This document discusses lipids and fatty acids. It defines lipids and lists their main functions. Lipids are classified as simple, complex, or derived, and as saponifiable or non-saponifiable. Fatty acids are described, including their chemistry, classification as saturated or unsaturated, nomenclature, and examples of biologically important fatty acids. Essential fatty acids are discussed along with their importance.
bio chemistry
كيمياء حيوية جامعة الملك سعود
chemistry
كيمياء جامعية
0503964728
محمد منير كيمياء
ابو يوسف
all branched of chemistry bio chemistry - organic chemistry - inorganic chemistry - analytically - spectra - d-block
A complete review of carbohydrates. definition, source of carbohydrates. Importance, function of carbohydrates. translocation of carbohydrates in plants.
Carbohydrates are the most abundant organic molecules in nature.
They are commonly known as saccharides or sugars.
They are primarily composed of the elements carbon, hydrogen and oxygen.
The name carbohydrate literally means “hydrates of carbon”.
Carbohydrates are widely distributed in nature in plants and animals.
The most important carbohydrate found in plants is starch.
It occurs abundantly in roots, tubers, vegetables and grains. The carbohydrate found in animals is glycogen.
It is a storage form of carbohydrate present in liver and muscles, which serves as important sources of energy for vital activities.
bio chemistry
كيمياء حيوية جامعة الملك سعود
chemistry
كيمياء جامعية
0503964728
محمد منير كيمياء
ابو يوسف
all branched of chemistry bio chemistry - organic chemistry - inorganic chemistry - analytically - spectra - d-block
A complete review of carbohydrates. definition, source of carbohydrates. Importance, function of carbohydrates. translocation of carbohydrates in plants.
Carbohydrates are the most abundant organic molecules in nature.
They are commonly known as saccharides or sugars.
They are primarily composed of the elements carbon, hydrogen and oxygen.
The name carbohydrate literally means “hydrates of carbon”.
Carbohydrates are widely distributed in nature in plants and animals.
The most important carbohydrate found in plants is starch.
It occurs abundantly in roots, tubers, vegetables and grains. The carbohydrate found in animals is glycogen.
It is a storage form of carbohydrate present in liver and muscles, which serves as important sources of energy for vital activities.
Lipids may be regarded as organic substances which is insoluble in water, soluble in organic solvents (alcohol , ether etc.), Triacylglycerols (formerly triglycerides) are the esters of glycerol with fatty acids.
“These are the naturally Organic compounds, insoluble in water, soluble in organic solvents (alcohol, ether, etc.), which are potentially related to fatty acids & utilized by living cells."
Lipids are a heterogeneous group of compounds.
They are esters of fatty acids. Lipids occur widely in plants and animals. Lipids include fats, oils, waxes, and related compounds.
Lipids are a family of organic compounds, composed of fats and oils. These molecules yield high energy and are responsible for different functions within the human body.
Monounsaturated fatty acids contain nine calories per gram and should be consumed in moderation in order to regulate calories to acceptable daily intake levels. MUFAs are so important dietarily is because they have anti-inflammatory properties that contribute to the overall health of the body. KTV1 groundnut oil contains mufa pufs which is the best cooking oil.
Lipids may be regarded as organic substances which is insoluble in water, soluble in organic solvents (alcohol , ether etc.), Triacylglycerols (formerly triglycerides) are the esters of glycerol with fatty acids.
“These are the naturally Organic compounds, insoluble in water, soluble in organic solvents (alcohol, ether, etc.), which are potentially related to fatty acids & utilized by living cells."
Lipids are a heterogeneous group of compounds.
They are esters of fatty acids. Lipids occur widely in plants and animals. Lipids include fats, oils, waxes, and related compounds.
Lipids are a family of organic compounds, composed of fats and oils. These molecules yield high energy and are responsible for different functions within the human body.
Monounsaturated fatty acids contain nine calories per gram and should be consumed in moderation in order to regulate calories to acceptable daily intake levels. MUFAs are so important dietarily is because they have anti-inflammatory properties that contribute to the overall health of the body. KTV1 groundnut oil contains mufa pufs which is the best cooking oil.
Lipids-Introduction, properties and functions.
Classification-Simple lipids, complex lipids and derived lipids.
Lipids contain fatty acid and alcohol.
Saturated and Unsaturated fatty acids. Nomenclature of fatty acids, Cis-trans isomerism, essential fatty acids
Simple lipids-Fats, waxes
Compound lipids-Structure, function with examples of Phospholipids, Glycolipids, sulpholipids and lipoproteins.
Derived lipids: Structure, types, and functions of steroids, terpenes and carotenoids.
Lipoproteins-classified into chylomicrons, very low-density lipoproteins (VLDL), low density lipoproteins (LDL) and high-density lipoproteins (HDL) and their function.
Eicosanoids-prostanoids, leukotrienes (LTs), and lipoxins (LXs).
Functions of Eicosanoids
Lipids, micelles and liposomes.
Lipids-definition, functions.
Fatty acids- saturated and unsaturated fatty acids-definition, examples
Essential and non essential fatty acids, melting point of fatty acids.
Triacylglycerol and wax, phospholipids, glycolipids, Eicosanoids, plasma lipoproteins
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Chemistry of lipids
1. LIPIDS
In pursuit of quality education
DR. USMAN SALEEM
Pharm.D, M.Phil. Scholar, R.Ph,
Lecturer Pharmaceutical Biochemistry
Rashid Latif College of Pharmacy
2. CHAPTER OUTLINES
Chemistry of Fatty acids and Lipids
Classification
Saponifiable and non-saponifiable lipids
Simple, Complex and Derived lipids
Reactions of Fatty acids and other Lipids,
Essential fatty acids,
Biological and pharmaceutical importance of lipids.
3. 1. Define and List the Functions of Lipids
Learning
Objective
4. DEFINITION
The lipids are a heterogeneous group of compounds
related to fatty acids and include fats, oils, waxes and
other related substances.
These are oily or greasy organic substances, relatively insoluble in
water, and considerably soluble in organic solvents like ether,
chloroform and benzene.
The term ‘lipid’ was first used by the German biochemist Bloor
in 1943 for a major class of tissue components and foodstuffs.
5. FUNCTIONS OR BIOLOGICAL IMPORTANCE
1. Storage form of energy (triacylglycerol)
2. Structural components of biomembranes (phospholipids and cholesterol)
3. Metabolic regulators (steroid hormones and prostaglandins)
4. Act as surfactants, detergents and emulsifying agents (amphipathic lipids)
5. Act as electric insulators in neurons
6. FUNCTIONS OR BIOLOGICAL IMPORTANCE
6. Provide insulation against changes in external temperature (subcutaneous fat)
7. Give shape and contour to the body
8. Protect internal organs by providing a cushioning effect (pads of fat)
9. Help in absorption of fat soluble vitamins (A, D, E and K)
10. Improve taste and palatability of food.
7. 2. Classify Lipids as Simple, Complex and
Derived, and as Saponifiable or Nonsaponifiable.
Learning
Objective
8. CLASSIFICATION OF LIPIDS
Two commonly used classification systems exist for lipids:
A system based on chemical composition of lipids (Bloor’s Classification), and
A system based on particular chemical reaction (Saponification) that lipids
undergo.
9. CLASSIFICATION OF LIPIDS
Bloor has proposed the following classification of lipids based on their chemical
composition.
1. Simple lipids: These are esters of fatty acids with various alcohols.
a) Neutral Fats (Triacylglycerol,TAG):
These are esters of fatty acids with trihydroxy alcohol, glycerol. Oils are fats in the
liquid state.
b) Waxes:
These are esters of fatty acids with higher molecular weight monohydric alcohols.
10. CLASSIFICATION OF LIPIDS
2. Compound lipids: These are esters of fatty acids with alcohol and possess
additional group(s) also.
a) Phospholipids:
These are lipids containing, in addition to fatty acids and glycerol, a phosphoric acid,
a nitrogen base and other substituents. For example, in glycerophospholipids the
alcohol is glycerol and in sphingophospholipids, the alcohol is sphingosine.
b) Glycolipids:
These are lipids containing a fatty acid, sphingosine, and carbohydrate.
11. CLASSIFICATION OF LIPIDS
3. Derived Lipids: These are compounds obtained by hydrolysis of simple of
compound lipids. These include fatty acids, alcohols, mono- and diglycerides, steroids,
terpenes and carotenoids.
Glycerides and cholesterol esters, because of their uncharged nature, are also
called neutral lipids.
12. CLASSIFICATION OF LIPIDS
Lipids are grouped into two main classes in the chemical reaction (saponification)
classification system:
1) Saponifiable lipids
2) Nonsaponifiable lipids.
Saponification refers to the process in which esters are hydrolyzed under
basic conditions.
13. CLASSIFICATION OF LIPIDS
Saponifiable Lipids
Saponifiable lipids are esters that
undergo hydrolysis in basic solution to
yield two or more smaller product
molecules.
Triglycerides, waxes, phospholipids, and
sphingolipids are all belong to this class.
Non-Saponifiable Lipids
Nonsaponifiable lipids are not esters
and cannot be hydrolyzed into smaller
components.
Steroids and prostaglandins belong to
this class.
16. FATTY ACIDS
Fatty acids are long, unbranched hydrocarbon chains with a carboxylic acid group at
one end.
It is represented by a chemical formula R-COOH, where R stands for hydrocarbon
chain.
Fatty acids are amphipathic compounds because the carboxyl group is hydrophilic
and the hydrocarbon tail is hydrophobic.
The carboxyl group can ionize as the carboxylate anion (–COO- ) under the proper
conditions of physiological pH.
17. FIGURE: The molecular structure of fatty acid. A. Lauric acid and B. a simplified
diagram of a fatty acid with a nonpolar tail and a polar head.
18. FATTY ACIDS
• In aqueous solution, the ions of fatty
acids associate to form spherical
clusters, called micelles.
• In micelles, the nonpolar chains extend
toward the interior of the structure
away from water, and the polar
carboxylate groups face outward in
contact with the water.
19. FATTY ACIDS
The fatty acids found in natural lipids have several characteristics in common:
1. They are usually straight-chain carboxylic acids (no branching).
2. The sizes of most common fatty acids range from 10 to 20 carbons.
3. Fatty acids usually have an even number of carbon atoms (including the carboxyl
group carbon).
4. Fatty acids can be saturated (containing no double bonds between carbons) or
unsaturated (containing one or more double bonds between carbons).
20. FATTY ACIDS
5. In terms of carbon chain length, fatty acids are characterized as:
Long-chain fatty acids (C12 to C26),
Medium chain fatty acids (C8 and C10), or
Short-chain fatty acids (C4 and C6).
6. Fatty acids are rarely found free in nature but rather occur as part of the structure
of more complex lipid molecules.
21. CLASSIFICATION OF FATTY ACIDS
The hydrocarbon chain of a fatty acid may or may not contain carbon–carbon double
bonds.
On the basis of this consideration, fatty acids are classified as:
1. Saturated fatty acids (SFAs),
2. Unsaturated Fatty Acids
3. Monounsaturated fatty acids (MUFAs), and
4. Polyunsaturated fatty acids (PUFAs).
22. CLASSIFICATION OF FATTY ACIDS
1. Saturated Fatty Acids
A saturated fatty acid is a fatty acid with a carbon chain in which all carbon–
carbon bonds are single bonds.
Examples include:
Propionic acid
Palmitic acid
Stearic acid
23. CLASSIFICATION OF FATTY ACIDS
2. Unsaturated Fatty Acids
They are classified further according to degree of unsaturation.
a) Monounsaturated Fatty Acids (MUFA’s)
b) Polyunsaturated Fatty Acids (PUFA’s)
24. CLASSIFICATION OF FATTY ACIDS
a) Monounsaturated Fatty Acids
A monounsaturated fatty acid
is a fatty acid with a carbon chain
in which one carbon–carbon
double bond is present.
For example, Oleic acid is a
monounsaturated fatty acid, that is
found in nearly all fats.
25. CLASSIFICATION OF FATTY ACIDS
b) Polyunsaturated Fatty Acids
A polyunsaturated fatty acid is a fatty acid with a carbon chain in which two
or more carbon–carbon double bonds are present.
Up to six double bonds are found in biochemically important PUFAs; they
include:
• Dienoic acids series have two double bonds, e.g. linoleic acid
• Trienoic acids series have three double bonds, e.g. linolenic acid
• Tetraenoic acid series with four double bonds, e.g. arachidonic acid
26. NOMENCLATURE OF FATTY ACIDS
The systematic nomenclature of the fatty acids is based on the Genevan system.
According to this system, the fatty acid is named after the hydrocarbon with the
same number of carbon atoms.
The suffix -oic is written in place of the final letter e in the name of the hydrocarbon.
The names of saturated fatty acids end with the suffix –anoic e.g., Octadecanoic
acid.
The names of unsaturated fatty acids end with the suffix –enoic e.g.,
Octadecenoic acid (Oleic acid).
27. NOMENCLATURE OF FATTY ACIDS
The position of carbon atoms in the fatty
acid chain is indicated either:
By numbering - in which case the
carboxyl carbon is numbered as C1, the
carbon adjacent to C1 as C2 and so on;
or
By the use of Greek letters - in which
case C2 is denoted as a-carbon, C3 as b-
carbon and so on, while the terminal
methyl (-CH3) carbon is known as w-
carbon.
28. NOMENCLATURE OF FATTY ACIDS
The notation most commonly used for fatty acids indicates the:
• Number of carbon atoms, and
• Number of double bonds.
The notation 18:0 denotes an C18 fatty acid with no double bonds, while 18:1
signifies an C18 fatty acid with one double bond.
29. NOMENCLATURE OF FATTY ACIDS
To specify double-bond positioning within the carbon chain of an unsaturated fatty
acid, the preceding notation is expanded by adding the Greek capital letter delta (D)
followed by one or more superscript numbers.
The notation 18:3(D9,12,15) denotes a C18 PUFA with three double bonds at locations
between carbons 9 and 10, 12 and 13, and 15 and 16.
30. SELECTED FATTY ACIDS OF BIOLOGICAL IMPORTANCE
Saturated Fatty Acids
Common Name Structural
Notation
Formula Common Sources
Lauric Acid 12:0 CH3(CH2)10COOH Laurel oil, Spermaceti
Myristic Acid 14:0 CH3(CH2)12COOH Butter and wool fat
Palmitic Acid 16:0 CH3(CH2)14COOH Palm Oil
Stearic Acid 18:0 CH3(CH2)16COOH Animal and plant fats
Arachidic Acid 20:0 CH3(CH2)18COOH Peanut Oil
31. SELECTED FATTY ACIDS OF BIOLOGICAL IMPORTANCE
Unsaturated Fatty Acids
Common
Name
Structural
Notation
Formula Common
Sources
Oleic Acid 18:1 – D9
CH3(CH2)7CH=CH(CH2)7COOH
Animal and plant
fats
Linoleic Acid 18:2 – D9,12
CH3(CH2)4CH=CH(CH2)CH=CH(CH2)7COOH
Peanut &
cottonseed Oil
Linolenic Acid 18:3 – D9,12,15
CH3(CH2CH=CH)3(CH2)7COOH Linseed Oil
Arachidonic Acid 20:4 – D5,8,11,14
CH3 (CH2)4(CH=CHCH2) 4(CH2)2COOH Animal fats
32. ISOMERISM IN FATTY ACIDS
The unsaturated fatty acids exhibit geometric (or cis-trans) isomerism at the double
bonds.
In biochemically important MUFAs, the configuration about the double bond is nearly
always cis rather than trans.
‘Cis’ form is comparatively unstable and is more reactive.
For example, Oleic acid can exist in two forms: cis-oleic acid and trans-oleic acid which is
also called elaidic acid.
34. ISOMERISM IN FATTY ACIDS
‘Cis’ configuration creates a rigid
30o
bend, or kink, in the fatty acid
chain that is not found in
saturated fatty acids.
Such a bend affects the physical
properties of a fatty acid.
35. ESSENTIAL FATTY ACIDS
Essential fatty acids are those polyunsaturated fatty acids that cannot be synthesized
by our cells and we should obtain them from plants through diet.
Linoleic acid and linolenic acid are the only essential fatty acids for animals.
Other polyunsaturated fatty acids can be synthesized from these essential fatty acids.
For example, arachidonic acid can be synthesized only from linoleic acid.
Therefore, in deficiency of linoleic acid, arachidonic acid also becomes an essential
fatty acids.
36. IMPORTANCE OF ESSENTIAL FATTY ACIDS
Linoleic acid is the starting material for the biosynthesis of arachidonic acid.
Arachidonic acid is the major starting material for eicosanoids, substances that help
regulate blood pressure, clotting, and several other important body functions.
Linolenic acid is the starting material for the biosynthesis of two additional omega-3
fatty acids.
Linolenic acid (18:3) → EPA (20:5) → DHA (22:6)
37. IMPORTANCE OF ESSENTIAL FATTY ACIDS
EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are important
constituents of the communication membranes of the brain and are necessary for
normal brain development.
EPA and DHA are also active in the retina of the eye.