Astigmatic lens used in ophthalmology and eyeRACHANA KAFLE
different types and classifications of astigmatic lens used
availability of astigmatic lens
uses of astigmatic lens
advantages and disadvantages of astigmatic lens
magnification, It's definition, types, clinical uses, Uses in Optical instruments like microscopes, telescopes, Uses in Optical instruments like direct Ophthalmoscopes, indirect ophthalmoscopes and slit lamps, In low vision
Astigmatic lens used in ophthalmology and eyeRACHANA KAFLE
different types and classifications of astigmatic lens used
availability of astigmatic lens
uses of astigmatic lens
advantages and disadvantages of astigmatic lens
magnification, It's definition, types, clinical uses, Uses in Optical instruments like microscopes, telescopes, Uses in Optical instruments like direct Ophthalmoscopes, indirect ophthalmoscopes and slit lamps, In low vision
Polarization and it's application in OphthalmologyRaju Kaiti
Polarization, types of polarization, mechanisms to produce polarization, Applications of polarization, precautions with polarizing sunglasses, ophthalmic uses of polarization
Polarization and it's application in OphthalmologyRaju Kaiti
Polarization, types of polarization, mechanisms to produce polarization, Applications of polarization, precautions with polarizing sunglasses, ophthalmic uses of polarization
Basics of clinical optics and their application in clinical ophthalmology. Introduction to principles of interaction of light and its travel through different media. The basic principles, objectives and methods of ophthalmic instruments are also explained.
Nodal Points - The Emerging Real-Time Social Web (@Reboot 10)Jyri Engeström
Activity streams are turning social services into a flow of updates, filtered through people. Mobility is introducing new types of social objects that change the nature of the update streams both into something more frequent and more ambient, but also more vulnerable to noise. In this world the capability to aggregate updates from across the Web and and filter out noise becomes a key problem. I'll demonstrate how the concepts of social objects and social peripheral vision can be applied to make sense of this shift in the locus of innovation on the social Web, and share some personal war stories along the way.
Laboratory session in Physics II subject for September 2016-January 2017 semester in Yachay Tech University (Ecuador). Topic covered: optics, lenses, convergence, divergence, eye, abnormality
Based on Bruna Regalado's work
When light travelling in one medium falls on the surface of second medium the following three effect may occur.
1:- A part of incident light is reflected back into the same medium. This is called Reflection of light.
2:- A part of light is passes through the medium.This Is known as Refraction of light.
3:- And remaining part of the light is absorbed by the surface on which the light fall. This is known as Absorption of light.
Color vision physiology, defects and different testing ProceduresRaju Kaiti
Color vision Physiology, Different types of Color vision defects, different testing procedures, trichromatic theory, color opponent theory, inheritance of color vision defect, management of color vision defect
Pediatric Ophthalmic dispensing in different visual problemsRaju Kaiti
Pediatric dispensing, introduction, different from adult dispensing, frame selection, lens selection, special case fitting, Do's and Dont's, Measurements, Down's syndrome, albinism, aphakia, strabismus, syndromes
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. Thick-Lens Optics
•Baker
Optics, Refraction and Contact Lens
•AAO section 3
Optics
•A. H. Tunacliff
Optics
•Fincham Freeman
Principles of optics
•Hardy and Perrind
Optics and Refraction
• A.K Khurana
Ophthalmic optics and refraction (vol. 5)
•Duke Elder
3. INTRODUCTION
Are a set of six points situated on the
optical axis which are defined in such a way
so as to facilitate the image formation by the
lens system.
4. CARDINAL POINTS
Every Optical systems has 6 CARDINAL POINTS
1. Focal Points- Primary & Secondary
2. Principal Points- Primary & Secondary
3. Nodal Points- Primary & Secondary
*These points are defined following the tradition that light is
always supposed to travel from left to right in optical system.
5. SIGNIFICANCE
Knowing the location of cardinal points;
we can find out various information about the
image of an object produced by an optical
system.
•Information about;
Size
Location of image
6. FOCAL POINTS
can be defined as “ the points on the optical
axis to which the light rays that arrive
parallel to the optical axis, are brought to a
common focus after refraction.
7. PRIMARY FOCAL POINTS
Rays diverging form this point for a system
with positive power or converging to this
point for a system with negative power
before refraction, will emerge parallel to the
optical axis after refraction.
9. Focal Points
Secondary focal point (F’):
Rays parallel to the optic axis before
refraction will converge to {or appear to
diverge from) this point after refraction.
Fig: showing focal points in a converging and diverging system
10. PRINCIPAL POINTS
Are the points at the intersection of two imaginary rays,
created by extending the incident and the emergent rays.
H H1
11. PRINCIPAL POINTS AND PLANES
A perpendicular drawn to the optical
axis from any other principal points
cross the optical axis at the main
principal point.
The principal planes are the planes
normal to the optical axis, intersecting
the principal points on the optical axis.
For all incident rays having equal
angles of incidence have their
principal points on the same plane.
12. PRINCIPAL PLANES
Two Principle Planes (Primary & Secondary)
Unit planes = magnification and size of 1st
& 2nd
is unity i.e; (1st
= obj. = 2nd
image)
All distances relating to optical systems are
measured from principal planes.
14. • Thick lens in meniscus form the
principal planes are in front of
the lens with their spacing equal
to the lens thickness
15. • Thick lens in afocal form, for
which the equivalent power is
zero
• Occasionally met in contact lens
• The principal points and the
focal points are at infinity
16. Convexo-plane
thick lens
The principal
point coincides
with the vertex
at the front
surface while P’
lies at the
distance t’ from
the back surface
17. Fig: N and N’, Primary and Secondary nodal points
NODAL POINTS
18. NODAL POINTS
Are two axial points, such that a ray, directed at
the first will seem to emerge from the second
nodal point parallel to its original direction.
A ray directed to a nodal point at a certain angle,
will exit the lens at the same angle.
Graphically,extending the incident and emergent
ray towards the inside of the lane will intersect
the optical axis at the primary and second nodal
point.
19. NODAL POINTS
When an optical axis is bounded on both sides by
the same medium (same n on both sides) then the
nodal points coincide with the principal points.
For differing indices for converging system the
nodal points move towards the higher index side
and converse occurs for diverging system.
When an optical system has equal curvature and
R.I on both sides, it will have a single principal
point and a single nodal point for one set of
incident ray and they will coincide.
21. Ray tracing
Many simple optical systems can be analyzed by just
tracing selected rays through the whole system of
optical components.
All rays that pass through a focal point on one side of a lens will
emerge from the other side as parallel rays.
Any ray passing through the center of a lens will continue
through the lens, and emerge out of the other side in a straight
line.
All rays of a parallel bundle on one side of a lens go through a
single point in the focal plane on the other side, and visa versa.
This point is easily found by following where the ray that passes
through the center of the lens hits the focal plane.
22. Ray Tracing (considering cardinal points)
Ray OB, parallel to the system axis will appear to refract at
the second principal plane, it will then pass through the
second focal point F2.
The ray OF1C passing through the first focal point F1 will
emerge from the system parallel to the axis, refracted at the
first principal plane.
23. A third ray may be constructed from O to the first nodal point . This ray
appear to emerge from the second nodal point and would be parallel
to the entering ray. ( as n1=n2, nodal points coincide with principal
points)
The intersection of three rays at point O' locates the image of point O.
A similar construction for other points on the object would locate
additional image points which would lie along the O'A' arrow
24. CHANGES IN CARDINAL POINTS
IN APHAKIA
Eye becomes highly hyperopic
Power of eye reduces from +60D to +44D
Anterior focal point becomes23.2mm in front of
cornea
Posterior focal point is about 31mm behind the
cornea i.e. 7mm behind the eyeball
Nodal points are very near to each other and are
located about 7.75mm behind the anterior surface
of cornea
The two principal points are almost at anterior
surface of cornea
25. CARDINAL POINTS IN….
Nodal points in myopic eye is further away
from the retina.
So, the image formed will be appreciably
larger than it would be in the emmetropic
eye and in spectacle corrected eye.
The concept of schematic eye is strongly
dependent on cardinal points.
In PSCC-hyperopic shift
In nuclear sclerosis-myopic shift
26. LENS??
“ an optical system of two refracting
interfaces where one or both of this is
curved ”
Lens : Lentille (French)
Form of the lentil seed
27. A lens is an optical medium bounded by two
surfaces, surrounded by two media
Used to correct ametropia
Must be designed to reduce secondary optical
problems e.g.; aberration
28. Classification;
According to nature of its surfaces:
Most common – spherical (their surfaces are
portions of surfaces of sphere)
Other important forms; plane, cylindrical,
toroidal and aspherical surfaces
According to its effect on light rays;
Converging / diverging
Depending on its thickness;
Thick / thin
31. Forms of lenses
Thin lens is one where the aperture is
small compared to the radii of curvature
of its surfaces and where the thickness
can be ignored.
Two classes according to curvature of
their surfaces;
Convex / positive
Concave / negative
32. CONVERGING SYSTEM(F>0)
Positive lenses
Against motion of images with movement
Magnify images
Thicker in centre and thinner at edge
Adds positive vergence to eye
Use to correct hyperopia
33. DIVERGING SYSTEM(F<O)
Negative lenses
With motion of images with movement
Minify images
Thinner at centre and thicker at edge
Adds negative vergence to eye
Use to correct myopia
34. Approximate power of thick lens
F=F1+F2
-can be measured with lens clock
-Only approximation because thickness
doesn’t enter the calculation
35. Measurement of Curvature
Lens Clock (lens measure, lens gauge)
measures sagittal depth of lens surface
39. Lens specifications:
Radius of curvature of first surface: r1
Radius of curvature of second surface: r2
Refractive index of lens material
Centre thickness and edge thickness
Aperture (diameter)
Position of optical centre and optical axis
40. Incident light: left to right;
First surface/ second
surface
Centre of curvature C1 /
C2
Optical axis
Principal axis
Front and back
vertex(A1 and A2)
Centre thickness t
41. Optical centre - O
Defined as “ point on the lens axis,
where the nodal rays, as it passes
between the lenses, crosses or appears
to cross the principal axis of the system.
For thin lens A1, A2 and O may be
considered as a single point.
43. Image formation:
Lens - affects vergence or curvature of
wave fronts of the light incident upon it
• Image formation :- position and nature of
image, and its size relative to object size
depends on lens and the object position
Two methods:
By scale drawing - graphical construction
By calculation - analytical method using
formulae.
52. Image formation by a diverging lens
Characteristics of the image regardless of
object position:
Virtual, Erect, Smaller than object, Between
object and lens
53. Calculations of images:
-the conjugate foci formula -
Two surfaces - subscript no 1 and 2
L1 , L2 –reduced vergence on 2 surfaces
Thin lens – considered as one refracting
surface followed by a second refracting
surface with negligible separation between
them
54.
55. For refraction at first surface;
n1’ – n1 = n 1’ – n1
l1’ l1 r1
Or reduced vergence notation:
L1’ - L1 = F1
For refraction at second surface;
n2’ – n2 = n 2’ – n2
l2’ l2 r2
Or reduced vergence notation:
L2’ - L2 = F2
56. Let n1’ = n2
As thickness is negligible; reduced
vergence emerging from surface (1)
inside lens is same as reduced
vergence of light arriving at surface (2)
i.e.:- L1’ = L2
Hence:
L1’ - L1 + L2’ – L2 = F1 + F2 or
L2’- L1 = F1 + F2
57. L1’ / L2’
by dropping reduced vergence and using
l2’ = l’ = l1 = l
We get:- L’ – L = F = F1 + F2
Difference – change in reduced vergence
of light – hence power of lens
58. General formula of lens
Relates power of lens with reduced
vergence of incident and emergent
rays respectively
Also called conjugate foci formula,
Because of fact, object and its real image
are interchangeable.
59. As lens power is F = F1 +F2
F1 = n’ - n 1 = ng – 1
r1 r1
F2 = n2’ - n 2 = 1 - ng
r2 r2
Power of lens in air = F = (ng – 1) 1 - 1
r1 r2
Often know as lens maker formula
In terms of radii of curvature; 1/r1 = R1 , 1/r2 = R2
F = (n – 1)(R - R )
60. Image magnification
l = n/L , l’ = n’/L’
m = l’ = n’/L’ = L
l n/L L’
m = h’ / h = L / L’
incident reduced
vergence
emergent reduced
vergence
61. Thick lens
Thickness of the lens
When the thickness of the lens cant
be regarded as negligible, the thin
lens equation and some thin lens
formulae are not valid and the lens
is described to be THICK LENS
With central thickness >0.1mm
The vergence change on transfer
cant be ignored
69. Power of front surface F1=n’1-n1/r1=ng-n1/r1
Power of back surface F2=n’2-n2/r2=n’2-ng/r2
Equivalent power Fe=F1+F2- t‘F1F2
Back vertex power F’v=Fe/1- t’ F1
Back vertex focal length f’v=n’2/F’v
Front vertex power Fv = Fe/1-t’F2
Front vertex focal
length
fv = -n1/Fv
Summary of thick lens FORMULA:
70. Power Measurement
Hand Neutralization
measures front vertex power of a lens
○ most meniscus lenses prohibit placing a trial
lens in contact with the back surface
can be used when lensometer is not working
or unavailable
71. Power Measurement
Lensometer (a.k.a. lensmeter,
vertometer, focimeter)
measures vertex power of lens
and prism power
combines Badal system (I.e.,
standard lens) and Keplerian
telescope