Sickle cell Anemia: A worldwide popular blood disorder, basically a inheritable disease. This document provides you with basic introduction to blood, Anemia its general considerations, signs and symptoms and lastly about Sickle cell Anemia in detail.
Sickle cell Anemia: A worldwide popular blood disorder, basically a inheritable disease. This document provides you with basic introduction to blood, Anemia its general considerations, signs and symptoms and lastly about Sickle cell Anemia in detail.
THALASSEMIA is a group of Hemoglobin Disorder in which the production of normal hemoglobin is partly or completely suppressed as a result of defective synthesis of one or more globin Chains.
Anemia is a reduction in RBCs
which in turn decreases the oxygen
carrying capacity of blood.
Anemia is not a specific
disease state but a sign of an
underlying disorder.
A presentation made about Sickle cell disease by Yara Mostafa, Yasser Osama, Yaser Mostafa ,Ain shams university, Medicine faculty, first year students.
presented by HAFIZ M WASEEM
university of education LAHORE Pakistan
i am from mailsi vehari and studied in lahore
bsc in science college multan
msc from lahore
In the work-up of a disease, the peripheral smear gives a very good information of what disease the patient may be suffering from. It also gives direction for further evaluation, all impacting the treatment and well being of the patient.
THALASSEMIA is a group of Hemoglobin Disorder in which the production of normal hemoglobin is partly or completely suppressed as a result of defective synthesis of one or more globin Chains.
Anemia is a reduction in RBCs
which in turn decreases the oxygen
carrying capacity of blood.
Anemia is not a specific
disease state but a sign of an
underlying disorder.
A presentation made about Sickle cell disease by Yara Mostafa, Yasser Osama, Yaser Mostafa ,Ain shams university, Medicine faculty, first year students.
presented by HAFIZ M WASEEM
university of education LAHORE Pakistan
i am from mailsi vehari and studied in lahore
bsc in science college multan
msc from lahore
In the work-up of a disease, the peripheral smear gives a very good information of what disease the patient may be suffering from. It also gives direction for further evaluation, all impacting the treatment and well being of the patient.
Anaemia results from a lack of red blood cells or dysfunctional red blood cells in the body. This leads to reduced oxygen flow to the body's organs.
Symptoms may include fatigue, skin pallor, shortness of breath, lightheadness, dizziness or a fast heartbeat.
Treatment depends on the underlying diagnosis. Iron supplements may be used for iron deficiency. Vitamin B supplements maybe used for low vitamin levels. Blood transfusions may be used for blood loss. Medications to induce blood formation may be used if the body’s blood production is reduced.
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Physiotherapy can provide relief from symptoms of uncontrolled asthma, including coughing, wheezing, tightness in the chest, shortness of breath and QOL.
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2. Anaemia is a condition where either
the RBC count or the Hb
concentration , or both are deficient.
Anemia is not a diagnosis, but a
presentation of an underlying
condition.
3. Normal range of Hemoglobin
(Hgb)
13.5 to 18.0 g/dL in men
12.0 to 15.0 g/dL in women
11.0 to 16.0 g/dL in children
Most patients experience some
symptoms related to anemia when the
hemoglobin drops below 7.0 g/dL.
4. Normal range of RBCs
A normal RBC count:
Men – 4.7 to 6.1 million cells per
microlitre (cells/mcL) women – 4.2 to
5.4 million cells/mcL
5. RBC are produced in the bone marrow
and released into circulation.
Approximately 1% of RBC are
removed from circulation per day.
Imbalance in production to removal or
destruction of RBC leads to anemia.
8. Terminologies
Anisocytosis: Even in normal blood
film, some variations between the size
of the RBCs do occur. But if the
variation is too great , then the
condition is called anisocytosis.
Hypochromia: Pale RBCs due to less
Hb.
9. Target cells:
Normally the central
part of RBC does
not take stain, or
stains poorly, while
the peripheral part
takes stain so that
the central part
looks vaculated .
But under some
abnormal
conditions, the
central part takes
strain but
peripheral part
stains poorly. Such
cells are target
cells.
10. Burr cells: RBCs with spiky projections,
characteristics of hemolytic anaemia.
11. Spherocyte: Rounded RBCs that are
smaller in diameter than normal RBCs, lack
central pallor, and have a denser
(hyperchromic) staining quality.
12. B12- folate deficiency
anaemia:
Vitamin B12-folate deficiency anaemia
occurs when a lack of vitamin B12 or
folate causes the body to produce
abnormally large red blood cells that
cannot function properly.
13. Iron deficiency anaemia
It occurs typically in chronic bleeders,
e.g.- menorrhagic women, suffers
from pile, hookworm infestation and
whose diet contain poor amount of
iron.
14. Hemolytic anaemia
Hemolytic anemia is defined by the
premature destruction of red blood
cells due to causes outside the RBCs
(hypersensitivity against some drugs,
malaria, snake bites), or causes
residing RBCs (sperocytosis, sickle
cell anaemia).
15. Bone marrow aplasia
Also called hypoplasia, may be due to
the action of known destructive agents
( Xray irradiation), or idiopathic.
16. Sign
Easy fatigue and loss of energy
Unusually rapid heart beat, particularly
with exercise
Shortness of breath and headache,
particularly with exercise
Difficulty concentrating
Dizziness
Pale skin
Leg cramps
Insomnia
17. Symptoms
Brittle nails
Koilonychia (spoon shaped nails)
Angular stomatitis, causes swollen,
red patches in the corners on the
outside of your lips
Brittle hair
Dysphagia and
Glossitis-inflammation of tongue
