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
Nanobiopharmaceutics
 Nanobiomechanics
 Nanomedicine
 Bio-induced Nanopatterning
 Nanocrystals and bio-crystallization processes
 Biomedical sciences
 Injectable gold nanoparticles
 Polymeric nanoparticles
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BioMed Research Management Services,
India
Dr. Gopinath Packirisamy
Assistant Professor, Department of
Biotechnology, Indian Institute of Technology
Roorkee (Uttarakhand), India
Prof. Balaji Panchapakesan
Worcester Polytechnic Institute,
United States
Dr. Joydeep Chowdhury
Department of Physics, Sammilani
Mahavidyalaya, E.M. Bypass, Baghajatin,
Kolkata, India
Dr Venu Perla
West Virginia State University Research &
Development Corporation,
United States
Prof. Javed Musarrat
Professor of Ag. Microbiology Department of
Ag. Microbiology Faculty of Agricultural
Sciences Aligarh Muslim University Aligarh,
India
Dr. Nayira S. Sayeeda
Dean, Assistant Professor College of Medicine-
Imam university, Saudi Arabia
Dr. Rajesh Das
Haldia Institute of technology, Haldia Purba-
Medinipur (West Bengal), India
Dr. Agnishwar Girigoswami
Chettinad Academy of Research & Education
(CARE), India
Dr. Gulam Mohammed Nazeruddin Nasiruddin
Principal & Head, Department of Chemistry
Poona College of Art, Science and Commerce,
Camp, Pune India
Dr. Koppula Purushotham Reddy
Dept. of Internal Medicine, University of
Missouri,Columbia, Missouri,
United States.
Dr. Mohanan PV
Sree Chitra Tirunal Institute for Medical
Sciences and Technology (Govt. of India)
Dr. Dinesh Kumar
National Research Centre for Citrus, India
Dr. Chaitanya Lakshmi G.
Sapthagiri College of Engineering, India
Dr. A. K. Trivedi
National Bureau of Plant Genetics Resources,
New Delhi, India
Dr. Neeraj Dilbaghi
Guru Jambheshwar University of Science &
Technology, Hisar, India
Dr. Lonchin Suguna
Scientist, Department of Biochemistry Central
Leather Research Institute Adyar, Chennai, India
Dr. S Chidananda Sharma
Department of Microbiology and
Biotechnology Bangalore University,
Jnanabharathi, Bangalore (Karnataka), India
Prof. G. Baskar
Professor, Department of Biotechnology, St.
Joseph's College of Engineering, Chennai,
India

From the Editor's Desk
Dear Readers,
We would like to present, with great pleasure, the inaugural volume of a new scholarly
journal, International Journal of Nanobiotechnology. This journal is part of the Applied
Sciences, and is devoted to the scope of present Nanobiotechnology issues, from
theoreticalaspectstoapplication-dependentstudiesand thevalidationofemergingtechnologies.
This new journal was planned and established to represent the growing needs of Nanobiotechnology as an
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International Journal of Nanobiotechnology focuses on original high-quality research in the realm of
Nanobiopharmaceutics, Nanobiomechanics, Nanomedicine, Bio-induced, Nanopatterning, Nanocrystals
and bio-crystallization processes, biomedical sciences, Injectable gold nanoparticles, Polymeric
nanoparticles. The Journal is intended as a forum for practitioners and researchers to share the techniques
ofNanobiotechnologyandsolutionsinthearea.
Many scientists and researchers have contributed to the creation and the success of the Nanobiotechnology
community. We are very thankful to everybody within that community who supported the idea of creating an
innovative platform. We are certain that this issue will be followed by many others, reporting new
developmentsinthefieldofNanobiotechnology.
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editorialstaffofJournalsPub,who supported us ateverystageoftheproject.
It is our hope that this fine collection of articles will be a valuable resource for Nanobiotechnology readers
and willstimulatefurtherresearchintothevibrantareaofNanobiotechnology.
PuneetMehrotra
ManagingDirector

1. Biosynthesis, Characterization of Gold Nanoparticles Using M. indica Leaf Extract and
Their Anticancer Activity
Nabeel Ahmad, Syed Mohd. Danish Rizvi, Nitin Sahai, Rajiv Dutta 1
2. Nanofinishing of HDPE/Al2O3/HAp Ternary Composite-Based Acetabular Socket Using
Polymer Rheological Abrasive Semisolid Medium
Mamilla Ravi Sankar, Deepak Taye, M. Manohar, Debasish Sarkar, Bikramjit Basu 5
3. Synthesis and Characterization of Magnetite Bionanocomposite
Monika Sharma, Gaurav Mehra 9
4. Editorial Review: Go Green – Sustainable Nanomaterials
Sachi Saxena 13
5. Blend of Biocompatible Magnesium Oxide Nanomolecule and Its Anticancer Action
Against Human Colon Cell Line
Y.J. Jeba Jane Ratney, S. Begila David 15
Contents

IJN (2016) 1–4 © JournalsPub 2016. All Rights Reserved Page 1
International Journal of Nanobiotechnology
eISSN: 2456-0111
Vol. 2: Issue 2
www.journalspub.com
Biosynthesis, Characterization of Gold Nanoparticles Using M.
indica Leaf Extract and Their Anticancer Activity
Nabeel Ahmad1
, Syed Mohd. Danish Rizvi2
, Nitin Sahai3
, Rajiv Dutta4*
1
Department of Biotechnology, School of Engineering and Technology, IFTM University, Lodhipur Rajput
Moradabad, UP, India
2
Department of Biosciences, Integral University, Lucknow, UP, India
3
Department of Biomedical Engineering, North eastern Hill University, Shillong, Meghalaya, India
4
Department of Biotechnology, Sharda University, Greater Noida, UP, India
ABSTRACT
The present study involves the novel approach for the synthesis of nanomaterial holds infinite
possibilities as nanotechnology has a major impact on medicine and its application. Leaf
extract of Mangifera indica is a very good bioreductant for gold chloride (HAuCl4·4H2O)
which leads to the synthesis of gold nanoparticles. Leaf extract of Mangifera indica was
mixed with gold chloride (HAuCl4·4H2O) and UV–Vis spectroscopy was used to detect the
synthesis of nanoparticles. TEM and FESEM were used for size, shape and structural
morphology of synthesized nanoparticles. Synthesized gold nanoparticles were in range of
less than ~75 nm and hexagonal in shape. The gold nanoparticles also showed potent
cytotoxic effect against A549 lung cancer cell lines with an IC 50 value of 59 μg/ml/24 h by
the MTT assay.
Keywords: biosynthesis, characterization, cytotoxicity gold chloride, nanotechnology
INTRODUCTION
Current development in nanotechnology
lead to the fabrication of engineered
metallic nanoparticles those are capable
and applicable towards human
development. Metallic nanoparticles have
been shown to reveal unusual properties
that they didn’t exhibit in their bulk in
form. Because of these singular properties,
nanoparticles applications are being
researched extensively and these materials
are edging the conventional materials in
various purposes across wide range of
disciplines. Metallic nanoparticles such as
gold, silver, copper and zinc are being
used as catalysts, chemical and biological
sensors in several biomedical applications.
In medicine, they are likely to be applied
as antimicrobial, antifungal and as drug
delivery agents. Metallic nanoparticles are
the most promising because of their high
surface to volume ratio.[1–3]
Several methods like physical and
chemicals are available for the synthesis of
metallic nanoparticles but they are very
hazardous, toxic, costly vacuum system,
environment containment and time taking
process.[4]
Thus, the green synthesis
bioprocess is much needed and hence has
been finding widespread interest. The
biosynthesis of metallic nanoparticles from
corresponding metals carries out several
routes like plant extracts, enzymes and
using micro- organisms. The potential of
plants to synthesis nanoparticles have
featured excitingly very large toward the
increased of natural nano-factories.[5,6]
This remarkable development has brought
an insight among researchers for

eISSN: 2456-0111
Vol. 2: Issue 2
www.journalspub.com
Nanofinishing of HDPE/Al2O3/HAp Ternary Composite-Based
Acetabular Socket Using Polymer Rheological Abrasive Semisolid
Medium
Mamilla Ravi Sankar1*
, Deepak Taye2
, M. Manohar3
, Debasish Sarkar4
, Bikramjit Basu5
1
Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Assam, India
2
Department of Mechanical Engineering, Girijananda Chowdhury Institute of Management and Technology,
Guwahati, Assam, India
3
Vikram Sarabhai Space Centre, Indian Space Research Organisation, Thiruvananthapuram, India
4
Department of Ceramic Engineering, National Institute of Technology Rourkela, India
5
Materials Research Centre, Indian Institute of Science Bengaluru, India
ABSTRACT
Acetabular socket is one of the important parts of the hip joint. The surface roughness in the
acetabular socket decides the friction and wear during the motion of the human. Low surface
roughness in the acetabular socket gives free motion of hip joint as well as high joint life.
Nano surface roughness on the inner surface of acetabular socket also reduce the particles
generation during the dynamic motion between hip joint head and socket as well as increases
the bearing area between two components. Complete metal or ceramics leads to brittle
fracture on extreme loads as well as sound generation when there is dynamic motion between
them. Thus, polymer-ceramic composites came into existence. In the current work, high
density polyethylene/Alumina/Hydroxyapatite (HDPE/Al2O3/HAp) based polymer ceramic
composite acetabular socket is fabricated using spark plasma sintering. Finishing of this
polymer-ceramic composite is big challenge as hardness variation between polymer and
ceramic is too high. So, conventional finishing processes (Ex. Grinding etc.) are not suitable
because it exerts high finishing forces which might permanently damage the component.
Hence, in the current research work, HDPE/Al2O3/HAp based polymer-ceramic acetabular
socket is finished to nano scale using polymer rheological abrasive semisolid medium
(medium). Since this medium is semi solid to liquid based viscoelastic in nature and exert low
finishing forces (<5 N). This polymer rheological abrasive semisolid medium can able to
finish the acetabular socket with average initial surface roughness of about 4.00 µm to 0.45
µm. Thus it enhances the comfort and life of acetabular socket.
Keywords: bioimplants, nanobiotechnolohy, polymers
INTRODUCTION
Bio implants are 3-D sculptured complex
surfaces that required nano surface finish
to perform the desired physical and
biological functions efficiently. In present
research work, an attempt has been made
to improve the morphology of complex
HDPE/Al2O3/HAp hip joint acetabular
socket by polymer rheological abrasive
medium.
During compression moulding process of
HDPE/Al2O3/HAp acetabular socket,
mould surface roughness, input processing
parametres, materials heterogeneity affects
surface roughness on acetabular socket.[1–3]
But the acetabular socket in side surface

eISSN: 2546-0111
Vol. 2: Issue 2
www.journalspub.com
Synthesis and Characterization of Magnetite Bionanocomposite
Monika Sharma*, Gaurav Mehra
Chemistry Department, Jaypee Institute of Technology, Noida, India
ABSTRACT
It is a one pot synthesis of hybrid bionanocomposite comprising of inorganic magnetite with
stabilizer biopolymer pectin and alginate in co-precipitation method using sodium hydroxide
and ammonium hydroxide as precipitating agents. A lot of comparison and investigation has
been done in particle size of nanocomposite by changing the stoichiometric ratio of both
magnetite and bio polymer concentration and drying condition of composite. The
nanocomposite has been characterized using infrared spectroscopy (FTIR), scanning
electron microscopy (SEM), X-ray powder diffraction (XRD) and (UV-analyzer). SEM
showed particle size of the nanocomposite and FTIR data confirmed the COO-Fe linkage
between polymer COOH group and Fe3O4.
Keywords: alginate, biopolymer, nanocomposite, pectin
INTRODUCTION
The current and growing interest of
nanotechnology results a lot of numerous
potential application such as material
development, biomedical sciences,
electronic, optics, magnetism, energy
storage and electrochemistry [1–6].
Superparamagnetic nanocomposite is an
important class of advanced nanomaterial.
Nano sized material display properties that
differ from their respective bulk material
[7]. Magnetic nanomaterials are one of
important and interesting classes because
of their current and potential is biological,
biomedical and environmental application.
Due to low toxicity, biocompatibility, cost-
effectiveness and high surface area to
volume ratio as function of particle size,
when combined with their ability for
surface chemical modification, represent
major advantages compared to other
nanoparticle [3, 8–11]. Magnetite and
maghemite are two main form of iron
oxide nanoparticle with diverse
applications. Magnetite nanoparticle size
less than 20nm are regarded as
superparamagnetic as each particle is
composed of a single domain. The
successful approaches to the synthesis of
magnetic nanoparticle uses capping/
stabilization agents which may be a simple
molecule or polymeric material. Among
the polymeric capping agents, biopolymer
like pectin, chitosan, alginate, zein and
chitin are special interest due to their
biocompatibility and biodegradability.
Pectin and alginate are complex
polysaccharide that contain 1,4-α-D-
galucturanic acid [12]. Pectin has a very
complex structure that depends on both its
source and extraction process. Its
properties depend on degree of
esterification [13]. Pectin has been used
extensively in food, cosmetics,
pharmaceutical and biomedical industries
for their gel forming properties in the
presence of multivalent cations. Pectin is
biodegradable, biocompatible, and
bioactive [14]. Pectin also contains the
hydroxyl group which enhances the
chemical properties and COOH group
which binds Fe3O4 with coordinate

eISSN 2546-0111
Vol. 2: Issue 2
www.journalspub.com
Editorial Review: Go Green – Sustainable Nanomaterials
Sachi Saxena*
Department of Chemistry, LPU, India
ABSTRACT
The field of nanoscience has experienced a staggering number of advances in recent years
with regards to a wide range of disciplines including physics, chemistry, materials science,
biology and medicine. Although most of these are still closely related to laboratory practices
and yet far from entrepreneurial activities, many of these nanomaterials are currently
commercially available (e.g. silica nanowires, silicon wafers, carbon nanotubes, graphene
and derivatives) and have paved the way to enormous developments in the preparation of
functional nanomaterials for various applications.
Keywords: carbon nanotubes, nanomaterials
INTRODUCTION
Generally speaking, environment and
sustainable considerations around the
synthetic protocols currently in place for
the fabrication of nanoentities are scarce
and nanosafety procedures in terms of
toxicity, handling of nanomaterials and
their environmental impact are still not yet
sufficiently developed (in the available
cases) [1, 2].
Considering the synthesis of some of these
nanomaterials, protocols often involve
high temperatures and pressures, the use
of hazardous reagents and/or solvents or
include little details to be accounted for in
terms of environmental considerations
(e.g. environmental impact, green metrics,
handling risks, toxicity). Taking into
account the essentially different nature and
properties (often unknown) of such
nanoentities, an increasing number of
restrictions, handling practices and safety
procedures are currently present in several
laboratories and working places in which
nanomaterials are handled on a daily basis
[3,4].
A complete set of new and updated
information on characteristics and
properties (as well as risks and toxicity
issues in their manipulation) is truly
needed to better understand and establish
the most acceptable working practices for
nanotechnologies. However, a benign by
design concept should be promoted in all
nano-related practices, aiming to target the
development of future sustainable
nanoprotocols and environmentally
compatible nanomaterials [5,6].
This editorial contribution advocates for
more thoughtful and carefully design
methodologies that take into account
environmentally sound protocols for
nanomaterials development. These should
range from low temperature ambient
pressure methods, avoidance of hazardous
chemicals, solvent-free protocols to
alternative greener technologies such as
mechanochemistry-ball milling [7],
microwave irradiation [2,8,9] and
sonication [10] as well as life cycle and
risks assessments (whenever possible and
appropriate) [11] to analyze and
considerate toxicity, risks and

eISSN: 2456-0111
Vol. 2: Issue 2
www.journalspub.com
Blend of Biocompatible Magnesium Oxide Nanomolecule and Its
Anticancer Action Against Human Colon Cell Line
Y.J. Jeba Jane Ratney*, S. Begila David
Department of Chemistry, Scott Christian College, Nagercoil, Tamil Nadu, India
ABSTRACT
Metal oxides occupy a critical part in numerous zones of science, and material science.
Metal oxide nano materials are vital and fantastic materials. Present work concentrated on
to union of MgO nanoparticle by Green technique utilizing [6]-gingerol, were subjected to
sub-atomic docking ponders for the restraint of leukotriene A4 hydrolase (LTA4H) protein is
viewed as a significant focus for disease treatment. In silico expectation utilizing a docking
approach uncovered that LTA4H may be a potential focus of MgO np utilizing [6]-gingerol.
It stifles safe haven autonomous tumor cell development by restraining LTA4H action in HT
29 colorectal disease cells. All things considered, these discoveries show a critical part of
LTA4H in malignancy furthermore bolster the anticancer adequacy of MgO np utilizing [6]-
gingerol focusing of LTA4H for the counteractive action of colorectal disease. The actuation
space of LTA4H docked with the MgO np utilizing [6]-gingerol demonstrated the docking
scoring of –218.92, Kcal.mol-1
. The outcomes uncovered that MgO np utilizing [6]-gingerol
is considered as a decent inhibitor of LTA4H. The incorporated Magnesium oxide
nanoparticles have been described by auxiliary, optical, warm, and indicated powerful
cytotoxic impact against HT29 colon growth cell line with in IC50 estimation of 25 µg/ml by
the MTT assay. The present study shows the green incorporated Magnesium oxide
nanoparticle is utilized noteworthy higher anticancer movement. From the outcomes got it is
recommended that the green combined MgO nanoparticle which is a compelling anticancer
specialist.
Keywords: cytotoxic effect, [6]-gingerol, LTA4H, metal oxides, nontoxic nature
INTRODUCTION
Nanoparticles have same properties like
hydrobhobic, photograph synergist,
steadiness and so forth as opposed to mass
materials. They are utilized as coatings,
impetuses, hostile to bacterial, therapeutic
sciences, sensors, semiconductors,
capacitors and batteries. So a large portion
of the analysts are working with metal
oxide nanoparticles [1]. MgO nanoparticle
is a useful material. It is broadly utilized
as a part of different range which is found
to have great bactericidal execution in
fluid situations because of the arrangement
of superoxide O2-suface [2, 3]. It serves as
an impetus, harmful waste remediation,
paint, hostile to bacterial movement [4, 5].
Magnesium is II A gathering component
with the nuclear number 12 and oxygen is
V1 A gathering component with the
nuclear number 8.
Plants and their concentrates give an
organic amalgamation course of a few
metallic nano molecule which are more
eco-friendly [6]. Plant removes assume a
crucial part in green combination of nano
particles [7]. Developing green strategies

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