6. The Helix-Turn-Helix Motif
• Contain two alpha helices separated by a
loop with a beta turn
• The C-terminal helix fits in major groove of
DNA; N-terminal helix stabilizes by
hydrophobic interactions with C-terminal
helix
7.
8. The Zn-Finger Motif
Zn fingers form a folded beta strand and an alpha helix
that fits into the DNA major groove.
9. The Leucine Zipper Motif
• Forms amphipathic alpha helix and a coiled-coil
dimer
• Leucine zipper proteins dimerize, either as
homo- or hetero-dimers
• The basic region is the DNA-recognition site
• Basic region is often modeled as a pair of helices
that can wrap around the major groove