En el Aula Virtual online de Educagratis ( http://www.educagratis.org ) es posible encontrar un Curso de Acondicionamiento Físico para Adolescentes ( http://entrenamiento.educagratis.org ) .
Curso orientado al desarrollo y mejoramiento de las cualidades físicas básicas, derivadas y complementarias del individuo a través de sistemas y métodos de entrenamiento.
Los objetivos del curso son:
- el desarrollar y mejorar las capacidades físicas básicas, derivadas y complementarias a través de una preparación física sistemática.
- Y el de identificar y practicar diferentes métodos y sistemas de entrenamiento que puedan servirle para una posterior práctica de la actividad física.
Más cursos de Preparación Física: http://entrenamiento.educagratis.org
Y muchos otros cursos de diversas áreas:
- Animales, Aves y Peces ( http://animales.educagratis.org )
- Artes, Diseño, Pintura y Dibujo ( http://artes.educagratis.org )
- Autoayuda ( http://autoayuda.educagratis.org )
- Belleza y Moda ( http://belleza.educagratis.org )
- Ciencias Alternativas ( http://alternativas.educagratis.org )
- Ciencias Naturales ( http://ciencias.educagratis.org )
- Ciencias Sociales y Juridicas ( http://sociales.educagratis.org )
- Cocina, Bebidas, Pastelería y Repostería ( http://cocina.educagratis.org )
- Computación e Informática ( http://computacion.educagratis.org )
- Construcción, Arquitectura y Paisajismo ( http://construccion.educagratis.org )
- Deportes y Educación Física ( http://deportes.educagratis.org )
- Educación, Religión y Filosofía ( http://educacion.educagratis.org )
- Historia, geografía, tradiciones y cultura ( http://historia.educagratis.org )
- Hogar, Tejido, Borado y Jardín ( http://hogar.educagratis.org )
- Idiomas, Lenguaje y Letras ( http://idiomas.educagratis.org )
- Juegos, Recreación y Pasatiempos ( http://juegos.educagratis.org )
- Matemáticas ( http://matematicas.educagratis.org )
- Mecánica, Autos y Motos ( http://mecanica.educagratis.org )
- Medicina, Psicología y Salud ( http://medicina.educagratis.org )
- Musica, Baile y Danza ( http://musica.educagratis.org )
- Negocios, Empresa y Economía ( http://negocios.educagratis.org )
- Técnicos, Oficios y Manualidades ( http://tecnicos.educagratis.org )
La electroencefalografía es una técnica que permite estudiar la actividad cerebral. Por tanto, la utilizamos para conocer mejor el diagnóstico y la localización de su enfermedad, y en muchos casos la intensidad de una posible lesión. De esta forma, podemos orientar a su médico especialista sobre el diagnóstico y tratamiento a seguir.
En el Aula Virtual online de Educagratis ( http://www.educagratis.org ) es posible encontrar un Curso de Acondicionamiento Físico para Adolescentes ( http://entrenamiento.educagratis.org ) .
Curso orientado al desarrollo y mejoramiento de las cualidades físicas básicas, derivadas y complementarias del individuo a través de sistemas y métodos de entrenamiento.
Los objetivos del curso son:
- el desarrollar y mejorar las capacidades físicas básicas, derivadas y complementarias a través de una preparación física sistemática.
- Y el de identificar y practicar diferentes métodos y sistemas de entrenamiento que puedan servirle para una posterior práctica de la actividad física.
Más cursos de Preparación Física: http://entrenamiento.educagratis.org
Y muchos otros cursos de diversas áreas:
- Animales, Aves y Peces ( http://animales.educagratis.org )
- Artes, Diseño, Pintura y Dibujo ( http://artes.educagratis.org )
- Autoayuda ( http://autoayuda.educagratis.org )
- Belleza y Moda ( http://belleza.educagratis.org )
- Ciencias Alternativas ( http://alternativas.educagratis.org )
- Ciencias Naturales ( http://ciencias.educagratis.org )
- Ciencias Sociales y Juridicas ( http://sociales.educagratis.org )
- Cocina, Bebidas, Pastelería y Repostería ( http://cocina.educagratis.org )
- Computación e Informática ( http://computacion.educagratis.org )
- Construcción, Arquitectura y Paisajismo ( http://construccion.educagratis.org )
- Deportes y Educación Física ( http://deportes.educagratis.org )
- Educación, Religión y Filosofía ( http://educacion.educagratis.org )
- Historia, geografía, tradiciones y cultura ( http://historia.educagratis.org )
- Hogar, Tejido, Borado y Jardín ( http://hogar.educagratis.org )
- Idiomas, Lenguaje y Letras ( http://idiomas.educagratis.org )
- Juegos, Recreación y Pasatiempos ( http://juegos.educagratis.org )
- Matemáticas ( http://matematicas.educagratis.org )
- Mecánica, Autos y Motos ( http://mecanica.educagratis.org )
- Medicina, Psicología y Salud ( http://medicina.educagratis.org )
- Musica, Baile y Danza ( http://musica.educagratis.org )
- Negocios, Empresa y Economía ( http://negocios.educagratis.org )
- Técnicos, Oficios y Manualidades ( http://tecnicos.educagratis.org )
La electroencefalografía es una técnica que permite estudiar la actividad cerebral. Por tanto, la utilizamos para conocer mejor el diagnóstico y la localización de su enfermedad, y en muchos casos la intensidad de una posible lesión. De esta forma, podemos orientar a su médico especialista sobre el diagnóstico y tratamiento a seguir.
Most states in the US require separation distances between livestock production/ manure storage facilities and water resources
Iowa, for example, for liquid manure from animal buildings and manure storages requires 150 -300 meters separation
Brief explanation of dybiosis and leaky gut syndrome. Herbal and dietary recommendations using Inno-Vita formulas. This information is for education purposes only. Herbal programs should be monitored by a qualified health professional.
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“A neoplasm is an abnormal mass of tissue, the growth
of which exceeds and is uncoordinated with that of
the normal tissues and persists in the same excessive
manner after cessation of the stimuli which evoked
the change” - Willis
Genetic changes
Autonomous
Clonal
133. Figure 23-22 A, Well-differentiated invasive carcinoma of no special type. Well-formed tubules
and nests of cells with small monomorphic nuclei invade into the stroma with a surrounding
desmoplastic response. B, Poorly differentiated invasive carcinoma of no special type. Ragged
sheets of pleomorphic cells without tubule formation infiltrate into the adjacent stroma.
Papillary adenoma of colon. Note the fingerlike projections of the tumor.
Iowa Histopathology
Figure 7-2 Colonic polyp.. Gross appearance of several colonic polyps.
Colonic polyp. This benign glandular tumor (adenoma) is projecting into the colonic lumen and is attached to the mucosa by a distinct stalk.
This view shows the transition from normal squamous epithelium into invasive carcinoma.
A hallmark of well differentiated squamous cell carcinoma is that the nests of invading cells still attempt to make keratin which then gets deposited in the center of the nests, resulting in a keratin "pearl".
From the Iowa Collection
Another characteristic of a well differentiated squamous cell carcinoma is that it still makes visible intercellular bridges.
Adenocarcinoma of color arising in a case of ulcerative colitis
Lymph node with undifferentiated large cell carcinoma
From the Iowa collection
Figure 7-4 A, Gross appearance of an opened cystic teratoma of the ovary. Note the presence of hair, sebaceous material, and tooth.
A microscopic view of a similar tumor shows sebaceous glands, respiratory epithelium, bone, and bone marrow.
Dermoid cyst of ovary (a component of benign cystic teratoma)
Iowa Collection
Leiomyoma of the uterus. This benign, well-differentiated tumor contains interlacing bundles of neoplastic smooth muscle cells that are virtually identical in appearance to normal smooth muscle cells in the myometrium.
Anaplastic large cell carcinoma of lung showing cellular and nuclear variation in size and shape. No differentiation into squamous or glandular epithelium is evident.
This epithelium shows severe dysplasia: Note that dysplastic basal cells characterized by cuboidal shape, high nuclear cytoplasmic ratio, hyperchromatism, mitotic activity, and some loss of orientation to the basement membrane, occupy the lower two thirds of the surface rather than just the basal row of cells. More differentiated cells which occupy the outer third, though still retaining some dysplastic nuclear features have the appearance of maturing squamous cells rather than basal cells, and eventually become flattened on the surface.
Carcinoma in situ: This section shows that the dysplastic basiloid cells go all the way to the surface and never undergo significant differentistion towards more differentiated flattened squamous cells. Note however that the basement membrane is still intact.
Figure 7-12 Biology of tumor growth. The left panel depicts minimal estimates of tumor cell doublings that precede the formation of a clinically detectable tumor mass. It is evident that by the time a solid tumor is detected, it has already completed a major portion of its life cycle as measured by cell doublings. The right panel illustrates clonal evolution of tumors and generation of tumor cell heterogeneity. New subclones arise from the descendants of the original transformed cell, and with progressive growth the tumor mass becomes enriched for those variants that are more adept at evading host defenses and are likely to be more aggressive. (Adapted from Tannock IF: Biology of tumor growth. Hosp Pract 18:81, 1983.)
Figure 7-13 Schematic representation of tumor growth. As the cell population expands, a progressively higher percentage of tumor cells leaves the replicative pool by reversion to G0, differentiation, and death. Radiation and chemotherapy work on dividing cells, so the size of the non-proliferative pool is important.
Figure 7-14 Fibroadenoma of the breast. The tan-colored, encapsulated small tumor is sharply demarcated from the whiter breast tissue.
Note the sharply demarcated border and a thin capsule in this neoplasm which is composed of both proliferating fibrous stroma (fibro) and glands (adenoma). The tumor is at the right and normal breast is at the left. As shown in this view the fibroadenoma, a benign tumor, is well circumscribed and has a fibrous capsule. This view shows the proliferation of benign appearing fibroblasts (arrows) (i.e. the "fibro" component), and several glands (the "adeno" component).
Figure 7-16 Cut section of an invasive ductal carcinoma of the breast. The lesion is retracted, infiltrating the surrounding breast substance, and would be stony hard on palpation.
Adenocarcinoma of the breast. Note that the fibrous stroma of the beast is infiltrated by tumor cells arranged in nests with some gland formation. The dense fibrous stroma results in the tumor having a very firm consistency (schirrous carcinoma)
Figure 7-20 A liver studded with metastatic cancer
Lymph node with metastatic adenocarcinoma.
Adjuvant chemotherapy in breast cancer reduces the incidence of recurrence and metastasis, but is toxic. Such treatment is not advised when the risk of recurrence is very low. Grade and stage are important prognostic factors, but are being supplemented by newer biologic markers.
Figure 1 indicates the most common cancers expected to occur in men and women in 2005. Among men, cancers of the prostate, lung and bronchus, and colon and rectum account for more than 56% of all newly diagnosed cancers. Prostate cancer alone accounts for approximately 33% (232,090) of incident cases in men. Based on cases diagnosed between 1995 and 2000, about 90% of these estimated new cases of prostate cancer are expected to be diagnosed at local or regional stages, for which 5-year relative survival approaches 100%.
Figure 7-25 The change in incidence of various cancers with migration from Japan to the United States provides evidence that the occurrence of cancers is related to components of the environment that differ in the two countries. The incidence of each kind of cancer is expressed as the ratio of the death rate in the population being considered to that in a hypothetical population of California whites with the same age distribution; the death rates for whites are thus defined as 1. The death rates among immigrants and immigrants' sons tend consistently toward California norms. (From Cairns J: The cancer problem. In Readings from Scientific American-Cancer Biology. New York, WH Freeman, 1986, p. 13.)
Awesome chart flowing the dynamics of molecular carcinogenesis factors!
Cyclins coupled with CDKs (Cyclin Dependent Kinases) regulate the various phases of the cell cycle.
Figure 7-27 Flow chart depicting a simplified scheme of the molecular basis of cancer.
Note that the receptor protein is located on the cell surface as would be expected.
Figure 7-32 Model for action of RAS genes. When a normal cell is stimulated through a growth factor receptor, inactive (GDP-bound) RAS is activated to a GTP-bound state. Activated RAS recruits RAF and stimulates the MAP-kinase pathway to transmit growth-promoting signals to the nucleus. The mutant RAS protein is permanently activated because of inability to hydrolyze GTP, leading to continuous stimulation of cells without any external trigger. The anchoring of RAS to the cell membrane by the farnesyl moiety is essential for its action.
Figure 7-30. In a resting cell, RB is a component of the E2F/DP1/RB complex, which represses gene transcription through the recruitment of histone deacetylase, an enzyme that alters the conformation of chromatin, making it more compact. Phosphorylation of RB by cyclin D-CDK4 removes histone deacetylase from chromatin, allowing the activation of E2F transcriptional activity (RB can also be phosphorylated by cyclin E-CDK2). E2F-mediated transcription of cyclins E and A, and of genes required for DNA replication, permit the passage through the G1 restriction point. (Adapted from Pollard TD, Earnshaw WC: Cell Biology. Philadelphia, WB Saunders, 2002, p. 689.)
Figure 7-35 Pathogenesis of retinoblastoma. Two mutations of the RB locus on chromosome 13q14 lead to neoplastic proliferation of the retinal cells. In the familial form, all somatic cells inherit one mutant RB gene from a carrier parent. The second mutation affects the Rb locus in one of the retinal cells after birth. In the sporadic form, on the other hand, both mutations at the RB locus are acquired by the retinal cells after birth.
Figure 7-38 A, The role of APC in regulating the stability and function of β-catenin. APC and β-catenin are components of the WNT signaling pathway. In resting cells (not exposed to WNT), β-catenin forms a macromolecular complex containing the APC protein. This complex leads to the destruction of β-catenin, and intracellular levels of β-catenin are low. B, When cells are stimulated by secreted WNT molecules, the destruction complex is deactivated, β-catenin degradation does not occur, and cytoplasmic levels increase. β-catenin translocates to the nucleus, where it binds to TCF, a transcription factor that activates several genes involved in the cell cycle. C, When APC is mutated or absent, the destruction of β-catenin cannot occur. β-Catenin translocates to the nucleus and coactivates genes that promote the cell cycle, and cells behave as if they are under constant stimulation by the WNT pathway.
Figure 7-37 The role of p53 in maintaining the integrity of the genome. Activation of normal p53 by DNA-damaging agents or by hypoxia leads to cell-cycle arrest in G1 and induction of DNA repair, by transcriptional up-regulation of the cyclin-dependent kinase inhibitor p21, and the GADD45 genes, respectively. Successful repair of DNA allows cells to proceed with the cell cycle; if DNA repair fails, p53-induced activation of the BAX gene promotes apoptosis. In cells with loss or mutations of p53, DNA damage does not induce cell-cycle arrest or DNA repair, and hence genetically damaged cells proliferate, giving rise eventually to malignant neoplasms.
Figure 14-11 BCL2 expression in reactive and neoplastic follicles. BCL2 protein was detected by using an immunohistochemical technique that produces a brown stain. In reactive follicles (A), BCL2 is present in mantle zone cells but not follicular center B cells, whereas follicular lymphoma cells (B) exhibit strong BCL2 staining (Courtesy of Dr. Jeffrey Jorgenson, Department of Pathology, Brigham and Women's Hospital, Boston, MA.)
Figure 7-47 Schematic illustration of the pathways of malignancy initated by mutation of the gatekeeper genes (e.g., APC, NF-1, RB) or caretaker genes (e.g., hMSH2, BRCA-1, BRCA-2).
Florescent in-situ hybridization (FISH) showing telomeres in metaphase spreads and interphase cells.
Figure 7-31 Subcellular localization and functions of major classes of cancer-associated genes. The protooncogenes are colored red, cancer suppressor genes blue, DNA repair genes green, and genes that regulate apoptosis purple.
Figure 7-44 A-D, Schematic illustration of the sequence of events in the invasion of epithelial basement membranes by tumor cells. Tumor cells detach from each other because of reduced adhesiveness, and cells then attach to the basement membrane via the laminin receptors and secrete proteolytic enzymes, including type IV collagenase and plasminogen activator. Degradation of the basement membrane and tumor cell migration follow.
Figure 7-42 The metastatic cascade. Schematic illustration of the sequential steps involved in the hematogenous spread of a tumor.
Figure 7-45 Schematic representation of the steps required for the analysis of global gene expression by DNA microarray. RNA is extracted from tumor and normal tissue. cDNA synthesized from each preparation is labeled with fluorescent dyes (in the example shown, normal tissue cDNA is labeled with a green dye; tumor cDNA is labeled with a red dye). The array consists of a solid support in which DNA fragments from many thousands of genes are spotted. The labeled cDNAs from tumor and normal tissue are combined and hybridized to the genes contained in the array. Hybridization signals are detected using a confocal laser scanner and downloaded to a computer for analysis (red squares, expression of the gene is higher in tumor; green square, expression of the gene is higher in normal tissue; black squares, no difference in the expression of the gene between tumor and normal tissue). In the display, the horizontal rows correspond to each gene contained in the array; each vertical row corresponds to single samples.
Kaplan-Meier Analysis of the Probability That Patients Would Remain Free of Distant Metastases and the Probability of Overall Survival among All Patients (Panels A, and B, Respectively), Patients with Lymph-Node-Negative Disease (Panels C and D, Respectively), and Patients with Lymph-Node-Positive Disease (Panels E and F, Respectively), According to Whether They Had a Good-Prognosis or a Poor-Prognosis Signature
Molecular model for the evolution of colorectal cancers through the adenoma-carcinoma sequence. Although APC mutation is an early event and loss of p53 occurs late in the process of tumorigenesis, the timing for the other changes may show variations. Note also that individual tumors may not have all of the changes listed. (Adapted from Vogelstein B, Kinzler KW: Colorectal tumors. In Vogelstein B, Kinzler KW: The Genetic Basis of Human Cancer. New York, McGraw-Hill, 2002, p. 583.)
Dysplastic epithelium is in upper portion of picture. Note that the nuclei are stratified and hyperchromatic with increased numbers of mitotic figures. The epithelium in the lower portion of the picture is non-neoplastic. The nuclei are basally situated with no anaplasia.
Low power view of a polyp with dysplasia and carcinoma. The carcinoma is identified by invasion into the stalk below the level of the lamina propria.
Iowa Histopathology Series.
Figure 7-48 Experiments demonstrating the initiation and promotion phases of carcinogenesis in mice. Group 2: application of promoter repeated at twice-weekly intervals for several months. Group 3: application of promoter delayed for several months and then applied twice weekly. Group 6: promoter applied at monthly intervals.
Figure 7-49 General schema of events in chemical carcinogenesis. Note that promoters cause clonal expansion of the initiated cell, thus producing a preneoplastic clone. Further proliferation induced by the promoter or other factors causes accumulation of additional mutations and emergence of a malignant tumor.
Figure 7-51 Schema depicting the possible evolution of Epstein-Barr virus (EBV)-induced Burkitt lymphoma. The translocation involves translocation of immunoglobulin heavy-chain locus with the MYC proto-oncogene locus. Factors driving immunoglobulin secretion now drive tumor proliferation.
Figure 17-15 Helicobacter pylori. A Steiner silver stain demonstrates the numerous darkly stained Helicobacter organisms along the luminal surface of the gastric epithelial cells. Note that there is no tissue invasion by bacteria.
Chronic gastritis. Note atrophic glands on left and lymphoid follicle on right.
Figure 7-52 Tumor antigens recognized by CD8+ T cells. (Modified from Abbas AK, Lichtman AH: Cellular and Molecular Immunology, 5th ed. Philadelphia, WB Saunders, 2003.)
The strongest evidence against the immune surveillance theory also derives from the study of malignancies in immunodeficient states as outlined in this slide.
Target therapy targets
HER2-breast cancer (Herceptin)
HER1-lung cancer ( Iressa )
ERB- colon cancer ( Erbitrux)
Poorly differentiated carcinoma of breast.
Iowa Histopathology