A mixture forms when two or more substances are combined such that each substance retains its own chemical identity. Everywhere around us are made up of mixtures. We can see them in nature, along the surface of the earth, in the oceans and in the foods we eat. There are infinite numbers of mixtures that can be combined into homogeneous or heterogeneous.
This is a presentation about some of the major characteristics of microorganisms (fungi, protists and bacteria)
Acknowledgement to all internet sources of this presentation.
A mixture forms when two or more substances are combined such that each substance retains its own chemical identity. Everywhere around us are made up of mixtures. We can see them in nature, along the surface of the earth, in the oceans and in the foods we eat. There are infinite numbers of mixtures that can be combined into homogeneous or heterogeneous.
This is a presentation about some of the major characteristics of microorganisms (fungi, protists and bacteria)
Acknowledgement to all internet sources of this presentation.
Matter is seen in variety of shape, texture, sizes and colours. The matter has physical and chemical characteristics which defines its category. In this chapter we will study about characteristics of mixtures and its types, how they are different from pure substances, colloids, suspensions and solutions, separation techniques for components of mixtures and their commercial use, physical and chemical changes, metals, non metals and metalloids, elements and compounds.
I Hope You all like it very much. I wish it is beneficial for all of you and you can get enough knowledge from it. Clear and appropriate objectives, in terms of what the audience ought to feel, think, and do as a result of seeing the presentation. Objectives are realistic – and may be intermediate parts of a wider plan.
Unit 9, Lesson 3 - The Hydrosphere
Lesson Outline:
1. The Hydrosphere
2. Water or Hydrologic Cycle (Review)
3. The Earth’s Oceans
4. Water Currents
5. Aquatic Organisms
6. Water Systems
7. The Underground Water System
8. Water Pollution
Unit 9, Lesson 2 - The Lithosphere
Lesson Outline:
1. The Lithosphere
2. Rocks
3. Igneous, Sedimentary and Metamorphic Rocks
4. Minerals
5. Properties of Minerals
6. The Soil
Unit 9, Lesson 1 - Locating Places on Earthjudan1970
Unit 9, Lesson 1 - Locating Places on Earth
Lesson Outline:
1. Locating Places By Latitudes and Longitudes
2. Latitude and Longitude Distance Measurements
3. Layers of the Earth
Unit 6, Lesson 5 - Newton's Laws of Motionjudan1970
Unit 6, Lesson 5 - Newton's Laws of Motion
Lesson Outline:
1. Law of Inertia
2. Law of Acceleration
3. Law of Interaction
4. Momentum and Impulse: An Overview
Unit 6, Lesson 1 - Force
Lesson Outline:
1. Force
2. Kinds of Forces
3. Contact Forces (Ex. Friction)
4. Non-contact Forces
A. Gravity, Weight, Law of Universal Gravitation
B. Magnetic Force
C. Electrical Force
D. Magnetism and Electricity
E. Strong and Weak Nuclear Forces
F. Resultant Force
Unit 5, Lesson 5.7- Ecological Successionjudan1970
Unit 5, Lesson 5.7- Ecological Succession
Lesson Outline:
Ecological Succession
1. Primary and Secondary Succession
2. Succession from Bare Rock
3. Succession from Disturbed Vegetation
Unit 5, Lesson 5.5- Major Ecosystems and Resources in the Philippinesjudan1970
Unit 5, Lesson 5.5- Major Ecosystems and Resources in the Philippines
Lesson Outline:
1. Importance of Ecosystems
2. Major Ecosystem and Resources
3. Population Growth and Sustainable Development
Unit 4, Lesson 4.5 - Sexual Reproduction in Animalsjudan1970
Unit 4, Lesson 4.5 - Sexual Reproduction in Animals
Lesson Outline:
1. Internal and External Fertilization
2. Internal and External Development
3. Sexual Reproduction Among Some Animals
4. Sexual vs. Asexual Reproduction
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
3. Before we watch the video, copy
these questions first in your
notebook. Be sure to make spaces
for your answers. You will find the
answers on the video.
4. 1. What is a solvent?
2. What is a solute?
3. Give examples of solvent and solute?
4. Give examples of dissolvable and non-
dissolvable in water.
5. What are the factors that affect
solubility?
5.
6. ANSWER FOR 5 MINUTES IN YOUR NOTEBOOK:
1. What is a solvent?
2. What is a solute?
3. Give examples of solvent and solute.
4. Give examples of soluble and insoluble
substances in water.
5. What are the factors that affect
solubility?
7. 1. WHAT IS A SOLVENT?
The one that dissolves solute
It makes up most of the solution
Water is the universal solvent
8. 2. WHAT IS A SOLUTE?
That one that is being dissolved in
the solvent
They are less than solvents.
9. 3. GIVE EXAMPLES OF SOLVENT AND
SOLUTE.
Solvents are those that dissolves the
solutes. They usually make up most
of the volume of a solution.
(ex. Solvents- water, oil; Solutes- salt,
sugar)
10. 4. GIVE EXAMPLES OF SOLUBLE AND
INSOLUBLE SUBSTANCES IN WATER.
Miscible means soluble (ex. sugar,
salt, juice powder, milk powder, soil)
Immiscible means insoluble (ex. oil,
sand, white pepper, rubber, paper)
11. 5. WHAT ARE THE FACTORS THAT AFFECT
SOLUBILITY?
Mixing
Quantity of solvent
Temperature
Time
Pressure
Nature of solute and solvent (miscible and
immiscible)
13. SATURATED SOLUTIONS
Contains the maximum amount of solute
dissolved in a given amount of solvent
If you add more solute to the solvent, it won’t
dissolve anymore.
14. UNSATURATED SOLUTIONS
Contains less dissolved solute than a saturated
solution under given temperature and
pressure.
Solubility changes with temperature.
15.
16. SUPERSATURATED SOLUTIONS
Contains more dissolved solute
than a saturated given the same
temperature (ex. cloud seeding)
Becomes unstable, crystals form
Can be created by heating the
solution then cooling it down
23. DISCUSSION: NOTEBOOK
1. Find the percent by mass of the following
solutes:
a. 70 g of salt in 350 g solution
b. 1 kg of sugar in 2 kg solution
24. DISCUSSION: NOTEBOOK
2. Find the percent by volume of the following
solutes:
a. 250 mL oil in 750 mL of water
b. 1 L of chlorine in 1,000 L pool solution
25. ANSWERS:
1. Find the percent by mass of the following
solutes:
a. 70 g of salt in 350 g solution
70 g ÷ 350 g × 100 = 20%
b. 1 kg of sugar in 2 kg solution
1 kg ÷ 2 g × 100 = 50%
26. ANSWERS:
2. Find the percent by volume of the following
solutes:
a. 250 mL oil in 750 mL of water
250 mL ÷ (750 mL + 250 mL) × 100
250 mL ÷ 1,000 mL × 100 = 25%
Based on the formula, we divide the volume of
solvent by the volume of solution, not by the
volume of solvent.
Volume of solution = vol. of solute + vol. of solvent
27. ANSWERS:
2. Find the percent by volume of the following
solutes:
b. 1 L of chlorine in 1,000 L pool solution
1 L ÷ 1,000 L × 100 = 0.1%
28. ASSIGNMENT: NOTEBOOK
1. Find the percent by mass of the following
solutes:
a. 80 g of oil in 5600 g solution
b. 100 g of juice powder in 900 g water
29. ASSIGNMENT: NOTEBOOK
2. Find the percent by volume of the following
solutes:
a. 25 mL ice cube in 875 mL of oil
b. 500 mL of chlorine in 1,000 L pool solution