Fractures of the humeral shaft are commonly caused by falls onto the hand or elbow. While most can be treated non-operatively, operative treatment may be necessary to restore alignment and stability through plate osteosynthesis, intramedullary nailing, or external fixation. Nerve injuries, particularly to the radial nerve, are a common complication and usually recover spontaneously, though exploration may be needed if function does not return within 12 weeks. Conservative treatment involves immobilization in a hanging cast with early range of motion exercises to prevent stiffness.
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
Tendoachilles rupture and its managementRohan Vakta
Achilles tendon is the strongest tendon of body. There are many causes of its rupture. It can be acute or chronic rupture. Management of chronic rupture by semitendinosus tendon is mentioned here.
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
Tendoachilles rupture and its managementRohan Vakta
Achilles tendon is the strongest tendon of body. There are many causes of its rupture. It can be acute or chronic rupture. Management of chronic rupture by semitendinosus tendon is mentioned here.
The upper limb consists of various joints that enable movement and provide flexibility. These joints can be classified into different types based on their structure and function.
Understanding the anatomy and function of these joints is crucial for assessing and managing conditions related to the upper limb, as well as for rehabilitation and therapeutic interventions. Joint injuries, arthritis, and other disorders may affect the functionality of these joints, and appropriate medical care may be necessary for optimal outcomes.
paediatric injuries around the elbow
supracondylar elbow injuries
pulled elbow in paediatric age r
radiological signs around elbow in supracondylar fracture humerus
The precipitating factors of rupture TendoAchilles is due to Aging process, DM, Tendinitis, Tendinosis, Local steroid injection, History of repetitive micro trauma. There are different methods of reconstructing the ruptured TendoAchilles. Maximum of these procedure are described in this presentation. All information are taken from the text books of orthopedics. Majority of the information taken from Campbell's operative orthopedics Thirteen Edition.
Lumbar spinal canal stenosis is one of the difficult topic of spine. All the information are taken from Campbell's operative orthopedics Thirteen edition and from internet. I also took help from the lectures of renowned orthopedics professors of Bangladesh.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
1. Fracture Shaft of Humerus
Dr. Ashiqur Rahman
Resident Orthopedics
Dhaka Medical college Hospital
2. Epidemiology:
- 3% of all fractures;
- Most can be treated non- operatively
Mechanism of injury:
- Spiral fracture: A fall on the hand may twist the humerus.
- Oblique or transverse fracture: A fall on the elbow with the
arm abducted exerts a bending force.
- A direct blow to the arm causes a fracture which is either
transverse or comminuted.
- Fracture of the shaft in an elderly patient may be due to a
metastasis.
3.
4. Pathological anatomy:
With # above the deltoid insertion, the proximal fragment is
adducted by pectoralis major.
With # lower down, the proximal fragment is abducted by deltoid.
Injury to the radial nerve is common, though fortunately recovery is
usual.
5. Clinical features:
The arm is painful, bruised and swollen.
It is important to test for radial nerve function before and after
treatment.
This is best done by assessing active extension of the
metacarpophalangeal joints; active extension of the wrist can be
misleading because extensor carpi radialis longus is sometimes
supplied by a branch arising proximal to the injury.
6. Conservative treatment:
- A ‘hanging cast’ is applied from shoulder to wrist with the
elbow flexed 90 degrees.
- The forearm section is suspended by a sling around the
patient’s neck.
- This cast may be replaced after 2–3 weeks by a short (shoulder
to elbow) cast or a functional polypropylene brace which is
worn for a further 6 weeks.
- The wrist and fingers are exercised from the start.
7. - Pendulum exercises of the shoulder are begun within a week.
- Active abduction is postponed until the fracture has united
(about 6 weeks for spiral fractures but often twice as long for
other types).
- Once united, only a sling is needed until the fracture is
consolidated.
8. ****Patients often find the hanging cast uncomfortable, tedious
and frustrating.
-they can feel the fragments moving and that is sometimes quite
distressing.
-The temptation is to ‘do something’, and the ‘something’
usually means an operation.
9. It is as well to remember:
(i) That complication rate after internal fixation of humerus is
high.
(ii) That great majority of humeral # unite with non-operative
treatment and
(iii) There is no good evidence that union rate is higher with
fixation(and the rate may be lower if there is distraction with
nailing or periostel stripping with plating).
(iv) There are nevertheless, some well-defined indications for
surgery.
10.
11. The goal of operative treatment:
- Reestablish length, alignment, and rotation
- Stable fixation that allows early motion and ideally
- Early weight bearing on the fractured extremity.
Options for fixation:
1. Plate osteosynthesis (“gold standard”)
2. Intramedullary nailing, and
3. External fixation.
12.
13.
14. - In 1963, Holstein and Lewis associated a special type of
fracture of the distal humerus, a simple displaced spiral
fracture, with the distal end deviating toward the radial side,
with an increased rate of radial nerve palsy.
-They reported a high incidence of entrapment of the nerve
within this type of fracture and recommended radial nerve
exploration in the presence of clinical symptoms.
15. - Subsequent studies confirmed an increased risk of radial nerve
injury with this type of fracture but supported the expectant
policy even in the presence of clinical symptoms.
- As their findings indicated that the radial nerve usually recovers
regardless of the pattern and location of the humeral shaft
fracture.
16. - Heckler and Bamberger114 surveyed practice tendencies in
USA by sending a questionnaire to 2,650 physicians regarding
their practice in cases of humeral shaft fracture associated with
radial nerve palsy.
- From 558 responses, the authors concluded that most
physicians agreed that:
…The incidence of recovery is high and observation is
justified.
22. Anatomy of arm
Arm is well enveloped with muscles and soft tissues. So prognosis is good.
Medial and lateral intermuscular septa are tough fibrous band that divide
the arm in anterior and posterior compartment.
- Anterior compartment has three muscles:
o Biceps brachii,
o Brachialis,
o Coracobrachialis
- Posterior compartment:
o Triceps Brachii
Anterior compartment muscles BBC is supplied by musculocutaenious
branch and arterial supply by branches of brachial artery.
25. Antero-lateral approach to the shaft of the Humerus
(Thompson;Henry)
- Incise the skin in line with the anterior border of the deltoid
muscle from a point midway between its origin and insertion,
distally to the level of its insertion, and proceed in line with the
lateral border of the biceps muscle to within 7.5 cm of the
elbow joint.
- Divide the superficial and deep fasciae, and ligate the cephalic
vein.
- In the proximal part of the wound, retract the deltoid laterally
and the biceps medially to expose the shaft of the humerus.
26. - Distal to the insertion of the deltoid, expose the brachialis
muscle, split it longitudinally to the bone, and retract it sub-
periosteally, the lateral half to the lateral side and the medial
half to the medial.
-Retraction is easier when the tendon of the brachialis is relaxed
by flexing the elbow to a right angle. The lateral half of the
brachialis muscle protects the radial nerve as it winds around
the humeral shaft.
29. Complications of Shaft Humerus #
Early:
1. Vascular injury: Any injury to brachial artery
2. Nerve injury:
a. Nerve injury Radial nerve palsy (wrist drop and paralysis of
the metacarpophalangeal extensors) may occur with shaft
fractures. The commonest associated injury to a closed
diaphyseal humeral fracture is the injury of the radial nerve
(10% to 12% of all closed humeral shaft fractures.
b. Particularly oblique fractures at the junction of the middle
and distal thirds of the bone (Holstein–Lewis fracture).
30. c. If nerve function was intact before manipulation but is
defective afterwards, it must be assumed that the nerve has
been snagged and surgical exploration is necessary.
d. Otherwise, in closed injuries the nerve is very seldom divided,
so there is no hurry to operate as it will usually recover.
e. The wrist and hand must be regularly moved through a full
passive range of movement to preserve joint motion until the
nerve recovers.
31. f. If there is no sign of recovery by 12 weeks, the nerve should be
explored.
g. It may just need a neurolysis, but if there is loss of continuity
of normal-looking nerve then a graft is needed.
h. The results are often satisfactory but, if necessary, function
can be largely restored by tendon transfers
Median and ulnar nerve can be injured in 1.3 % and 2.4%
respectively.