This document discusses different types of breathing circuits used in anesthesia. It begins by introducing open, semi-closed, and closed breathing circuits. Open circuits are now obsolete and involved pouring anesthetic agents over a mask. Semi-closed circuits include Mapelson circuits A-F, with Type D (Bain) most commonly used for controlled ventilation. Closed circuits involve rebreathing of exhaled gases after carbon dioxide absorption by soda lime, making them very economical. Key components and properties of soda lime and factors affecting its carbon dioxide absorption are described.
mapleson circuits used in anesthesia practice, are in their way out but it is as important to know the mechanism with which the gases flow to and fro through them.
mapleson circuits used in anesthesia practice, are in their way out but it is as important to know the mechanism with which the gases flow to and fro through them.
Breathing circuits connects the patient to the anaesthesia machine through endotracheal tube or mask.
A pathway in which volatile agents and oxygen is delivered and co2 is removed.
These are divide into: Open system
Semi-closed system
Closed system
Breathing circuits connects the patient to the anaesthesia machine through endotracheal tube or mask.
A pathway in which volatile agents and oxygen is delivered and co2 is removed.
These are divide into: Open system
Semi-closed system
Closed system
oxygen is a medication. oxygen therapy must be known to all health professionals for optimum management of patient and optimum use of resourses. even more oxygen can cause oxygen toxicity and can harm the patient in many ways. There are various methods for giving oxygen,varieties of face masks, cylinders. also there is criteria when to give oxygen ,how to give oxygen,what are the benefits and mechanism of oxygen therapy.
Simple,inexpensive and rugged,parts are easy to dismentle and sterilize, safe to use.
Delivers the right gas mixture
Allows all methods of ventilation in all age groups
Resistence low at flows in practice
Compression and compliance loss is less.
Sturdy, small and light
Allows easy removal of waste gases
Easy to maintain with low running costs
A breathing system is a device that conducts gases such as oxygen and anesthetic agents to the patient and conducts waste gases such as CO2 away.
Breathing systems are classified as
Open,
Semi-open,
Semi-closed
Closed.
Semi-closed systems are further divided into
Rebreathing Systems With CO2 Absorption,
Rebreathing Systems Without CO2 Absorption
Non-rebreathing Systems.
More simply, systems can be classified in two groups:
systems with CO2 washout (includes open and semi-open systems)
systems with CO2 absorption (includes closed and semi-closed systems).
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
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Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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2. INTRODUCTION
Breathing circuits connects the patient to the
anaesthesia machine through endotracheal tube or
mask.
These are divide into:
Open system
Semi-closed system
Closed system
3. OPEN SYSTEM
This is now the obsolete technique .
Inhalational agent is directly poured over patients
mouth and nostril.
A mask called a Schimmelbush mask is placed over
patient mouth over which a layer of gauge piece is put
and inhalational agent (especially ether) is poured in
drops (open drop anaesthesia)
4.
5.
6.
7. Disadvantages
There is a lot of wastage and uncontrollable pollution.
Accurate concentration can not be delivered.
Time consuming induction.
Gauge piece may become sodden and increases the dead
space
Fire hazard
Skin and eye irritation
If a folded towel is placed over schimmelbusch mask to
prevent early escape of inhalation agent it constitutes semi
open system.
Other gases which can be given by open method are
chloroform and ethyl chloride.
8. SEMICLOSED CIRCUITS
These circuits were described by MAPELSON
therefore also called as Mapelson circuits.
These are divided into six types:
Type A, B , C, D, E , F
Because of similarity in characteristics some authors
have classified them in 3 groups- A, BC, DEF
9.
10. Type A
Also called as Magill circuit.
Fresh gases coming from machine reaches the patient.
Exhaled gases from patient are mostly exhaled from
pressure relief valve but some of the gases go back in
tubing(that is why these circuits are called semi closed
circuits)
The expiratory gases which has gone back in the
tubing may be reinhaled by the patient in next breath.
This is called as rebreathing
11. APL valve is at the patients end.
Fresh gas flow should be equal to minute
volume(70ml/kg/min).
Circuit of choice for spontaneous ventilation.
It is not suitable for use with children of less than 25-
30 kg body weight. This is because of increased dead
space.
It should not be used in controlled ventilation
12.
13.
14. Type B
Fresh gas flow inlet brought near APL valve
It does not offer any advantage, so is no more used.
Functionally almost equally efficient for spontaneous
and controlled ventilation
15.
16. Type C
Corrugated tubing is shortened
Also called as Water`s circuit.
Functionally almost equally efficient for spontaneous
and controlled ventilation
Offers no advantage and is no more used
17.
18. Type D
APL valve is brought near the bag
Modification was made by Bain that it why it is also
called as Bain`s circuit.
Bain made it a coaxial system in which a fresh gases are
delivered through a inner tube so that mixing of fresh
gases and exhaled gases can be minimized.
Bain`s circuit is most commonly used semiclosed
circuit in anaesthesia
Bain`s circuit is a circuit of choice for controlled
ventilation
19.
20.
21. Fresh gas flow for controlled ventilation is 1.6 times of
minute ventilation at normal respiratory rates(12
breaths/min)
70-100 ml/kg/min (which is equal to minute
ventilation) if respiratory rate is increased to 16
breaths/min
Bain circuit can be used for spontaneous ventilation
but fresh gas requirement is higher ,2.5 times of
minute ventilation
22. Advantages of Bain circuit
Light weight
Corrugated tube is long(1.8 meter), so good for head
and neck surgeries where anaesthetist is away from
patient and there is less fire hazard as exhaled gases
escapes away from machine.
Less resistant
Sterilization is easy
Outer tube is transparent
24. TYPE E
It is Ayer`s T piece with corrugated tubing.
Paediatric circuit.
It does not have breathing bag, so it is not a complete
circuit.
It is only for spontaneous ventilation as it does not
contain breathing bag.
It can be used for controlled ventilation by occluding
the expiratory limb .
25. TYPE F
It is a modification of Ayer`s T piece
Most commonly used semi closed circuit used in
children <6years of age or less than 20 kg.
Fresh gas flow is similar to Bain i.e. 1.6 times of minute
volume for controlled ventilation. and 2.5 times of
minute volume for spontaneous ventilation
Type E and Type F circuits are valve less to decrease
the resistance
F circuits have holes in the tail of bag but valve may be
present in some type of F circuits
26. CLOSED CIRCUIT
In human being`s this technique was used by Water`s
in 1923
In this system no gas escapes to atmosphere( that`s
why called as closed circuit) ,
Exhaled gases after absorption of carbon dioxide are
re-inhaled by the patient .
Same gases can be re-used very low flows are
sufficient therefore anaesthesia given with closed
circuit is called as low flow anaesthesia
27. There are two types of closed circuits:
1. CIRCLE SYSTEM: commonly used
2. TO & FRO SYSTEM; no more used
28. CIRCLE SYSTEM
The exhaled gases of patient through expiratory limb
reaches sodalime canister containing sodalime which
absorbs carbon dioxide and the same gases can be
reused. Since the same gases are in circulation they are
called as circle system.
The advantage is that it is very economical ( same gases
and inhalational agents can be reused)
The canister are made up of transparent plastic material
and have capacity of 4 lb
29. CARBON DIOXIDE ABSORBANT
SODALIME:
Soda lime is the most commonly used carbon dioxide
absorbent.
COMPOSITION OF SODALIME :
• Ca(OH)2 : 94%
• NaOH : 5%
• KOH : 1%
• Indicator
• Silica (to prevent dust formation)
30. COLOUR INDICATORS OF
SODALIME
There are many colour indicators used with sodalime
1. Ethyl violet: which is white when fresh and becomes
purple on exhaustion.
2. Phenolphthalein: white when fresh and becomes pink on
exhaustion
3. Clayton: red when fresh and becomes yellow on
exhaustion
4. Durasorb : which is pink on fresh and becomes white on
exhaustion. Most commonly used and is a good quality
sodalime with prolonged life.
SO ,Colour change of indicator is one of the signs of
exhaustion of sodalime
31. Other signs of exhaustion
Tachycardia
Hypertension
Increased oozing from wound site
Increased end tidal CO2 on capnography
32. Properties of sodalime granules
Hardness of granule should be more than 75% . Sodalime
is made hard by adding silica.
Moisture (14-19 %) is needed for CO2 absorption.
Size of sodalime granule is 4-8 mesh(or 3-6 mm).
CO2 absorption is heat generating process. A lot of
calories and water is produced during reaction.
1 lb canister lasts for 2 hours if used continuously.
100 gram of sodalime can absorb 24 to 26 liters of carbon
dioxide.
33. Factors affecting carbon dioxide
absorption in closed circuit
1. Freshness of sodalime: fresh absorbent has better
carbon-dioxide absorbing capacity
2. Tidal volume of patient: large tidal volume will pass
through canister without CO2 being absorbed
3. High flow : high flows allows less time for CO2
absorption
4. Dead space
5. Inadequate filling of sodalime