This lecture was the opening lecture on the ‘Physiology of Coagulation’ at the Continuing Medical Education (CME) Grand Rounds, 2011. Organised by Kuwait Anesthesia Council, Kuwait
Platelet and coagulation post graduate lecture Monkez M Yousif
This lecture is prepared for postgraduate students in Internal medicine. It presents a physiologic and basic background of the process of homeostasis followed by a practical approach to diagnosis and brief information of different causes of bleeding disorders
Here's important & condensed ppt slides about hemostasis and its orchestrated steps and cogulation cascade, roles of endothelium,platelets and Coagulation protiens....!
Hemostasis definition, types and steps.
Hemostasis and coagulation physiology and pathology in steps and illustrated in simple way by diagrams.
Intrinsic and extrinsic pathways are mentioned in details.
Platelet function as a corner stone hemostasis in case of endothelial injury or another pathology taht affect endothelium or blood vessels.
Some pharmacological notes about drugs related to hemostasis and its clinical significance.
A detailed description of various stages in blood coagulation, clotting factors involved, the role of calcium, vitamin K, thrombin, phospholipids in blood coagulation, various tests for blood clotting, the significance of bleeding disorders in the treatment of periodontal disease and management.
This lecture was the opening lecture on the ‘Physiology of Coagulation’ at the Continuing Medical Education (CME) Grand Rounds, 2011. Organised by Kuwait Anesthesia Council, Kuwait
Platelet and coagulation post graduate lecture Monkez M Yousif
This lecture is prepared for postgraduate students in Internal medicine. It presents a physiologic and basic background of the process of homeostasis followed by a practical approach to diagnosis and brief information of different causes of bleeding disorders
Here's important & condensed ppt slides about hemostasis and its orchestrated steps and cogulation cascade, roles of endothelium,platelets and Coagulation protiens....!
Hemostasis definition, types and steps.
Hemostasis and coagulation physiology and pathology in steps and illustrated in simple way by diagrams.
Intrinsic and extrinsic pathways are mentioned in details.
Platelet function as a corner stone hemostasis in case of endothelial injury or another pathology taht affect endothelium or blood vessels.
Some pharmacological notes about drugs related to hemostasis and its clinical significance.
A detailed description of various stages in blood coagulation, clotting factors involved, the role of calcium, vitamin K, thrombin, phospholipids in blood coagulation, various tests for blood clotting, the significance of bleeding disorders in the treatment of periodontal disease and management.
Hemostasis is the maintenance of blood flow is fluid state within the vascular system, the major components of hemostasis are vascular system, platelets, coagulation factors, inhibitors of coagulation and fibrinolytic system. details are given
Hello Docs ! My name is Maharshika It's my small presentation on hemorrhagic syndromes, hemostasis and It's Disorder i hope you guys likes it. Please like it and share it and keep studying 🙂
Hemostasis is normal physiological mechanism by which blood in fluid state in vascular system normally and prevention of bleeding by Hemostasis by complex interactions of blood vessels wall, plasma proteins and platelets.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
2. HEMOSTASIS balance of the physiological processes prevent excessive bleeding after vessel injury maintain a viable circulation by keeping the blood in an uncoagulated state “Self-sealing” system to prevent excessive bleeding and potentially life threatening states
3. Four components Vessel function constriction of injured vessels Platelet function formation of platelet plugs Coagulation formation of fibrin plugs Fibrinolysis dissolution of blood clots
4. Normal Hemostasis Means stopping of blood – prevents blood loss Imbalance in one direction may lead to excessive bleeding, imbalance in the other may lead to thrombus formation
5. Overview of blood coagulation PRIMARY HEMOSTASIS SECONDARY HEMOSTASIS
6. Hemostasis Primary Hemostasis Formation of platelet plug Secondary Hemostasis Formation of blood clot response is dependent on overlapping and interdependent responses
7. Vascular Endothelium Blood vessel wall integrity is essential for prevention of blood loss – provides potent anticoagulation surface.
8. Vascular Endothelium ECs form monolayer resting on continuous basement membrane; constitutes first barrier of defense from hemostasis and thrombosis
9. EC Products Secreted into the Subendothelium LUMEN EC surface products secreted into the blood stream
10. ECs provides numerous proteins to subendothelium essential for cell–to-cell interactions and formation of diffusion barrier to prevent blood loss. Vascular Endothelium
11. EC Products Secreted into the Subendothelium ● basement membrane ● elastin ●fibronectin ● collagen III and IV ● lamilin ● mucopolysaccharides ● microfibrils ● vibronectin ● vWf ● protease inhibitors These proteins essential for cell–to-cell interactions and formation of diffusion barrier to prevent blood loss into extravascular spaces.
12. Vascular Endothelium ECs also secrete numerous substances into the vascular lumen to prevent clotting (e.g. heparin) which promote fluidity of the blood
13. Procoagulants Anticoagulants ● PGI2 ●glycosaminoglycans ● tissue factor ● EDRF ● ATIII/heparin sulfate ● vWf ● t-PA ● protein kinase/thrombomodulin ● Factor V ● urokinase ● plasminogen activators ● inhibitors (PAI-1, PAI-2 ● nitric oxide ATIII) ● IL1, TNFα ● endothelin-1 ● PAF EC surface products secreted into the blood stream These substances promote fluidity of the blood.
14. Vascular Endothelium Normal endothelium acts as a potent anti-coagulation surface, upon stimulation or injury, endothelium transforms into a potent pro-coagulation surface as subendothelial collagen is exposed
16. Primary Hemostasis response to vascular injury that produces a platelet plug at the site of damage immediately limit bleeding through the formation of a loose platelet plug
17. Platelets Minute round or oval discs (1-4 mm diameter). Do not have a nucleus and can not divide. Formed from megakaryocytes in bone morrow Normally 150-450,000 per ml of blood
18. Platelets Adhering to the endothelial wall at the site of injury Releasing potent anticoagulant compounds Aggregating to form a plug Providing a phospholipid surface for activated coagulation enzyme complexes
19. Platelets Have many functional characteristics of whole cells Contains contractile proteins (actin, myosin and thrombosthenin) Residuals of ER and Golgi apparatus Mitochondria and enzymes to form ATP and ADP Can synthesis prostaglandins (thromboxane A2) Forms fibrin stabilizing factor Forms growth factors
20. Platelets Cell membrane contains glycoproteins that reduces adherence to normal endothelium yet promotes adherence to injured areas of vessel wall, especially injured ECs and collagen of subendothelium. Membrane also contains phospholipids that play activating role at multiple points in the clotting process. Platelets have a half life of 8-12 days Eliminated from the circulation mainly by tissue macrophages, especially in spleen.
21. Platelets Endothelial cell injury exposes subendothelial collagen which causes change in platelet shape and adherence. vWf- bridges platelet membrane glycoprotein to the exposed collagen at site of injury.
23. Vasoconstriction an immediate reflex Initial response to injury diminishing blood loss Local constriction of smooth muscle
24. Vasoconstriction Transient, typically lasts minutes (severed limbs) Result of release of local humoral actors, neural reflexes (caused by pain), local myogenic spasm Small blood vessels, release of vasoconstrictor thromboxane A2 from platelets is primarily responsible
25. Platelet adhesion Exposed collagen from the damaged site will promote the platelets to adhere undergo degranulation and release cytoplasmic granules Occurs within 15 secs after injury
28. Forms a bridge between platelet glycoprotein IB and exposed collagen in the subendothelium
29. It is the “glue” that binds platelets to collagen.
30.
31. Platelet adhesion serotonin, a vasoconstrictor ADP attracts more platelets to the area thromboxane A2 promotes platelet aggregation, degranulation, and vasoconstriction
32. EM of normal and activated platelets Normal Aggregated Platelets
33. ADP and thromboxane A2 promote more platelet adhesion therefore more ADP and thromboxane “Second wave”
34. Platelet plug The positive feedback promotes the formation of a platelet plug
35. Primary platelet plug is only good for stopping bleeding in the first minute- it can not sustain hemostasis. Heparin does NOT interfere with this reaction
40. Secondary Hemostasis Cascade of enzymatic reactions that ultimately results in the conversion of fibrinogen to fibrin monomers cross-linked into insoluble strands that serve to stabilize the loose platelet clot formed in primary hemostasis
41. Secondary Hemostasis triggered by the release of tissue factor from epithelial cells Platelets, vascular wall and multiple circulating or membrane-bound coagulation factors
42. Formation of Prothrombin Activator Prothrombin activator formed in two ways: Extrinsic pathway Intrinsic pathway In both pathways, inactive forms of blood clotting factors are converted to active forms. Designated by Roman numerals, small “a” for active
43. The common pathway Vessel Injury Prothrombin Activator Complex (rate limiting step) Ca++ Note that both the Extrinsic and Intrinsic Pathways converge on Factor X
44. Characteristics of clotting reactions in the cascade A proteolytic enzyme generates the next enzyme in the cascade by cleavage of a proenzyme The reactions occur on a phospolipid surface ( platelet membrane ) Each reaction requires a helper protien to bring the enzyme and substrate together
46. Extrinsic Pathway Process begins with trauma to vascular wall initiated by tissue factor release by damaged tissue initiated by contact with Factor VII and platelets with collagen in vessel wall Clotting begins within seconds
47. Extrinsic Pathway Release of Tissue Factor (thromboplastin). Functions as a proteolytic enzyme complex Activation of Factor X. Tissue Factor further complexes with Factor VII which in the presence of Ca++ activates Factor X to Xa. Formation of Prothrombin Activator Xa combines with phospholipids and Factor V to form prothrombin activator complex In the presence of Ca++, this splits prothrombin into thrombin in the Common Pathway
48. Extrinsic Pathway Release of Tissue Factor (thromboplastin). Functions as a proteolytic enzyme complex
49. Extrinsic Pathway Activation of Factor X. Tissue Factor further complexes with Factor VII which in the presence of Ca++ activates Factor X to Xa.
50. Extrinsic Pathway Formation of Prothrombin Activator Xa combines with phospholipids and Factor V to form prothrombin activator complex
52. Intrinsic Pathway Initiated by trauma to blood or exposure of blood to vascular wall collagen Takes 1-6 minutes to cause clotting All components are “intrinsic to the circulating plasma” and NO surface is required to initiate clotting
53. Intrinsic Pathway Causes activation of Factor XII (to XIIa) and release of platelet phospholipids Activation of Factor XI by Factor XII. This reaction also requires High Molecular Weight (HMW) kininogen and is accelerated by prekallikrein.
60. Common Pathway Fibrinogen large plasma protein formed in liver Acted on by thrombin (removes 4 peptides) to form fibrin which polymerizes into fibrin fibers
61. Common Pathway Fibrin-stabilizing factor from platelets trapped in clot is activated which causes formation of covalent bonds between fibrin monomer molecules
63. INTRINSIC PATHWAY (12-11-9-8-10) XII (Hageman Factor) XIIa XI XIa + Ca ++ IXa + VIII + Ca++ + phospholipid, F3,Plt Xa Prothrombin (Factor II) Thrombin Fibrinogen Fibrin Clot XIII a EXTRINSIC PATHWAY Tissue thromboplastin + VII + Ca++ V
64.
65.
66. Feedback inhibition of cascade Tissue factor pathway inhibitor (TFPI ) Antithrombin III Protien C system