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Bones, Cartilages
and Joints
Objectives
1. Determine the structure of the bones
1.1 Classify bones as to size and shape
1.2 Contrast compact from spongy bone
1.3 Locate the axial and appendicular bone
1.4 Identify the parts of long bones
1.5 List the functions of the bones
1.6 Give the types of bone formation
1.7 Discuss the process of bone healing
2 Determine the types of cartilage
2.1 Name the composition of the intracellular
substance
2.2 Identify the histologic features of each
type
2.3 Give the functions of each type
3. Describe the different types of Joints
3.1 Cite locations of joints
3.2 Demonstrate joint movements
4. Identify some abnormalities in bones and
joints
Tissues
 Epithelial
 Connective
> Bone
> Cartilage
> Fibrous connective tissue
> Blood
 Muscle
 Nerve
Bones
Composition
 Cells: osteoblasts, osteoclasts, osteocytes
 Collagen fibers
- to withstand shearing forces
 Dense mineralized ground substance:
inorganic salts of calcium and
phosphate = hydroxyapatite
- for weight bearing
Bone cells
Functions of
bones
Description
Movement Maintain or change position of body
parts by interacting with skeletal
muscles
Protection Enclose and protect the brain,
lungs, and other organs
Support Support and anchor muscles
Mineral storage Serve as a depot for storing and
withdrawing mineral ions; indirectly
helps maintain body fluids and
support metabolic activities
Blood cell
formation
Site for production of red blood cells
and other blood cells
Types of bones
According to
 Density:
compact and spongy
 Size and shape:
long, short, flat & irregular
 Location:
axial and appendicular
axial
appendicular
Types of bones according to size and shape
1. Long = bones of the upper and lower extremities
2. Short = bones of the wrist and ankle
3. Flat = clavicle, sternum, scapula and pelvis
4. Irregular = vertebrae and facial bones
Long bones
Parts of
Long Bones
Spongy
compact
Humerus
Radius
Ulna
Metacarpals
Phalanges
Femur
Tibia
Fibula
Metatarsals
Toes
Bone density
 Spongy bone - cancellous
- consists of trabeculae
- found within the epiphysis and
metaphysis
 Compact bone – cortical
- usually found on the bone surface
- making up most of the diaphysis
Organization of lamella in compact bone
1. Haversian system – osteons
- long cylinders running parallel to the
long axis of the diaphysis
2. Interstitial lamella
3. Outer and inner circumferentil lamellae
Short bones = resemble blocks
Flat bones
 Composed of 2 thin plates of compact bones with central
region of spongy bone
 Skull bones, scapulae, ribs, sternum and pelvic bones
Clavicle
Ribs
Irregular bones
Patella
Blue: Vomer (1)
Yellow: Maxilla (2)
Purple: Mandible (1)
Pink: Nasal bones (2)
Red: Palatine bones (2)
Bright blue: Lacrimal bones (2)
Dark green: Zygomatic bones (2)
Bright green: Inferior nasal concha (2)
Bone formation
Intramembranous ossification
Endochondral ossification
Epiphyseal Plate
Bone remode
Wolff’s Law
Bone formation after fracture
Cartilage
 Supporting connective tissue with tensile strength
 Composition of ground substance
> chondroitin sulfate
> keratin sulfate
> chondronectin
> collagen:
Type I = fibrocartilage
Type II = hyaline and elastic
 no blood and nerve supply
 Produced by chondroblasts to become chondrocytes
• Growth of Cartilage
- Appositional growth results in outward
expansion due to the production of cartilage
matrix on the outside of the tissue
- Interstitial growth results in expansion from
within the cartilage matrix due to division of
lacunae-bound chondrocytes and secretion of
matrix
Types of cartilage
1. Hyaline - most common, found in
the ribs, nose, larynx, trachea
- a precursor of bone
2. Fibro - is found in vertebral discs,
joint capsules, ligaments
3. Elastic - is found in the external
ear, and epiglottis
Hyaline cartilage
• consists of living chondrocytes situated
far apart in fluid-filled lacunae
• contains a number of collagenous fibers
• occurs in trachea, the larynx, the tip of the
nose, in the connection between the ribs
and the breastbone
• provides a sliding area
which reduces friction
Elastic cartilage
 has interlacing fibers
 contains many yellow elastic
fibers lying in solid matrix
 found in the epiglottis, external
ear, and eustachian tube
 maintains the shape of a
structure while allowing great
flexibility
Fibrous cartilage
 dense collagen fibers and limited
amount of ground substance
 chondrocytes are between the bundles of collagen
 has great tensile strength
 predominates in body areas that bear great amounts of
weight
 Found in the pubic symphysis.skull bones, and disks
between the vertebrae, in the tendonous and ligamentous
insertions
Functions of fibrocartilage:
1. Shock absorbers – cartilage between the
adjacent vertebrae while we run or walk
2. Provides sturdiness without impeding movement
- forms a firm joint between bones but still
allows for a reasonable degree of movement
3. Deepens sockets – in articular cavities (such as
the ball-and-socket joints in the hip and shoulder
regions) white fibrocartilage deepens the
sockets to make dislocation less possible
Characteristic Cartilage Bone
Ground
substance
component
Chondroitin
sulfate, keratin
sulfate, chondro-
nectin, no mineral
component
Chondroitin sulfate,
keratin sulfate,
osteocalrin, osteo-
pontin, sialoprotein,
hydroxyapatite,
citrate, carbonate
Collagen
types
Type I fibrocar-
tilage
Type II hyaline &
elastic
Type I
Blood vessels Absent, nutrient
via diffusion
Present
Nerves Absent Present
Repair (regene-
ration capacity)
Low High
Mitosis Chondroblasts
Yes
Chondrocytes
Yes
Osteoprogenitor
Yes
Osteoblasts No
Osteocytes No
Communication No junctions
between
chondrocytes
Gap junctions
between
osteocytes
Hormonal
influence
T3, T4, testos-
terone, GH,
cortisone,
estradiol
PTH, Calcitonin,
GH, Estrogens,
Androgens
Joints
 Articulation
 Where bones come in contact with each other
 Basic types of joints
1. those that have little or no movement
a. Synarthroses - immovable
b. Amphiarthroses - semimovable
2. those that are freely movable =
Diarthroses
Joints that restrict movement
1. Fibrous joints – bones are joined together by strong
fibrous tissues = Synarthroses
a. Sutures
b. Syndesmoses
c. Gomphoses
2. Cartilaginous joints – bones are joined
together by cartilaginous material
= Amphiarthroses
a. Symphysis
b. Synchrondroses
Sutures
Syndesmoses
 Between radius and ulna
 Between tibia and fibula
Gomphoses
 Between the root of tooth and jaw
(upper = maxilla and lower = mandible)
Amphiarthroses
 Slightly movable joints
 Consists of two adjacent bone separated by
substantial amount of hyaline cartilage
 Some cases bones are separated by
ligaments
Symphysis pubis Intervertebral discs
Manubriosternal joint
Synchondrosis joint
Sacroiliac joint
Joints that allow movement
 Diarthroses
 Synovial joints – 2 bones encased within a cavity
 Architecture of synovial joints
1. surface where bones come in contact
and move against each other is covered
by articular or hyaline cartilage
2. surrounded by a strong fibrous joint
capsule
3. contains joint cavity within the fibrous
capsule
4. non epithelial synovial membrane secretes
synovial fluid
Movements by synovial joints:
- Axis of motion:
= Nonaxial - slipping movements
= Uniaxial - movement in one plane;
phalanges, radius/ulna, femur/tibia
= Biaxial - movement in two planes;
occipital bone/atlas
= Multiaxial - movement in three planes;
scapula/humerus, and coxal bone/
femur
Types of synovial joints
1. Plane or gliding
2. Hinge
3. Pivot
4. Condyloid
5. Saddle
6. Ball and socket
plane
condyloid
Bursa
 Closed fluid-filled sac
 Lined with synovial
membranes
 Commonly found
between the skin
and bony prominences
 Assist the movement of
tendons that pass over bones
Joint movements
 Flexion – Extension
 Abduction – adduction
 Pronation – supination
 Median rotation – lateral rotation
 Elevation – depression
 Protraction – retraction
 Dorsiflexion – plantar flexion
 Eversion – inversion
Fracture – discontinuity with the anatomy of
bone
Sprain - stretching/tearing of a ligament
Dislocation - (luxation), bones forced out of
their normal position
Bursitis - inflammation of bursa
Arthritis - inflammatory or degenerative
disease; synovial membrane thickens,
fluid production decreases, increase in
friction and pain
Types of arthritis:
• Osteo arthritis - degenerative
• Rheumatoid arthritis - autoimmune
• Gouty arthritis - uric acid accumulation
Synovitis - inflammation of synovial
membrane
Tendinitis - inflammation of tendon sheaths
Signs and symptoms of arthritis
pain
swelling
stiffness
fatigue
fever
rashes
lumps under
the skin
limitation of body
movement
References
 Alcamo, Edward: Anatomy and Physiology The Easy Way,
Barron’s Educational Series, USA 1996
 Tesoriero, John, Anatomy. Sulzburger & Graham Publishing,
Ltd, New York 1994
 Gartner, LP et al. Board Review Series Cell Biology and
Histology. Williams & Wilkins, USA 1993
 Dudek, RW. High-Yield histology. Williams & Wilkins, USA
1996
 Moore, KL & Agur,AM. Essential Clinical Anatomy . Lippincott
Williams & Wilkins, Maryland, USA 1995
 Snell, RS Clinical Anatomy by Regions 8th ed. Lippincott
Maryland, USA 2007
 Mescher, AL Junquiera’s Basic Histology Text and Atlas.
McGraw Hill, Singapore 2010

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Bones and cartilage

  • 2. Objectives 1. Determine the structure of the bones 1.1 Classify bones as to size and shape 1.2 Contrast compact from spongy bone 1.3 Locate the axial and appendicular bone 1.4 Identify the parts of long bones 1.5 List the functions of the bones 1.6 Give the types of bone formation 1.7 Discuss the process of bone healing
  • 3. 2 Determine the types of cartilage 2.1 Name the composition of the intracellular substance 2.2 Identify the histologic features of each type 2.3 Give the functions of each type 3. Describe the different types of Joints 3.1 Cite locations of joints 3.2 Demonstrate joint movements 4. Identify some abnormalities in bones and joints
  • 4. Tissues  Epithelial  Connective > Bone > Cartilage > Fibrous connective tissue > Blood  Muscle  Nerve
  • 5. Bones Composition  Cells: osteoblasts, osteoclasts, osteocytes  Collagen fibers - to withstand shearing forces  Dense mineralized ground substance: inorganic salts of calcium and phosphate = hydroxyapatite - for weight bearing
  • 7. Functions of bones Description Movement Maintain or change position of body parts by interacting with skeletal muscles Protection Enclose and protect the brain, lungs, and other organs Support Support and anchor muscles Mineral storage Serve as a depot for storing and withdrawing mineral ions; indirectly helps maintain body fluids and support metabolic activities Blood cell formation Site for production of red blood cells and other blood cells
  • 8. Types of bones According to  Density: compact and spongy  Size and shape: long, short, flat & irregular  Location: axial and appendicular axial appendicular
  • 9. Types of bones according to size and shape 1. Long = bones of the upper and lower extremities 2. Short = bones of the wrist and ankle 3. Flat = clavicle, sternum, scapula and pelvis 4. Irregular = vertebrae and facial bones
  • 12.
  • 13.
  • 14.
  • 15. Bone density  Spongy bone - cancellous - consists of trabeculae - found within the epiphysis and metaphysis  Compact bone – cortical - usually found on the bone surface - making up most of the diaphysis
  • 16.
  • 17.
  • 18.
  • 19.
  • 20. Organization of lamella in compact bone 1. Haversian system – osteons - long cylinders running parallel to the long axis of the diaphysis 2. Interstitial lamella 3. Outer and inner circumferentil lamellae
  • 21.
  • 22.
  • 23. Short bones = resemble blocks
  • 24.
  • 25. Flat bones  Composed of 2 thin plates of compact bones with central region of spongy bone  Skull bones, scapulae, ribs, sternum and pelvic bones
  • 26.
  • 27.
  • 28.
  • 30. Ribs
  • 32.
  • 33.
  • 34.
  • 35.
  • 36.
  • 37.
  • 38. Blue: Vomer (1) Yellow: Maxilla (2) Purple: Mandible (1) Pink: Nasal bones (2) Red: Palatine bones (2) Bright blue: Lacrimal bones (2) Dark green: Zygomatic bones (2) Bright green: Inferior nasal concha (2)
  • 39.
  • 40.
  • 44.
  • 46.
  • 47.
  • 48.
  • 50.
  • 52.
  • 53.
  • 54.
  • 55. Cartilage  Supporting connective tissue with tensile strength  Composition of ground substance > chondroitin sulfate > keratin sulfate > chondronectin > collagen: Type I = fibrocartilage Type II = hyaline and elastic  no blood and nerve supply
  • 56.  Produced by chondroblasts to become chondrocytes • Growth of Cartilage - Appositional growth results in outward expansion due to the production of cartilage matrix on the outside of the tissue - Interstitial growth results in expansion from within the cartilage matrix due to division of lacunae-bound chondrocytes and secretion of matrix
  • 57. Types of cartilage 1. Hyaline - most common, found in the ribs, nose, larynx, trachea - a precursor of bone 2. Fibro - is found in vertebral discs, joint capsules, ligaments 3. Elastic - is found in the external ear, and epiglottis
  • 58. Hyaline cartilage • consists of living chondrocytes situated far apart in fluid-filled lacunae • contains a number of collagenous fibers • occurs in trachea, the larynx, the tip of the nose, in the connection between the ribs and the breastbone • provides a sliding area which reduces friction
  • 59.
  • 60. Elastic cartilage  has interlacing fibers  contains many yellow elastic fibers lying in solid matrix  found in the epiglottis, external ear, and eustachian tube  maintains the shape of a structure while allowing great flexibility
  • 61. Fibrous cartilage  dense collagen fibers and limited amount of ground substance  chondrocytes are between the bundles of collagen  has great tensile strength  predominates in body areas that bear great amounts of weight  Found in the pubic symphysis.skull bones, and disks between the vertebrae, in the tendonous and ligamentous insertions
  • 62. Functions of fibrocartilage: 1. Shock absorbers – cartilage between the adjacent vertebrae while we run or walk 2. Provides sturdiness without impeding movement - forms a firm joint between bones but still allows for a reasonable degree of movement 3. Deepens sockets – in articular cavities (such as the ball-and-socket joints in the hip and shoulder regions) white fibrocartilage deepens the sockets to make dislocation less possible
  • 63.
  • 64. Characteristic Cartilage Bone Ground substance component Chondroitin sulfate, keratin sulfate, chondro- nectin, no mineral component Chondroitin sulfate, keratin sulfate, osteocalrin, osteo- pontin, sialoprotein, hydroxyapatite, citrate, carbonate Collagen types Type I fibrocar- tilage Type II hyaline & elastic Type I Blood vessels Absent, nutrient via diffusion Present
  • 65. Nerves Absent Present Repair (regene- ration capacity) Low High Mitosis Chondroblasts Yes Chondrocytes Yes Osteoprogenitor Yes Osteoblasts No Osteocytes No Communication No junctions between chondrocytes Gap junctions between osteocytes Hormonal influence T3, T4, testos- terone, GH, cortisone, estradiol PTH, Calcitonin, GH, Estrogens, Androgens
  • 66. Joints  Articulation  Where bones come in contact with each other  Basic types of joints 1. those that have little or no movement a. Synarthroses - immovable b. Amphiarthroses - semimovable 2. those that are freely movable = Diarthroses
  • 67. Joints that restrict movement 1. Fibrous joints – bones are joined together by strong fibrous tissues = Synarthroses a. Sutures b. Syndesmoses c. Gomphoses 2. Cartilaginous joints – bones are joined together by cartilaginous material = Amphiarthroses a. Symphysis b. Synchrondroses
  • 69. Syndesmoses  Between radius and ulna  Between tibia and fibula
  • 70. Gomphoses  Between the root of tooth and jaw (upper = maxilla and lower = mandible)
  • 71. Amphiarthroses  Slightly movable joints  Consists of two adjacent bone separated by substantial amount of hyaline cartilage  Some cases bones are separated by ligaments
  • 74.
  • 76. Joints that allow movement  Diarthroses  Synovial joints – 2 bones encased within a cavity  Architecture of synovial joints 1. surface where bones come in contact and move against each other is covered by articular or hyaline cartilage 2. surrounded by a strong fibrous joint capsule 3. contains joint cavity within the fibrous capsule 4. non epithelial synovial membrane secretes synovial fluid
  • 77.
  • 78. Movements by synovial joints: - Axis of motion: = Nonaxial - slipping movements = Uniaxial - movement in one plane; phalanges, radius/ulna, femur/tibia = Biaxial - movement in two planes; occipital bone/atlas = Multiaxial - movement in three planes; scapula/humerus, and coxal bone/ femur
  • 79. Types of synovial joints 1. Plane or gliding 2. Hinge 3. Pivot 4. Condyloid 5. Saddle 6. Ball and socket
  • 80. plane
  • 82. Bursa  Closed fluid-filled sac  Lined with synovial membranes  Commonly found between the skin and bony prominences  Assist the movement of tendons that pass over bones
  • 83. Joint movements  Flexion – Extension  Abduction – adduction  Pronation – supination  Median rotation – lateral rotation  Elevation – depression  Protraction – retraction  Dorsiflexion – plantar flexion  Eversion – inversion
  • 84.
  • 85.
  • 86. Fracture – discontinuity with the anatomy of bone Sprain - stretching/tearing of a ligament Dislocation - (luxation), bones forced out of their normal position Bursitis - inflammation of bursa Arthritis - inflammatory or degenerative disease; synovial membrane thickens, fluid production decreases, increase in friction and pain
  • 87.
  • 88.
  • 89.
  • 90. Types of arthritis: • Osteo arthritis - degenerative • Rheumatoid arthritis - autoimmune • Gouty arthritis - uric acid accumulation Synovitis - inflammation of synovial membrane Tendinitis - inflammation of tendon sheaths
  • 91.
  • 92. Signs and symptoms of arthritis pain swelling stiffness fatigue fever rashes lumps under the skin limitation of body movement
  • 93. References  Alcamo, Edward: Anatomy and Physiology The Easy Way, Barron’s Educational Series, USA 1996  Tesoriero, John, Anatomy. Sulzburger & Graham Publishing, Ltd, New York 1994  Gartner, LP et al. Board Review Series Cell Biology and Histology. Williams & Wilkins, USA 1993  Dudek, RW. High-Yield histology. Williams & Wilkins, USA 1996  Moore, KL & Agur,AM. Essential Clinical Anatomy . Lippincott Williams & Wilkins, Maryland, USA 1995
  • 94.  Snell, RS Clinical Anatomy by Regions 8th ed. Lippincott Maryland, USA 2007  Mescher, AL Junquiera’s Basic Histology Text and Atlas. McGraw Hill, Singapore 2010