Niosomes are a novel drug delivery system, in which the medication is encapsulated in a vesicle. The vesicle is composed of a bilayer of non-ionic surface active agents and hence the name niosomes.

1. NIOSOMES
By-Lovnish Thakur

2.  Niosomes are a novel drug delivery system,
in which the medication is encapsulated in a
vesicle. The vesicle is composed of a bilayer
of non-ionic surface active agents and hence
the name niosomes.
Nios = non ionic surfactant
somes = vesicles


3.  They are vesicular systems similar to liposomes that can be
used as carriers of hydrophilic, ampiphilic and lipophilic drugs.
 The niosomes are very small, and microscopic in size.
 Their size lies in the nanometric scale.
www.pharmatutor.org

4.  Most surface active agents when immersed in water yield
micellar structures, however some surfactants can yield
bilayer vesicles which are niosomes.
Niosomes may be-
 unilamellar
 multilamellar

5. Small
Unilamellar
Vesicle
(SUV)
Large
Unilamellar
Vesicle
(LUV)
Multilamellar
Vesicle
(MLV)
Typical Size Ranges: SLV: 20-50 nm – MLV:100-1000 nm

7. MECHANISMS OF NIOSOMAL SKIN DELIVERY
Noisomes interact with stratum corneum with aggregation, fusion
and adhesion to the cell surface which causes a high
thermodynamic activity gradient of the drug at the vesicle-stratum
corneum surface, which is the driving force for the penetration of
lipophilic drugs across the stratum corneum
New smaller vesicles are formed in skin
Niosomes diffuse from the stratum corneum layer of skin
as a whole

8. NIOSOMES V/S LIPOSOMES
.Niosomes do not have any of these
problems:
1) Niosomes are made of
uncharged single-chain surfactant
molecules
2) Structure of niosomes is different
from that of liposomes
Liposomes face problems such as:
1) expensive
2) chemically unstable

9. ADVANTAGES OF NIOSOMES
 Osmotically active
 Increase the stability of the entrapped drug
 Handling and storage of surfactants do not require
any special conditions.
 Can increase the oral bioavailability of drugs
 Can enhance the skin penetration of drugs
 can be used for oral, parenteral as well topical use.
 The surfactants are biodegradable, biocompatible,
and non-immunogenic .
 Improve the therapeutic performance of the drug
by protecting it from the biological environment and
restricting effects to target cells

10. CONCLUSION
 Niosomes are thoughts to be better candidates
drug delivery as compared to liposomes due to
various factors like cost, stability etc.
 Various type of drug deliveries can be possible
using niosomes like targeting, ophthalmic, topical,
parentral etc.

11.  file:///E:/M.PHARM%202SEM/Niosomes/niosomess/Niosome.htm
 Book- Controlled and Novel Drug Dilevery by N.K. JAIN
 Malhotra, M. & Jain, N.K., (1994). Niosomes as drug carriers. Ind
Drugs, Vol. 31
 Azeem, A.; Anwer, M.K. & Talegaonkar, S., (2009).
 Niosomes in sustained and targeted drug delivery: some recent
advances. J Drug Target, Vol. 17
 NIOSOME: A PROMISING PHARMACEUTICAL DRUG
DELIVERY(http://www.ijpda.com/admin/uploads/AzYyEr.pdf)

12. Thank You