The document summarizes the histology of the urinary system. It describes the structures and cell types found in the kidney, nephron, ureter, bladder, and urethra. In the kidney, nephrons contain glomeruli and Bowman's capsules for blood filtration. The ureter transports urine from the kidney to the bladder via smooth muscle layers. The bladder stores urine in transitional epithelium before exiting the body through the urethra, lined with stratified squamous epithelium in males and females. Clinical correlates of urinary structures include incontinence and overactive bladder.
01.28.09(b): Histology of the Male Reproductive SystemOpen.Michigan
Slideshow is from the University of Michigan Medical School's M1 Endocrine / Reproduction sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M1Endo
01.28.09(b): Histology of the Male Reproductive SystemOpen.Michigan
Slideshow is from the University of Michigan Medical School's M1 Endocrine / Reproduction sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M1Endo
GASTROINTESTINAL PHYSIOLOGY (The Guyton and Hall Physiology)Maryam Fida
ANATOMY OF GASTROINTESTINAL TRACT
Consists of
Gastrointestinal (GI) tract
Accessory glandular organs
Anatomy and functions of the GI tract
GI tract
◦ mouth, pharynx, esophagus,
◦ stomach, small intestine,
◦ large intestine, anus
◦ Accessory Glandular Organs
salivary glands, liver, gallbladder, pancreas
Histology/organization of the Gut Wall
From esophagus to anus, GI tract has the same basic arrangement of tissues.
There are following layers from outer surface to inward.
Serosa
Longitudinal smooth muscle
Circular smooth muscle layer
Submucosa
Mucosa
Layers of Alimentary Canal
Gastrointestinal Smooth Muscle Functions as a syncytium
The individual smooth muscle fibers in the gastrointestinal tract are 200 to 500 micrometers in length and 2 to 10 micrometers in diameter, and they are arranged in bundles of as many as 100 parallel fibers.
In the LONGITUDINAL MUSCLE LAYER, the bundles extend longitudinally down the intestinal tract.
In the CIRCULAR MUSCLE Layer, they extend around the gut.
Within each bundle, the muscle fibers are electrically connected with one another through large numbers of GAP JUNCTION .
Because of these gap junction electrical signals that initiate muscle contractions can travel readily from one fiber to the next within each bundle but more rapidly along the length of the bundle than sideways.
Each muscle layer functions as a SYNCYTIUM . That is , when an action potential is elicited anywhere within the muscle mass, it generally travels in all directions in the muscle.
MAIN FUNCTIONS
1. Ingestion or consumption of food substances.
2. Breaking them in to small particles.
3. Transport of small particles to different areas of the digestive tract.
4. Secretion of necessary enzymes and other substances for digestion.
GASTROINTESTINAL PHYSIOLOGY (The Guyton and Hall Physiology)Maryam Fida
ANATOMY OF GASTROINTESTINAL TRACT
Consists of
Gastrointestinal (GI) tract
Accessory glandular organs
Anatomy and functions of the GI tract
GI tract
◦ mouth, pharynx, esophagus,
◦ stomach, small intestine,
◦ large intestine, anus
◦ Accessory Glandular Organs
salivary glands, liver, gallbladder, pancreas
Histology/organization of the Gut Wall
From esophagus to anus, GI tract has the same basic arrangement of tissues.
There are following layers from outer surface to inward.
Serosa
Longitudinal smooth muscle
Circular smooth muscle layer
Submucosa
Mucosa
Layers of Alimentary Canal
Gastrointestinal Smooth Muscle Functions as a syncytium
The individual smooth muscle fibers in the gastrointestinal tract are 200 to 500 micrometers in length and 2 to 10 micrometers in diameter, and they are arranged in bundles of as many as 100 parallel fibers.
In the LONGITUDINAL MUSCLE LAYER, the bundles extend longitudinally down the intestinal tract.
In the CIRCULAR MUSCLE Layer, they extend around the gut.
Within each bundle, the muscle fibers are electrically connected with one another through large numbers of GAP JUNCTION .
Because of these gap junction electrical signals that initiate muscle contractions can travel readily from one fiber to the next within each bundle but more rapidly along the length of the bundle than sideways.
Each muscle layer functions as a SYNCYTIUM . That is , when an action potential is elicited anywhere within the muscle mass, it generally travels in all directions in the muscle.
MAIN FUNCTIONS
1. Ingestion or consumption of food substances.
2. Breaking them in to small particles.
3. Transport of small particles to different areas of the digestive tract.
4. Secretion of necessary enzymes and other substances for digestion.
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Urinary.pptx knowledge about tracts and inauguration of the dayakshayamritanshuru40
The urinary tract is the system in the body that is responsible for producing, storing, and eliminating urine. It includes the kidneys, ureters, bladder, and urethra. The kidneys filter waste products from the blood to produce urine, which then travels through the ureters to the bladder for storage. When the bladder is full, urine is expelled from the body through the urethra. The urinary tract plays a crucial role in maintaining the body's fluid balance and removing waste products from the bloodstream.
The genitourinary system, or urogenital system, are the organs of the reproductive system and the urinary system. These are grouped together because of their proximity to each other, their common embryological origin and the use of common pathways, like the male urethra.
At the end of this lesson, you should be able to:
i. component organs of the urinary system;
ii. describe the structure of the kidneys;
iii. describe the structure of the ureters;
iv. describe the structure of the urinary bladder;
v. describe the structure of the urethra; and
vi. explain the formation of urine and it's composition
Kidney is a vital organ. Each individual has a pair of kidneys .
kidney is bean shaped organ on either side of your spine, below your ribs and behind your belly. Each kidney is about 4 - 5 inches long, roughly the size of a large fist.
The kidney job is to filter the blood.
kidney is reddish brown in color.
kidneys are also called as retro-peritoneal organ.
There are three layers of tissues that surrounds kidney
1. renal capsule
2. adipose capsule
3. renal fascia.
This was done as a Student presentation on the kidney.
Here following topics are covered.
Macroscopic structure of the urinary system
Microscopic anatomy of the urinary system
Functions of the nephron
Renal blood supply
Kidneys and blood pressure regulation
Structure of ureters and urinary bladder to perform its function
Renal failure
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Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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2 Case Reports of Gastric Ultrasound
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2. Contents
Kidney
* Parts of nephron and structures
juxtaglomerular apparatus
Functional aspects
Blood circulation
Ureter and urinary bladder
• General features
Urinary epithelium Urethra
* Structure of male and female urethra
3. Kidney
Main organ of the excretory system
Kidney is built of billions of little tubes called the
nephrons.
At the beginning of each nephron, a web of capillaries
releases much water and other molecules into the
nephron.
The urine is collected in the urinary bladder and, when it
fills up, it is excreted via urethra into the outside
environment.
4. Kidney's Internal Structure
Cortex -- the outer part of the kidney;
Medulla -- the inner portion of the kidney;
Pyramids -- the triangular-shaped divisions of the
medulla of the kidney;
Papilla -- narrow, innermost tip of the pyramid;
Pelvis -- the kidney or renal pelvis is an extension of
the upper end of the ureter (the tube that drains
urine into the bladder);
Calyx -- each calyx is a division of the renal pelvis;
opening into each calyx is the papilla of a pyramid.
5.
6.
7. Nephron
basic structural and functional unit of the
kidney.
Its chief function is to regulate the
concentration of water and soluble
substances like sodium salts by filtering the
blood, reabsorbing what is needed and
excreting the rest as urine.
8. Nephron
A nephron eliminates wastes from the body,
regulates blood volume and blood pressure,
controls levels of electrolytes and metabolites,
and regulates blood pH. Its functions are vital to
life and are regulated by the endocrine system by
hormones such as antidiuretic hormone,
aldosterone, and parathyroid hormone.
9.
10. microscopic units of a kidney, have 2 main parts,
1. renal corpuscle (Bowman's capsule with glomerulus)
2. renal tubule.
11. RENAL CORPUSCLERENAL CORPUSCLE
glomeruli surrounded by Bowman's capsules.
Bowman's capsule -- the cup-shaped top of a nephron.
It is the sack-like Bowmans's capsule that surrounds the
glomerulus.
Glomerulus -- a network of blood capillaries tucked
into Bowman's capsule.
12.
13. Juxtaglomerular apparatus
The juxtaglomerular apparatus is a microscopic structure
in the kidney, which regulates the function of each
nephron.
There are three cellular components of the apparatus
which are the;
1. macula densa,
2. extraglomerular mesangial cells,
3. juxtaglomerular cells (also known as granular cells).
14. RENAL TUBULE
Proximal convoluted tubule -- the first segment of a renal
tubule, called proximal because it lies nearest the tubule's
origin from Bowman's capsule, and convoluted because it has
several bends in it.
Loop of Henle -- the extension of the proximal tubule;
observe that the loop of Henle consists of a straight
descending (directed downward) limb, a loop, and a straight
ascending limb (directed upwards).
15. Cont.
Distal convoluted tubule -- the part of the tubule distal to
the ascending limb of Henle. It is the extension of the
ascending limb of Henle.
Collecting tubule -- a straight (not convoluted) part of a
renal tubule; distal tubules of several nephrons join to
form a single collecting tubule
16. Histology Bowman's capsule
Cells of the outer or parietal layer of Bowman's capsule form a simple squamous
epithelium.
Cells of the inner layer, podocytes in the visceral layer, are extremely complex in
shape. Small foot-like processes, pedicles, of their cytoplasm form a fenestrated
epithelium around the fenestrated capillaries of the glomerulus.
The openings between the pedicles are called filtration slits.They are spanned by a
thin membrane, the filtration slit membrane. Between the podocytes and the
endothelial cells of the capillaries a comparatively thick basal lamina, which can be
subdivided into an outer lamina externa, a middle lamina densa and an inner lamina
interna.
The basal lamina and the slit membranes form the glomerular filtration barrier,
which prevents some large molecules from entering the capsular space between
the outer and inner epithelial layers of Bowman's capsule.
Mesangial cells in the glomerulus form the connective tissue that gives structural
support to podocytes and vessels.
17. Histo: proximal tubule
walls - low columnar epithelium.
The eosinophilic cells of the epithelium have a wide brush
border and are active in endocytosis.
18. Histo of Loop of Henle
It is 'U' shaped and has descending and ascending
segments.
Thin descending segment has flattened
epithelium( squamous). It is permeable to water but not
solutes.
19. Histo: Distal convoluted tubule
straight part of the DCT is formed by the low cuboidal
cells without a brush border.The diameter of the tubule
gradually expands to about 35 microns.
convoluted part and comes in contact with the
Glomerulus forming the Macula Densa.
20.
21.
22.
23. Nephron structure characteristic
Renal corpusle Capillary ball covered by podocyte &
surrounded by simple squamous epithelial
capsule, capsular space.
Proximal convulated Lined with simple cubodial epithelium &
prominent brush border
Loop of Henle Tubule that form a loop, there are thick &
thin ascending & desecnding portion; the
most distal part of the loop often extends
into the medulla.
Thick limb are lined with simple
squamous/ cuboidal epithelium
Thin limb are lined with simple squamous
epithelium
Distal convulated Lined with simple cuboidal with only
sparse brush border; cytoplasm of cells
tend to be paler than that of proximal
convulated
24. Ureter
The wall of the ureter is made 3 layers. From inside
outwards they are :
1. Mucosa- which is made up of epithelium &
lamina propria
2. Muscular coat – made of smooth muscles
3. Fibrosa – made of fibrous connective tissue
Mucosa- is thrown into folds and thus gives the
appearance of star shaped lumen.
25. 1. Transitional epithelium. 3-5 layers thickness.
2. Lamina propria- dense, irregular layer of
fibroelastic connective tissue
The epithelium is separated from the lamina propria by a
basal lamina.
26.
Muscular layer – Upper 2/3 of the ureter is made of
two layers of smooth muscle cells.
Inner longitudinal and outer circular layer( in contrast to the
wall of GIT which has inner circular & outer longitudinal !).
Lower 1/3 of the ureter has a third outer layer of longitudinal
muscles( inner longitudinal, middle circular, outer
loingitudinal ).
Fibrous coat – is made up of fibrous connective tissue
27.
28.
29. The urethra:
Female: relatively short, exits just anterior to the vagina
Male: longer, divided into three sections the prostatic,
membranous and spongy urethra. The prostatic urethra
is enclosed in the prostate gland. The membranous
urethra is a short section that penetrates the urogenital
diaphragm. The spongy urethra or penile urethra extends
from the membranous urethra to the external urethral
orifice (meatus).
30. Histology: In both male and females the urethra starts
out as transitional cell but quickly becomes stratified
squamous in the female.
The male urethra is more variable but ends up stratified
squamous as well.
31.
32. Histology of the bladder
mucosa of transitional epithelium, Submucosa, and thick
muscular layer know as the detrusor muscle
33.
34.
35. Clinical correlates
Urinary incontinence
Childbirth and other events can injure the scaffolding that helps
support the bladder in women. Pelvic floor muscles, the vagina, and
ligaments support your bladder.
Overactive bladder
Specifically, the symptoms of overactive bladder include
urinary frequency—bothersome urination eight or more times a day
or two or more times at night
urinary urgency—the sudden, strong need to urinate immediately
urge incontinence—leakage or gushing of urine that follows a sudden,
strong urge
nocturia—awaking at night to urinate