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The Physiology of coagulation How to clot But not too much
Basis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Haemostasis ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Platelet shape change ,[object Object],[object Object],[object Object]
Platelet adhesion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Platelet release reaction  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Platelet Phospholipid Arachadonic   acid Endoperoxidases Thromboxane A2 Calcium   flux Phospholipase A2 Cyclooxygenase Thromboxane   synthase Phosphodiesterase
Platelet aggregation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Coagulation forms fibrin mesh ,[object Object],[object Object],[object Object]
General concepts ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cascade effect -> amplification 2x10 8 mol   Fibrin mesh 1 mol
 
Coagulation cascade XII XI IX X VIII Prothrombin (II) thrombin fibrinogen fibrin STABILISED FIBRIN V, Ca, P/L VII Intrinsic pathway Extrinsic  pathway XIII APTT PT
X Xa II (Prothrombin) IIa (Thrombin) INITIATION VIIa TF Va VIIIa Va XIa
AMPLIFICATION IXa Xa-Va-II Prothrombinase Platelet IXa- VIIa-X “ tenase” TF IX VIIa THROMBIN (IIa) FIBRIN
Fibrinogen -> fibrin ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Inhibitors: ANTI-coagulants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Anticoagulants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Fibrinolysis ,[object Object],[object Object],[object Object]
Components: fibrinolysis ,[object Object],[object Object],[object Object],[object Object]
                                                                          
Effect of plasmin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Blood Vessel: endothelium ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Haemostatic response ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Haemostatic response ,[object Object],[object Object],[object Object],[object Object]
Haemostasis reaction ,[object Object],[object Object],[object Object],[object Object]
A test tube is not a person ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 

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Physiologyof Coagulation

Editor's Notes

  1. Essential cofactor for FVIIa FVIIa: inefficient serine protease. Complex with TF and oriented to phospholipid membrane Phospholipid surface increases the rate of substrate activation (FX, FIX) by 10 4 -10 7