The document outlines the six main steps of the water cycle: 1) evaporation, 2) condensation, 3) precipitation, 4) surface runoff where water flows into streams and rivers and eventually back to the oceans, 5) infiltration where rainwater soaks into the ground to become groundwater or returns to the surface, and 6) transpiration where plants evaporate water through their leaves. These steps describe the continuous movement of water on, above, and below the surface of the Earth.
Hydrologic Cycle is also called as Water Cycle. It basically deals with transformation of water in different forms starting from gaseous stage (water vapor) to liquid state (water on earth's surface), and water inside soil as underground water.and again back to gaseous stage. The cycle has no starting or end.
Hydrologic Cycle is also called as Water Cycle. It basically deals with transformation of water in different forms starting from gaseous stage (water vapor) to liquid state (water on earth's surface), and water inside soil as underground water.and again back to gaseous stage. The cycle has no starting or end.
Components of Environment | Atmosphere, Hydrosphere, Lithosphere and BiosphereAdeel Abbas
In this ppt lecture, the author has explained environmental chemistry, earth environment, and its components such as Atmosphere, lithosphere, hydrosphere, and Bio or ecosphere.
Read complete articles here
https://themasterchemistry.com/earth-environment-and-its-spheres/
This topic is all about Glaciation. This includes; the causes of glaciation, the origin of glaciers, formation, primary types, movement, the erosional, transportation and depositional mechanisms. This also includes the common landforms brought by glaciers.
Water is the most precious gift of mother nature. Hydrology is the scientific study of the origin, occurrence, properties, distribution, and effects of water on the Earth’s surface, in the soil and in the underlying rocks, and also in the atmosphere. This module explain's the distribution of water in the global hydrosphere.
Erosion is when wind, water, and ice take sediments away.
Erosion on coasts by wind and water.
Water is major agent of erosion.
About 21% of all erosion in done by coastal erosion.
Components of Environment | Atmosphere, Hydrosphere, Lithosphere and BiosphereAdeel Abbas
In this ppt lecture, the author has explained environmental chemistry, earth environment, and its components such as Atmosphere, lithosphere, hydrosphere, and Bio or ecosphere.
Read complete articles here
https://themasterchemistry.com/earth-environment-and-its-spheres/
This topic is all about Glaciation. This includes; the causes of glaciation, the origin of glaciers, formation, primary types, movement, the erosional, transportation and depositional mechanisms. This also includes the common landforms brought by glaciers.
Water is the most precious gift of mother nature. Hydrology is the scientific study of the origin, occurrence, properties, distribution, and effects of water on the Earth’s surface, in the soil and in the underlying rocks, and also in the atmosphere. This module explain's the distribution of water in the global hydrosphere.
Erosion is when wind, water, and ice take sediments away.
Erosion on coasts by wind and water.
Water is major agent of erosion.
About 21% of all erosion in done by coastal erosion.
Unit 9, Lesson 1 - Locating Places on Earthjudan1970
Unit 9, Lesson 1 - Locating Places on Earth
Lesson Outline:
1. Locating Places By Latitudes and Longitudes
2. Latitude and Longitude Distance Measurements
3. Layers of the Earth
Unit 4, Lesson 4.5 - Sexual Reproduction in Animalsjudan1970
Unit 4, Lesson 4.5 - Sexual Reproduction in Animals
Lesson Outline:
1. Internal and External Fertilization
2. Internal and External Development
3. Sexual Reproduction Among Some Animals
4. Sexual vs. Asexual Reproduction
Unit 5, Lesson 5.5- Major Ecosystems and Resources in the Philippinesjudan1970
Unit 5, Lesson 5.5- Major Ecosystems and Resources in the Philippines
Lesson Outline:
1. Importance of Ecosystems
2. Major Ecosystem and Resources
3. Population Growth and Sustainable Development
Unit 5, Lesson 5.7- Ecological Successionjudan1970
Unit 5, Lesson 5.7- Ecological Succession
Lesson Outline:
Ecological Succession
1. Primary and Secondary Succession
2. Succession from Bare Rock
3. Succession from Disturbed Vegetation
Biogeochemical cycle is a pathway by which a chemical substance moves through both biotic (biosphere) and abiotic (lithosphere, atmosphere, and hydrosphere) compartments of Earth.
Description about hydrological cycle, how water lost, condense and replenish on earth. It explains the process of hydrological cycle and factors influencing hydrological cycle.
The water cycle describes the processes that drive the movement of water throughout the hydrosphere.
Nature recycles the earth's water supply through a process known as the water cycle or hydrologic cycle.
Unit 9, Lesson 2 - The Lithosphere
Lesson Outline:
1. The Lithosphere
2. Rocks
3. Igneous, Sedimentary and Metamorphic Rocks
4. Minerals
5. Properties of Minerals
6. The Soil
Unit 6, Lesson 5 - Newton's Laws of Motionjudan1970
Unit 6, Lesson 5 - Newton's Laws of Motion
Lesson Outline:
1. Law of Inertia
2. Law of Acceleration
3. Law of Interaction
4. Momentum and Impulse: An Overview
Unit 6, Lesson 1 - Force
Lesson Outline:
1. Force
2. Kinds of Forces
3. Contact Forces (Ex. Friction)
4. Non-contact Forces
A. Gravity, Weight, Law of Universal Gravitation
B. Magnetic Force
C. Electrical Force
D. Magnetism and Electricity
E. Strong and Weak Nuclear Forces
F. Resultant Force
Unit 3, Lesson 3.3 - The Cell Theory
Lesson Outline:
1. Cells and Scientists
2. The Cell Theory
3. The Modern Cell Theory
4. The Modern Interpretation of the Cell Theory (Summary)
Unit 2, Lesson 2.6 - Elements and Compoundsjudan1970
Unit 2, Lesson 2.6 - Elements and Compounds
Lesson Outline:
1. Matter: An Overview
2. Pure Substance
3. Element vs. Compound
4. Metals, Metalloids, Nonmetals
5. Law of Definite Composition
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
9. Water Cycle Steps
1. Evaporation – liquid to gas
2. Condensation – gas to liquid
3. Precipitation – water falls back to the ground either
as rain, snow, or hail
These three are the main processes of the water cycle
(Review from Lesson 5.6)
10. Water Cycle Steps
4. Surface Runoff – much of the water that return to
Earth as precipitation runs off the surface of the land,
and flows down hill into streams, rivers, ponds, and
lakes. Small streams flow into larger streams, then
into rivers, and eventually the water flows into the
ocean.
Surface runoff is an important part of the water cycle
because, through surface runoff, much of the water returns
again to the oceans, where a great deal of evaporation
occurs
(Review from Lesson 5.6)
11. Water Cycle Steps
5. Infiltration – process where rain water soaks into the
ground, through the soil and underlying rock layers,
Some of this water ultimately returns to the surface at
springs or in low spots downhill. Some of the water
remains underground and is called groundwater. As
the water infiltrates through the soil and rock layers,
many of the impurities in the water are filtered out.
This filtering process helps clean the water.
(Review from Lesson 5.6)
12. Water Cycle Steps
6. Transpiration – process where plants remove water
through its stomata in the leaves. This is the process
of evaporation in plants (also called
evapotranspiration).
(Review from Lesson 5.6)