Tertiary Structure basically of Hydrophobic interactions, (interactions in side chains), hydrogen bonding, salt bridges, Vander Waals interactions.
e.g. Globular proteins & Fibrous Proteins
Gives in detail primary, secondary, tertiary and Quaternary structure of proteins. Gives classification of secondary structure: alpha helix, beta pleated sheet and different types of tight turns and explains most commonly found tight turn in proteins i.e. beta turn. Briefs about the Ramachandran plot of proteins, dihedral or torsion angles and explains why glycine and proline act as alpha helix breakers. Explains tertiary structure of proteins and different covalent and non covalent bonds in the tertiary structure and relative importance of these bonding interactions. Details about the quaternary structure of proteins and explains why hemoglobin is a quaternary protein and insulin is not.
Conformational study of polynucleotideKAUSHAL SAHU
Introduction
History
The conformation of nucleic acid
Types of polynucleotide
DNA- types and conformation of DNA
B- DNA
A-DNA Z-DNA
RNA – types and conformation of RNA
Coding DNA
Non coding DNA
structure of RNA
Primary structure of RNA
Secondary structure of RNA
Tertiary structure of RNA
Analyzing techniques
Conclusion
References
Macronutrients:-
Nutrients are substances needed for growth, metabolism, and for other body functions. Since “macro” means large, macronutrients are nutrients needed in large amounts.
The prefix makro is from the Greek and means big or large
Macronutrients are nutrients that provide calories or energy.
Minerals and Vitamins are called micronutrients since they are needed in SMALL amounts.
Tertiary Structure basically of Hydrophobic interactions, (interactions in side chains), hydrogen bonding, salt bridges, Vander Waals interactions.
e.g. Globular proteins & Fibrous Proteins
Gives in detail primary, secondary, tertiary and Quaternary structure of proteins. Gives classification of secondary structure: alpha helix, beta pleated sheet and different types of tight turns and explains most commonly found tight turn in proteins i.e. beta turn. Briefs about the Ramachandran plot of proteins, dihedral or torsion angles and explains why glycine and proline act as alpha helix breakers. Explains tertiary structure of proteins and different covalent and non covalent bonds in the tertiary structure and relative importance of these bonding interactions. Details about the quaternary structure of proteins and explains why hemoglobin is a quaternary protein and insulin is not.
Conformational study of polynucleotideKAUSHAL SAHU
Introduction
History
The conformation of nucleic acid
Types of polynucleotide
DNA- types and conformation of DNA
B- DNA
A-DNA Z-DNA
RNA – types and conformation of RNA
Coding DNA
Non coding DNA
structure of RNA
Primary structure of RNA
Secondary structure of RNA
Tertiary structure of RNA
Analyzing techniques
Conclusion
References
Macronutrients:-
Nutrients are substances needed for growth, metabolism, and for other body functions. Since “macro” means large, macronutrients are nutrients needed in large amounts.
The prefix makro is from the Greek and means big or large
Macronutrients are nutrients that provide calories or energy.
Minerals and Vitamins are called micronutrients since they are needed in SMALL amounts.
It contain more information about Amino acids and their structure. Then , contain both physical and chemical properties. Next Classification of amino acids based on nutritional requirements, based on metabolic fate, Position of NH2 group, etc.,
Chemistry of amino acids with their clinical applicationsrohini sane
A comprehensive presentation on Chemistry of Amino acids with their clinical applications for MBBS , BDS, B Pharm & Biotechnology students to facilitate easy- learning.
This presentation the chemical structure of natural amino acids. It also classifies amino acids according to several criteria e.g., structure (aliphatic, aromatic, and heterocyclic amino acids), reaction (Neutral, acidic and basic amino acids), polarity (polar and nonpolar amino acids), and metabolic fate ( glucogenic, ketogenic and glucoketogenic amino acids)
This covers the topic on Proteins, in general. This discusses the different amino acids, bonds formed, structure of proteins and also the different chemical reactions involved with it.
This material is a great help for high school students and students taking up medical and science courses.
Table of Contents
What are Amino Acids?
Properties of Amino acids
Physical Properties
Chemical Properties
Structure of Amino acids
Classification of amino acids on the basis of R-group
Classification of amino acids on the basis of nutrition
Essential amino acids (Nine)
Non-essential amino acids (Eleven)
Classification of amino acids on the basis of the metabolic fate
Functions of Amino acids
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Editable Toolkit to help you reuse our content: 700 Powerpoint slides | 35 Excel sheets | 84 minutes of Video training
This PowerPoint presentation is only a small preview of our Toolkits. For more details, visit www.domontconsulting.com
Premium MEAN Stack Development Solutions for Modern BusinessesSynapseIndia
Stay ahead of the curve with our premium MEAN Stack Development Solutions. Our expert developers utilize MongoDB, Express.js, AngularJS, and Node.js to create modern and responsive web applications. Trust us for cutting-edge solutions that drive your business growth and success.
Know more: https://www.synapseindia.com/technology/mean-stack-development-company.html
Recruiting in the Digital Age: A Social Media MasterclassLuanWise
In this masterclass, presented at the Global HR Summit on 5th June 2024, Luan Wise explored the essential features of social media platforms that support talent acquisition, including LinkedIn, Facebook, Instagram, X (formerly Twitter) and TikTok.
Building Your Employer Brand with Social MediaLuanWise
Presented at The Global HR Summit, 6th June 2024
In this keynote, Luan Wise will provide invaluable insights to elevate your employer brand on social media platforms including LinkedIn, Facebook, Instagram, X (formerly Twitter) and TikTok. You'll learn how compelling content can authentically showcase your company culture, values, and employee experiences to support your talent acquisition and retention objectives. Additionally, you'll understand the power of employee advocacy to amplify reach and engagement – helping to position your organization as an employer of choice in today's competitive talent landscape.
LA HUG - Video Testimonials with Chynna Morgan - June 2024Lital Barkan
Have you ever heard that user-generated content or video testimonials can take your brand to the next level? We will explore how you can effectively use video testimonials to leverage and boost your sales, content strategy, and increase your CRM data.🤯
We will dig deeper into:
1. How to capture video testimonials that convert from your audience 🎥
2. How to leverage your testimonials to boost your sales 💲
3. How you can capture more CRM data to understand your audience better through video testimonials. 📊
Enterprise Excellence is Inclusive Excellence.pdfKaiNexus
Enterprise excellence and inclusive excellence are closely linked, and real-world challenges have shown that both are essential to the success of any organization. To achieve enterprise excellence, organizations must focus on improving their operations and processes while creating an inclusive environment that engages everyone. In this interactive session, the facilitator will highlight commonly established business practices and how they limit our ability to engage everyone every day. More importantly, though, participants will likely gain increased awareness of what we can do differently to maximize enterprise excellence through deliberate inclusion.
What is Enterprise Excellence?
Enterprise Excellence is a holistic approach that's aimed at achieving world-class performance across all aspects of the organization.
What might I learn?
A way to engage all in creating Inclusive Excellence. Lessons from the US military and their parallels to the story of Harry Potter. How belt systems and CI teams can destroy inclusive practices. How leadership language invites people to the party. There are three things leaders can do to engage everyone every day: maximizing psychological safety to create environments where folks learn, contribute, and challenge the status quo.
Who might benefit? Anyone and everyone leading folks from the shop floor to top floor.
Dr. William Harvey is a seasoned Operations Leader with extensive experience in chemical processing, manufacturing, and operations management. At Michelman, he currently oversees multiple sites, leading teams in strategic planning and coaching/practicing continuous improvement. William is set to start his eighth year of teaching at the University of Cincinnati where he teaches marketing, finance, and management. William holds various certifications in change management, quality, leadership, operational excellence, team building, and DiSC, among others.
1. Your first major hurdle is to learn the structures of the amino
acids …all 20 of them. This will tax anyone’s memory if it is not done
properly. Students who resort to flash cards or rote memory never
solidify the lesson. In reality flash cards only press the memory to see
structural differences which makes the chore of learning all 20 that much
more difficult. The best approach is to use logic and name recognition
and to look for similarities, not differences in structures. In this tutorial
you will see how the name tells you the structure. You will see how
structures build on one another and interrelate. Yes, some memory will
be needed before all the amino acids are mastered. But, follow these few
simple rules and what you learn will stay with you as you continue into
biochemistry. Learning amino acids now is preparing you later for
proteins structure, enzyme catalysis, and eventually metabolic pathways.
Amino Acid Structures – Look for Similarities
not Differences
2. Lets start with the basics. All amino acids have a common structural
unit that is built around the alpha carbon (click 1). Lets call this the “core”
structure. The figure shows the core with one of the bonds on the α-carbon
unassigned. A group in this location is represented by the letter R (click 1).
R groups are the only variable groups in the structure. Consider R the only
unknown and focus on this group to learn the structures. Hence, Rule (1) is
amino acids are composed of a core group and an R group. Rule (2) is the R
group gives an amino acid its structural identity and, later as we will see, its unique
biochemical properties. Thus, if you insist on using flash cards, draw them as
shown above (click 1) with the box representing the core. Click to go on.
R
BASICS
R
COOH
C+
H3N
α
H
3. Building an R Group
You saw the importance of the R group. Now, you will see how R
groups build and interrelate. Four that illustrate this point are “glycine, alanine,
phenylalanine and tyrosine. The R groups of each will be shown below (click 1).
CH3 CH2
With an H, glycine is the simplest amino acid, so named because of its sugary taste
(click 1). Alanine with a methyl group is the next simplest (click 1). The red color
helps you see how each R group structure differs from the preceding. Phenylalanine
arises when a phenyl group replaces an H on alanine’s methyl group (click 1).
Tyrosine evolves by adding an –OH group to the para position on the phenyl ring of
phenylalanine (click 1). Click to go on.
H CH2
OH
Glycine Alanine Phenylalanine Tyrosine
4. Acidic and Amide Amino Acids
The acidic amino acids have (–) charges in their R group. There are
two, aspartic acid and glutamic acid (click 1). Note their similarity. Glutamic acid
has one more –CH2 group (click 1). Note that both have a –COO–
group which
gives the negative charge.
CH2
Aspartic
acid
COO–
CH2
CH2
Glutamic
Acid
COO–
The –COO–
can exchange a proton with the solvent and hence behave as an acid.
The suffix “ate” is used to designate an ionized acid (more properly called a salt).
Hence, you will see aspartic acid and glutamic acid referred to as “aspartate” and
“glutamate” (click 1). By forming the amide derivatives of aspartate and glutamate
you give rise to asparagine and glutamine (click 1). Note name and structure
similarities between the “open” and the corresponding “amide” amino acids. Click
to go on.
CH2
COO–
C=O
NH2
Asparagine
CH2
CH2
COO–C=O
NH2
Glutamine
Aspartate
Glutamate
5. The (+) charged amino acids are represented by lysine, arginine and
histidine. Unfortunately, R structures for basic amino acids have little resemblance
to one another. But each is characterized by a (+) N in the R group.
CH2
CH2
CH2
CH2
NH3
+
Lysine
CH2
CH2
CH2
NH
+
H2N=C
NH2
CH2
HN NH+
Arginine Histidine
Guanidinium
Imidazole
It will help you to remember that each (+) N is part of a group. For lysine this
group is called the epsilon amino group (click 1). In arginine it’s the
guanidinium group and for histidine it’s the imidazole group. Remember these
group names and you will remember the structures of the basic amino acids.
Click to go on.
Epsilon amino
6. Serine,Threonine, Cysteine and Methionine
Start with serine. Serine has a simple –CH2OH for it R group (click 1).
Threonine is serine with a methyl group (click 1). And, if you replace the O in
serine with an S, you generate cysteine (click 1).
CH2OH H-C-OH
CH3
CH2SH
Methionine appears to combine cysteine with threonine. The name tells you
methionine has a sulfur (thio) and a methyl group in the structure. Like
threonine methionine has a 2 carbon chain attached to the alpha carbon (click
1). This is followed by sulfur and ends with a methyl on the sulfur. Click to go
on.
CH2
CH2
S
CH3
Serine Threonine Cysteine Methionine
7. Valine, Leucine, Isoleucine
These 3 branched-chain hydrophobic amino acids have only C and H in
their R groups. Valine is easy to remember because the carbon chain is
arranged as the letter V (click 1). Leucine and isoleucine both have a 4 carbon
R group. Leucine resembles valine but with a -CH2 before the V (click 1).
Isoleucine’s side chain resembles the letter L, just the opposite of what you
would predict from the name (click 1). To distinguish the 3, focus only on the
branched chains in the R structure. Valine and leucine have only methyl groups,
whereas isoleucine’s branches are one methyl and one ethyl group (click 1).
Click to go on.
C
CC
C–
C
C
C
C
C
CC
Valine
Leucine Isoleucine
Ethyl group
8. CH2
Tryptophan
The last 2 amino acid to consider are tryptophan (pronounced trip-toe-
fane) and proline. Tryptophan is unique in having an indole ring (click 1). Attach
this ring to the core via a CH2 group and you complete the structure of tryptophan
(click 1). Proline also has a ring, but this ring is saturated. In fact proline’s ring
looks like “home plate” in baseball (click 1). Note proline does not have a core
structure. This is because the alpha amino group is incorporated into the ring.
Tryptophan and Proline
N
H
Proline
N COO–
H
CH2
H2C
H2C
C
H
Indole This completes all the amino acids.
Review this lesson as many times as necessary.
Use paper and pencil to draw out the structures.
Soon you will have mastered amino acid structures.
Click to go on to quiz.
9. Q: What structural feature is common to alanine, serine and cysteine?
Test Your Knowledge. Click to see the answer.
A: All three have a single carbon in their R groups.
Q: What R group structural feature is common to phenylalanine, tyrosine,
tryptophan, and histidine?
A: All four have rings that are attached to the core via a –CH2 group
Q: What structural feature is common to isoleucine and threonine
A: Both have an asymmetric carbon in their R group
Q: What amino acid has the shortest carbon chain in its R group?
A: Glycine. It has no carbon in its R group.
Q: Which amino acid has the longest straight chain of carbons in its R
group?
A: Lysine. It has 4. Leucine and isoleucine have 4 but their chains are branched
10. Q: What structural feature is common to alanine, serine and cysteine?
Test Your Knowledge. Click to see the answer.
A: All three have a single carbon in their R groups.
Q: What R group structural feature is common to phenylalanine, tyrosine,
tryptophan, and histidine?
A: All four have rings that are attached to the core via a –CH2 group
Q: What structural feature is common to isoleucine and threonine
A: Both have an asymmetric carbon in their R group
Q: What amino acid has the shortest carbon chain in its R group?
A: Glycine. It has no carbon in its R group.
Q: Which amino acid has the longest straight chain of carbons in its R
group?
A: Lysine. It has 4. Leucine and isoleucine have 4 but their chains are branched