This document summarizes key aspects of insulin including its history, structure, biosynthesis, transport, degradation, effects, and clinical correlations. It describes how insulin was first extracted from dog pancreases in 1921. Insulin is a polypeptide hormone composed of two chains that are held together. It regulates carbohydrate, lipid, and protein metabolism. Insulin increases glucose uptake and storage while decreasing gluconeogenesis. Clinically, insufficient insulin production can lead to symptoms of diabetes like frequent urination.
Insulin is a peptide hormone produced by beta cells of the pancreatic islets, and it is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of, especially, glucose from the blood into fat, liver and skeletal muscle cells.
Insulin is a peptide hormone produced by beta cells of the pancreatic islets, and it is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of, especially, glucose from the blood into fat, liver and skeletal muscle cells.
biological Insulin, synthesis, factors affecting synthesis, primary structure of insulin, different insulin preparations, mechanism of action of Insulin and pathway, physiological & biochemical effect of Insulin, Disorders related with insulin production, treatment strategy, Drugs Used to treat Diabetes Mellitus
Definition of hormones
Pancreas
Intro of insulin
Chemistry
Biosynthesis
Action of insulin
Metabolic effect on insulin
Factors effect insulin secretion
Disorders related to insulin hormone
Treatment
Brand name of insulin in market
Just the type of presentation a top presenter would look for.
The topic is well introduced, the designs of the slides are simple yet the explanation is very powerful.
Insulin Types
By Dr. Usama Ragab Youssif
In light of Insulin Workshop - 3rd Annual ISMA Conference 2021
It includes Insulin history, insulin types, insulin action
Insulin is a peptide hormone, produced by beta cells of the pancreas, and is central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, skeletal muscles, and fat tissue to absorb glucose from the blood. In the liver and skeletal muscles, glucose is stored as glycogen, and in fat cells (adipocytes) it is stored as triglycerides.
biological Insulin, synthesis, factors affecting synthesis, primary structure of insulin, different insulin preparations, mechanism of action of Insulin and pathway, physiological & biochemical effect of Insulin, Disorders related with insulin production, treatment strategy, Drugs Used to treat Diabetes Mellitus
Definition of hormones
Pancreas
Intro of insulin
Chemistry
Biosynthesis
Action of insulin
Metabolic effect on insulin
Factors effect insulin secretion
Disorders related to insulin hormone
Treatment
Brand name of insulin in market
Just the type of presentation a top presenter would look for.
The topic is well introduced, the designs of the slides are simple yet the explanation is very powerful.
Insulin Types
By Dr. Usama Ragab Youssif
In light of Insulin Workshop - 3rd Annual ISMA Conference 2021
It includes Insulin history, insulin types, insulin action
Insulin is a peptide hormone, produced by beta cells of the pancreas, and is central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, skeletal muscles, and fat tissue to absorb glucose from the blood. In the liver and skeletal muscles, glucose is stored as glycogen, and in fat cells (adipocytes) it is stored as triglycerides.
INTRODUCTION of Insulin
Insulin structure
Biosynthesis of Insulin
Insulin function
Mechanism of insulin
Effects of Insulin
Transport of Insulin
Degradation of Insulin
Clinical correlations
medical #students #doctors #foodandnutrition #nurses #NEET #PCM #doctors #nutritioneducation #mscdfsm #dietician #nationaldieticians #RD #REGISTERED #DIETICIANS
#NUTRITIONIST #INTERNATIONAL DIETICIANS
This content is made for all student of medical ,nutrition ,doctors ,zoology ,chemistry ,medical who are still preparing for examination .feel free to give suggestion.
blood glucose homeostasis and the role of tissues and hormones, roles of Insulin and glucagon in regulating blood glucose, regulation of glucose metabolism during exercise, insulin receptor and its mechanism
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
4. Introduction
History
Structure of insulin
Biosynthesis
Transport and catabolism
Degradation
Release of insulin
Effects of insulin
Clinical coorelations
5. INTRODUCTION
Insulin
> protein hormone
> by islets of langerhans
> pancreas
Anabolic hormone
> growth & development
6. HISTORY
• Canadian scientist
(1921)
–Fredrick G. Banting
–Charles H. Best
• extracted insulin
–from dog’s pancreas
7. STRUCTURE OF INSULIN
• Insulin
– Polypeptide hormone
– 51 amino acids
– Two chains
• A chain 21 a.a.
• B chain 30 a.a.
• Held by interchange disulfide
bridges
8.
9. BIOSYNTHESIS OF
INSULIN
Synthesis of Preproinsulin.
Conversion of preproinsulin to
proinsulin.
Conversion of proinsulin to insulin.
10. GENETICS OF INSULIN SYNTHESIS
The proinsulin precursor of
insulin is encoded by the INS
gene
15. CATABOLISM OF
INSULIN
Half life: 3-5 minutes
Major organs of degradation
> Liver.
>Kidney.
>Placenta.
50% of insulin removed in a single pass through
liver.
MECHANISM :
Insulin specific protease.
Glutathione insulin transhydrogenase (Insulinase
25. Effect on carbohydrate
metabolism (contd)
In s u lin in d e p e n d e n t t is s u e s
B r a in
RB C
Te s t i s
K id n e y
R e t in a
In t e s t in a l m u c o s a l c e lls
28. Lipid Metabolism
Metabolism Net effect Effect on important
enzymes
Lipogenesis Increased
DeNovo FA Synthesis Increased Acetyl CoA carboxylase
Avalbility of NADPH
Adipose tissue Increased Provide α-glycerol-3-PO4
Lipoprotein lipase
Lipolysis Decreased Hormone sensitive lipase
Ketogenesis Decreased HMG CoA synthetase
Lipoprotein Increased Utilization of VLDL & LDL
29. Protein Metabolism
Metabolism Net Effect Effect on important
enzymes
Protein Increased RNA polymerase
synthesis Amino acids up take
Protein Decreased Transaminases
degradation Deaminases
30. CELL GROWTH &
DEVELOPMENT
• Promote cell growth and development
• Mediated by
• Epidermal growth factors.
• Platelet derived growth factor.
• Prostaglandings.
38. Insulin shock
High level of insulin.
Fall in blood glucose level.
CNS depression.
50-70 mg/dl CNS excitability
20-50 mg/dl CONVULSION&
COMA
< 20 mg/dl COMA
39. HYPOGLYCAEMIA IN FETUS
OF DIABETIC MOTHER
Maternal blood glucose level.
Transfered through placenta.
Fetal blood glucose level.
o β-cells of fetus secrete insulin.
o Saturation of placenta 30 mmol/L
o Hypoglycaemia
40. REFERENCES
• Lectures on “Endocrinology” by C.J.Baired
MD/PhD
• www.dtu.ox.ac.uk/4-T
• Lectures on “Signaling Through Insulin
Receptors” by Oksana Matveinko
• Wikipedia
• Arthur C.Guyton, John E.Hall, “Textbook Of
Medical Physiology” 11th edition Ch: 78
Page:961-970
• Lectures By MA Hussain & ND Theise “ Stem-Cell
Therapy For Diabetes Mellitus”
41. Contd.
• Robert K.Murray, Daryl K.Granner, Victor
W.Rodwell, “Harper’s Illustrated Biochemistry” 27TH
edition Ch:41 Page: 457
• John T.Hensen, Bruce M.Koeppen, “Netter’s Atlas
Of Physiology” 5th edition Ch:8 Fig. 8.19,8.20
• Robert B.Dunn “Kaplan Medical Physiology USMLE
Step 1 Lecture Notes” Section:9 Ch: 5 Page:
407-413
• Insulin by Dr. Dana Armstrong and
Dr. Allen Bennett King
42. Acknowledgements
• Almighty Allah for giving me
audacity for my each step to its triumphant
completion
My Parents
Head of Biochemistry Department
Dr. Shafqat Nazir
All teachers of biochemistry department
My Friends
Library staff
Projectionist