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NIOSOMES- A NOVELAPPROACH FOR
TARGETED DRUG DELIVERY
By
Mr. Dipesh Adesh Gamare
Content
Introduction
Methods of preparation of Niosomes
Evaluation of Niosomes
Applications of Niosomes
Recent studies on Niosomal preparations
References
2
INTRODUCTION
 Niosomes are one of the promising drug carriers that have a
bilayer structure and are formed by self-association of nonionic
surfactants and cholesterol in an aqueous phase.
 Niosomes are biodegradable, biocompatible, and
nonimmunogenic.
 They have long shelf life, exhibit high stability, and enable the
delivery of drug at target site in a controlled and/or sustained
manner.
 In recent years, the potential of niosomes as a drug carrier has
been extensively studied. Various types of nonionic surfactants
have been reported to form niosomes and enable the entrapment of
a large number of drugs with a wide range of solubility .
 The composition, size, number of lamellae, and surface charge of
niosomes can be varied and optimized to enhance the performance
of niosomes for drug delivery.
 The unique structure of niosomes allows the development of
effective novel drug delivery systems with ability of loading both
hydrophilic and lipophilic drugs. Hydrophilic drugs and lipophilic
drugs are entrapped into the aqueous core and membrane bilayer
of niosome.
3 STRUCTURE OF NIOSOME
1.Thin-Film
Hydration
Method (TFH)
2. Ether
Injection
Method (EIM)
3. Reverse
Phase
Evaporation
Method (REV)
4. Proniosomes
5. Supercritical
Carbon Dioxide
Fluid (SC-CO2)
6. The “Bubble”
Method
METHODS OF PREPARATION
4
1.Thin-Film Hydration Method (TFH)
2. Ether Injection Method (EIM)
5
3. Reverse Phase Evaporation Method (REV)
4. Proniosome
6
5. Supercritical Carbon Dioxide Fluid (SC-CO2)
6. The “Bubble” Method
7
Evaluation parameters of Niosomes
8
ANTICANCER DRUG
DELIVERY
TARGETED
DELIVERY
ANTI-VIRAL DRUGS ANTIBIOTICS
APPLICATIONS
OF NIOSOMES
9
RECENT STUDY
10
11
12
REFERENCE:
1. Şeleci et al., Niosomes as nanoparticular Drug Carriers: Fundamentals and recent applications.
Journal of Nanomaterials, 2016, 1–13. https://doi.org/10.1155/2016/7372306
2. Yasamineh et al., A state-of-the-art review on the recent advances of niosomes as a targeted
drug delivery system. International Journal of Pharmaceutics, 2022, 1-21.
https://doi.org/10.1016/j.ijpharm.2022.121878
13
THANK YOU
14

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Niosomes-Method of preparation,evaluation,applications.pptx

  • 1. NIOSOMES- A NOVELAPPROACH FOR TARGETED DRUG DELIVERY By Mr. Dipesh Adesh Gamare
  • 2. Content Introduction Methods of preparation of Niosomes Evaluation of Niosomes Applications of Niosomes Recent studies on Niosomal preparations References 2
  • 3. INTRODUCTION  Niosomes are one of the promising drug carriers that have a bilayer structure and are formed by self-association of nonionic surfactants and cholesterol in an aqueous phase.  Niosomes are biodegradable, biocompatible, and nonimmunogenic.  They have long shelf life, exhibit high stability, and enable the delivery of drug at target site in a controlled and/or sustained manner.  In recent years, the potential of niosomes as a drug carrier has been extensively studied. Various types of nonionic surfactants have been reported to form niosomes and enable the entrapment of a large number of drugs with a wide range of solubility .  The composition, size, number of lamellae, and surface charge of niosomes can be varied and optimized to enhance the performance of niosomes for drug delivery.  The unique structure of niosomes allows the development of effective novel drug delivery systems with ability of loading both hydrophilic and lipophilic drugs. Hydrophilic drugs and lipophilic drugs are entrapped into the aqueous core and membrane bilayer of niosome. 3 STRUCTURE OF NIOSOME
  • 4. 1.Thin-Film Hydration Method (TFH) 2. Ether Injection Method (EIM) 3. Reverse Phase Evaporation Method (REV) 4. Proniosomes 5. Supercritical Carbon Dioxide Fluid (SC-CO2) 6. The “Bubble” Method METHODS OF PREPARATION 4
  • 5. 1.Thin-Film Hydration Method (TFH) 2. Ether Injection Method (EIM) 5
  • 6. 3. Reverse Phase Evaporation Method (REV) 4. Proniosome 6
  • 7. 5. Supercritical Carbon Dioxide Fluid (SC-CO2) 6. The “Bubble” Method 7
  • 9. ANTICANCER DRUG DELIVERY TARGETED DELIVERY ANTI-VIRAL DRUGS ANTIBIOTICS APPLICATIONS OF NIOSOMES 9
  • 11. 11
  • 12. 12
  • 13. REFERENCE: 1. Şeleci et al., Niosomes as nanoparticular Drug Carriers: Fundamentals and recent applications. Journal of Nanomaterials, 2016, 1–13. https://doi.org/10.1155/2016/7372306 2. Yasamineh et al., A state-of-the-art review on the recent advances of niosomes as a targeted drug delivery system. International Journal of Pharmaceutics, 2022, 1-21. https://doi.org/10.1016/j.ijpharm.2022.121878 13