This document summarizes information on femoral neck fractures including:
1) The anatomy, blood supply, epidemiology, classification systems, and treatment options for femoral neck fractures.
2) ORIF is the standard treatment for non-displaced fractures while hemiarthroplasty is preferred over ORIF for displaced fractures in elderly patients.
3) Stress fractures of the femoral neck present differently than traumatic fractures and often require urgent ORIF if the fracture line extends over 50% across the neck.
Tensor fascia lata[tfl] muscle pedicle grafting for avn hip dr mohamed ashraf...drashraf369
slide presentation of a very promising surgical technic for a very elusive condition called avascular necrosis of femoral head.good clinical and surgical demo by dr mohamed ashraf,HOD, govt TD medical college ,alleppey,kerala, india
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
2. Anatomy
• Physeal closure age 16
• Neck-shaft angle
130° ± 7°
• Anteversion
10° ± 7°
• Calcar Femorale
Posteromedial
dense plate of bone
3. Blood Supply
• Lateral epiphysel artery
– terminal branch MFC artery
– predominant blood supply to
weight bearing dome of head
• Artery of ligamentum teres
– from obturator artery
– supplies anteroinferior head
• Lateral femoral circumflex a.
– less contribution than MFC
4. Blood Supply
fracture displacement=vascular disruption
• revascularization of the head
– intact vessels
– vascular ingrowth across fracture site
• importance of quality of reduction
– metaphyseal vessels
5. Epidemiology
• 250,000 Hip fractures annually
– Expected to double by 2050
• At risk populations
– Elderly: poor balance&vision, osteoporosis, inactivity,
medications, malnutrition
• incidence doubles with each decade beyond age 50
– higher in white population
– Other factors: smokers, small body size, excessive
caffeine & ETOH
– Young: high energy trauma
7. Classification
• Garden [1961]
I Valgus impacted or
incomplete
II Complete
Non-displaced
III Complete
Partial displacement
IV Complete
Full displacement
** Portends risk of AVN
and Nonunion
I II
III IV
9. Treatment
• Goals
– Improve outcome over natural history
– Minimize risks and avoid complications
– Return to pre-injury level of function
– Provide cost-effective treatment
10. Treatment
• Options
– Non-operative
• very limited role
• Activity modification
• Skeletal traction
– Operative
• ORIF
• Hemiarthroplasty
• Total Hip Replacement
11. Treatment
Decision Making Variables
• Patient Characteristics
– Young (arbitrary physiologic age < 65)
• High energy injuries
– Often multi-trauma
• High Pauwels Angle (vertical shear pattern)
– Elderly
• Lower energy injury
• Comorbidities
• Pre-existing hip disease
• Fracture Characteristics
– Stable
– Unstable
12. Treatment
Young Patients
(Arbitrary physiologic age < 65)
– Non-displaced fractures
• At risk for secondary displacement
• Urgent ORIF recommended
– Displaced fractures
• Patients native femoral head best
• AVN related to duration and degree of displacement
• Irreversible cell death after 6-12 hours
• Emergent ORIF recommended
13. Treatment
Elderly Patients
• Operative vs. Non-operative
– Displaced fractures
• Unacceptable rates of mortality, morbidity, and poor outcome
with non-operative treatment [Koval 1994]
– Non-displaced fractures
• Unpredictable risk of secondary displacement
– AVN rate 2X
– Standard of care is operative for all femoral neck
fractures
• Non-operative tx may have developing role in select patients
with impacted/ non-displaced fractures [Raaymakers 2001]
14. Treatment
Pre-operative Considerations
• Skin Traction not beneficial
– No effect on fracture reduction
– No difference in analgesic use
– Pressure sore/ skin problems
– Increased cost
– Traction position decreases capsular volume
• Potential detrimental effect on blood flow
15. Treatment
Pre-operative Considerations
• Regional vs. General Anesthesia
– Mortality / long term outcome
• No Difference
– Regional
• Lower DVT, PE, pneumonia, resp depression, and
transfusion rates
– Further investigation required for definitive
answer
16. Treatment
Pre-operative Considerations
• Surgical Timing
– Surgical delay for medical clearance in
relatively healthy patients probably not
warranted
• Increased mortality, complications, length of stay
– Surgical delay up to 72 hours for medical
stabilization warranted in unhealthy patients
18. Non-displaced Fractures
• ORIF standard of care
• Predictable healing
– Nonunion < 5%
• Minimal complications
– AVN < 8%
– Infection < 5%
• Relatively quick procedure
– Minimal blood loss
• Early mobilization
– Unrestricted weight bearing with assistive device PRN
19. ORIF
• Ideal reduction is Anatomic
– Acceptable: < 15º valgus < 10º AP angulation
* may need to open in order achieve reduction
• Fixation: Multiple screws in parallel
– No advantage to > 3 screws
– Uniform compression across fracture
– In-situ pin impacted fractures
* ↑ AVN with disimpaction [Crawford 1960]
– Fixation most dependent on bone density
21. ORIF
• Compression Hip Screws
– Sacrifices large amount of bone
– May injure blood supply
– Biomechanically superior in
cadavers
– Anti-rotation screw often needed
– Increased cost and operative time
• No clinical advantage over
parallel screws
* May have role in high energy/ vertical
shear fractures
22. ORIF
Intracapsular Hematoma
• incidence- 75% have some
– no difference displaced/nondisplaced
• ? Amount of > 100 mm in 25%
• sensitive to leg position
– extension + internal rotation= bad
• animal models: pressure= perfusion
• Theoretical benefit with NO clinical proof
– but it doesn’t hurt
23. Displaced Fractures
Hemiarthroplasty vs. ORIF
• ORIF is an option in elderly
** Surgical emergency in young patients **
• Complications
• Nonunion 10 -33%
• AVN 15 – 33%
• AVN related to displacement
• Early ORIF no benefit
• Loss of reduction / fixation failure 16%
24. Displaced Fractures
Hemiarthroplasty vs. ORIF
• Hemi associated with
• Lower reoperation rate (6-18% vs. 20-36%)
• Improved functional scores
• Less pain
• More cost-effective
• Slightly increased short term mortality
• Literature supports hemiarthroplasty for displaced
fractures [Lu-yao JBJS 1994]
[Iorio CORR 2001]
26. Hemiarthroplasty
Unipolar vs. Bipolar
• Bipolar
– Disadvantages
• Cost
• Dislocation often requires open
reduction
• Loss of motion interface
(effectively unipolar)
• Polyethylene wear/ osteolysis
not yet studied for Bipolars
27. Hemiarthroplasty
Unipolar vs. Bipolar
– Complications / Mortality / Length of stay
• No Difference
– Hip Scores / Functional Outcomes
• No significant difference
• Bipolar slightly better walking speeds, motion, pain
– Revision rates
• Unipolar 20% vs. Bipolar 10% (7 years)
– Unipolar more cost-effective
• Literature supports use of either implant
28. Hemiarthroplasty
Cemented vs. Non-cemented
• Cement (PMMA)
– Improved mobility, function, walking aids
– Most studies show no difference in morbidity /
mortality
• Sudden Intra-op cardiac death risk slightly increased:
– 1% cemented hemi for fx vs. 0.015% for elective arthroplasty
• Non-cemented (Press-fit)
– Pain / Loosening higher
– Intra-op fracture (theoretical)
29. Hemiarthroplasty
Cemented vs. Non-cemented
• Conclusion:
– Cement gives better results
• Function
• Mobility
• Implant Stability
• Pain
• Cost-effective
– Low risk of sudden cardiac
death
• Use cement with caution
30. Treatment
Pre-operative Considerations
• Surgical Approach
– Posterior approach to hip
• 60% higher short-term mortality vs. anterior
– Dislocation rate
• No significant difference [Lu-Yao JBJS 1994]
31. Total Hip Replacement
• Dislocation rates:
– Hemi 2-3% vs. THR 11% (short term)
• 2.5% THR recurrent dislocation [Cabanela Orthop
1999]
• Reoperation:
– THR 4% vs. Hemi 6-18%
• DVT / PE / Mortality
• no difference
• Pain / Function / Survivorship / Cost-effectiveness
• THR better than Hemi [Lu –Yao JBJS 1994]
[Iorio CORR 2001]
32. ORIF or Replacement?
• Prospective, randomized study ORIF vs.
cemented bipolar hemi vs. THA
• ambulatory patients > 60 years of age
– 37% fixation failure (AVN/nonunion)
– similar dislocation rate hemi vs. THA (3%)
– ORIF 8X more likely to require revision
surgery than hemi and 5X more likely than
THA
– THA group best functional outcome
Keating et al OTA 2002
33. Stress Fractures
• Patient population:
– Females 4–10 times more common
• Amenorrhea / eating disorders common
• Femoral BMD average 10% less than control
subjects
– Hormone deficiency
– Recent increase in athletic activity
• Frequency, intensity, or duration
• Distance runners most common
34. Stress Fractures
• Clinical Presentation
– Activity / weight bearing related
– Anterior groin pain
– Limited ROM at extremes
– ± Antalgic gait
– Must evaluate back, knee, contralateral hip
35. Stress Fractures
• Imaging
– Plain Radiographs
• Negative in up to 66%
– Bone Scan
• Sensitivity 93-100%
• Specificity 76-95%
– MRI
• 100% sensitivity / specificity
• Also Differentiates: synovitis, tendon/
muscle injuries, neoplasm, AVN,
transient osteoporosis of hip
39. Femoral Neck
Nonunion
• Definition: not healed by one year
• 0-5% in Non-displaced fractures
• 9-35% in Displaced fractures
• Increased incidence with
– Posterior comminution
– Initial displacement
– Inadequate reduction
– Non-compressive fixation
40. Femoral Neck
Nonunion
• Clinical presentation
– Groin or buttock pain
– Activity / weight bearing related
– Symptoms
• more severe / occur earlier than
AVN
• Imaging
– Radiographs: lucent zones
– CT: lack of healing
– Bone Scan: high uptake
– MRI: assess femoral head
viability
41. Femoral Neck
Nonunion
• Treatment
– Elderly patients
• Arthroplasty
– Results typically not as good as primary elective
arthroplasty
• Girdlestone Resection Arthroplasty
– Limited indications
– deep infection?
42. Femoral Neck
Nonunion
• Young patients
(must have viable femoral head)
– Varus alignment or limb
shortened
• Valgus-producing
osteotomy
– Normal alignment
• Bone graft / muscle-pedicle
graft
• Repeat ORIF
44. Osteonecrosis (AVN)
Femoral Neck Fractures
• Clinical presentation
– Groin / buttock / proximal thigh pain
– May not limit function
– Onset usually later than nonunion
• Imaging
– Plain radiographs: segmental collapse /
arthritis
– Bone Scan: “cold” spots
– MRI: diagnostic
45. Osteonecrosis (AVN)
Femoral Neck Fractures
• Treatment
– Elderly patients
» Only 30-37% patients require reoperation
• Arthroplasty
– Results not as good as primary elective
arthroplasty
• Girdlestone Resection Arthroplasty
– Limited indications
46. Osteonecrosis (AVN)
Femoral Neck Fractures
• Treatment
– Young Patients
» NO good option exists
• Proximal Osteotomy
– Less than 50% head collapse
• Arthroplasty
– Significant early failure
• Arthrodesis
– Sugnificant functional limitations
** Prevention is the Key **