This document summarizes forefoot fractures, including anatomy, biomechanics, classification, and treatment principles. It describes fractures of the metatarsals, sesamoids, and phalanges. Treatment often involves closed or open reduction with pinning or plating to restore alignment and allow weight bearing. More comminuted fractures sometimes require bone grafting. Proximal fifth metatarsal fractures are classified into zones with implications for healing and management approaches.
Lisfranc and Forefoot fracture in adult.pptxKaushal Kafle
Lisfranc injuries are notorious injuries easily missed and difficult to diagnose in subtle cases. Diagnosis and management is changing with changing time and fixation is the dictum. If significant injury or only ligamentous injury the newer trend is arthodesis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
2. Foot Trauma and Outcomes
Turchin et al, JOT, 1999
28 patients: Polytrauma +/- foot injury
Age, gender, ISS matched
Results SF-36 5/8 components worse with foot injury
WOMAC All 3 components worse with foot injury
Jurkovich et al, JT, 1995
Highest Sickness Impact Profile (SIP) @ 6 & 12 months
Patients with foot trauma (compared to other lower extremity injuries)
3. Foot Function
Hindfoot: Shock absorption, propulsion,
deceleration
Midfoot: Controls relationship between
hindfoot and forefoot
Forefoot: Platform for standing and lever for
push off
8. Biomechanics
Metatarsal heads in
contact with floor 60-
80% of stance phase
Toes in contact with
floor 75% of stance
phase
Cavanagh, PR, F&A, 1987
Hughes, J, JBJS[Br], 1990
12. Treatment Principles
Hindfoot: Protect subtalar, ankle and
talonavicular joints
Midfoot: restore length and alignment of
medial and lateral “columns”
Forefoot: Even weight distribution
14. First MT Shaft Fractures
Nondisplaced
Consider conservative treatment
Immobilization with toe plate
Displaced
Most require ORIF
Strong muscle forces (TA, PL)
Deformity common
Bears 2/6 body weight
ORIF
Plate and screws
Anatomically reduce
May cross first MTP joint (temp)
18. 43 year old male injured in a MVC
Observe the articular segment impaction of the base of the first.
The first MT is shortened and dorsally displaced while the
plantar ligaments remain attached.
19. The patient underwent ORIF of the
base of the first metatarsal with
spanning of the first TMT, given
the level of comminution observed.
Additionally, temporary spanning
external fixation was used.
21. Non-displaced Metatarsal Fractures 2-4
Single metatarsal fractures
Treatment usually nonoperative
Symptomatic: hard shoe vs AFO vs cast
Multiple metatarsal fractures
Usually symptomatic treatment (as above)
May require ORIF if other associated injuries
22. Displaced Metatarsal Shaft Fractures
Sagittal plane displacement & angulation is most important.
Reestablish length, rotation, & declination
Dorsal deformity can produce transfer metatarsalgia
Plantar deformity can produce increased load at affected metatarsal
Treatment Options
Closed Reduction
Intramedullary pinning with k-wire (0.054” or 0.062”)
Pinning of distal segment to adjacent metatarsal
ORIF with dorsal plate fixation
23. This patient sustained an open
second metatarsal fracture in a
crush injury. Given the soft
tissue injury and continued
pressure on the dorsal skin,
operative fixation was elected.
24. Fixation consisted of a dorsal
2.0 mm plate application after
appropriate irrigation of the
open fracture.
25. This patient was
treated with ORIF
of multiple
metatarsal
fractures (3,4,5)
through a dorsal
approach.
Fixation consisted
of a 2.7 mm DCP
on the fifth and
2.0 mm plates on
the third and
fourth
metatarsals.
26. Medullary K-wires
in Lesser MTs
Exit wire distally through
the proximal phalanx
Plantar wire exit may
produce a hyperextension
deformity of the MTP
ST Hansen,
Skeletal Trauma
27. Stress Fractures of Metatarsals 2 - 4
Identify Cause
First ray hypermobility
Short first ray
Tight gastrocnemius
Long metatarsal
Treatment
Treat cause if identifiable
If overuse, activity restriction
Reserve ORIF for displaced fractures
28. Usually displace plantarly
May require reduction and
fixation:
Closed reduction and pinning
Open reduction and pinning
ORIF (dorsal plate)
Metatarsal Neck Fractures
29. This patient sustained
multiple metatarsal neck
fractures after an MVA.
Note additional fractures at
the first and fifth metatarsals
31. Unusual
Articular injuries
May require ORIF
(especially if first MT)
Metatarsal Head Fractures
Circular saw injury to the
articular surface of the first MT head
33. Proximal Fifth Metatarsal Fractures
Dameron, TB, JAAOS, 1995
Zone 1 cancellous tuberosity
insertion of PB & plantar fascia
involve metatarsocuboid joint
Zone 2 distal to tuberosity
extend to 4/5 articulation
Zone 3 distal to proximal ligaments
usually stress fractures
extend to diaphysis for 1.5 cm
34. Proximal Fifth Metatarsal Fractures
Dameron, TB, JAAOS, 1995
Relative Frequency
Zone 1 93%
Zone 2 4%
Zone 3 3%
35. Fifth Metatarsal Blood Supply
Smith, J et al, F&A, 1992
Cadaver Arterial Injection
Study (n = 10)
Nutrient artery with intramedullary
branches (retrograde flow to
proximal fifth metatarsal)
Multiple metaphyseal arteries
Conclusions: Fracture distal to the
tuberosity disrupts the nutrient
arterial supply and creates relative
avascularity
Shereff, M et al, F&A, 1991
Fresh leg specimens (after
BKA) (n = 15)
Extraosseus circulation:
dorsal metatarsal artery
plantar metatarsal artery
fibular plantar marginal artery
Intraosseus circulation:
Nutrient artery
Metaphyseal vessels
Periosteal complex
37. Zone 1 Fractures: Tuberosity
Etiology
Avulsion from lateral plantar aponeurosis
(Richli & Rosenthal, AJR, 1984)
Treatment
Symptomatic
Hard shoe
Healing usually uneventful
(Dameron, T, JBJS, 1975)
Lawrence, SL, Foot
Ankle, 1993
38. Zone 1 Fractures: Tuberosity
Weiner, et al, F & A Int, 1997
60 patients
Randomized to short leg cast vs soft dressing only
Weight bearing in hard shoe in all
Healing in 44(average) - 65(all) days
Soft dressing only: shorter recuperation (33 vs 46
days) and similar foot score (92 vs 86)
Conclusions: Faster return to function without
compromising radiographic union or clinical
outcome in patients treated without casting.
46. First MTP Dislocations
Jahss, F&A, 1980
Type I: Hallux dislocation without disrupting sesamoid
Irreducible closed!
MT incarcerated by conjoined tendons and intact
sesamoid
Open reduction required (dorsal, plantar, or medial
approach)
Type II: Disruption of intersesamoid ligament (type A)
Transverse fracture of one of the sesamoids (type B)
Usually stable after reduction
Treatment usually conservative and symptomatic
(hard shoe for 4-6 weeks)
47. Lesser MTP Dislocations
Uncommon
Dorsal vs Lateral
Usually stable post reduction
Rarely require open reduction
If unstable post reduction, consider k-wire fixation
48. Proximal Phalanx Fractures
ORIF for transverse & displaced (?)
ORIF intraarticular fractures (?)
Interphalangeal Joint Fractures
Nonoperative treatment usually
Distal Phalanx Fractures
Taping usually adequate
Hard shoe
Fractures of the
Great Toe
49. Sesamoid Injuries
Sesamoiditis
Acute fractures
Stress fractures in dancers and runners
Treatment
Acute: padding
strap MTP @ neutral or slight flexion
immobilization in cast/shoe
Chronic: consider bone grafting
sesamoidectomy: not a simple procedure, assoc
with hallux drift and transfer lesions, requires tendon
(FHB) repair.
50. Fractures of the LesserToes
Correct alignment & rotation
Attempt taping to adjacent
toe
May require open reduction
and pinning if adequate
reduction not obtained
ST Hansen,
Skeletal Trauma
51. The Crushed Foot
Soft Tissue Evaluation
Assess whether salvageable
sensate, perfused, adequate plantar tissue
Wash open wounds
Reposition bone deformity that
threatens the skin
Reduce dislocations
Release compartments as needed
52. Recommended Readings
Cavanaugh, PR, et al. Pressure Distribution Patterns under Symptom-free
Feet during barefoot standing. Foot Ankle, 7:262-276, 1987
Dameron, TB, Fractures of the Proximal Fifth Metatarsal: Selecting the Best
Treatment Option. J Acad Orthop Surg, 3(2): 110-114, 1995.
Holmes, James. AAOS Monograph “The Traumatized Foot”, pages 55-75,
2002.
Lawrence, SJ, and Botte, MJ. Foot Fellow’s Review: Jones’ Fractures and
Related Fractures of the Proximal Fifth Metatarsal. Foot & Ankle, 14(6),
358-365, 1987.
Smith, JW, et al. The Intraosseus Blood Supply of the Fifth Metatarsal:
Implications for Proximal Fracture Healing. Foot & Ankle, 13(3), 143-
152, 1992
53. Thank You
Sean E. Nork, MD
Harborview Medical Center
University of Washington
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