Fournier's gangrene is a necrotizing fasciitis of the genital region that is usually polymicrobial in nature. It is more common in males ages 30-60 and risk factors include diabetes, alcoholism, malignancy, and immunosuppression. The infection spreads rapidly in fascial planes due to bacterial enzymes and can cause tissue death. Treatment involves aggressive surgical debridement and broad spectrum antibiotics. Complications can include organ failure, shock, and death if not treated promptly.
NECROTISING FASCIITIS- the flesh eating infection
#surgicaleducator #necrotisingfasciitis #surgicaltutor #babysurgeon #usmle
· Dear Viewers
· Greetings from “Surgical Educator”
· Today in this episode I have discussed about Necrotising Fasciitis- the flesh eating infection
· It is common in immunocompromised patients even after trivial trauma.
· I have discussed about the overview,etiology,types,clinical features,complications and treatment of Necrotising Fasciitis
· I hope this video is interesting and also useful to all of you
· You can watch the video in the following links:
· surgicaleducator.blogspot.com youtube.com/c/surgicaleducator
Thank you for watching the video
NECROTISING FASCIITIS- the flesh eating infection
#surgicaleducator #necrotisingfasciitis #surgicaltutor #babysurgeon #usmle
· Dear Viewers
· Greetings from “Surgical Educator”
· Today in this episode I have discussed about Necrotising Fasciitis- the flesh eating infection
· It is common in immunocompromised patients even after trivial trauma.
· I have discussed about the overview,etiology,types,clinical features,complications and treatment of Necrotising Fasciitis
· I hope this video is interesting and also useful to all of you
· You can watch the video in the following links:
· surgicaleducator.blogspot.com youtube.com/c/surgicaleducator
Thank you for watching the video
Disclaimer: A lot from this slides were taken also from https://www.slideshare.net/babysurgeon/scrotal-swellings-1 (Dr Selvaraj Balasubramani)
This covers only :
ANATOMY
CAUSES
TORSION OF TESTIS
EPIDIDYMO-ORCHITIS
HYDROCELE
EPIDIDYMAL CYST
VARICOCELE
Disclaimer: A lot from this slides were taken also from https://www.slideshare.net/babysurgeon/scrotal-swellings-1 (Dr Selvaraj Balasubramani)
This covers only :
ANATOMY
CAUSES
TORSION OF TESTIS
EPIDIDYMO-ORCHITIS
HYDROCELE
EPIDIDYMAL CYST
VARICOCELE
DETAILED DISCUSSION OF NECROTIZING FASCIITIS.
A SOFT TISSUE INFECTION. USUALLY CALLED AS FLESH EATING BACTERIAL INFECTION. CAUSED BY BACTERIA. AFFECTS THE SOFT SKIN TISSUES
Meningococci are a type of bacteria that cause serious infections. The most common infection is meningitis, which is an inflammation of the thin tissue that surrounds the brain and spinal cord. Meningococci can also cause other problems, including a serious bloodstream infection called sepsis. In its early stages, you may have flu-like symptoms and a stiff neck. But the disease can progress quickly and can be fatal. Early diagnosis and treatment are extremely important. Lab tests on your blood and cerebrospinal fluid can tell if you have it. Treatment is with antibiotics. Since the infection spreads from person to person, family members may also need to be treated.
A vaccine can prevent meningococcal infections.
Necrotizing fasciitis has also been referred to as haemolytic streptococcal gangrene, Meleney ulcer, acute dermal gangrene, hospital gangrene, suppurative fasciitis, and synergistic necrotizing cellulitis.
Fournier gangrene is a form of necrotizing fasciitis that is localized to the scrotum and perineal area.
The health hazards associated with obesity. Mortality morbidity
Complications related to obesity
type 2 diabetes.
high blood pressure.
heart disease and strokes.
certain types of cancer.
sleep apnea.
osteoarthritis.
fatty liver disease.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
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Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
4. Definition
Named after French venereologist
Jean Alfred Fournier (1883).
Fournier gangrene is defined as a
polymicrobial necrotizing fasciitis
of the perineal, perianal, or genital
areas.
6. Etiology & risk factors
• Initially described as idiopathic
• Now in more than 75% cases
inciting cause in known
• Necrotizing process commonly
originates from infection in
anorectum, urogenital tract or skin
of genitalia
7. Etiology
1. Ano-rectal causes –
– infection in the perineal glands
– Manifestation of colorectal injury,
malignancy or diverticulitis
2. Uro-genital causes –
– infection in the bulbourethral glands
– urethral injury
– Iatrogenic injury
– Lower urinary tract infections
8. Etiology (contd.)
3. Dermatologic causes –
– Hidradenitis suppurativa
– Ulceration from scrotal pressure
– Trauma to scrotum or perineum
4. Other less common causes –
– Consequence of bone marrow
malignancy
– Systemic lupus erythematosus
– Crohn’s diseases
9. Causative Bacteria
• Polymicrobial infection
• Minimum of four isolates per case
• Most common aerobe – E. coli
• Most common anaerobes – Bacteroids
• Others – Streptococcus, Staphylococcus,
MRSA – Methicillin Resistant Staphylococcus
aureus, Klebsiella Pseudomonas, Proteus &
Clostridium.
10. Mechanism of spread
Entry of bacteria (act through synergism)
Fibrinoid coagulation of nutrient vessels
Decreased locally blood supply to skin
Decreased tissue oxygen tension
Growth of anaerobes & microaerophilic
organisms
Production of enzyme (Collagenase, Lecithinase,
Hyaluronidase )
Digestion of fascial barrier
Rapid spread of infection
11. Pathology
Pathognomonic findings on pathological
evaluation of tissue are :-
• Necrosis of superficial & deep fascial planes
• Fibrinoid coagulation of the nutrient
arterioles
• Polymorphonuclear cell infiltration
• Presence of micro organisms with in the
involved tissues
• Air in the perineal tissue
12. Incidence
• Age – 30 – 60 years
• Sex – 10 times more common in
males
• Social habits – More common in male
homosexuals (more prone
for Rectal injury)
13. Clinical features
• Begins with insidious onset of pruritus and
discomfort of external genitalia
• Prodromal symptoms of fever and lethargy, which
may be present for 2-7 days before gangrene
• The hallmark of Fournier gangrene is out of
proportion pain and tenderness in the genitalia.
• Increasing genital pain and tenderness with
progressive erythema of the overlying skin
• Dusky appearance of the overlying skin;
subcutaneous crepitation; feculent odor
• Obvious gangrene of a portion of the genitalia;
purulent discharge from wounds
• As gangrene develops, pain subsides (Nerve necrosis)
19. Ultrasonography
• Can be used to detect fluid or
gas in soft tissue
• “Sonographic hallmark” –
Presence of gas in scrotal
tissue
• Excludes other conditions
• Testicular blood flow - N
• Limitations – Direct pressure on
involved tissue causes
inconvenience
20. C.T. Scanning
• Can detect smaller amount of
soft tissue gas
• Defines extent more specifically
• Identifies underlying causes eg.
Small perineal abscess
MRI
• Yields greater soft tissue details
• Create logistic challenges,
especially in critically ill
patients
22. Medical Treatment
1. Restoration of normal organ perfusion
2. Reduction of systemic toxicity
3. Broad spectrum antibiotics to cover anaerobes as well
(cipro+clinda+metro)
4. Vancomycin for MRSA
5. Tetanus prophylaxis
6. Irrigation with super oxidised water
7. Hyperbaric oxygen therapy
8. IV immunoglobulins to neutralize super antigen as
streptotoxin A & B (as adjuvant)
9. Antifungal – if required
10. Non – conventional
- Unprocessed honey – enzyme action
- dressing with gauge soaked with zinc per oxide
23. Surgical treatment
• Repeated aggressive debridement
• Preservation of testes (subcutaneous
pocket from desiccation)
• Reconstruction after infection is over
• Fecal diversion
• Urinary diversion
• Vacuum assisted closure (VAC)
27. Let us revise
• Definition
• Etiology & risk factors
• Pathogenesis & pathology
• Incidence
• Clinical features
• Differential diagnosis
• Investigations
• Treatment –
- Medical
- Surgical
• Complications
Editor's Notes
Bacteria act synergistically causing obliterative endarteritis & production of various enzymes causing destruction
There is imbalance between host immunity & virulence of organism