I. Lipids provide stored energy in the form of triacylglycerols and participate in cell membranes as phospholipids. They are hydrophobic and insoluble in water.
II. The main types of lipids include fatty acids, triacylglycerols, phospholipids, sterols, and derived lipids produced from hydrolysis.
III. Phospholipids are important structural components of cell membranes and contain a phosphate group. Sterols include cholesterol and are amphipathic with a polar hydroxyl group.
Proteins are the macromolecules responsible for the biological processes in the cell. They consist at their most basic level of a chain of amino acids, determined by the sequence of nucleotides in a gene. Depending on the amino acid sequence (different amino acids have different biochemical properties) and interactions with their environment, proteins fold into a three-dimensional structure, which allows them to interact with other proteins and molecules and perform their function
Proteins are the macromolecules responsible for the biological processes in the cell. They consist at their most basic level of a chain of amino acids, determined by the sequence of nucleotides in a gene. Depending on the amino acid sequence (different amino acids have different biochemical properties) and interactions with their environment, proteins fold into a three-dimensional structure, which allows them to interact with other proteins and molecules and perform their function
Carbohydrates are generally classified into monosaccharides (simple sugars), oligosaccharides (containing few sugar units) and polysaccharides (containing many sugar units).
Monosaccharides are sugar molecules containing short chain of carbon atoms, one aldehydic or ketonic group and hydroxyl groups attached to remaining Carbon atoms.
Oligosaccharides are formed by polymerisation of monosaccharide molecules by elimination of water molecules.
Polysaccharides are high molecular weight substances composed of large number of moosaccharide units combined to form one large polymer molecule. They may be straight chain or branched chain polymers.
Lipid metabolism is the synthesis and degradation of lipids in cells.
It involves the breakdown or storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes.
In animals, these fats are obtained from food or synthesized by the liver.
Carbohydrates are generally classified into monosaccharides (simple sugars), oligosaccharides (containing few sugar units) and polysaccharides (containing many sugar units).
Monosaccharides are sugar molecules containing short chain of carbon atoms, one aldehydic or ketonic group and hydroxyl groups attached to remaining Carbon atoms.
Oligosaccharides are formed by polymerisation of monosaccharide molecules by elimination of water molecules.
Polysaccharides are high molecular weight substances composed of large number of moosaccharide units combined to form one large polymer molecule. They may be straight chain or branched chain polymers.
Lipid metabolism is the synthesis and degradation of lipids in cells.
It involves the breakdown or storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes.
In animals, these fats are obtained from food or synthesized by the liver.
1. LIPIDS.
2. PROPERTIES OF LIPIDS.
3. FATTY ACIDS.
4. USES AND CLASSIFICATION OF FATTY ACIDS.
5. STRUCTURE AND CLASSIFICATION OF LIPIDS.
PHOSPHOLIPIDS: A class of lipid that is a key component of all cell membranes, as they can form lipid biomarkers. Composition: It is composed of phospholipids. i. Glycerol: one molecule ii. Fatty acids: Two molecules. iii. Phosphoric acid: one molecule. When a nitrogen-containing phospholipid group is attached to the end of the phospholipid, it is called phosphatidylcholine. Phospholipids consist of two parts i) Chapter: The head is polar in nature, soluble in water (hydrophilic). n) Tails: Nature has a non-polar tail, insoluble in water (hydrophobic).
Washes: Wax lipids are derived. Wax is a fatty acid ester and chronic alcohol: The wax is composed of i) a long-chain fatty acid ... one molecules ii) long-chain alcohol with one hydroxyl group (-OH), i.e. Cylinder wax is hydrophobic in nature. They have a high melting point, solid at room temperature. it gives stability and declines. On the surfaces of parts of plants, e.g. The leaves and fruits produce a waterproof layer, reducing the rate of perspiration. Wax is also a layer of wax that covers the bodies of animals, e.g., slime, insects, etc.
STEROIDS: Steroids fall under the lipid categories: Steroids are derived from lipid composition: proper arrangement of 3 cyclohexyl rings and 1 cyclopentane ring, a total of 17 carbon atoms in four carbon rings. Steroids do not contain alcohol and fatty acids.
Steroids Examples of steroids: i) Cholesterol: an important factor in animal cells. The precursor of all hormonal molecules such as aldosterone, sex hormone, and vitamin D ii) Aldosterone helps regulate Na+ions in the blood iii) Sex hormones e.g. testosterone, progesterone, and estrogens help to preserve the characteristics of males and females.
TERPENOIDES: It contains a very different class of organic compounds. Terpenoids are lipid derivatives, soluble in fat and soluble in water. Don't use molecule acids like fats. Composite units which they call isoprenoid or isoprenes. Isoprene unit: Hydrocarbon containing five carbon atoms with a branched-chain structure. Isoprene units bind to each other through the condensation process resulting in different types of compounds, e.g. Carotenoids, terpenes, and rubbers, etc.
CAROTENOIDS: Carotenoids are yellow, orange, red, or brown in plants. There are two kinds: i) Carotene: ii) Xanthophylla, i) Carotene: Orange is the genus of carotene, with red color, beta carotene. carrot & rice. Breakdown of beta-carotene leaves two molecules of vitamin A in the human body. n) Xanthophyllus: the auxiliary yellow color found in plants.
6 STORAGE LIPIDS.
7. USES OF LIPIDS.
# ALL ABOUT LIPIDS BY AUTHENTIC BOOKS.
Lipids-definition, functions.
Fatty acids- saturated and unsaturated fatty acids-definition, examples
Essential and non essential fatty acids, melting point of fatty acids.
Triacylglycerol and wax, phospholipids, glycolipids, Eicosanoids, plasma lipoproteins
Lipids may be regarded as organic substances which is insoluble in water, soluble in organic solvents (alcohol , ether etc.), Triacylglycerols (formerly triglycerides) are the esters of glycerol with fatty acids.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
2. The word lipid is derived from a Greek word
“lipos” which means Fat.
Biological lipids are a chemically diverse
group of organic compounds which are
insoluble in water.
They are soluble in non-polar solvents such
as- ether, chloroform, or benzene.
Lipids are hydrophobic in nature due to the
predominance of hydrocarbon chains.(-CH2-
CH2-CH2-) in their structures.
3. Unlike the proteins, nucleic acids, and
polysaccharides, lipids are not polymer.
They are the chief storage form of energy, they
provide 6-fold as much energy as an equivalent
mass of glycogen.
Fat and oils are the principle stored forms of
energy in many organism.
Lipids participate in oxidative phosphorylation.
4. neutral lipids upon hydrolysis yield glycerol
and fatty acids
Many lipid molecules are amphipathic.
In aqueous environment lipid molecules
associate by non-covalent interactions to form
supramolecular structures such as monolayers,
micelles, bilayers and vesicles.
5. Lipids may be regarded as organic substances
relatively insoluble in water, soluble in
organic solvents, potentially related to fatty
acids and utilized by the living cells.
6. They serve as a storage form of metabolic
fuel.
(fatty acid, Triacyglycerol).
they serve as a transport form of metabolic
fuel.(free fatty acid, triglyceride and
cholesterol ester)
They provide the structural components of
membranes(phospholipids, glycolipids,
galactolipids, sphingolipids)
7. they have protective functions in bacteria,
plants, insects, and vertebrates, serving as a
part of the outer coating between the body of
the organism and the environment.
It serve as pigment(carotene),
hormones(vitamin A & D), signaling
molecules(eicosanoids, phosphatidylinositol,
steroid hormone) cofactors(vitamin E, K and
lipid quinones) detergent(bile salt).
8.
9.
10.
11. Derived lipids are the substances derived
from simple and compound lipids by
hydrolysis.
These includes fatty acids, alcohols,
monoglycerides and diglycerides, steroids,
carotenoids.
12. Fatty acids are the simplest form of lipids.
These are monocarboxylic, straight,
unbranched hydrocarbon chains containing
even number of carbon atoms (betweeen 4-
36)
Fatty acids are also known as acyl group
when it is a part of ester.
Fatty acids are amphipathic in nature.
The fatty acids may be free or esterified
with glycerol to form triglycerides.
13.
14. Saturated fatty acids have no double bonds
in the chain or contain single chain.
Their general formula is CH3-(CH2)n-COOH,
where n specifies the number of methylene
groups between the methyl and carboxyl
carbons.
They have higher melting points
They are solid at room temperature.
Examples- lauric, myristic, palmitic acid etc.
15.
16. These fatty acid contain one or more double
bonds along the length of the hydrocarbon chain.
They are liquid at room temperature.
Have low melting point.
The commonly used system for designating the
position of double bond in unsaturated fatty acid
is the delta(∆) numbering system.
Example- linoleic acid, oleic acid, palmitoleic
acid.
In the naturally occurring unsaturated fatty acid
the double bond are in cis configuration and
trans fatty acid are produced by fermentation in
the rumen of dairy animals and are obtained
from dairy products and meat.
17. Monounsaturated fatty acid :-
They contain only one double bond per fatty
acid.
The double bond is between C-9 and C-10(∆9)
18. Polyunsaturated fatty acid or PUFAs:-
They contain two or more double bonds
along the length of the hydrocarbon chains.
PUFAs are also known as essential fatty acid.
Examples- linoleic and linolenic acid
19.
20. Triacylglycerol(triglycerides/fats/neutral
fats) are triesters of fatty acids and glycerol.
They are composed of three fatty acids and a
glycerol molecules.
Triacylglycerols are of two types-
a) Simple- these contains single type of fatty
acids.
b) Mixed- contains two or more different kind
of fatty acid.
21.
22. Triacylglycerols are nonpolar, hydrophobic in
nature and a major form of stored lipids.
These molecules contain fatty acids of
various length and they be saturated or
unsaturated.
They can be distinguished as fat and oil on
the basis of physical state at room
temperature.
23. Saponification
:-
Fats when boiled
with alkali(NaOH,
KOH) or
hydrolysis with
alkali forms soap
and are called
saponification.
Rancidity:-
The fats turns
rancid when
exposed to air. it
is unsuitable for
human
consumption.
24. Esterification:-
Carboxyl group of
fatty acid is
esterified when
reacts with alcohol,
resulting in an ester.
Hydrogenation:-
Double bonds on
unsaturated fatty
acids
Can be oxidised or
hydrogen can be
added to them in
the presence of a
catalyst(nickel,
platinum).
25. I. Triacylglycerols provide stored energy
II. It also provides insulation.
III. Partial hydrogenation of cooking oils
produces trans Fatty acids.
26. A phospholipids is an amphipathic molecule
constructed from four components: fatty
acids, phosphate, alcohol and glycerol or
sphingosine.
Also called as phosphatides, contains a
phosphorous atom.
The phospholipids are very important
structural components of all cell membranes
including those of the cell organelles.
Lecithin may also play an important role in
transport of ion across the membranes.
27. Phospholipids are of different kinds but all of
them contain a glyceryl residue to which are
attached in ester linkage two long chain fatty
acid and a phosphorylated component.
Sometimes phospholipid grouped under ‘polar
lipid’ because they are readily soluble in polar
solvents such as ethanol.
Phospholipids can be broken down to their
residue by the enzyme phosphatidases which
hydrolyse their fatty acids and phosphoric acid
ester bonds specifically.
28. Phosphatidyl choline(lecithin)- this
phospholipid has nitrogen containing choline
in its phosphorylated component.
Phosphatidyl lethanolamine(cephalin)- the
phosphorylated component contains
ethanolamine.
Phosphatidyl linositol- this phospholipid
contains hexahydric alcohol called inositol in
its phosphorylated component.
29. Phosphatidyl glycerol- this has glycerol in its
phosphorylated component.
Diphosphatidylglycerol(cardiolipin)- it consist of
two glycerol residues with their usual esterified
fatty acid chains. Both these residues in turn are
linked to a common glycerol molecule which is
phosphorylated on both of its side.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39. It is a subgroup of steroids with a hydroxyl
group at the 3- position of the A- ring. And
the hydroxyl group is polar, and rest of the
aliphatic chain is non-polar.
They are amphipathic lipid synthesized from
acetyl-coenzyme A via the HMG-CoA
reductase pathway.
The overall molecule is quite flat
40. Cholestrol forms part of the cellular
membrane in animals and serve as secondary
messenger in developmental signaling.
Cortisol act as signaling compound in cellular
communication and general metabolism.
It is common component of human skin oils.
41. Sterols functions as a precursor to fat soluble
vitamins and steroid hormones.
cholesterol is vital to cell membrane.
42.
43. DAVID L NELSON, MICHAEL M. COX. FIFTH
EDITION. LEHNINGER PRINCIPLES OF
BIOCHEMISTRY. PAGE NO-343-370.
S.C.RASTOGI, 2003, OUTLINES OF
BIOCHEMISTRY. PAGE NO-53-59.