Basic information on the Graphics displayed on the Ventilators. Prepared to educate about the graphics to train the professionals who work with Ventilators.
Mechanical Ventilation of Patient with COPD ExacerbationDr.Mahmoud Abbas
Mechanical Ventilation of Patient with COPD Exacerbation lecture presented by Dr Andres Esteban at the Egyptian Critical care Summit 2015 held at Cairo, egypt.
The Egyptian Critical Care Summit is the leading medical event and exhibition for Intensive Care Medicine in Egypt.
Mechanical ventilation ppt including airway, ventilator, tubings and connections, nursing management, trouble shooting common problems and issues, suctioning etc.
Basic information on the Graphics displayed on the Ventilators. Prepared to educate about the graphics to train the professionals who work with Ventilators.
Mechanical Ventilation of Patient with COPD ExacerbationDr.Mahmoud Abbas
Mechanical Ventilation of Patient with COPD Exacerbation lecture presented by Dr Andres Esteban at the Egyptian Critical care Summit 2015 held at Cairo, egypt.
The Egyptian Critical Care Summit is the leading medical event and exhibition for Intensive Care Medicine in Egypt.
Mechanical ventilation ppt including airway, ventilator, tubings and connections, nursing management, trouble shooting common problems and issues, suctioning etc.
Short review of the practical elements to consider in the interruption of the mechanical ventilation in a hospitalized patient in the Critical Care Unit.
Caring patient on Mechanical Ventilator Shanta Peter
Mechanical ventilators are used now in general wards , not only in ICU -to save patient's life. We need to care patient and ventilator while working with it ..
Predictors of weaning from mechanical ventilator outcomeMuhammad Asim Rana
This is a very useful presentation for respiratory therapists and ICU and Emergency physicians. Intended to teach how to assess you patient's readiness for weaning from mechanical ventilator and successful separation from machine.
Basic concepts of organic chemistry such as structural formulas, different kinds of representation, types of isomerism, examples, alkanes, alkenes, alkynes etc.
Weaning from mechanical ventilation , also called ventilator liberation, refers to the process of the patient assuming more and more of the work of breathing and finally demonstrating that ventilator support is no longer required.
Simply it means the process of withdrawing mechanical ventilatory support and transferring the work of breathing from the ventilator to the patient . Weaning can be accomplished with an endotrachel tube ( ETT) or a tracheostomy tube in place.
In the case of the ETT, the final step in the process is the removal of the tube( extubation). With a tracheostomy, the final step may be the ability to breath spontaneously for a designated period of time with the tube in place.
Weaning success is defined as absence of ventilatory support 48 hours following the extubation.
While the spontaneous breaths are unassisted by mechanical ventilation, supplemental oxygen, bronchodilators, low level pressure support ventilation or continuous positive airway pressure (CPAP) may be used to support and maintain adequate spontaneous ventilation and oxygenation.
Purpose
The purpose is to assess the probability that mechanical ventilation can be successfully discontinued.as
75% of mechanically ventilated patients are easy to be weaned off the ventilator with simple process.
10-15% of patients require a use of a weaning protocol over a 24-72 hours.
5-10% require a prolonged weaning plan.
1% of patients become dependent on chronic mechanical ventilation.
Indication
Improvement of the cause of respiratory failure.
Absence of major system dysfunction.
Appropriate level of oxygenation.
Adequate ventilatory status.
Intact airway protective mechanism.
Contraindication
Altered sensorium either drowsiness or restlessness.
Spo2 ˂90%
Rising PaCO2 with drop in PH
Tachypnoea ˃35/ min
Tachycardia ˃120 /min
Drop in systolic blood pressure
Sweating
Cold clammy skin
Signs of diaphragmatic weakness
Paradoxical abdominal wall movement
Assessment of readiness for weaning
Hemodynamic stability
Minimum inotropic support
Adequate cardiac output
Afebrile
Hematocrite greater than 25%
Respiratory stability
Improved chest x-ray
Arterial oxygen tension (PaO2) greater than 60mm Hg with fraction of inspired oxygen ( FiO2) less than 0.5
PaO2/FiO2 greater than 300 mm Hg
Positive end expiratory pressure (PEEP) less than 0-5 cm H2O
Vital capacity (VC) 10-15ml/kg
Spontaneous tidal volume (VT) 5ml/Kg
Respiratory rate less than 30 breaths/mim
Minute ventilation 5-10 L/min
Negative inspiratory pressure greater than -20cm H2O
Rapid shallow breathing index (RSBI) less than 105
metabolic factors stable
Electrolytes within normal range.
ABGs( Arterial blood gases) normalized
Other
Adequate management of pain and anxiety.
Patient is well rested
Weaning criteria
Weaning criteria are used to evaluate the readiness of a patient for a weaning trial and the likelihood of weaning success.
Clinical criteria
Ventilatory criteria
Oxygenation criteria
This slide include information regarding ventilators, modes of ventilators , its parts, weaning process, nursing care of patient in mechanical ventilation.
MECHANICAL VENTILATION IN NEUROLOGICAL AND NEUROLOGICAL CASES.pptxNeurologyKota
20% of all patients requiring mechanical ventilation suffer from neurological dysfunction.
Major contributor to prolongation of mechanical ventilation in over a third of patients admitted in ICU.
Demonstration on Mechanical Ventilator.pptxShashi Prakash
Consist of
Definition of mechanical ventilator
Purpose of mechanical ventilator
Indications of mechanical ventilations
Normal cycle of Respiration
Lung volumes
Modes of ventilator Types of mechanical ventilators
Describe the alarms of mechanical ventilator
Contraindications of mechanical ventilation
Complication of mechanical ventilator
Role of nurses during weaning and care of patient with VAP
Similar to Weaning from mechanical ventilation (20)
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Weaning from mechanical ventilation
1. Weaning from mechanical VentilationWeaning from mechanical Ventilation
By.
Alaa metwally
Ass. Prof. chest department
Zagazig university
2. Aim and objectives
• Definition of weaning
• Why weaning ??
• Decision of weaning (indication)
• Trimming of weaning (is he/she weanable?)
• Assessment of steadiness for weaning
• Methods of weaning
• Weaning protocols.
• Assessment of weaning outcome.
• What after weaning.
3. •The process of withdrawing the patient from
dependence and /or assistance on/from the
ventilator.
•Weaning from mechanical ventilation can be
defined as the process of abruptly or gradually
withdrawing the ventilatory support.
•Weaning includes tow separate but closely related
processes, discontinuation of mechanical and
removal of the artificial airway
4. • 75% of mechanically ventilated patients are
easy to be weaned off the ventilator with
simple process.
• 10-15% of patients require a use of a weaning
protocol over a 24-72 hours.
• 5-10% require a prolonged weaning plan.
• 1% of patients become dependent on chronic
MV
5. Decision of weaning, indication
• Weaning is started when the patient is recovering
from the acute stage of medical and surgical
problems
or
• When the cause of ventilation is sufficiently or
completely reversed.
9. • Numerous trials performed to develop criteria for
successful weaning, however, no one criterion can
predict the weaning outcome.
• Physicians must rely on clinical judgment.
• Reversal of initial process that indicated MV.
• Daily screening may reduce the duration of MV.
10. Readiness To Wean
• Improvement of the cause of respiratory failure
• Absence of major system dysfunction
• Appropriate level of oxygenation
• Adequate ventilatory status
• Intact airway protective mechanism (needed for
extubation)
11. Factors to be corrected before weaning
• CNS; Absence of cough, gag, level of consciousness
• Respiratory, rate, volume and color of secretions
• Renal; Correction of acid-base/electrolyte disorders
• Hematologic; correction of anemia, leukocytosis
• Infections; amount and purulence of secretions
• Nutrition; Poor nutritional status, low phosphorus,
excessive nutrition.
• CVS; Arrhythmias (less than 120/m, more than 40/m),
BP (Shock), if supported (max 5 mic/kg/min)
12. Assessment of readiness for weaning
• Respiratory Muscle status:
• NIP (NIF) (; maximum Inspiratory pressure:
• PI max generated by a patient from FRC
approximately 10 sec after occluding the Inspiratory
circuit.
• Rapid Shallow Breathing Index :
• RR/TV (in liters). Inspiratory muscle weakness leads
to rapid shallow breathing
13. Weaning Parameters
• Respiratory Muscle Strength
• Vital Capacity VC >15mL/kg body weight
• The maximum amount of gas that can be inhaled from
residual volume or exhaled from total lung capacity
• Requires patient cooperation
14. Weaning Parameters
• Respiratory Muscle endurance:
• Minute Ventilation VE;
• the amount of air that must be moved in or out of the
lungs over 1 min to maintain a given PaCO2. <10
L/min
• VE will be determined by CO2 production
• Increased on critical care illness, high fever, over
feeding, excess carbohydrate load, Increase death
space.
• RR; Muscle fatigue, patient resorts shallow breathing >35
15. Weaning Parameters
• Respiratory Muscle Demand
• Maximum Voluntary Ventilation; MVV >2 times
the VE
• Requires a motivated and cooperative patient
• The maximum amount of air that can be inhaled or
exhaled over 1 min.
• Respiratory Compliance >33ml/cmH2O
• Work must be performed by inspiratory muscles to
overcome the elastic properties of both the lungs and
chest wall.
16. Weaning Parameters
• Respiratory Gas Exchange
• Significant hypoxemia constitutes a relative
contraindication.
• A PaO2 <60mmHG with and FIO2>.040.
• Arterial to Inspired O2 ratio (PaO2/FIO2)>200
18. Maximal Inspiratory Pressure
• PI max: Excellent negative predictive value if less
than –20 (in one study 100% failure to wean at this
value)
• An acceptable PImax however has a poor positive
predictive value (40% failure to wean in this study
with a Pmax more than –20)
19. Frequency/Volume Ratio RSBI
• Index of rapid and shallow breathing RR/Vt
• Single study results:
• RR/Vt>105 95% wean attempts unsuccessful
• RR/Vt<105 80% successful
• One of the most predictive bedside parameters.
20. Weaning is a multidisciplinary process :-
Successful weaning
Physician
Nurse
Patient
21.
22. Methods of weaning
• No one or method of weaning has been
definitely found to be superior:
• Initial Trial of Spontaneous Ventilation
• T-piece trial
• Spontaneous trial on ventilator
• Gradual Weaning
• SIMV
• Pressure Support Ventilation (PSV)
• SIMV + PSV
• Extubation + noninvasive ventilation
23. Patient Preparation
Physiological consideration:-
The nurse must consider the patient as a whole, taking into
account factors that impair the delivery of oxygen and elimination
of carbon dioxide as well as those that increase oxygen demand
(sepsis, seizures, thyroid imbalances) or decrease the patient’s
overall strength (nutrition,neuromuscular disease).
Psychological consideration:-
•The nurse explains what will happen during weaning and role the
patient will play in the procedure.
•The nurse emphasizes that someone will be with or near the
patient at all times, and answers any questions simply and
concisely.
24. Weaning trials using a T-piece
• Weaning trials using a T-piece or tracheostomy mask
are normally conducted with the patient disconnected
from the ventilator, receiving humidified oxygen
only, and performing all work of breathing.
• Patients have to overcome the resistance of the
ventilator, may find this mode more comfortable, or
they may become anxious as they breathe with no
support from the ventilator.
25. Nursing role
• The Nurse should : Explain, monitor, and provide
encouragement.
• This method of weaning is usually used when the
patient is awake and alert, is breathing without
difficulty, has good gag and cough reflexes, and is
hemodynamically stable.
• During the weaning process, the patient is maintained
on the same or a higher oxygen concentration than
when on the ventilator.
26. Nursing Assessment:-
• While on the T-piece, the patient should be observed
for signs and symptoms of hypoxia, increasing
respiratory muscle fatigue, or distress. These include:
• Restlessness ,
• Increased RR more than 35 breaths/min,
• Use of accessory muscles,
• Tachycardia with premature ventricular contractions,
• Paradoxical chest movement
• Fatigue or exhaustion is initially manifested by an increased
respiratory rate associated with a gradual reduction in tidal volume;
later there is a slowing of the respiratory rate.
27. If the patient tolerating the T-piece trial, a second
set of arterial blood gas measurements is drawn 20 minutes
after the patient has been on spontaneous ventilation at a constant
FiO2 pressure support ventilation. (Alveolar–arterial equilibration
takes 15 to 20 minutes to occur.)
Signs of exhaustion and hypoxia correlated with deterioration in the
blood gas measurements indicate the need for ventilatory support. The
patient is placed back on the ventilator each time signs of fatigue or
deterioration develop.
If clinically stable, the patient usually can be extubated within 2 or 3
hours of weaning and allowed spontaneous ventilation by means of a
mask with humidified oxygen.
28. Pressure Support Ventilation (PSV)
• Depends on supplying a fixed (pushing) pressure
during inspiration
• Patient initiated and terminated
• More comfortable, depth & length of breath
controlled by patient
• Counteract work/resistance of ETT & ventilator
circuit, airway obstruction.
29. PSV + SIMV
• The pressure support ventilation (PSV) mode
assists the patient by applying pressure to the
airway throughout the patient triggered
inspiration to decrease resistance by the endo-
tracheal tube and ventilator tubing.
• Pressure support is reduced gradually as the
patient’s strength increases.
30. Nurse role in PSV
• The nurse must closely observe the patient’s
respiratory rate and tidal volumes on initiation
of PSV.
• It may be necessary to adjust the pressure
support to avoid tachypnea or large tidal
volumes.
31. Synchronized intermittent mandatory
ventilation (SIMV)
• Synchronized intermittent mandatory ventilation (SIMV) delivers
a preset tidal volume and number of breaths per minute.
• Between ventilator-delivered breaths, the patient can breathe
spontaneously with no assistance from the ventilator on those
extra breaths.
• As the patient’s ability to breathe spontaneously increases, the
preset number of ventilator breaths is decreased and the patientpatient
do more of the work of breathingdo more of the work of breathing.
• SIMV is indicated if the patient satisfies all the criteria for
weaning but cannot sustain adequate spontaneous ventilation for
long period.
32. SIMV Protocol
• Switch to SIMV from assist mode or decrease RR
• Begin with RR 8/min decrease SIMV rate by two
breaths per hour unless clinical deterioration
• If assume to fail, increase SIMV rate to previous level,
until stable
• If stable at least 1 hour of rate 0/ min extubate
• In patient without respiratory disorders, decrease rate
with half an hour interval, 2 hr extubate
33. Nursing role in SIMV:-
Nursing interventions include:-
1.Monitoring progress by recording respiratory
rate, minute volume, spontaneous and
machine-generated tidal volume, FiO2,
2. Arterial blood gas levels.
34. Weaning outcome
• How often will the patient need to be re-
intubated?
• Accepted rate: 5% - 15%
35. Failed to Wean
• Associated with intrinsic lung disease
• Associated with prolonged critical illness
• Increased risk in patient with longer
duration of mechanical ventilation
• Increased risk of complications, mortality
36. Weaning Failure Criteria
• Rapid shallow breathing
• RR > 35/min or > 10/min increase
• Tachycardia
• > 120 bpm or > 20 bpm increase
• BP change > 20%
• Mental status change
39. Evidence-based medicine
• Patients receiving MV who fail an SBT
should have the cause determined.
• Once causes are corrected, and if the patient
still meets the criteria of DS, subsequent
SBTs should be performed every 24 hours.
40. Failure to Wean
• Unresolved cause of mechanical ventilation
• Auto-PEEP
• Cardiac disease, CHF, ischemic heart disease
• Nutrition and electrolyte imbalance
• Inadequate rest following previous trial
• May need up to 24 hours
• Muscle weakness
• Paralysis or polyneuropathy of critical illness
41. Successful weaning should be followed by the
following:
• Oxygen therapy
• Close monitoring: ABGs evaluation, Pulse oximetry
• Bronchodilator therapy
• Chest physiotherapy
• Adequate nutrition, hydration, and humidification
• Incentive spirometry
What after weaning,
42. Weaning From the Tube:-
•Weaning from the tube is considered when the
patient can breathe spontaneously, maintain an
adequate airway by effectively coughing up
secretions, swallow, and move the jaw.
•If frequent suctioning is needed to clear secretions,
tube weaning may be unsuccessful (Ecklund, 1999)