The document discusses lubrication of synovial joints. It states that synovial fluid and articular cartilage are much slipperier than ice or lubricated metals. It then describes the various lubrication processes for articular cartilage - boundary lubrication, fluid-film lubrication, hydrodynamic lubrication, and squeeze-film lubrication. Boundary lubrication occurs with an adsorbed layer preventing surface contact while the others involve fluid films. The lubrication type depends on factors like loading and movement. Mixed lubrication involving different areas is common. Elastohydrodynamic lubrication also occurs as cartilage deforms under pressure. In summary, the key lubrication modes work together dynamically based on joint loading and motion.
Basic Introduction about Joint Mobilisation and Manipulation, This article gives clear notes for the students to understand the Mobilisation techniques.
Biomechanics of Tendon, Ligament, Cartilage,, Bone
Wolf's Law
Mechnical Behavior
stress strain curve (Young's Moudulas)
viscoelasticity
time depended and rate depended properties
creep stress relaxation, hyteresis,
Thank You
Basic Introduction about Joint Mobilisation and Manipulation, This article gives clear notes for the students to understand the Mobilisation techniques.
Biomechanics of Tendon, Ligament, Cartilage,, Bone
Wolf's Law
Mechnical Behavior
stress strain curve (Young's Moudulas)
viscoelasticity
time depended and rate depended properties
creep stress relaxation, hyteresis,
Thank You
Hello everyone here I upload mckenzie exrercise basic details and some of its position.Its technique for use to cervical, Lumabar pain relief via particular position.Thank you.
Hello everyone here I upload mckenzie exrercise basic details and some of its position.Its technique for use to cervical, Lumabar pain relief via particular position.Thank you.
Forces associated with blood flow are major determinants of vascular morphogenesis and physiology. Blood flow is crucial for blood vessel development during embryogenesis and for regulation of vessel diameter in adult life. It is also a key factor in atherosclerosis, which, despite the systemic nature of major risk factors, occurs mainly at regions of arteries that experience disturbances in fluid flow. Recent data have highlighted the potential endothelial mechanotransducers that mediate responses to flow, the effects of atheroprotective versus atherogenic flow, and the mechanisms that contribute to progression of the disease over time and how systemic factors interact with flow patterns to cause atherosclerosis.
Frm:- Nat Rev Mol Cell Biol. 2009 Jan; 10(1): 53–62. doi: 10.1038/nrm2596
Teaching How to use the CFD Approach by an Example: Hydrodynamics within a Pa...Nelson García Polanco
The CDF methodology is applied to the study of the air flow around a 2-D car and its interaction with the cabin internal air. The flow visualization or computational works enable engineers to calculate different car characteristics like drag coefficient, external and internal air flow patterns.The results show the physics behavior of the flow and the presence of flow structures, as for instance, indoor air recirculation zones.
NTM Corp: Mobil SHC Presentation on power cost reduction using mobil shc - cu...japjaca
Presentation on power cost reduction using Mobil SHC Industrial Lubricants as part of the offer on value proposition.
NOTE: This contains parts of the standard Mobil SHC presentation decks.
A slide show of the paper- Tribology of artificial joints, T D Stewart BSc PhD Lecturer in Medical Engineering, Institute of Medical and Biological Engineering, The University of Leeds, Leeds, UK, Journal- ORTHOPAEDICS AND TRAUMA 24:6
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
2. HOW MUCH SLIPPERY ?
Synovial fluid and articular cartilage are a
very slippery combination.....
3 times more slippery than skating on ice,
4-10 times more slippery than a metal on a
plastic hip replacement,
and more than 30 more times as slippery
as metal on metal using the best
petroleum-based lubricant.
3. Lubrication of Articular Cartilage
• Synovial joints subjected to enormous range
of loading conditions
• Cartilage typically sustains little wear
--------------------------------------------------------
Implication:
Sophisticated lubrication process required
6. Fluid-film Lubrication
• Thin film of lubricant separates bearing
surfaces
• Load on bearing surfaces supported by
pressure developed in fluid-film
• Lubrication characteristics determined by
lubricant’s properties
– Rheological properties
– Viscosity and elasticity
– Film geometry
– Shape of gap between surfaces
– Speed of relative motion of two surfaces
8. Hydrodynamic Lubrication
• Occurs when 2 nonparallel rigid bearing
surfaces lubricated by a fluid-film that moves
tangentially with respect to each other
• Wedge of converging fluid formed
• Lifting pressure generated in wedge by fluid
viscosity as the bearing motion drags fluid into
gap
12. Squeeze-film Lubrication
• Occurs when weight bearing surfaces move
perpendicularly toward each other
• Wedge of converging fluid formed
• Pressure in fluid-film result of viscous resistance of
fluid that acts to impede its escape from the gap
• Sufficient to carry high loads for short durations
(eventually contact between asperities in bearing
surfaces)
16. Boundary Lubrication
• Surfaces of cartilage protected by an adsorbed layer of
boundary lubricant
– Direct surface-to-surface contact is prevented
– Most surface wear eliminated
– Lubricin (glycoprotein) synovial fluid constituent responsible
for boundary lubricant
• Absorbed as monolayer to each articular surface
• Able to carry loads (normal forces) and reduce friction
• Independent of physical properties of lubricant (e.g.,
viscosity) and bearing material (e.g., stiffness)
• Primarily depends on chemical properties of lubricant
• Functions under high loads at low relative velocities,
preventing direct contact between surfaces
18. Articular Cartilage Asperities and
Lubrication
• Articular cartilage not perfectly smooth;
asperities
• Fluid film lubrication in regions of cartilage
non-contact
• Boundary lubricant (lubricin) in areas of
asperities
• Low rates of interfacial wear suggests that
asperity contact rarely occurs in articular
cartilage
19. Schematic of Boundary Lubricant
Synovial fluid constituent
responsible for boundry
lubrication
• glycoprotein – lubricin
or
• phospholipid –
dipalmitoyl
phosphatidylcholine ??
21. Modes of Mixed Lubrication
1. Combination of fluid-film and boundary lubrication
– Temporal coexistence of fluid-film and boundary lubrication at spatially
distinct locations
– Joint surface load sustained by fluid-film and boundary lubrication
– Most friction in boundary lubricated areas; most load supported by fluid-
film
22. Modes of Mixed Lubrication
2. Boosted lubrication
– Shift of fluid-film to boundary
lubrication with time over the
same location
– Articular surfaces protected
during loading by ultrafiltration
of synovial through the
collagen-PG matrix
23. Modes of Mixed Lubrication
2. Boosted lubrication (continued)
– Solvent component of synovial fluid passes into the articular
cartilage during squeeze-film action yielding a concentrated gel
of HA protein complex that coats and lubricates the surfaces
– As articular surfaces approach each other, difficult for HA
macromolecules to escape from gap between surfaces
24. Variation of Lubrication Processes for Articular Cartilage
Boundary LubricationFluid-film Lubrication
Hydrodynamic Lubrication Squeeze-film Lubrication
Elastohydrodynamic Lubrication
- associated with deformable articular cartilage
- pressure from fluid-film deforms surfaces
26. Elastohydrodynamic Lubrication
• Beneficial increase in surface areas
– Lubricant escapes less rapidly from between
the bearing surfaces
– Longer lasting lubricant film generated
– Stress of articulation lower and more
sustainable
• Elastohydrodynamic lubrication greatly
increases load bearing capacity
27. To Summerise…
The Boundary lubrication appears to be the most
important when the joint is stationary and under
conditions of severe loading.
As movement commences and loading is
reduced,there is a transition to a mixture of
Boundary and fluid film lubrication.
Under these conditions Boundary lubrication
occures between asparities while fluide film
lubrication occures at other regions.
In this ‘mixed’ lubrication,it is probable that most of
the friction is generated in the boundary lubricated
areas while most of the load is carried by the fluid
film.
28. As speed increases,a conversion to
elastohydrodynamic lubrication occurs.
During slowing,squeez film lubrication
begins to operate once again and this
continues until the limb is at rest.
After a period of immobility,boundary
lubrication again takes over.
29. Swing phaseSupport phase
Dynamic Relationship between Vertical Load and Hip Joint Lubrication
Support phase
•Initial load on hip at heel contact
likely supported by hydrodynamic
lubrication
•As load continues, fluid is squeezed
between articular surfaces and is
supported more by squeeze-film
lubrication
Swing phase
•Small vertical load on hip articular
cartilage supported by hydrodynamic
lubrication
30. Dynamic Relationship between Vertical Load and Hip Joint Lubrication
time = start time = 3 minutes
Time = start
•Load on hip supported by
squeeze-film lubrication
Time = 3 minutes
•Over time fluid-film may be
eliminated and surface-to-
surface contact may occur
•Surfaces protected by thin
layer of ultrafiltrated synovial
gel (boosted lubrication) or by
the adsorbed lubricin
monolayer (boundary
lubrication)