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 MACULA : Round yellow area at posterior

pole 5.5 mm size – 3 mm temporal
1 mm inferior to disc
Fovea - 1.5 mm wide , thin bottom- 22” clivity
thick basement margin
- prone for macular holes
-Henle’s layer-oblique cones
Foveola - 0.35 mm wide , thin pit , Densely cones
Bowing vitreally- fovea externa
Umbo - Tiny depression - Foveal light reflex
0.15 mm - bouquet of cones - narrowed
gateau nucleaire
 A dehiscence in the Retina at the location of

Fovea.
 In Lamellar hole - some layer are intact
 Full thickness hole - RPE exposed
 Older female patients
 Younger Myopic patients
 Post Traumatic
 Chronic cystoid macular edema
 Associated with Retinal detachment
 Inadvertent exposure to laser therapy
 Loss of Central Vision
 Central Scotoma
 Metamorphospia
 Oblique/anteroposterior traction via a persistent

vitreofoveolar attachment following perifoveal vitreous
separation.
 Tangential vitreoretinal traction.
 Stage O – Premacular hole

- Perifoveal vitreous detachment
- Loss of foveal depression
- Subtle macular topograph changes
- Normal visual acuity
 Stage 1a: ‘Impending’ macular hole

- flattening of the foveal depression with an underlying
yellow spot.
- Pseudocyst – a perifoveal vitreoretinal detachment
Pathology: inner retinal layers detach from the
underlying photoreceptor layer, with the formation of
a schisis cavity.
 Stage 1b: Occult macular hole

Signs: a yellow ring with metamorphopsia or a mild
decrease in visual acuity.
- Progression of pseudocyst to outer foveal layer
separation
Pathology: loss of structural support with centrifugal
displacement of photoreceptors.
 Stage 2: Small /Early full-thickness hole

Signs: full-thickness hole < 400 µm in diameter
The defect may be central, eccentric or crescent-shaped.
Pseudo operculum – prefoveal cortical vitreous
contraction
Pathology: a dehiscence develops in the roof [inner
layer]of the schitic cavity, often with persistent
vitreofoveolar adhesion.
 Stage 3: Full-size /Established macular hole

Signs: full-thickness hole > 400 µm in diameter
red base with yellow-white dots seen.
Surrounding grey cuff of subretinal fluid
Pathology: Avulsion of the roof of the cyst with an
operculum and persistent parafoveal and optic disc
attachment of the vitreous cortex.
 Stage 4: Full-size macular hole with complete PVD

Pathology: the posterior vitreous is completely
detached, often suggested by the presence of a Weiss ring.
 Fluorescein Angiography

Hyperfluorescence -transmission defect (RPE
atrophy)
 OCT

Evaluation of retinal thickness and staging of macular
hole.

 Watzke Allen test

On projecting a thin slit beam of light on to the
macula ,a broken or thinned out appearance is
poistive.
 Laser aiming beam test

A spot of laser beam of 50 microns when projected on
macula has disappeared.
 Surgery not recommended in stage 1  50 % chance

of spontaneous resolution .
 Stage 3 and 4 with visual acuity < 6/18 require surgery
 Contraindications for surgery
- Coexisting choroidal rupture
- Traumatic RPE rupture
- Chronic Cystoid macular edema
- Optic nerve disorders


Pars Plana Vitrectomy



Anaesthesia is local or general .



Conjunctival peritomy is done.



Three sclerotomies in superotemporal ,superonasal and
inferotemporal at 3.5 mm from limbus .



Induction of Posterior vitreous detachment by suction of cutter
, suction cannula or forceps close to disc.



Use of intravitreal triamcinolone acetonide for improving
visualization.
 Internal gas tamponade :

A non expansile mixture of C3F8 and air is used and
patient lie down in prone for 14 hours for first 10 days .
 Internal Limiting Membrane (ILM) Peeling :

Stains like trypan blue , Brilliant blue , ICG
, Triamcinolone acetonide to improve visualization
of ILM.
Special forceps to grasp ILM membrane in a circular
fashion around macular hole for 2 disc diameters.
 Cataract formation
 Iatrogenic retinal breaks
 Rhegmatogenous retinal detachment
 Transient rise in Intraocular pressure.
 Following a macular pucker , there is a centripetal pull

of the inner sides of epiretinal membrane – resembles
Macular hole.
 Partial thickness macular hole where the inner layers

of fovea are involved with traction and detached from
underlying cellular layers.




Gass Atlas of Macular diseases by Anita Agarwal
American Academy of Ophthalmology , Vol 12 ,
Retina and Vitreous
Kanski ,Clinical Ophthalmology , a Systemic Approach
7 th edition

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Macular hole

  • 1.
  • 2.
  • 3.  MACULA : Round yellow area at posterior pole 5.5 mm size – 3 mm temporal 1 mm inferior to disc
  • 4. Fovea - 1.5 mm wide , thin bottom- 22” clivity thick basement margin - prone for macular holes -Henle’s layer-oblique cones Foveola - 0.35 mm wide , thin pit , Densely cones Bowing vitreally- fovea externa Umbo - Tiny depression - Foveal light reflex 0.15 mm - bouquet of cones - narrowed gateau nucleaire
  • 5.  A dehiscence in the Retina at the location of Fovea.  In Lamellar hole - some layer are intact  Full thickness hole - RPE exposed
  • 6.  Older female patients  Younger Myopic patients  Post Traumatic  Chronic cystoid macular edema  Associated with Retinal detachment  Inadvertent exposure to laser therapy
  • 7.  Loss of Central Vision  Central Scotoma  Metamorphospia
  • 8.  Oblique/anteroposterior traction via a persistent vitreofoveolar attachment following perifoveal vitreous separation.  Tangential vitreoretinal traction.
  • 9.  Stage O – Premacular hole - Perifoveal vitreous detachment - Loss of foveal depression - Subtle macular topograph changes - Normal visual acuity
  • 10.  Stage 1a: ‘Impending’ macular hole - flattening of the foveal depression with an underlying yellow spot. - Pseudocyst – a perifoveal vitreoretinal detachment Pathology: inner retinal layers detach from the underlying photoreceptor layer, with the formation of a schisis cavity.
  • 11.  Stage 1b: Occult macular hole Signs: a yellow ring with metamorphopsia or a mild decrease in visual acuity. - Progression of pseudocyst to outer foveal layer separation Pathology: loss of structural support with centrifugal displacement of photoreceptors.
  • 12.  Stage 2: Small /Early full-thickness hole Signs: full-thickness hole < 400 µm in diameter The defect may be central, eccentric or crescent-shaped. Pseudo operculum – prefoveal cortical vitreous contraction Pathology: a dehiscence develops in the roof [inner layer]of the schitic cavity, often with persistent vitreofoveolar adhesion.
  • 13.  Stage 3: Full-size /Established macular hole Signs: full-thickness hole > 400 µm in diameter red base with yellow-white dots seen. Surrounding grey cuff of subretinal fluid Pathology: Avulsion of the roof of the cyst with an operculum and persistent parafoveal and optic disc attachment of the vitreous cortex.
  • 14.  Stage 4: Full-size macular hole with complete PVD Pathology: the posterior vitreous is completely detached, often suggested by the presence of a Weiss ring.
  • 15.
  • 16.
  • 17.  Fluorescein Angiography Hyperfluorescence -transmission defect (RPE atrophy)  OCT Evaluation of retinal thickness and staging of macular hole.
  • 18.
  • 19.
  • 20.  Watzke Allen test On projecting a thin slit beam of light on to the macula ,a broken or thinned out appearance is poistive.  Laser aiming beam test A spot of laser beam of 50 microns when projected on macula has disappeared.
  • 21.  Surgery not recommended in stage 1  50 % chance of spontaneous resolution .  Stage 3 and 4 with visual acuity < 6/18 require surgery  Contraindications for surgery - Coexisting choroidal rupture - Traumatic RPE rupture - Chronic Cystoid macular edema - Optic nerve disorders
  • 22.  Pars Plana Vitrectomy  Anaesthesia is local or general .  Conjunctival peritomy is done.  Three sclerotomies in superotemporal ,superonasal and inferotemporal at 3.5 mm from limbus .  Induction of Posterior vitreous detachment by suction of cutter , suction cannula or forceps close to disc.  Use of intravitreal triamcinolone acetonide for improving visualization.
  • 23.  Internal gas tamponade : A non expansile mixture of C3F8 and air is used and patient lie down in prone for 14 hours for first 10 days .  Internal Limiting Membrane (ILM) Peeling : Stains like trypan blue , Brilliant blue , ICG , Triamcinolone acetonide to improve visualization of ILM. Special forceps to grasp ILM membrane in a circular fashion around macular hole for 2 disc diameters.
  • 24.  Cataract formation  Iatrogenic retinal breaks  Rhegmatogenous retinal detachment  Transient rise in Intraocular pressure.
  • 25.  Following a macular pucker , there is a centripetal pull of the inner sides of epiretinal membrane – resembles Macular hole.
  • 26.  Partial thickness macular hole where the inner layers of fovea are involved with traction and detached from underlying cellular layers.
  • 27.
  • 28.    Gass Atlas of Macular diseases by Anita Agarwal American Academy of Ophthalmology , Vol 12 , Retina and Vitreous Kanski ,Clinical Ophthalmology , a Systemic Approach 7 th edition