Cartilage and bone are connective tissues that provide structure and support. There are three main types of cartilage - hyaline, elastic, and fibrocartilage. Hyaline cartilage is the most common and forms joints, respiratory airways, and parts of long bones. It contains chondrocytes and an extracellular matrix with collagen fibers and proteoglycans. Bone is a calcified connective tissue that provides structure, protects organs, and stores calcium. It is formed through intramembranous or endochondral ossification and contains osteoblasts, osteocytes, osteoclasts, and an extracellular matrix with collagen and hydroxyapatite. Cartilage and bone are maintained through the actions of regulatory factors like par
SKELETAL SYSTEM PART 1 IS AN INTRODUCTION CLASS ABOUT BONE ANATOMY , DEVELOPMENT & OSSIFICATION PROCESS. BONE & CARTILAGE NORMAL HISTOLOGY & OSSIFICATION PROCESS ARE DISCUSSED IN DETAIL. HREST OF THE BONE PATHOLOGY WILL BE DISCUSSED IN OTHER SECTIONS.
Cartilage is a resilient and smooth elastic connective tissue, a rubber-like padding that covers and protects the ends of long bones at the joints, and is a structural component of the rib cage, the ear, the nose, the bronchial tubes, the intervertebral discs, and many other body components.
Histology
Junqueira’s Basic Histology Text and Atlas, 15th Ed
articular cartilage present in joint surface of articulating bone .role of articular cartilage in load bearing is important its damage cause arthritis so should know about its biomechanics
SKELETAL SYSTEM PART 1 IS AN INTRODUCTION CLASS ABOUT BONE ANATOMY , DEVELOPMENT & OSSIFICATION PROCESS. BONE & CARTILAGE NORMAL HISTOLOGY & OSSIFICATION PROCESS ARE DISCUSSED IN DETAIL. HREST OF THE BONE PATHOLOGY WILL BE DISCUSSED IN OTHER SECTIONS.
Cartilage is a resilient and smooth elastic connective tissue, a rubber-like padding that covers and protects the ends of long bones at the joints, and is a structural component of the rib cage, the ear, the nose, the bronchial tubes, the intervertebral discs, and many other body components.
Histology
Junqueira’s Basic Histology Text and Atlas, 15th Ed
articular cartilage present in joint surface of articulating bone .role of articular cartilage in load bearing is important its damage cause arthritis so should know about its biomechanics
10.08.08: Histology - Cartilage/Mature Bone Open.Michigan
Slideshow is from the University of Michigan Medical School's M1 Musculoskeletal Sequence
View additional course materials from Open.Michigan:
openmi.ch/med-M1Muscu
a brief ppt description about cartilage which may be usefull for teaching for first year mbbs, bds and paramedical students, hope it is helpfull to everyone
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
A presentation on Articular Cartilage Repair for my Functional Anatomy Course. The presentation was short as we were limited to 6 slides.
I hope you find the information of some use.
Bone tissue also called (osseous tissue) is a type of specialized dense connective tissue.
Histology
Junqueira’s Basic Histology Text and Atlas, 15th Ed
The bone of the skeleton is a mineralized vascular type of connective tissue with a solid matrix. The alveolar process is the bony extension of the mandible and maxilla that provides the necessary support for the teeth and serves as a site of attachment for the periodontal ligament fibers. By its resorption and deposition, it also compensates for tooth movement.
CONTENTS
FORMATION OF BONE
CLASSIFICATION OF BONES
STRUCTURE OF BONE
BLOOD SUPPLY
COMPOSITION OF BONE
FRACTURE HEALING
CARTILAGE
TYPES OF CARTILAGE
BONE (syn – Os; Osteon)
Osseous tissue, a specialised form of dense connective
tissue consisting of bone cells (osteocytes)
Embedded in a matrix of calcified intercelluar
substance
Bone matrix contains collagen fibres and the minerals
calcium phosphate and calcium carbonate
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
Essentials of Automations: Optimizing FME Workflows with ParametersSafe Software
Are you looking to streamline your workflows and boost your projects’ efficiency? Do you find yourself searching for ways to add flexibility and control over your FME workflows? If so, you’re in the right place.
Join us for an insightful dive into the world of FME parameters, a critical element in optimizing workflow efficiency. This webinar marks the beginning of our three-part “Essentials of Automation” series. This first webinar is designed to equip you with the knowledge and skills to utilize parameters effectively: enhancing the flexibility, maintainability, and user control of your FME projects.
Here’s what you’ll gain:
- Essentials of FME Parameters: Understand the pivotal role of parameters, including Reader/Writer, Transformer, User, and FME Flow categories. Discover how they are the key to unlocking automation and optimization within your workflows.
- Practical Applications in FME Form: Delve into key user parameter types including choice, connections, and file URLs. Allow users to control how a workflow runs, making your workflows more reusable. Learn to import values and deliver the best user experience for your workflows while enhancing accuracy.
- Optimization Strategies in FME Flow: Explore the creation and strategic deployment of parameters in FME Flow, including the use of deployment and geometry parameters, to maximize workflow efficiency.
- Pro Tips for Success: Gain insights on parameterizing connections and leveraging new features like Conditional Visibility for clarity and simplicity.
We’ll wrap up with a glimpse into future webinars, followed by a Q&A session to address your specific questions surrounding this topic.
Don’t miss this opportunity to elevate your FME expertise and drive your projects to new heights of efficiency.
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024Albert Hoitingh
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But there’s more:
In a second workflow supporting the same use case, you’ll see:
Your campaign sent to target colleagues for approval
If the “Approve” button is clicked, a Jira/Zendesk ticket is created for the marketing design team
But—if the “Reject” button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
2. PRINCIPAL FUNCTIONS OF
CARTILAGE
supporting soft tissues
covering the surfaces of bones
forming the bone joints
(shock absorber and sliding area)
development and growth of long
bones
4. PERICHONDRIUM
The capsule of connective tissue covering
the cartilage
outer layer - dense connective tissue
collagen type I
fibroblasts
the source of nutrients for avascular
cartilage
inner layer
chondroblasts - precursors of chondrocytes
5.
6. TYPES OF CARTILAGE
Hyaline cartilage
the most common form
contains mainly collagen type II fibers
Elastic cartilage
many elastic fibers near the collagen type II
more pliable than hyaline cartilage
Fibrocartilage
dense network type I collagen fibers
present in regions subject to great mechanical
stress
7. HYALINE CARTILAGE
articular surfaces of bones forming
movable joints
the walls of big respiratory passages
larynx, trachea, bigger bronchi
epiphyseal plates of long bones
the cartilaginous parts of ribs
covered by perichondrium
(except articular cartilage)
8.
9. HYALINE CARTILAGE
CHONDROCYTES
develop from chondroblasts - cells present in
the inner layer of the perichondrium
at the periphery - elliptic shape
farther in - become round , form isogenous
groups
isogenous group - develops by mitosis of
single chondrocyte (5-8 cells in group)
produce all components of extracellular matrix
well developed RER, Golgi complex
10.
11. HYALINE CARTILAGE
EXTRACELLULAR MATRIX
collagen type II fibrils embedded in ground
substance
ground substance :
proteoglicans
chondroitin sulfate, keratan sulfate
long chains of hyaluronic acid
chondronectin - glycoprotein providing
adherence of collagen and chondrocytes
water bound to the negative charges of
glicosaminoglicans
12. Territorial matrix
surrounds each chondrocyte of isogenous
group
rich in proteoglicans poor in collagen fibrils
Interterritorial matrix
occurs between isogenous groups
numerous collagen type II fibrils
Characteristics
firm, resistant to compression
13.
14.
15. ELASTIC CARTILAGE
auricle of the ear
the wall of external auditory canals
auditory tubes (Eustachian tubes )
epiglottis
Presence of perichondrium
16. ELASTIC CARTILAGE
Chondrocytes
similar to cells of hyaline cartilage
smaller isogenous groups ( 2- 3 cells)
Extracellular matrix
abundant network of elastic fibers
collagen type II fibrils
ground substance : the same components
like in hyaline cartilage
20. FIBROCARTILAGE
Chondrocytes
identical to cells of hyaline cartilage
single or in groups
groups - long raws of chondrocytes
Extracellular matrix
ground substance - less abundant
numerous collagen type I fibers - bundles
collagen bundles:
parallel to raws of cells
visible in light microscope
21. BONE
Specific type of connective tissue with
calcified extracellular substance
Functions
supporting soft tissues
protection of important organs
CNS in skull
thoracic contents in chest
reservoir of calcium
22.
23. OSTEOBLASTS
form a layer which resembles the simple
epithelium on the surface of bone
surround themselves with matrix and become
ostecytes
basophilic cytoplasm
abundant RER, well developed Golgi complex
Functions:
synthesize the organic components of matrix
responsible for calcification of bone matrix
play certain role in bone resorption
24.
25. OSTEOCYTES
develop from osteoblasts which surrounded
themselves with matrix
are located in matrix lacunae
(one cell per lacuna)
contact to each other by mean of cytoplasmic
processes existing in canaliculi of matrix
surrounded by thin layer of noncalcified matrix
less RER, smaller Golgi complex condensed
nuclear chromatin
Function: maintenance of the matrix
28. OSTEOCLASTS
large, multinuclear cells
derive from monocytes
(belong to phagocyte
system)
ruffled border - surface facing
bone ruffled
clear zone - adhesion the cell to
the matrix
acidophilc cytoplasm
abundant RER and Golgi
complex numerous
mitochondria and lisosomes
Functions: bone resorption
bone growth and bone
remodeling
32. BONE
EXTRACELLULAR MATRIX
Organic components ( 30-35% of bone weight)
collagen type I fibers ( 90%)
noncollagenous proteins :
osteonectin, osteocalcin, sialoproteins,
phosphoproteins, proteolipids
proteoglicans
Inorganic components ( 70% of bone weight)
calcium phosphate - hydroxyapatyte crystals
33. Periosteum
Layer of connective tissue covering the bone
Outer layer - dense connective tissue
fibroblasts
numerous collagen fibers
rich in blood vessels
(source of vessels for bone)
Inner layer
osteoprogenitor cells
(reservoir of osteoblasts)
34. Endosteum
Thin layer of connective tissue with
osteoprogenitor cells
Lines internal surfaces of the bone
35. Types of bone
IMMATURE BONE = PRIMARY BONE =
= woven bone
MATURE BONE = SECUNDARY BONE =
= lamellar bone
Compact bone
Cancellous bone = spongy bone
36. SECUNDARY BONE
MATURE BONE
Present in adults
Characteristics
smaller number of osteocytes
bone matrix
abundant, well calcified
arranged in lamellae
regular arrangement of collagen fibers
lamellae form osteons (Haversian systems)
great resistance to mechanical forces
38. Endosteum
Thin layer of connective tissue with
osteoprogenitor cells
Lines internal surfaces of the bone
39.
40.
41.
42. PRIMARY BONE
IMMATURE BONE
formed in embryo during bone formation
develops in repair process after fracture
replaced by mature bone
irregular array of collagen fibrils in the organic
part of matrix
smaller calcification
many osteocytes, little of bone matrix
smaller mechanical resistance
43. HISTOGENESIS
Intramembranous ossification
on the ground of mesenchymal tissue
formation of flat bones
e.g. bones of the skull
Endochondral ossification
on the ground of cartilaginous model
of the bone
formation of long bones
49. BONE GROWTH
FLAT BONES
1. Formation of bone on the external surface
osteoprogenitor cells of periosteum
(intramembranous ossification)
2. Resorption of bone on the internal surface
osteoclasts
50. BONE GROWTH
LONG BONES
epiphyses - radial growth of cartilage
cartilage is gradually replaced by bone
the diaphysis increases in width by
formation of bone by periosteum on the
external surface
diphyseal shaft grows in length as a result
of the osteogenic activity of epiphyseal
plate.
51. BONE AND CALCIUM REGULATORY FACTORS
Parathormone
(parathyroid)
Bone Resorption
Osteoclasts
Osteocytes
“osteocytic osteolysis”
Bone Growth
Somatotrophin
(pituitary)
Calcium
Flux
Calcitonin
(parafollicular cells
of thyroid)
Nutritional Factors:
Calcium & Vitamin D Deficiency
Child- Ricketts
Adult- osteomalacia
Vitamin C Deficiency
Scurvy- matrix not calicifiable