetration:
The magnitude of the transport driving force, of course, also plays an important
role:
Flow = Area x (Barrier) Permeability x (Trans-barrier) force.
Therefore, the chemically driven lipid flows across the skin
22. MATERIALS
Materials which are widely used in the formulation of transferosomes are various
phospholipids, Surfactants, alcohol, dye; buffering agent etc different additives used in the
formulation of transferosomes are
Phospholipids – (Vesicles forming component)
Example - Soya phosphatidyl choline.
Surfactant – (For providing flexibility)
Example – Sodium cholate, Sodium deoxycholate, Tween-80, Span-80
Alcohol –(As a solvent)
Example - Ethanol, methanol
Buffering agent – (As a hydrating medium)
Example- Saline phosphate buffer (pH 6.4)
Dye - {for Confocal scanning laser microscopy (CSLM)}
Example- Rhodamine 123, Nile-red
23. METHOD:
Phospholipids + surfactant
Dissolve in organic solvent Incorporate lipophilic drug
Prepare thin film (using Rotary Evaporator)
Keep under vaccum (12hr)
Hydrate using buffer (pH 6.5) at 60 rpm Incorporate hydrophilic drug
Sonicate 30 minutes
Homogenize (extrusion 10 times through sandwich of
200 and 100nm polycarbonate membranes)
Transferosomes
24. Preparation of Transfersomes
A. Thin film hydration technique is employed for the preparation of
transfersomes which comprised of three steps:
1). A thin film is prepared from the mixture of vesicles forming ingredients that is
phospholipids and surfactant by dissolving in volatile organic solvent (chloroform-
methanol). Organic solvent is then evaporated above the lipid transition temperature
(room temp. for pure PC vesicles, or 500C for dipalmitoyl phosphatidyl choline) using
rotary evaporator. Final traces of solvent were removed under vacuum for overnight.
2). A prepared thin film is hydrated with buffer (pH 6.5) by rotation at 60 rpm for 1 hr
at the corresponding temperature. The resulting vesicles were swollen for 2 hr at room
temperature
3). To prepare small vesicles, resulting vesicles were sonicated at room temperature or
500C for 30 min. using a bath sonicator or probe sonicated at 40C for 30 min. The
sonicated vesicles were homogenized by manual extrusion 10 times through a
sandwich of 200 and 100 nm polycarbonate membranes.
25. B. Modified hand shaking, lipid film hydration technique is also founded for
the preparation of transfersomes
1.) Drug, lecithin (PC) and edge activator were dissolved in ethanol: chloroform
(1:1) mixture. Organic solvent was removed by evaporation while hand shaking
above lipid transition temperature (43°C). A thin lipid film was formed inside the
flask wall with rotation. The thin film was kept overnight for complete evaporation
of solvent
2.) The film was then hydrated with phosphate buffer (pH 7.4) with gentle shaking
for 15 minute at corresponding temperature. The transfersome suspension further
hydrated up to 1 hour at 2-80C.
26. OPTIMIZATION OF FORMULATION CONTAINING
TRANSFERSOMES
There are various process variables which could affect the preparation and
properties of the transfersomes. The preparation procedure was accordingly
optimized and validated. The process variables are depending upon the procedure
involved for manufacturing of formulation. The preparation of transfersomes
involves various process variables such as,
Lecithin : surfactant ratio
Effect of various solvents
Effect of various surfactants
Hydration medium
Optimization was done by selecting entrapment efficiency of drug. During the
preparation of a particular system, the other variables were kept constant.
27. CHARACTERIZATION OF TRANSFERSOMES
Entrapment efficiency
Drug content
Vesicle morphology
Vesicle size distribution and zeta potential
No. of vesicles per cubic mm
Confocal scanning laser microscopy study
Degree of deformability or permeability measurement
Turbidity measurement
Surface charge and charge density
Penetration ability
Occlusion effect
physical stability
In vitro drug release
In vitro skin permeation studies
Skin deposition studies of optimized formulation
In Vivo Fate of Transfersomes and Kinetics of Transfersomes Penetration
28. TRANSFERSOMES VS OTHER CARRIER SYSTEM
Liposomes Vs Transfersomes
Structurally, Transfersomes are very similar to lipid bilayers vesicle, liposomes.
However in functional terms, transfersomes differ vastly from commonly used
liposomes in that they are much more flexible and adaptable because of edge
activator.
The extremely high flexibility of their membrane permits transfersomes to
squeeze themselves even through pores much smaller than their own diameter. This
is due to high flexibility of the transfersomes membrane and is achieved by
judiciously combining at least two lipophilic/amphiphilic components
(phospholipids plus bio surfactant) with sufficiently different packing characteristics
into a single bilayer. The high resulting aggregate deformability permits
transfersomes to penetrate the skin spontaneously. This tendency is supported by the
high transfersomes surface hydrophilicity that enforces the search for surrounding of
29. APPLICATIONS:
Delivery of proteins and peptides
Delivery of insulin
Delivery of interferons
Delivery of corticosteroids
Transdermal immunization
Delivery of anaesthetics
Delivery of NSAIDS
Delivery of anti-cancer drugs
Delivery of herbal drugs.
30. CONCLUSION
Ultra-deformable vesicles can provide the novel solution for the transport related
problems. They are free from the rigid nature of conventional vesicles and can
transport even the large molecules. They work on number of mechanisms working
together to provide an excellent carrier system for the drug transport. When tested
in artificial systems, Transfersomes can pass through even tiny pores (100 mm)
nearly as efficiently as water, which is 1500 times smaller. Drug laden
transfersomes can carry unprecedented amount of drug per unit time across the
skin (up to 100mg cm2h-1). Ultra-deformable vesicles hold great prospective in
delivery of huge range of drug substances which includes large molecules like
peptides, hormones and antibiotics, drugs with poor penetration due to unfavorable
physicochemical characters, drugs for quicker and targeted action, etc. All above
discussed properties of this technology strongly advocate its good future in
transdermal drug delivery.