Peripheral ulcerative keratitis (PUK) is a degenerative condition affecting the peripheral cornea. It is characterized by peripheral corneal thinning and ulceration that spreads circumferentially. PUK can be caused by infection, autoimmune diseases like rheumatoid arthritis, or idiopathic factors. Diagnosis involves examining for signs of peripheral epithelial defects, stromal infiltration, and thinning. Treatment depends on the underlying cause but may include topical antibiotics, steroids, or systemic immunosuppressants to reduce inflammation and prevent worsening of the condition. Prognosis depends on severity and associated systemic diseases, with mild-moderate PUK having a good prognosis generally.