Simple,inexpensive and rugged,parts are easy to dismentle and sterilize, safe to use.
Delivers the right gas mixture
Allows all methods of ventilation in all age groups
Resistence low at flows in practice
Compression and compliance loss is less.
Sturdy, small and light
Allows easy removal of waste gases
Easy to maintain with low running costs
mapleson circuits used in anesthesia practice, are in their way out but it is as important to know the mechanism with which the gases flow to and fro through them.
mapleson circuits used in anesthesia practice, are in their way out but it is as important to know the mechanism with which the gases flow to and fro through them.
A breathing system is a device that conducts gases such as oxygen and anesthetic agents to the patient and conducts waste gases such as CO2 away.
Breathing systems are classified as
Open,
Semi-open,
Semi-closed
Closed.
Semi-closed systems are further divided into
Rebreathing Systems With CO2 Absorption,
Rebreathing Systems Without CO2 Absorption
Non-rebreathing Systems.
More simply, systems can be classified in two groups:
systems with CO2 washout (includes open and semi-open systems)
systems with CO2 absorption (includes closed and semi-closed systems).
anaesthesia Breathing circuits and its classification and functional analysisprateek gupta
anaesthesia breathing circuits. mapleson circuits. classification of circuits. functional analysia of circuits. draw over circuit. advantages and disadvantages of different circuits.
A breathing system is a device that conducts gases such as oxygen and anesthetic agents to the patient and conducts waste gases such as CO2 away.
Breathing systems are classified as
Open,
Semi-open,
Semi-closed
Closed.
Semi-closed systems are further divided into
Rebreathing Systems With CO2 Absorption,
Rebreathing Systems Without CO2 Absorption
Non-rebreathing Systems.
More simply, systems can be classified in two groups:
systems with CO2 washout (includes open and semi-open systems)
systems with CO2 absorption (includes closed and semi-closed systems).
anaesthesia Breathing circuits and its classification and functional analysisprateek gupta
anaesthesia breathing circuits. mapleson circuits. classification of circuits. functional analysia of circuits. draw over circuit. advantages and disadvantages of different circuits.
Breathing circuits connects the patient to the anaesthesia machine through endotracheal tube or mask.
A pathway in which volatile agents and oxygen is delivered and co2 is removed.
These are divide into: Open system
Semi-closed system
Closed system
Dr rowan molnar anaesthetics study guide part iiiDr. Rowan Molnar
Dr rowan molnar anaesthetics study guide part iii
Recognise risk – pre anaesthetic consultation
Avoid risk if possible – e.g. can procedure be done under LA?
Mitigate risk – optimise patient condition, select safest technique/agents/resources – e.g “cardiac” anaesthetic & postop ventilation.
Plan & be prepared for emergencies – e.g. predrawn emergency drugs, backup airway plan.
Observe/monitor for deviations & crises.
Respond in a timely& appropriate fashion.
Call for help/backup if required.
Dr Rowan Molnar,
Dr Rowan Molnar Anaesthetics,
Dr Rowan
Anatomically the respiratory system is divided into
Upper respiratory tract
From the nostril to the vocal cord
Lower respiratory tract
The lower respiratory tract is from bellow the vocal cord upto the alveoli
Anatomically the respiratory system is divided into
Upper respiratory tract
From the nostril to the vocal cord
Lower respiratory tract
The lower respiratory tract is from bellow the vocal cord upto the alveoli
The most common type of anaesthetic machine in use in the developed world is the continuous flow anaesthetic machine, which is designed to provide an accurate & continuous supply of medical gases(such as O2 & NO2)mixed with an accurate concentration of anaesthetic vapour(such as halothane,isoflurane)& deliver this to the patient at a safe pressure & flow.
Modern machine incorporate a ventilator,suction unit & patient monitoring devices.
Consists of liver, biliary tree, gall bladder
Liver is the largest gland in the body
Multiple functions
Disease of the liver and biliary tree influences drug actions
Every anesthetic drugs are metabolized by the liver
So liver is very much important for anesthetists
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. The Ideal Breathing System
Simple,inexpensive and rugged,parts are easy to
dismentle and sterilize, safe to use.
Delivers the right gas mixture
Allows all methods of ventilation in all age groups
Resistence low at flows in practice
Compression and compliance loss is less.
Sturdy, small and light
Allows easy removal of waste gases
Easy to maintain with low running costs
3. Breathing System Components
Fresh Gas connection
Patient connection
Adjustable Pressure Limiting (APL) Valve
Reservoir (Bag or bellows)
Tubing
Waste gas connection
4. Open, semi open, semi closed?
• Open is the old fashioned method of dropping ether
or chloroform over a gauze or lint. Later modernised
by the likes of the Schimmelbusch mask.
• Semi-open systems used today such as the Mapleson
systems.
• Semi-closed and Closed systems use a CO2 absorbent
so that the gases are re-circulated, the classification is
defined by the amount of fresh gas flow.
5. Semi-open Systems
• In the early 1954’s, Prof. WW Mapleson from
University of Wales, Cardiff, classified the several
breathing systems depending on what components
they contained and what position they took in the
system.
• It is known today as ‘The Mapleson Alphabet’‘The Mapleson Alphabet’
7. Semi-open Circuit Anaesthesia
This is typically used for induction of the patient. It
is usually a single limb system that uses an APL valve
to control the pressure of the gas, and allows for
waste gas to leave the system.
High fresh gas flows (more than patients minute
volume) are required with these systems to stop
rebreathing of expired CO2.
8. Types of Semi-open Circuit Systems
Mapleson D or Bain System
Mapleson A or Magill System
Mapleson A or Lack System
Mapleson F or Ayres T Piece System
Mapleson F with APL Valve
Mapleson C Bagging System
9. Semi-open Circuit Anaesthesia
Mapleson D or Bain System
Mapleson A or Magill System
Mapleson A or Lack System
Mapleson E or Ayres T Piece System
Mapleson F ,Jackson Rees modification
Mapleson C Bagging System,Water’s to and fro
10. What FGF’s are needed?
Mapleson Systems Uses FGF SV FGF
IPPV
A
Magill
Lack
Spontaneous
Gen Anaesthesia
70-100 ml/kg/min Min 3 x MV
B
Very uncommon,
not in use today
C
Resuscitation
Bagging
Min 15 lpm
D
Bain Spontaneous
IPPV, Gen.
Anaes
150-200
ml/kg/min
70-100 ml/kg/min
E
Ayres T Piece Very uncommon,
not in use today
F
Jackson Rees Paediatric
<25 Kg
2.5 – 3 x MV
Min 4 lpm
11. Mapleson A (Magill) System
The Mapleson A or Magill system is good for
spontaneous breathing patients, so the fresh gas flow
can be lower. However as the APL valve is close to the
patient, it is regarded by many as difficult to use.
1950’s1950’s
12. Mapleson A (Lack) System
The Mapleson A or Lack system is a modification of the
Magill where the valve is moved to the machine end of
the system using another length of tubing. This adds
volume to the system and makes it rather heavy at the
patient end.
19761976
13. Advantage:
The expiratory valve is at the proximal end. So easier
to adjust & scavenging waste gases.
The patient end is lighter.
14. Disadvantages :
The system is bulky & relatively inflexible.
The system has greater resistance to expiration than
the magill system.
The system is not as efficient as the magill
attachment.
15. Mapleson D (Bain)
The Mapleson D or Bain System is a co-axial system
where the fresh gas is delivered directly to the patient.
It requires very high fresh gas flows to prevent
rebreathing of CO2. It is very convenient to use, thus is
very popular especially for induction of anaesthesia.
19721972
16. Mapleson D(Bain)
Advantages :
Lighter & longer.
Expiratory valve at the machine end,so allowing easy
adjustment & scavenging.
Long bain system may be used for distant
ventilation .
17. Mapleson D(Bain)
Disadvantages :
Some resistance to expiration .
Inner tube may be disconnected & result in
rebreathing ,awareness,hypoxemia,hypercapnoea.
Circuit dead space becomes much longer.
May not be as efficient as the mapleson D system
because of gas mixing at the patient end.
18. Mapleson F (Jackson Rees
Modification)
The Mapleson F or Jackson
Rees modification of the Ayres
T Piece is a basic system for
use with very small
patients,but big disadvantage
is that waste gases cannot be
removed safely.
Because this has a bag with an
open tail, it is technically a
Jackson-Rees Modification
system
Ayres – 1937Ayres – 1937
JR - 1950JR - 1950
19. Advantages :
It provides visual evidence of breathing during
spontaneous ventilation .
By occluding the open end of the bag temporarily , it
is possible to confirm that fresh gas is entering the
system .
It provides a degree of CPAP during spontaneous
ventilation positive end-expiratory pressure during
IPPV.
It provides a convenient method of assessing or
controlling ventilation.
21. Mapleson F with APL Valve
Intersurgical decided to
modify the Jackson-Rees
by using a closed tail bag
and a specially modified
APL valve. Now the
waste gases can be
removed safely from the
system via the APL
valve’s 30mm outlet.
19981998
22. Mapleson C Bagging System
The Mapleson C is more
than an anaesthesia
system. It can be found
all over the hospital for
use as an emergency
bagging system for
resuscitation or manual
ventilation using oxygen,
as well as being a
standard induction
system in some
countries.
23. Advantage of Mapleson sysytem:
1.Simple and inexpensive
2.Resistence is usually low
3.Light weight and not bulky
4.They are easy to position
5.No possibility of production of CO
24. Disadvantage of Mapleson system:
1.Require high fresh gas flow to prevent rebreathing.
2.Wastage of anesthetic agent.
3.Pollution of the operating Room environment.
4.Loss of patient’s heat & humidity.
25. Semi Closed Circuit Anaesthesia
This type of General Anaesthesia is used mainly for
maintenance of anaesthesia following induction. It
can be used for induction of anaesthesia, but this is a
slower process.
It requires an absorber system containing a CO2
Absorbent to remove CO2 from the expired patient
gases, and a higher level of patient monitoring,
specially respiratory gas monitoring to measure levels
of inspired and expired CO2and the volatile agent.
26. Semi Closed Anaesthesia Explained
Semi Closed Anaesthesia is where the expired
gases from the patient pass through a canister in
the breathing system which contains a CO2
absorbent. This absorbent by an exothermic
chemical reaction removes the CO2
, so the
patients expired gases can be rebreathed. Because
of this exothermic chemical reaction, some
warmth and humidity is added to the inspired
gases.
27. Semi Closed Anaesthesia Explained
Because the patients expired gases are re circulated (where
the ‘circle’ comes from), this means that we do not have to
add so much fresh gas to the system like an open system.
So the fresh gas flow rate can be reduced to low flow, i.e., 1
litre per minute. If the flows were as low as a few hundred
cc’s of gas, equivalent to the patients metabolic uptake of
gases, this would be closed circuit anaesthesia, or
metabolic (basal) flow, or minimal flow.
Circle systems were first used back in 1930 by Brian Sword
in the USA
28. Types of Semi Closed Circuit System
Standard Parallel Y System
Extendible Parallel Y System
Complete Semi Closed Circuit Systems
Co-Axial Semi Closed Circuit Systems
29. ‘Tight Connections’
It is important with
conical connectors
such as those used on
breathing systems,
always connect with a
firm push and twist.
This will ensure a
leak tight
connection.
30. The silver ion based anti-microbial
additive reduced the potential risk of
cross contamination from the outside of
the breathing system
Conclusion
31. This means that the anti-microbial additive in
Breathing Systems not only inhibits bacterial
growth but will reduce colonisation on the
circuit, and therefore can reduce cross
infection in the Intensive CareUnit( ICU) and
the operating theatre