This document provides an overview of lipids and fatty acids. It defines lipids as compounds that are insoluble in water but soluble in organic solvents. Lipids have important functions like energy storage, structural components of cell membranes, and as signaling molecules. Lipids are classified based on their chemical structure into simple lipids, compound lipids, and derived lipids. Fatty acids are the most common lipid component and can be saturated or unsaturated. The properties, synthesis, and breakdown of lipids are also discussed.
introduction of Lipids,Chemistry,Fuctions of lipids,Classification of lipids Structural elucidation of Essential Fatty acid,Prostaglandins, Vitamin A, Phospolipids,Cholesterol,Lanosterol,
introduction of Lipids,Chemistry,Fuctions of lipids,Classification of lipids Structural elucidation of Essential Fatty acid,Prostaglandins, Vitamin A, Phospolipids,Cholesterol,Lanosterol,
Fatty acids are obtained from the hydrolysis of fats.
Fatty acids that occur in natural fats usually contain an even number of carbon atoms (due to synthesis from 2-carbon units) and are straight chain derivatives.
The chain may be saturated (containing no double bonds) or unsaturated (containing one or more double bonds).
Fatty acids are the building blocks of the fat in our bodies and in the food we eat. During digestion, the body breaks down fats into fatty acids, which can then be absorbed into the blood. Fatty acid molecules are usually joined together in groups of three, forming a molecule called a triglyceride.
Lipids structure, classification, functions and propertiesKambhampatiChinmayi
This presentation would provide a better understanding of the basics required to get a grip on lipids. Hope it is useful. any suggestions would be humbly accepted. Thank you.
Chemistry of carbohydrates polysaccharides part 3 B heteroglycansRavi Kiran
Chemistry of carbohydrates polysaccharides part 3 B heteroglycans. To teach Ist year medical students.
Chemistry of carbohydrates Part-1 Monosaccharides
Part-2 Disaccharides
Part -3A Homoglycans
Part-3B Heteroglycans
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
4. Definition of lipids
• Lipids may be defined as compounds which are relatively insoluble in
water, but freely soluble in non-polar organic solvents, such as
benzene, chloroform, ether, hot alcohol, acetone, etc.
• Lipids constitute a heterogeneous group of compounds of
biochemical importance.
5. The functions of lipids are summarized
1. Storage form of energy (triacylglycerol).
2. Structural components of biomembranes (phospholipids and
cholesterol).
3. Metabolic regulators (steroid hormones and prostaglandins).
4. Act as surfactants, detergents and emulsifying agents (amphipathic
lipids).
5. Act as electric insulators in neurons.
6. The functions of lipids are summarized
6. Provide insulation against changes in external temperature
(subcutaneous fat).
7. Give shape and contour to the body.
8. Protect internal organs by providing a cushioning effect (pads of
fat).
9. Help in absorption of fat soluble vitamins (A, D, E and K).
10. Improve taste and palatability of food.
7. The clinical applications
1. Excessive fat deposits cause obesity. Truncal obesity is a risk factor
for heart attack.
2. Abnormality in cholesterol and lipoprotein metabolism leads to
atherosclerosis and cardiovascular diseases.
3. In diabetes mellitus, the metabolisms of fatty acids and lipoproteins
are deranged, leading to ketosis.
8. CLASSIFICATION OF LIPIDS
Based on the chemical nature, lipids are classified as:
1. Simple lipids
2. Compound lipids
3. Derived lipids
4. Lipids complexed to other compounds
9. CLASSIFICATION OF LIPIDS
Based on the chemical nature
1. Simple lipids:
• They are esters of fatty acids with glycerol or other higher
alcohols.
a. Triacylglycerol or Triglycerides or neutral fat
b. Waxes
10. CLASSIFICATION OF LIPIDS
Based on the chemical nature
2. Compound lipids
• They are fatty acids esterified with alcohol; but in addition they
contain other groups. Depending on these extra groups, they are
sub classified.
a. Phospholipids, containing phosphoric acid.
b. Non-phosphorylated lipids
11. CLASSIFICATION OF LIPIDS
Based on the chemical nature
3. Derived lipids
• They are compounds, which are derived from lipids or precursors of
lipids.
e.g. fatty acids, steroids – cholesterol, prostaglandins,
leukotrienes, terpenes, dolichols, etc.
12. CLASSIFICATION OF LIPIDS
Based on the chemical nature
4. Lipids complexed to other compounds
Proteolipids and lipoproteins
18. FATTY ACIDS
• Fatty acids, are included in the group of derived lipids.
• It is the most common component of lipids in the body.
• They are generally found in ester linkage in different classes of lipids.
• In the human body, free fatty acids are formed only during
metabolism.
19. FATTY ACIDS
• Fatty acids are aliphatic carboxylic acids and have the general
formula, R—CO—OH, where COOH (carboxylic group) represents the
functional group.
• Depending on the R group (the hydrocarbon chain), the physical
properties of fatty acids may vary.
23. SATURATED FATTY ACIDS
1. They have the general formula CH3-(CH2)n-COOH.
• For example,
a. Acetic acid CH3—COOH
b. Butyric acid CH3(CH2)2—COOH
c. Palmitic acid CH3—(CH2)14—COOH
d. Stearic acid CH3—(CH2)16—COOH
24. SATURATED FATTY ACIDS
2. They are named by adding the suffix ‘anoic' after the hydrocarbon.
3. The two carbon acetic acid and 4 carbon butyric acid are important
metabolic intermediates.
4. The C16 (palmitic acid) and C18 (stearic acid) are most abundant in
body fat.
25. SATURATED FATTY ACIDS
5. Each animal species will have characteristic pattern of fatty acid
composition. Thus, human body fat contains 50% oleic acid, 25%
palmitic acid, 10% linoleic and 5% stearic acid.
6. The carbon atoms of fatty acids are numbered as C1, C2, etc.
starting from the COOH group. Or, starting from the methyl end, the
carbon atoms may be numbered as omega (w)—1,2,3, etc.
26. UNSATURATED FATTY ACIDS
• They are named by adding the suffix ‘enoic' after the systematic
name.
• They are similar to saturated fatty acids in the reaction of the
carboxylic group but also show properties due to presence of the
double bond.
27. UNSATURATED FATTY ACIDS
• Unsaturated fatty acids exhibit geometrical isomerism at the double
bonds.
• All the naturally occurring fatty acids have the cis configuration.
However, in the body during metabolism trans fatty acids are formed.
Cis and trans forms of fatty acid
28. UNSATURATED FATTY ACIDS
• The polyunsaturated fatty acids (PUFA) exist in cis configuration in
naturally occurring lipids.
Clinical significance of PUFA is shown in Box.
30. UNSATURATED FATTY ACIDS
• Many clinical and epidemiologic studies have shown positive roles for
omega-3 fatty acids in infant development; cancer; cardiovascular
diseases; and more recently, in various mental illnesses, including
depression, attention-deficit hyperactivity disorder, and dementia.
omega-3 fatty acids
31. UNSATURATED FATTY ACIDS
• These fatty acids are known to have pleiotropic effects, including
effects against inflammation, platelet aggregation, hypertension, and
hyperlipidemia.
• These beneficial effects may be mediated through several distinct
mechanisms, including alterations in cell membrane composition and
function, gene expression, or eicosanoid production.
omega-3 fatty acids
32. TRANS FATTY ACIDS (TFA)
• They are present in dairy products and in hydrogenated edible oils.
They are generally considered to be injurious to health.
• However, they are used in food industry as they increase the shelf life
of the fried food.
• Oils containing PUFA also have high content of TFA. Fast food
preparations have a high TFA content.
33. TRANS FATTY ACIDS (TFA)
• Trans fatty acids adversely affects multiple risk factors for chronic
diseases, including composition of blood lipids and lipoproteins,
systemic inflammation, endothelial dysfunction, insulin resistance,
diabetes and adiposity.
34. TRANS FATTY ACIDS (TFA)
• It is high in processed foods and bakery products, where partially
hydrogenated vegetable oils are used for cooking.
35. Properties of Fatty Acids
• Hydrogenation
• Halogenation
• Melting Point
• Salt Formation
• Ester Formation
• Oxidation of Fatty Acids
36. Properties of Fatty Acids
• Hydrogenation
• Unsaturated fatty acids may be converted to the corresponding
saturated fatty acids by hydrogenation of the double bond.
• Hydrogenation of oils can lead to solidification and saturation, e.g.
Vanaspathi.
37. Properties of Fatty Acids
• Halogenation
• When treated with halogens under mild conditions, the unsaturated
fatty acids can take up two halogen atoms, at each double bond to
form the halogenated derivative of the fatty acid.
For example,
Oleic acid + I2 → Di-iodo oleic acid
38. Properties of Fatty Acids
• Halogenation
• The number of halogen atoms taken up will depend on the number of
double bonds and is an index of the degree of unsaturation.
39. Properties of Fatty Acids
• Melting Point
• The short and medium chain fatty acids are liquids, whereas long
chain fatty acids are solids at 25oC.
• The solubility in water decreases, while melting and boiling points
increase with increase in chain length.
40. Properties of Fatty Acids
• Melting Point
• The unsaturated fatty acids have lower melting point compared to
saturated fatty acids with the same chain length.
• For example, stearic acid (C18 fatty acid, no double bond) has the
melting point 69oC, oleic acid (C18, 1 double bond) has 13oC; linoleic
acid (C18, 2 double bonds) has –5oC and linolenic (C18, 3 double
bonds) has –10oC.
41. Properties of Fatty Acids
• Salt Formation
Saturated and unsaturated fatty acids form salts with alkali.
CH3—COOH + NaOH → CH3—COONa + H2O
Sodium and potassium salts of long chain fatty acids are called soaps.
Calcium and magnesium soaps are insoluble. Calcium soaps are used in
grease.
42. Properties of Fatty Acids
• Salt Formation
Alkyl sulfate (R—CH2—O—SO2—ONa) and alkyl sulfonate
(R—CH2—SO2—O—Na) are not precipitated by hard water and are
used as detergents.
43. Properties of Fatty Acids
• Ester Formation
• Both saturated and unsaturated fatty acids form esters with alcohols,
especially with glycerol. Fatty acids can form mono-, di- or tri- esters
with alcohol groups of glycerol.
Triacylglycerol (TAG) (Triglyceride)
44. Properties of Fatty Acids
• Ester Formation
• Triglycerides or triacylglycerols are also known as neutral fat.
• Glycerol + fatty acid → Monoacylglycerol
• Monoglyceride + fatty acid → Diacylglycerol
• Diglyceride + fatty acid → Triglyceride or triacylglycerol
45. Properties of Fatty Acids
• Oxidation of Fatty Acids
• All fatty acids undergo oxidation in the body to give energy. Beta-
oxidation is the major process by which acids are oxidized. However,
the unsaturated fatty acids can undergo auto-oxidation, due to the
presence of the highly reactive double bonds and a variety of
products are formed.
46. NEUTRAL FATS
• Neutral fats are also called as triacylglycerols (TAG) or triglycerides
(TG). These are esters of the trihydric alcohol, glycerol with fatty
acids.
Triacylglycerol (TAG) (Triglyceride)
47. NEUTRAL FATS
• Nomenclature of Carbon Atoms
• As per International Union of Biochemistry (IUB) the correct
designations are monoacylglycerol, diacylglycerol and triacylglycerol.
But the old terminology of monoglyceride, diglyceride and triglyceride
are still popular, especially among clinical laboratory workers.
48. NEUTRAL FATS
• Nomenclature of Carbon Atoms
• The carbon atoms of glycerol are designated as α, β and a' or as 1, 2,
3 as shown, where R represents the side chain of fatty acids. Enzymes
can distinguish between 1st and 3rd carbon atoms.
Triacylglycerol (TAG) (Triglyceride)
49. NEUTRAL FATS
• Mixed Triglycerides
1. Naturally occurring fats and oils are mixtures of triglycerides.
2. If all the three hydroxyl groups of the glycerol are esterified to the
same fatty acid, a simple triacylglycerol is formed, e.g. Tripalmitin,
Triolein, etc.
50. NEUTRAL FATS
Mixed Triglycerides
3. A mixed triglycerol is formed, when different fatty acids are
esterified to the hydroxyl groups of glycerol.
4. Generally, two hydroxyl groups are esterified to similar fatty acid
and the third with a different one, e.g. 1, 3-dipalmitoyl-2-olein; 1-
palmitoyl-2, 3-distearin, etc. When a PUFA is present, it is
commonly esterified to the 2nd or b-carbon atom.
51. Physical Properties of Triacylglycerols
1. They are hydrophobic and insoluble in water.
2. Oils are liquids at 20oC; they are triacylglycerols, which contain a
higher proportion of unsaturated fatty acids or short chain
triglycerides. Oils are generally of plant origin.
3. Fats are solids at room temperature and contain mainly saturated
long chain fatty acids. Fats are mainly of animal origin.
52. Physical Properties of Triacylglycerols
4. When the constituent fatty acids have a higher chain length and are
predominantly saturated, ‘hard fat' is formed, e.g. pig fat.
5. Fats containing medium chain triacylglycerols or unsaturated fatty
acids are soft fats, e.g. butter, coconut oil. Coconut oil contains
mainly medium chain TAG, e.g. Lauric and Myristic acids.
53. Storage of Energy as Fat
• The triacylglycerols are the storage form of lipids in the adipose
tissue.
• In a 70 kg normal person, body stores contain about 11 kg of
triacylglycerol, which is roughly equivalent to 100,000 kcal.
54. Storage of Energy as Fat
• If the same calories were stored as hydrated glycogen, the total
weight of this alone would have been 65 kg! When stored as TAG,
water molecules are repelled and space requirement is minimal.
Excess fat in the body leads to obesity.
55. Hydrolysis of Triacylglycerols
• This occurs in the body during digestion of dietary fat and
mobilization of TAG from adipose tissue.
• Triacylglycerols in the body are hydrolyzed by enzymes, lipases which
are hydrolases.
56. Hydrolysis of Triacylglycerols
• Triacylglycerol is sequentially hydrolyzed to diacylglycerol and
monoacylglycerol and finally glycerol plus 3 fatty acids.
Hydrolysis of triglycerides
57. Saponification
• When triacylglycerols are hydrolyzed by alkali, the process is known
as saponification. The products are glycerol and soaps.
Saponification
58. Saponification
• Saponification number is defined as the number of milligrams of
potassium hydroxide required to saponify one gram of fat.
• It is an indication of the molecular weight of the fat, and is inversely
proportional to it. Human fat has a saponification number of 194–
198, butter has 210– 230 and coconut oil has 253–262.
59. Iodine Number
• Iodine number of a fat is defined as the number of grams of iodine
taken up by 100 grams of fat.
• It is an index of the degree of unsaturation and is directly
proportional to the content of unsaturated fatty acids.
60. Iodine Number
• Higher the iodine number, higher is the degree of unsaturation, e.g.
iodine number of butter is 28, and that of sunflower oil is 130.
61. Rancidity of Fat
• Fats and oils have a tendency to become rancid.
• The term rancidity refers to the appearance of an unpleasant smell
and taste for fats and oils.
62. Rancidity of Fat
• Hydrolytic rancidity is due to partial hydrolysis of the triacylglycerol
molecules due to traces of hydrolytic enzymes present in naturally
occurring fats and oils.
63. Rancidity of Fat
• Oxidative rancidity is the result of partial oxidation of unsaturated
fatty acids with resultant formation of epoxides and peroxides of
small molecular weight fatty acids by peroxides and free radicals.
• The same process, if it occurs in vivo will affect the integrity of
biomembranes, leading to cell death
64. Rancidity of Fat
• Many natural fats and oils may contain antioxidants (e.g. vitamin E),
which prevent the occurrence of oxidative rancidity.
• PUFA are more easily oxidized; so vegetable oils with a high content
of PUFA are usually preserved with addition of antioxidants.
65. Rancidity of Fat
• Repeated heating of oils would lead to the formation and
polymerization of cyclic hydrocarbons.
• These will impart an unpleasant taste and color to the oil.
• Coconut oil having medium chain saturated fatty acids will withstand
such polymerization.
66. Waxes
• They form the secretions of insects, leaves and fruits of plants, e.g.
Lanolin or wool fat, beeswax, whalesperm oil, etc.
• They are esters of higher fatty acids with higher monohydroxy
aliphatic alcohols and so have very long straight chains of 60–100
carbon atoms.
• They are used as the base for the preparation of cosmetics,
ointments, polishes, lubricants and candles.