Niosomes are a novel drug delivery system composed of a bilayer vesicle encapsulating medication. They are similar to liposomes in using a vesicle structure to carry hydrophilic, amphiphilic, and lipophilic drugs. Niosomes are very small, on the nanoscale. Their bilayer vesicle structure forms from certain non-ionic surfactants immersed in water. Niosomes can be unilamellar, containing one bilayer, or multilamellar, containing multiple bilayers. They diffuse drugs across the skin's stratum corneum and can enhance skin penetration and oral bioavailability of medications. Niosomes have advantages over liposomes such as being cheaper, more stable

1. NIOSOMES
SURAJ MANDAL
M.Pharma

2.  Niosomes are a novel drug delivery system,
in which the medication is encapsulated in a
vesicle. The vesicle is composed of a bilayer
of non-ionic surface active agents and hence
the name niosomes.
Nios = non ionic surfactant
somes = vesicles

3.  They are vesicular systems similar to liposomes that can be
used as carriers of hydrophilic, ampiphilic and lipophilic drugs.
www.pharmatutor.org
 T h e niosomes are very small, and microscopic insize.
 Their size lies in the nanometric scale.

4. Most surface active agents when immersed in water yield
micellar structures, however some surfactants can yield
bilayer vesicles which are niosomes.
Niosomes may be-
unilamellar
 multilamellar

5. Small
Unilamellar
Vesicle
(SUV)
Large
Unilamellar
Vesicle
(LUV)
Multilamellar
Vesicle
(MLV)
Typical Size Ranges: SLV: 20-50 nm – MLV:100-1000 nm

7. MECHANISMS OF NIOSOMAL SKIN DELIVERY
Niosomes diffuse from the stratum corneum layer of skin
as a whole
New smaller vesicles are formed in skin
Noisomes interact with stratum corneum with aggregation, fusion
and adhesion to the cell surface which causes a high
thermodynamic activity gradient of the drug at the vesicle-stratum
corneum surface, which is the driving force for the penetration of
lipophilic drugs across the stratum corneum

8. lec
.Niosomes do not have any ofthese
problems:
Niosomes are made of uncharged single-chain surfactantmo
Structure of niosomes is diferent from that of liposomes
Liposomesface problems suchas:
expensive
chemically unstable
N/LIPOSOMES

9. ADVANTAGES OF NIOSOMES
Osmotically active
Increase the stability of the entrapped drug
Handling and storage of surfactants do not require
any special conditions.
Can increase the oral bioavailability of drugs
Can enhance the skin penetration of drugs
can be used for oral, parenteral as well topical use.
The surfactants are biodegradable,
biocompatible, and non-immunogenic .
Improve the therapeutic performance of the drug
by protecting it from the biological environment and
restricting effects to target cells

10. CONCLUSION
Niosomes are thoughts to be better candidates drug
delivery as compared to liposomes due to various
factors like cost, stability etc.
Various type of drug deliveries can be possible using
niosomes like targeting, ophthalmic, topical,
parentral etc.

11. file:///E:/M.PHARM%202SEM/Niosomes/niosomess/Niosome.htm
Book- Controlled and Novel Drug Dilevery by N.K. JAIN
Malhotra, M. & Jain, N.K., (1994). Niosomes as drug carriers.
Ind Drugs, Vol. 31
Azeem, A.; Anwer, M.K. & Talegaonkar, S., (2009).
Niosomes in sustained and targeted drug delivery: some
recent advances. J Drug Target, Vol. 17
NIOSOME: A PROMISING PHARMACEUTICAL DRUG
DELIVERY(http://www.ijpda.com/admin/uploads/AzYyEr.pdf)

12. Thank You